#=GF ID   Crystall_4
#=GF AC   PF17945.6
#=GF DE   Beta/Gamma crystallin
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF00195
#=GF GA   30.00 30.00;
#=GF TC   36.90 49.10;
#=GF NC   27.20 21.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 81514348 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF WK   Crystallin
#=GF CL   CL0333
#=GF RN   [1]
#=GF RM   22483117
#=GF RT   Structural insight into the bacterial mucinase StcE essential to
#=GF RT   adhesion and immune evasion during enterohemorrhagic E. coli
#=GF RT   infection.
#=GF RA   Yu AC, Worrall LJ, Strynadka NC;
#=GF RL   Structure. 2012;20:707-717.
#=GF DR   INTERPRO; IPR040966;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the C-terminal domain found in mucin glycoproteins such
#=GF CC   as secreted protease of C1 esterase inhibitor from EHEC (StcE).
#=GF CC   This domain adopts a beta/gamma crystallin fold and has been
#=GF CC   shown to be dispensable for substrate binding. Furthermore,
#=GF CC   deletion analysis suggest that lack of the C-terminal resulted
#=GF CC   in impaired association with the cell surface [1].
#=GF SQ   52
#=GS A0A2A5T4G2_9GAMM/223-312  AC A0A2A5T4G2.1
#=GS Q9KTH2_VIBCH/126-215      AC Q9KTH2.1
#=GS A0A0A2VZ22_BEABA/387-476  AC A0A0A2VZ22.1
#=GS A0A2N6N8D0_BEABA/387-475  AC A0A2N6N8D0.1
#=GS Q1LIQ7_CUPMC/286-375      AC Q1LIQ7.1
#=GS A0A545UZH8_9HYPO/386-475  AC A0A545UZH8.1
#=GS U4KDF4_9VIBR/34-123       AC U4KDF4.1
#=GS A0A6S7C1J0_9BURK/387-476  AC A0A6S7C1J0.1
#=GS J4UQ17_BEAB2/291-380      AC J4UQ17.1
#=GS Q9KTH2_VIBCH/29-118       AC Q9KTH2.1
#=GS A0A0A2VB51_BEABA/387-475  AC A0A0A2VB51.1
#=GS A0A2N6N9P3_BEABA/291-380  AC A0A2N6N9P3.1
#=GS STCE_ECO57/807-896        AC O82882.2
#=GS STCE_ECO57/807-896        DR PDB; 3UJZ A; 807-896;
#=GS A0A0B2X0M1_METAS/387-476  AC A0A0B2X0M1.1
#=GS A0A0B6S625_BURPL/321-416  AC A0A0B6S625.1
#=GS A0A0D9P4Z6_METAN/279-368  AC A0A0D9P4Z6.1
#=GS A0A168DY11_CORFA/388-477  AC A0A168DY11.1
#=GS A0A179IQ94_CORDF/387-476  AC A0A179IQ94.1
#=GS A0A2Z6U2L8_BURVI/270-359  AC A0A2Z6U2L8.1
#=GS J4VZK5_BEAB2/291-380      AC J4VZK5.1
#=GS A0A545WBV9_9HYPO/389-477  AC A0A545WBV9.1
#=GS A0A2A5T4G2_9GAMM/127-216  AC A0A2A5T4G2.1
#=GS A0A2A5T4G2_9GAMM/319-408  AC A0A2A5T4G2.1
#=GS E9EF41_METAQ/383-472      AC E9EF41.1
#=GS A0A0A2VB51_BEABA/291-380  AC A0A0A2VB51.1
#=GS E9EF41_METAQ/287-376      AC E9EF41.1
#=GS A0A135I8A1_9GAMM/21-110   AC A0A135I8A1.1
