Izvorni kod stranice Kanabinoidni receptor

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[[Datoteka:Cb1 cb2 structure.png|mini|237px|CB1 i CB2 strukture.]]
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{{Infobox protein-lat
|Name=[[Kanabinoidni receptor 1 (mozak)]]
|caption= [[Proteinska spektroskopija nuklearne magnetne rezonance|NMR]] rešenje strukture peptidnog mimetika četvrte citoplazmične petlje CB1 kanabinoidnog receptora, {{PDB|2b0y}}.
|image=WikiMedia_CB1_File.png
|HGNCid=2159
|Symbol=CNR1
|AltSymbols=CNR
|EntrezGene=1268
|OMIM=114610
|RefSeq=NM_033181
|UniProt=P21554
|PDB=
|ECnumber=
|Chromosome=6
|Arm=q
|Band=14
|LocusSupplementaryData=-q15
}}
{{Infobox protein-lat
|Name=[[Kanabinoidni receptor 2 (makrofag)]]
|caption=
|image=
|width=
|HGNCid=2160
|Symbol=CNR2
|AltSymbols=
|EntrezGene=1269
|OMIM=605051
|RefSeq=NM_001841
|UniProt=P34972
|PDB=
|ECnumber=
|Chromosome=1
|Arm=p
|Band=
|LocusSupplementaryData=
}}
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'''Kanabinoidni receptori''' su klasa [[ćelijska membrana|membranskih]] [[Receptor (biohemija)|receptora]] iz familije [[G protein spregnuti receptori|G protein-spregnutih receptora]].<ref name="pmid12432948">{{cite journal | author = Howlett AC | title = The cannabinoid receptors | journal = Prostaglandins Other Lipid Mediat. | volume = 68-69 | issue = | pages = 619–31 | year = 2002 | month = August | pmid = 12432948 | doi = 10.1016/S0090-6980(02)00060-6| url =https://archive.org/details/sim_prostaglandins-other-lipid-mediators_2002-08_68-69/page/619}}</ref><ref name="pmid18426493">{{cite journal | author = Mackie K | title = Cannabinoid receptors: where they are and what they do | journal = J. Neuroendocrinol. | volume = 20 Suppl 1 | issue = | pages = 10–4 | year = 2008 | month = May | pmid = 18426493 | doi = 10.1111/j.1365-2826.2008.01671.x | url = }}</ref><ref name="pmid19273110">{{cite journal | author = Graham ES, Ashton JC, Glass M | title = Cannabinoid receptors: a brief history and "what's hot" | journal = Front. Biosci. | volume = 14 | issue = | pages = 944–57 | year = 2009 | pmid = 19273110 | doi = | url = }}</ref> Oni su tipični G protein-spregnuti receptori, sa sedam transmembranskih domena.<ref name="pmid7556170">{{cite journal | author = Sylvaine G, Sophie M, Marchand J, Dussossoy D, Carriere D, Carayon P, Monsif B, Shire D, LE Fur G, Casellas P | title = Expression of Central and Peripheral Cannabinoid Receptors in Human Immune Tissues and Leukocyte Subpopulations | journal = Eur J Biochem. | volume = 232 | issue = 1 | pages = 54–61 | year = 1995 | pmid = 7556170 | doi = 10.1111/j.1432-1033.1995.tb20780.x| url = }}</ref> Kanabinoidne receptore aktiviraju tri glavne gurpe [[ligand (biohemija)|liganda]], [[kanabinoid|endokanabinoidi]] (koji se proizvode ut telu sisara), biljni kanabinoidi (poput [[THC]], iz biljke [[kanabis]]) i [[hemijska sinteza|sintetičkih]] kanabinoida (kao što je [[HU-210]]). Svi endokanabinoidi i biljni kanabinoidi su [[lipofilnost|lipofilni]], i.e. jedinjenja rastvorna u masti.

