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The '''E-site''' is the third and final [[binding site]] for [[transfer RNA|t-RNA]] in the [[ribosome]] during [[Translation (biology)|translation]], a part of [[protein synthesis]].<ref>{{Cite journal|last1=Chen|first1=C.|last2=Stevens|first2=B.|last3=Kaur|first3=J.|last4=Smilansky|first4=Z.|last5=Cooperman|first5=B. S.|last6=Goldman|first6=Y. E.|date=2011-10-03|title=Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis|journal=Proceedings of the National Academy of Sciences|volume=108|issue=41|pages=16980–16985|doi=10.1073/pnas.1106999108|pmid=21969541|pmc=3193197|bibcode=2011PNAS..10816980C|issn=0027-8424|doi-access=free}}</ref> The "E" stands for exit, and is accompanied by the [[P-site]] (for peptidyl) which is the second binding site, and the [[A-site]] (aminoacyl), which is the first binding site. It is involved in [[cellular processes]].<ref>{{cite journal |last1=Kirillov |first1=S.V. |last2=Makarov |first2=E.M. |last3=Semenkov |first3=Yu.P. |title=Quantitative study of interaction of deacylated tRNA with ''Escherichia coli'' ribosomes: Role of 50 S subunits in formation of the E site |journal=FEBS Letters |date=27 June 1983 |volume=157 |issue=1 |pages=91–94 |doi=10.1016/0014-5793(83)81122-3}}</ref> |
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https://youtube.com/shorts/DsincybKzDw?si=mwpl3vRkW5xnV3Mp |
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== References == |
== References == |
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{{Reflist}} |
{{Reflist}} |
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* {{Cite journal|last=Sergiev|first=Petr V.|last2=Lesnyak|first2=Dmitry V.|last3=Kiparisov|first3=Sergey V.|last4=Burakovsky|first4=Dmitry E.|last5=Leonov|first5=Andrei A.|last6=Bogdanov|first6=Alexey A.|last7=Brimacombe|first7=Richard|last8=Dontsova|first8=Olga A.|date=2005|title=Function of the ribosomal E-site: a mutagenesis study|journal=Nucleic Acids Research|volume=33|issue=18|pages=6048–6056|doi=10.1093/nar/gki910|issn=0305-1048|pmc=1266066|pmid=16243787}} |
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==Further reading== |
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* {{Cite journal|last=Chen|first=Chunlai|last2=Stevens|first2=Benjamin|last3=Kaur|first3=Jaskiran|last4=Smilansky|first4=Zeev|last5=Cooperman|first5=Barry S.|last6=Goldman|first6=Yale E.|date=2011-10-11|title=Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis|journal=Proceedings of the National Academy of Sciences|language=en|volume=108|issue=41|pages=16980–16985|doi=10.1073/pnas.1106999108|issn=0027-8424|pmid=21969541|pmc=3193197|bibcode=2011PNAS..10816980C|doi-access=free}} |
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*{{cite journal |last1=Wilson |first1=D. N. |last2=Nierhaus |first2=K. H. |title=The E-site story: the importance of maintaining two tRNAs on the ribosome during protein synthesis |journal=Cellular and Molecular Life Sciences |date=December 2006 |volume=63 |issue=23 |pages=2725–2737 |doi=10.1007/s00018-006-6125-4|pmc=11136154 }} |
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* Molecular Biology of the Gene, 7th Edition, James D. Watson, Tania A. Baker,Stephen P. Bell,Alexander Gann, Michael Levine,Richard Losick, ©2014 Pearson |
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*{{cite journal |last1=Nierhaus |first1=K |title=Decoding errors and the involvement of the E-site |journal=Biochimie |date=August 2006 |volume=88 |issue=8 |pages=1013–1019 |doi=10.1016/j.biochi.2006.02.009}} |
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[[Category:Ribosomal RNA]] |
[[Category:Ribosomal RNA]] |
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Latest revision as of 05:46, 12 August 2024
The E-site is the third and final binding site for t-RNA in the ribosome during translation, a part of protein synthesis.[1] The "E" stands for exit, and is accompanied by the P-site (for peptidyl) which is the second binding site, and the A-site (aminoacyl), which is the first binding site. It is involved in cellular processes.[2]
References
[edit]- ^ Chen, C.; Stevens, B.; Kaur, J.; Smilansky, Z.; Cooperman, B. S.; Goldman, Y. E. (2011-10-03). "Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis". Proceedings of the National Academy of Sciences. 108 (41): 16980–16985. Bibcode:2011PNAS..10816980C. doi:10.1073/pnas.1106999108. ISSN 0027-8424. PMC 3193197. PMID 21969541.
- ^ Kirillov, S.V.; Makarov, E.M.; Semenkov, Yu.P. (27 June 1983). "Quantitative study of interaction of deacylated tRNA with Escherichia coli ribosomes: Role of 50 S subunits in formation of the E site". FEBS Letters. 157 (1): 91–94. doi:10.1016/0014-5793(83)81122-3.
Further reading
[edit]- Wilson, D. N.; Nierhaus, K. H. (December 2006). "The E-site story: the importance of maintaining two tRNAs on the ribosome during protein synthesis". Cellular and Molecular Life Sciences. 63 (23): 2725–2737. doi:10.1007/s00018-006-6125-4. PMC 11136154.
- Nierhaus, K (August 2006). "Decoding errors and the involvement of the E-site". Biochimie. 88 (8): 1013–1019. doi:10.1016/j.biochi.2006.02.009.
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