#=GS A0A135I8A1_9GAMM/213-302  AC A0A135I8A1.1
#=GS C5AGQ3_BURGB/421-510      AC C5AGQ3.1
#=GS A0A2A5T4G2_9GAMM/31-120   AC A0A2A5T4G2.1
#=GS A0A166WM82_METRR/294-383  AC A0A166WM82.1
#=GS A0A2N6N9P3_BEABA/387-476  AC A0A2N6N9P3.1
#=GS A0A2N6N8D0_BEABA/291-380  AC A0A2N6N8D0.1
#=GS U4KDF4_9VIBR/131-220      AC U4KDF4.1
#=GS E3BMX4_9VIBR/130-218      AC E3BMX4.1
#=GS A0A0B2X0M1_METAS/291-380  AC A0A0B2X0M1.1
#=GS A0A179IQ94_CORDF/291-380  AC A0A179IQ94.1
#=GS A0A6S7C1J0_9BURK/291-380  AC A0A6S7C1J0.1
#=GS C5AGQ3_BURGB/319-414      AC C5AGQ3.1
#=GS A0A545WBV9_9HYPO/293-382  AC A0A545WBV9.1
#=GS A0A0D9P4Z6_METAN/375-464  AC A0A0D9P4Z6.1
#=GS A0A0B6S625_BURPL/423-512  AC A0A0B6S625.1
#=GS A0A135I8A1_9GAMM/117-206  AC A0A135I8A1.1
#=GS Q1LIQ7_CUPMC/382-471      AC Q1LIQ7.1
#=GS J4VZK5_BEAB2/387-476      AC J4VZK5.1
#=GS A0A0A2VZ22_BEABA/291-380  AC A0A0A2VZ22.1
#=GS A0A545UZH8_9HYPO/291-379  AC A0A545UZH8.1
#=GS A0A2Z6U2L8_BURVI/366-455  AC A0A2Z6U2L8.1
#=GS A0A168DY11_CORFA/292-381  AC A0A168DY11.1
#=GS E3BMX4_9VIBR/33-122       AC E3BMX4.1
#=GS J4UQ17_BEAB2/387-475      AC J4UQ17.1
#=GS A0A166WM82_METRR/390-479  AC A0A166WM82.1
A0A2A5T4G2_9GAMM/223-312             GCIISLESNDRFCLPVGQSS...GYALPNW...IKG.HEIYVQASQGAGVMLSN...WYDLT...DTN.VTAFAGTVNNQDLVSRRAVSGKEMDFSAPFSMKVV.
Q9KTH2_VIBCH/126-215                 ACIVSRQTGERFCLKEGERS...GYSLPAY...IYG.HEVDVEAPLGLGVMLSD...WDNLS...YNR.LAVFGGNTQNEQMRAVKAYNGETLDFSKPRSMRVV.
A0A0A2VZ22_BEABA/387-476             GCIFGLTSGRKYCLPAGQRS...GYELPGW...ISG.LDVQVQPASGAKVTLCD...WANLS...YNR.LATFDSFVQNWELKNVTAANGQMLDFSRPKSMRV-s
A0A2N6N8D0_BEABA/387-475             GCITALATVDRFCLPTGQKA...-LVLPAW...IIQ.TEVQVEAVAGAAVTLCD...FENLS...YNR.LARFTGFMQNWDLKSVTAANRAVLDFSRPRSMKV-s
Q1LIQ7_CUPMC/286-375                 GCIISLRNGAKYCLEAGQKS...DYSLPAW...IYA.HDVYVQADSGVSVVLSD...WDNLS...YHR.LAEFVGTVENDKLRGVKANNGETLDFSKPRSMEV-k
A0A545UZH8_9HYPO/386-475             GCITELTTCNKYCLPAGKEC...NF-FPSW...FDTvGGVQVEALPGAQVTLSD...FQDLS...HGH.LATFPGFVQNWELRSVKAENGQELDFSKPQSMRV-t
U4KDF4_9VIBR/34-123                  ACIVSRDTGAKYCLQAGQRS...GYSLPSY...IRG.HDVDVIAPEGLGVMLSD...WDNLS...YNR.LAVFERHTHNEAMEHVLARNGQYLDFSNPRSMRVV.
A0A6S7C1J0_9BURK/387-476             GCIVSLISAEKYCLPAEDRS...GYELPNW...IKG.HDVFVQADHGVAVMLSD...WDNLS...YSR.VATFSGVVEHEDLKHVRAQNGEDLDFSHPFSMRVI.
J4UQ17_BEAB2/291-380                 ACIVSTQTNDRYCMSPGDTA...EYALPKW...IRG.HTVRVDAGPGTAVELCD...MDNLS...YNR.VAEFVGSVENAALKAVKANNGETLDFSRPHSMRVV.