Poznate su dva tipa receptora. Oni se nazivaju [[kanabinoidni receptor tip 1|CB<sub>1</sub>]] i [[kanabinoidni receptor tip 2|CB<sub>2</sub>]].<ref name="pmid2165569">{{cite journal | author = Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI | title = Structure of a cannabinoid receptor and functional expression of the cloned cDNA | journal = Nature | volume = 346 | issue = 6284 | pages = 561–4 | year = 1990 | pmid = 2165569 | doi = 10.1038/346561a0 }}</ref><ref name="pmid1718258">{{cite journal | author = Gérard CM, Mollereau C, Vassart G, Parmentier M | title = Molecular cloning of a human cannabinoid receptor which is also expressed in testis | journal = Biochem. J. | volume = 279 (Pt 1) | issue = | pages = 129–34 | year = 1991 | pmid = 1718258 | doi = | issn = | url = http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=1718258 | pmc = 1151556}}</ref> CB<sub>1</sub> receptor je izražen uglavnom u [[ljudski mozak|mozgu]] ([[centralni nervni sistem|centralnom nervnom sistemu]], CNS), ali isto tako i u [[pluća|plućima]], [[jetra|jetri]] i [[bubreg|bubrezima]]. CB<sub>2</sub> receptor je prvenstveno izražen u [[imunski sistem|imunskom sistemu]] i u [[matične ćelije hematopoeze|hematopoetskim ćelijama]]<ref name="pmid21295074">{{cite journal | author = Pacher P, Mechoulam R| title = Is lipid signaling through cannabinoid 2 receptors part of a protective system? | journal = Prog Lipid Res. | in press | year = 2011 | pmid =21295074 | doi = 10.1016/j.plipres.2011.01.001 }}</ref>. Sve više dokaza sugeriše da postoje novi kanabinoidni receptori<ref name="pmid15866316">{{cite journal | author = Begg M, Pacher P, Bátkai S, Osei-Hyiaman D, Offertáler L, Mo FM, Liu J, Kunos G | title = Evidence for novel cannabinoid receptors | journal = Pharmacol. Ther. | volume = 106 | issue = 2 | pages = 133–45 | year = 2005 | pmid = 15866316 | doi = 10.1016/j.pharmthera.2004.11.005 }}</ref>, koji su izraženi u ćelijama [[endotel]]a i u CNS-u. Vezivanje nekoliko kanabinoida za [[G protein spregnuti receptori|G protein-spregnute receptore]] mozga je bilo opisano [[2007]]. godine.<ref name="pmid17876302">{{cite journal | author = Ryberg E, Larsson N, Sjögren S, Hjorth S, Hermansson NO, Leonova J, Elebring T, Nilsson K, Drmota T, Greasley PJ | title = The orphan receptor GPR55 is a novel cannabinoid receptor | url = https://archive.org/details/sim_british-journal-of-pharmacology_2007-12_152_7/page/1092 | journal = Br. J. Pharmacol. | volume = 152 | issue = 7 | pages = 1092–101 | year = 2007 | pmid = 17876302 | doi = 10.1038/sj.bjp.0707460 | pmc = 2095107 }}</ref>

Proteinske sekvence CB<sub>1</sub> i CB<sub>2</sub> receptora su oko 44% slične.<ref name="pmid7689702">{{cite journal | author = Munro S, Thomas KL, Abu-Shaar M | title = Molecular characterization of a peripheral receptor for cannabinoids | journal = Nature | volume = 365| issue = 6441 | pages = 61–65 | year = 1993 | pmid = 7689702 | doi = 10.1038/365061a0 }}</ref> Kad se samo transmembranski regioni receptora uzmu u obzir, aminokiselinska sličnost između ova dva tipa receptora je aproksimativno 68%.<ref name="pmid7556170"/> Manje varijacije ovih receptora su bile identifikovane. Kanabinoidi se vezuju reverzibilno i [[stereohemija|stereo-selektivno]] za kanabinoidne receptore. Afinitet individualnih kanabinoida za pojedini receptor određuje efekat liganda. Kanabinoidi koji su u većoj meri selektivni za pojedini receptor su poželjniji za medicinsku upotrebu.

== Literatura ==
{{reflist|2}}

== Spoljašnje veze ==
* {{MeshName|Cannabinoid+Receptors}}
* [http://www.endocannabinoid.net The Endocannabinoid System Network (ECSN) - CB<sub>1</sub> receptor] {{Webarchive|url=https://web.archive.org/web/20061107223341/http://www.endocannabinoid.net/ |date=2006-11-07 }}
* {{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1279 | title = Cannabinoid Receptors | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
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{{G protein spregnuti receptori-lat}}

[[Kategorija:G protein spregnuti receptori]]