#=GF ID   Colicin
#=GF AC   PF01024.24
#=GF DE   Colicin pore forming domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Bateman A
#=GF GA   23.40 23.40;
#=GF TC   24.40 26.40;
#=GF NC   23.30 20.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 81514348 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   1373773
#=GF RT   Refined structure of the pore-forming domain of colicin A at 2.4
#=GF RT   A resolution. 
#=GF RA   Parker MW, Postma JP, Pattus F, Tucker AD, Tsernoglou D; 
#=GF RL   J Mol Biol 1992;224:639-657.
#=GF DR   INTERPRO; IPR000293;
#=GF DR   SCOP; 1col; fa;
#=GF DR   HOMSTRAD; Colicin;
#=GF DR   TC; 1.C.1;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF SQ   18
#=GS A0A6M8U9Q6_9GAMM/7-207    AC A0A6M8U9Q6.1
#=GS A0A0Q4MTM7_9GAMM/75-260   AC A0A0Q4MTM7.1
#=GS B7LIA1_ECO45/437-623      AC B7LIA1.1
#=GS Q9I4Y4_PSEAE/310-494      AC Q9I4Y4.1
#=GS Q9I4Y4_PSEAE/310-494      DR PDB; 6THK A; 310-494;
#=GS A0A427K289_9GAMM/111-294  AC A0A427K289.1
#=GS A0A4P7L2K9_9GAMM/241-426  AC A0A4P7L2K9.1
#=GS A0A0Q4MWP4_9GAMM/5-184    AC A0A0Q4MWP4.1
#=GS M1SHS7_MORMO/1-116        AC M1SHS7.1
#=GS B2VE54_ERWT9/348-530      AC B2VE54.1
#=GS A0A370R0V1_9GAMM/17-108   AC A0A370R0V1.1
#=GS A0A8J3GJ04_9HYPH/175-369  AC A0A8J3GJ04.1
#=GS A4SH37_SHISS/337-518      AC A4SH37.1
#=GS A0A328TKF4_9GAMM/1-84     AC A0A328TKF4.1
#=GS A0A1C4CQI7_9ENTR/215-400  AC A0A1C4CQI7.1
#=GS A0A014PWS1_9GAMM/128-313  AC A0A014PWS1.1
#=GS A0A380QRI8_YERRU/265-451  AC A0A380QRI8.1
#=GS A0A2Z2EQH1_9CAUD/175-370  AC A0A2Z2EQH1.1
#=GS A0A8H9Z0Y0_9PSED/183-366  AC A0A8H9Z0Y0.1
A0A6M8U9Q6_9GAMM/7-207               ...........qkqAEEKASNgK.DALNKASTLVADMGEKVGAYLGQKYKFIANEIASDIknfQ...GKRIRSFNEAMKSLNK.VTQNPEMKINRNDRQAIVNAWKHINAADMANKLGNLSKAFKVADVVIKVE.KVRQKSIEGYETGNWGPLLLEVESwvvsgI.V.AGVALalfSSMVSL...FT......VagTFPATAI..MILGI-..L....SISWMASYIDEKLVDKIN--hq................................
A0A0Q4MTM7_9GAMM/75-260              kssyilsgtgnelg-------.-.------------------KLLGDKYSTIANEIAEDIknfQ...GKKIRSYDDVLKSINK.ITKNPAMVINDADKVAITNAIKSLEADDIAKNIKGISKSFAYANLAVKIE.NVRQKTIIGFENGDWGPLMLEVQSwvvggL.V.AGGALailSNFVAP...YL......A..LLLGIPL..TAVTIAgvI....IIGILASFIDDKLVDRINN-e.................................
B7LIA1_ECO45/437-623                 ...........aee-KRKQDE.L.KATKDAINFTTEFLKSVSEKYGAKAEQLAREMAGQA...K...GKKIRNVEEALKTYEK.YRADINKKINAKDRAAIAAALESVKLSDISSNLNRFSRGLGYAGKFTSLA.DWITEFGKGVRTENWRPLFVKTEA.....I.I.AGNAA...TALVAL...VF......S..ILTGSAL..GIIGYG..L....LMAVTGALIDESLVEKANK-f.................................