Q9KTH2_VIBCH/29-118                  GCIISRLNGEKYCLKVGERS...GYSLPSW...IYA.HPVDVQAPSGVSVMLSD...WDNLS...YNR.LAVFDRYTGNEDLKNVKAYNGAYLDFSKPRSMRVL.
A0A0A2VB51_BEABA/387-475             GCITALATVDRFCLSAGQKA...-LVLPAW...IIQ.TEVQVEAVAGAAVTLCD...FENLS...YNR.LARFTGFMQNWDLKSVTAANRAVLDFSRPRSMKV-s
A0A2N6N9P3_BEABA/291-380             GCIVNIDNDDKYCLQAGERS...PYSLPSW...IYN.KQVYVDAAPGTAVVLSD...WDNLS...YNR.LARFDGTVENDRLKAVKADNGETLDFSHPKSMRVV.
STCE_ECO57/807-896                   GCIVSVNSGKRYCLPVGQRS...GYSLPDW...IVG.QEVYVDSGAKAKVLLSD...WDNLS...YNR.IGEFVGNVNPADMKKVKAWNGQYLDFSKPRSMRVV.
#=GR STCE_ECO57/807-896        SS    EEEEETTT--EEEEETT-B-...-SS--TT...TTT.--EEEEE-TTEEEEEES...SSSS-...TT-.EEEE-SEE-GGGSSSEE-SSSSEE--SS-SEEEEE.
A0A0B2X0M1_METAS/387-476             GCITSLLSGARYCLPPGQRS...GYSLPAW...IYA.HDVQVHAAPGTAVMLSD...VENLA...YHR.FASFTGFVQNWELTKVRARNGKHVDFSRPRSMRVI.
A0A0B6S625_BURPL/321-416             ACLVNVQFGTQYCLPAGQESyngDRKWPVL...FSG.WDVRVQADDGVAVRLST...NPRLDaagIGK.SAQFFGTTDTDRLRHVKANNGEYLNFSQPNAMRV-t
A0A0D9P4Z6_METAN/279-368             GCIVSLHTKARYCMSAGTTP...VSSLPRW...IYE.HEIYVDAAPGTAVKLSD...FDNLS...YNR.IATFVGTVENNRLKSVKAANGKYLDFSRPHSMRVV.
A0A168DY11_CORFA/388-477             GCIFGLTSGDKYCLPAGQRS...GYELPAW...ISG.LDAQAQPAPGARVQLCD...WANLS...YNR.LATFDQFTQNWELRNVTAANGQVLDFSRPRSMRVL.
A0A179IQ94_CORDF/387-476             GCIVSLTSVKKYCLPAGQRS...GYSLPSW...IYA.QEVQVEAVPGAAVMLSD...SDDLS...YNR.IATFNGLVQNWELKRVKAANGEELDFSRPKSMRVL.
A0A2Z6U2L8_BURVI/270-359             GCIVSLQTAARYCLPVGQRS...GYALPSW...IYA.HDVFVDAAPGTAVMLSD...WDNLS...YNR.IATFVGTVENGGLKQVKAVNGQVLDFSRPHSMRV-e
J4VZK5_BEAB2/291-380                 GCIVNIDNDDKYCLQAGERS...PYSLPSW...IYN.KQVYVDAAPGTAVVLSD...WDNLS...YNR.LARFEGTVENDRLKAVKADNGETLDFSHPKSMRVV.
A0A545WBV9_9HYPO/389-477             GCIVSLTSVELYCLPKGKSA...GYSLPSR...IYG.HDVQAEGS-AAGVMLSD...WDNLS...YNR.IATFNKLVQNWELKKVRAVNGEVLDFSRPKSMRVV.
A0A2A5T4G2_9GAMM/127-216             GCIISLKTKDKYCLPVGKSS...DSSLPSW...IKG.HSVYVQASAGTAVMLSG...LNNLS...SDH.LATFSGTVTNDKLIAVKALNGETLNFSTPHSMRVV.
A0A2A5T4G2_9GAMM/319-408             GCIVSLETNAKYCSTVFWMG...RHKLPSW...IYE.HKISIQAAGGAAVAISE...RERLP...YQH.TVTFAGTVASKDINLIRADNYQLFDLSKPTYIEVV.
E9EF41_METAQ/383-472                 GCITSLITSARYCLPPEQQS...SDSLPPW...IYA.HDVQVEAAPGTAVILSD...SNNLS...HKR.LATFTGFIQNWELTKVRALNGEDVDFSRPKSMRVI.
