This book presents a detailed examination of the physical properties of proteins and their
associations with solvents, ligands, and each other. Incorporating observations from his
classic work on the thermodynamics of protein-protein and protein-ligand interactions, the
internationally recognized author offers a complete conceptual and quantitative description
of proteins and their associations. The book begins with an overview of basic
thermodynamic principles and goes on to describe the covalent and noncovalent binding of …

Recent studies report the application of isothermal titration calorimetry and differential
scanning calorimetry to the study of protein–ligand interactions, allosteric cooperativity and
aspects of protein folding. New methods of data analysis compare alternative methods for
determining ligand binding enthalpy and analyze potential sources of error in the
experimental measurement of other thermodynamic parameters. Several reports examine
issues concerning drug design and the correlation of thermodynamic and X-ray structural …