Q9I4Y4_PSEAE/310-494                 ..............AERKAAE.E.QALQDAIKFTADFYKEVTEKFGARTSEMARQLAEGA...R...GKNIRSSAEAIKSFEK.HKDALNKKLSLKDRQAIAKAFDSLDKQMMAKSLEKFSKGFGVVGKAIDAA.SLYQEFKISTETGDWKPFFVKIET.....L.A.AGAAA...SWLVGI...AF......A..TATATPI..GILGFA..L....VMAVTGAMIDEDLLEKANNL..................................
#=GR Q9I4Y4_PSEAE/310-494      SS    ..............HHHHHHH.H.HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH...T...T-B---HHHHHHHHHH.HHHHHHHHS-HHHHHHHHHHHHT--HHHHHHHHHHHHHHTT-------HH.HHHHHHHHHHHSS--HHHHHHHHH.....H.H.TT-BH...HHHHHH...HH......H..HHHHS--..HHHHHH..H....HHHHHHHTT-HHHHHHHHHH..................................
A0A427K289_9GAMM/111-294             .....aqinytred-------.-.--IANAVKATSDFYQEVTAKYGERASGLAQSFAEEA...K...GKTIRNMDQALAAFNN.YKNSLGVKFSAQDRNAIHSALKSMDYANMAKQLSIYNKAFGYYGKFSDLY.DITQELIKSLETDNWRPFFVKIET.....F.T.AGKVA...TAVTAF...AF......S..ILIGVPL..GIVSFA..V....IMATVGALVNDKLINKIN--ag................................
A0A4P7L2K9_9GAMM/241-426             ......kqnldnek-------.Q.NEIKDAVKFTADFYKEVTSKYGEQSAKIAKELAEAA...K...GKQIRNAEQALKSFDK.YKESLNKKFGVKDREAIAKALESLKRDEIAKNLKKFSKAFGLTSSFIDFH.DLLQELKKSIETNNWQPFFIKTES.....L.V.AGKAA...VAITAF...SF......S..IILGSPI..GALGYA..L....IIAVVGALINDELIEKANKL..................................
A0A0Q4MWP4_9GAMM/5-184               ........skspgk-------.-.---------------DISKAIENKYNEIAKEIAEDI...RnfqGKTIRSYDDAMKSLQK.IIENPSMKIKSSDKDAIVNALKGFDAKDMADKVGKLGRSFNVAGLILKVD.TVRQKFIEGIKTGNWGPLVLEVES.....W.VlSGIAS...TIALGVfsaALapwllaA..GMTTTAV..TVAGI-..I....VVAFLASLIDAKVAEKINN-e.................................
M1SHS7_MORMO/1-116                   ...........mns-------.-.------------------------------------...-...----------------.-----------EDRRAIVAALESIKSAETAKNFTKFSKGMGVLSHAINAF.DWVGELIKSVKTDNWRPFFVKTEV.....I.A.AGNAA...TVVVAF...IF......S..VLLGNPV..GLIGYG..L....IMAGTGVLIDDELAEKAN--lf................................
B2VE54_ERWT9/348-530                 ......ddekemge-------.-.--ILSAIKFTSDFYKELTEKWGEKSAEIAQELAWEA...K...GRQIRNADEALEAFEK.YKNVLNKKFSTKDQEAIGKALESLSQDEMTKNFARFSKGFGLIGSGIDAY.ETAIELKKAMDTNNWRPFYVKLET.....L.A.AGKVA...TFLTAF...AY......S..IILGTPM..GILGFA..L....IMTLVGFFVNDKFVEKIN--rk................................
A0A370R0V1_9GAMM/17-108              .......vvisviy-------.-.------------------------------------...-...----------------.-------------------------------------EAFGLVGTAIDIN.DMRVAVTKGVRTGDWNDAFRTAER.....L.A.TSGLA...SA--AV...AF......A..ALTATLM..GIVGYA..L....IMAFTSALIDDALMDRINK-f.................................
A0A8J3GJ04_9HYPH/175-369             nesqasvidttsgi-------.-.---------ITDSGKTLSGKLGDKYNTLAKEAADNIknfQ...GKKLRSFNDAMASINE.LANNPKMKLSQADKTVVSNALKQMDLSALADRFKGLEKAFTWGDRLLKAE.KIRDGVVTGVTTGDWQKLAFEVEA.....MyL.SGVAG...AVALGI...TT......A..MISTVAV..AL----..-....--------------------slpavavsaltvvsvigisiltsyidadkakaln
A4SH37_SHISS/337-518                 ........tnllns-------.-.-QIKDAVDATVSFYQTLSEKYGEKYSKMAQELADKS...K...GKKISNVNEALAAFEK.YKDVLNKKFSKADRDAIFNALEAVKYEDWAKHLDQFAKYLKITGHVSFGY.DVVSDILKIKDTGDWKPLFLTLEK.....K.A.VDAGV...SYVVVL...LF......S..VLAGTTL..GIWGIA..I....VTGILCAFIDKNKLNTINE-v.................................