A0A0A2VB51_BEABA/291-380             ACIVSTQTNDRYCMSPGDKA...EYALPEW...IRG.HTVRVDAGPGTAVELCD...MDNLS...YNR.VAKFVGSVDNSTLKAVKANNGETLDFSRPHSMRVL.
E9EF41_METAQ/287-376                 GCIVSLQTSARYCLSAGNTS...GYSLPRW...IYE.HEVYVDAAPGTAVQLSD...FDNLS...YKR.IATFVGTVENNRLKSAKAASGKYLNFSRPHSMRVV.
A0A135I8A1_9GAMM/21-110              GCIVSLQTGAEYCLPVGQRS...GYSLPSW...IYA.HEVRVQTEQGAAVMLSD...WDNLS...YNR.LAVFSGTVTNHELTNVKAYNGQHLDFSSPRSMRVV.
A0A135I8A1_9GAMM/213-302             GCIVSLETGARYCLPVGQRS...GYSLPSW...IRA.HEVYVEPSEGTAVMLSD...WDNLS...YNR.LAVFNCVTPNKQLENVRAYNGQNLDFSSPRSMRVV.
C5AGQ3_BURGB/421-510                 GCIVSLDSAQKYCLPAGQQP...VQQLPAW...IKG.QDVFVQADQGVAVRLSD...RPNFA...YNR.VATFSGTVSHDKLIKVRADNGEDLDFSRPVSMEVI.
A0A2A5T4G2_9GAMM/31-120              GCIVSLESNERYCLPVGQRS...GYSLPDW...ING.HEVYVQASEGAAVMLSD...MDNLS...YHR.LAIFSGTVTNQQLINVGAINGDRLNLSNPRSMRVV.
A0A166WM82_METRR/294-383             GCIVSMDSGARYCMTAGQKA...AYSLPAW...ING.HNVSVDAAPGTAVKLSD...FDALS...YNR.VASFVGTVGTDGLRKVRAANGQDLDFSRPKSMGV-t
A0A2N6N9P3_BEABA/387-476             GCIFGLTSGRKYCLPAGQRS...GYELPGW...ISG.LDVQVQPASGAKVTLCD...WANLS...YNR.LATFDSFVQNWELRNVTAANGQMLDFSRPKSMRV-s
A0A2N6N8D0_BEABA/291-380             ACIVSTQTNDRYCMSPGDKA...EYALPEW...IRG.HTVRVDAGPGTAVELCD...MDNLS...YNR.VAKFVGSVDNSTLKAVKANNGKTLDFSRPHSMRVL.
U4KDF4_9VIBR/131-220                 ACIVSRQTGAEYCLKAGQRS...GYSLPYY...IRG.HQVDVIAPEGLAVMLSD...WDNLS...YNR.LAVFTKDTNNEDMKNVRAYNGRYLDFSHPRSMRVL.
E3BMX4_9VIBR/130-218                 ACVISRLNGAEFCLKPEHRN..rKWFLPFY...MWG.HPVDVLAPEGLAVQLK-...-NKWS...HHRsWATVTTDTNNEDLTRVRTHHGY-ANVSRPFWMRVI.
A0A0B2X0M1_METAS/291-380             GCIVSLRTSARYCLSADQEA...EYSLPPW...IYE.HDVYVDAAPGTAVQLSD...FDNLS...YHR.IATFVGTVDNGRLKSVRAANGVLLDFSRPHSMRVV.
A0A179IQ94_CORDF/291-380             GCIVSLQTNDSYCLSAGERS...PYSLPAW...IYN.HQVYVDAAPGTAVVLSD...YDNLL...HNR.LATFVGTVENDKLKAVKAANGETIDFSYPKSMRV-q
A0A6S7C1J0_9BURK/291-380             GCIVSLRSGAKYCLKAGARS...GYSLPDW...IYS.QNVYVQADSGVSVMLSD...WDNLS...YAR.TALFYGTTENSKLKHVKADNGEYLDFSMPRSMRVV.
