Izvorni kod stranice Aguti signalni peptid

{{Infobox protein-lat
|Name=Aguti signalni protein
|caption=
|image=
|width=
|HGNCid=745
|Symbol=ASIP
|AltSymbols=AGTIL
|EntrezGene=434
|OMIM=600201
|RefSeq=NM_001672
|UniProt=P42127
|PDB=
|ECnumber=
|Chromosome=20
|Arm=q
|Band=11.2
|LocusSupplementaryData=-q12
}}
'''Aguti signalni peptid''' je [[peptid]] koji sadrži 131 aminokiseline. Njegovo otkriće i opis funkcionalnih osobina su objavljeni [[1994]] u naučnom žurnalu [[Nature (magazin)|Nature]]. On deluje kao [[inverzni agonist]] na [[melanokortinski receptor|melanokortinske receptore]], specifično, [[melanokortinski 1 receptor|MC1]].<ref name="pmid7935841">{{cite journal | author = Lu D, Willard D, Patel IR, Kadwell S, Overton L, Kost T, Luther M, Chen W, Woychik RP, Wilkison WO, et al | title = Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor | journal = Nature | volume = 371 | issue = 6500 | pages = 709–802 | year = 1994 | month = October | pmid = 7935841 | pmc = | doi =10.1038/371799a0 | url = | issn = }}</ref> Njega kodira aguti gen {{Gene|ASIP}}.<ref name="pmid7937887">{{cite journal | author = Kwon HY, Bultman SJ, Löffler C, Chen WJ, Furdon PJ, Powell JG, Usala AL, Wilkison W, Hansmann I, Woychik RP | title = Molecular structure and chromosomal mapping of the human homolog of the agouti gene | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 21 | pages = 9760–4 | year = 1994 | month = October | pmid = 7937887 | pmc = 44896 | doi = 10.1073/pnas.91.21.9760| url = | issn = }}</ref><ref name="pmid7757071">{{cite journal | author = Wilson BD, Ollmann MM, Kang L, Stoffel M, Bell GI, Barsh GS | title = Structure and function of ASP, the human homolog of the mouse agouti gene | journal = Hum. Mol. Genet. | volume = 4 | issue = 2 | pages = 223–30 | year = 1995 | month = February | pmid = 7757071 | doi = 10.1093/hmg/4.2.223 | url = | issn = }}</ref>

== Funkcija ==
Kod miševa, agouti gen kodira [[parakrina signalizacija|parakrini]] signalni molekul koji stimuliše [[melanocit]]e folikula dlake da sintetišu [[melanin|feomelanin]], žuti pigment, umesto crnog ili smeđeg pigmenta, [[melanin|eumelanina]]. Pleiotropni efekti konstitutivnog izražavanja ovog gena kod miševa obuhvataju [[gojaznost]], povećanu podložnost [[tumor]]ima, i preranu neplodnost.<ref name="entrez">{{cite web | title = Entrez Gene: ASIP | url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=434 | accessdate = }}</ref>

== Povezano ==
* [[Agutiju srodni peptid]]

== Reference ==
{{reflist|2}}

== Literatura ==
{{refbegin|2}}
* {{cite journal | author = Millington GW | title = Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors | journal = Clin. Exp. Dermatol. | volume = 31 | issue = 3 | pages = 407–12 | year = 2006 | month = May | pmid = 16681590 | doi = 10.1111/j.1365-2230.2006.02128.x | url = | issn = }}
{{refend}}

== Spoljašnje veze ==
* {{MeshName|agouti+protein}}
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{{Hormoni}}
{{Neuropeptidni ligandi}}

[[Kategorija:Peptidni hormoni]]
[[Kategorija:Agonisti melanokortin receptora]]