Melatoninski receptor
| Melatoninski receptor 1A | |
|---|---|
| Identifikatori | |
| Simbol | MTNR1A |
| Entrez | 4543 |
| Hugo | 7463 |
| OMIM | 600665 |
| RefSek | NM_005958 |
| UniProt | P48039 |
| Drugi podaci | |
| Lokus | Hrom. 4 q35.1 |
| Melatoninski receptor 1B | |
|---|---|
| Identifikatori | |
| Simbol | MTNR1B |
| Entrez | 4544 |
| Hugo | 7464 |
| OMIM | 600804 |
| RefSek | NM_005959 |
| UniProt | P49286 |
| Drugi podaci | |
| Lokus | Hrom. 11 q21-q22 |
Melatoninski receptor je G protein-spregnuti receptor koji vezuje melatonin.[1]
Tri tipa melatoninskog receptora su bila klonirana. MT1 (Mel1A ili MTNR1A) i MT2 (Mel1B ili MTNR1B) receptorski tipovi su prisutni kod čoveka i drugih sisara[2], dok je dodatni melatoninski receptor tipa MT3 (Mel1C ili MTNR1C) bio identifikovan kod vodozemaca u ptica.[3]
Kod sisara su melatoninski receptori nađeni u mozgu i pojedinim perifernim organima. Međutim, postoje znatne varijacije u gustini i lokaciji izražavanja melatoninskih receptora između vrsta.[4] MT1 tip je prisutan u pars tuberalis hipofize i suprahiazmatičnom jedru hipotalamusa. MT2 tip je uglavnom prisutan u retini. MT3 tip mnogih nižih kičmenjaka je izražen u raznim delovima mozga.[3]
- ↑ Reppert SM (1997). „Melatonin receptors: molecular biology of a new family of G protein-coupled receptors”. J. Biol. Rhythms 12 (6): 528–31. DOI:10.1177/074873049701200606. PMID 9406026.
- ↑ Reppert SM, Weaver DR, Godson C (1996). „Melatonin receptors step into the light: cloning and classification of subtypes”. Trends Pharmacol. Sci. 17 (3): 100–2. DOI:10.1016/0165-6147(96)10005-5. PMID 8936344.
- ↑ 3,0 3,1 Sugden D, Davidson K, Hough KA, Teh MT (2004). „Melatonin, melatonin receptors and melanophores: a moving story”. Pigment Cell Res. 17 (5): 454–60. DOI:10.1111/j.1600-0749.2004.00185.x. PMID 15357831.
- ↑ Morgan PJ, Barrett P, Howell HE, Helliwell R (1994). „Melatonin receptors: localization, molecular pharmacology and physiological significance”. Neurochem. Int. 24 (2): 101–46. DOI:10.1016/0197-0186(94)90100-7. PMID 8161940.
- ↑ Nickelsen T, Samel A, Vejvoda M, Wenzel J, Smith B, Gerzer R. Chronobiotic effects of the melatonin agonist LY 156735 following a simulated 9h time shift: results of a placebo-controlled trial. Chronobiology International. 2002 Sep;19(5):915-36. PMID 12405554
- „Melatonin Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2014-03-07.
- MeSH Melatonin+Receptors