C5AGQ3_BURGB/319-414                 ACLVNALFGVKYCLSEGQES...YNGDGKWtvmFSG.MDLGVQADDGVAVQLSTdrrMDAVG...SGK.SAEFVGTVESSRLKHVKANDGQYRDFSRPNAMRV-r
A0A545WBV9_9HYPO/293-382             GCIVSVKTNDAYCLTVGQSS...GYSLPSW...IYD.QQVYVRADPGTAVQLSD...YDNLS...YNR.LAKFDGTVENSQLKAVKANNGQTLDFSHPHSMRVV.
A0A0D9P4Z6_METAN/375-464             GCITSLTTSASYCLPAEQQS...EGSLPSW...IYA.HDVQVEAAPGTAVILSD...SDNLP...QDR.LATFTGFVQNWDLTKVRALNGEDLDFSRPKSMRVI.
A0A0B6S625_BURPL/423-512             GCIVSLDSAQKYCLPAGQPA...VGQLPAW...IKG.QAVFVQADPGVAVRLSD...RADFA...YNR.VATFSGTVDHDKLLKVRADNGEDLDFSRPVSMEVI.
A0A135I8A1_9GAMM/117-206             GCIISLQTGDKYCLPVGKRS...GYSLPSW...IYA.HEVYVQANEGAAVMLSD...WDNLS...YNR.LAVFSGTTENRKMTNVKAYNGQYLDFSAPRSMRVV.
Q1LIQ7_CUPMC/382-471                 GCIVSLVSVDKYCLPAGERS...AYSLPAW...IYA.HDVVVQADAGIGVMLSD...WDNLS...YNR.LAVFSDVVENENMKRVQAYDGQTLDFSKPRSMRVV.
J4VZK5_BEAB2/387-476                 GCIFGLTSGRKYCLPAGQRS...GYELPGW...ISG.LDVQVQPASGAKVTLCD...WANLS...YNR.LATFDSFVQNWELKNVTAANGQMLDFSRPKSMRV-s
A0A0A2VZ22_BEABA/291-380             GCIVNIDNDDKYCLQAGERS...PYSLPSW...IYN.KQVYVDAAPGTAVVLSD...WDNLS...YNR.LARFEGTVENDRLKAVKADNGETLDFSHPKSMRVV.
A0A545UZH8_9HYPO/291-379             GCIINTATSERYCLPPGH-A...ADSLPKW...IYG.KPVYVDAAPGTAVELCD...FENLS...YGR.IARFEGTVEHENLKSVAAESGETLDFSRPHSMRV-k
A0A2Z6U2L8_BURVI/366-455             GCIVSLTSGAKDCLPAGQRS...GRALPSW...IYA.NEVQVEAAAGIAVMLSD...TDDLA...FNR.VATFTGLTQNWELKKAKAWNGEALDFSRPKSMRVV.
A0A168DY11_CORFA/292-381             GCIVKVETGDRYCLPAGERS...PYSLPKE...FWN.QQVYVDAAPGTAVTLCD...WDNLS...YNR.LATFDGTVENDRLKAVKAANGETLDFSHPKSMRVV.
E3BMX4_9VIBR/33-122                  ACIVSRDTGAKYCLEAGQSS...GYSLPSY...IYG.HEVDVIAPDGLAVQLSD...WDNLS...YNR.VATFSRHTHNKALRRVRARNGHYLDFSNPRSMRVI.
J4UQ17_BEAB2/387-475                 GCITALATVDRFCMPAGQKA...-LALPAW...IIQ.TEVQVEAVAGAAVTLCD...FENLS...YNR.LATFTGFVQNWDLKRVTAANKAVLDFSRPRSMKV-s
A0A166WM82_METRR/390-479             GCIVSLTSCARYCLPAGQGS...GYSLPSW...VKA.HEVQVEAASGTAVVLSD...FENLA...YNR.LATFDGFVQNWELKKVKAENGQDLDFSRPKSMRVV.
#=GC SS_cons                         EEEEETTT--EEEEETT-B-...-SS--TT...TTT.--EEEEE-TTEEEEEES...SSSS-...TT-.EEEE-SEE-GGGSSSEE-SSSSEE--SS-SEEEEE.
#=GC seq_cons                        GCIVSLposs+YCLssGp+S...sYuLPuW...Ihu.+-V.VpAssGsAVhLSD...aDNLS...YNR.lAsFsGsVpNpcL+pV+AtNGphLDFS+P+SMRVl.
//