A0A328TKF4_9GAMM/1-84                ...maddivnnikn-------.-.-----------------------------------F...Q...GKKICSYNDAMNSLNK.VLSNPSLKISAGDKAALSNAMAHINANDMANKLGNLSKGFRVAGWAQKV-.------------------------.....-.-.-----...------...--......-..-------..------..-....--------------------snvlen............................
A0A1C4CQI7_9ENTR/215-400             .........ykqge-----AQ.R.ADVKDAVKFTADFYKEVTAKFSEQSAKVAQELAAAA...K...GKKIRNVEQALAAFDR.FQTVLDKKYSVADREAIAKALESVNRANMASSLAKFSKGFGYVGKAIDAYdAILVELPKAIRTKNWRPFFVKVEA.....I.A.AGNAA...TALTAF...VF......S..AITGSAL..GILGFA..L....MMAIVGALVDEAFITKVNAL..................................
A0A014PWS1_9GAMM/128-313             .......trkklpp-------.D.SEIQEAIKFTTDFYSVLTDKFSERFANHARNFANKA...K...GKRLRNATDAYNAFLKnYKDKNVMKFSKSDRMAMLNALNSVEYSSMARNLKRFSVAMGYYGTIADIV.DVVGEIRTALQTNQWRSVFVKLET.....I.A.AGKVA...VVATGF...AF......S..LIIGTPI..GIIGYA..V....IMAVVGAMINDSLINEIN--ss................................
A0A380QRI8_YERRU/265-451             ...........aed--KKAQE.EnDAVKDAVKFTADFYQTVTEKYGVQSAKIAQELAEAA...K...GKQLRSVDEALKAFDN.YKDVLNKKFSVKDREAIAKALESIDRDLMAKNLAKFSKAFGLVGKAIDGV.DVVKEINNGMETGNWRPLLVKLET.....L.A.AGRGA...ASLVAF...TF......G..VMTASPL..GILGFG..L....LMVITSTLINDALIEKINK-y.................................
A0A2Z2EQH1_9CAUD/175-370             nesqasvidttsgi-------.-.---------ITDSGKTLSGKLGDKYNTLAKEAADNIknfQ...GKKLRSFNDAMASINE.LANNPKMKLSQADKTVVSNALKQMDLSALADRFKGLEKAFTWGDRLLKAE.KIRDGVVTGVTTGDWQKLAFEVEA.....MyL.SGVAG...AVALGI...TT......A..MISTVAValSLPSVA..VsaltVVAVIG--------------isiltsyidadkakalnn................
A0A8H9Z0Y0_9PSED/183-366             ..........negl-----TE.R.EAYTSAIKMTADFYKEIGAKYGAQQAAIAKELEAAS...K...GKPMKNVDQAMAAFSK.NKAILDANLSTSNREAIANALKAVDRSKAAKQLVAFGKAFGIVGITMDMY.DLLASLQTSIKTNNWRPFFVKAES.....M.L.LAKEA...GVLTAW...AF......S..IMLGTPL..GIIGYA..V....IMAAVSALVNEALVNKVVN-t.................................
#=GC SS_cons                         ..............HHHHHHH.H.HHHHHHHHHHHHHHHHHHHHH-HHHHHHHHHHHHHH...T...T-B---HHHHHHHHHH.HHHHHHHHS-HHHHHHHHHHHHT--HHHHHHHHHHHHHHTT-------HH.HHHHHHHHHHHSS--HHHHHHHHH.....H.H.TT-BH...HHHHHH...HH......H..HHHHS--..HHHHHH..H....HHHHHHHTT-HHHHHHHHHH..................................
#=GC seq_cons                        ..........p.tp............h.pA.phssDhhpplotKhGp+.splApEhApth...+...GKpIRshs-AhtuhpK.hpss.shKhStpDRpAIssALculctsshAcpLspaSKuFGlsGpslcsh.clhpclhpulcTssWpPhalclEs.....l.s.AGtuA...oshsuh...sF......u..hlhuosl..GIlGaA..l....lhAhsuuhIs-pLlpKlN....................................
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