#=GF ID   Reovirus_M2
#=GF AC   PF05993.17
#=GF DE   Reovirus major virion structural protein Mu-1/Mu-1C (M2)
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_5584 (release 9.0)
#=GF GA   25.00 25.00;
#=GF TC   277.30 277.10;
#=GF NC   21.40 21.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 81514348 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   1328674
#=GF RT   A carboxy-terminal fragment of protein mu 1/mu 1C is present in
#=GF RT   infectious subvirion particles of mammalian reoviruses and is
#=GF RT   proposed to have a role in penetration. 
#=GF RA   Nibert ML, Fields BN; 
#=GF RL   J Virol 1992;66:6408-6418.
#=GF DR   INTERPRO; IPR009113;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several Reovirus major virion structural
#=GF CC   protein Mu-1/Mu-1C (M2) sequences. This family is family is
#=GF CC   thought to play a role in host cell membrane penetration [1].
#=GF SQ   19
#=GS G0YZM3_9REOV/2-673      AC G0YZM3.1
#=GS D6MM24_9REOV/2-672      AC D6MM24.1
#=GS A0A0B4ULC4_9REOV/2-650  AC A0A0B4ULC4.1
#=GS MU1_REOVL/2-674         AC P11077.4
#=GS MU1_REOVL/2-674         DR PDB; 6XF8 F; 43-674;
#=GS MU1_REOVL/2-674         DR PDB; 1JMU A; 10-42;
#=GS MU1_REOVL/2-674         DR PDB; 1JMU F; 43-674;
#=GS MU1_REOVL/2-674         DR PDB; 1JMU E; 10-42;
#=GS MU1_REOVL/2-674         DR PDB; 6ZTZ K; 10-674;
#=GS MU1_REOVL/2-674         DR PDB; 6ZTY I; 10-674;
#=GS MU1_REOVL/2-674         DR PDB; 6ZTZ M; 10-674;
#=GS MU1_REOVL/2-674         DR PDB; 6ZTY J; 10-674;
#=GS MU1_REOVL/2-674         DR PDB; 6XF8 K; 43-674;
#=GS MU1_REOVL/2-674         DR PDB; 1JMU D; 43-674;
#=GS MU1_REOVL/2-674         DR PDB; 1JMU C; 10-42;
#=GS MU1_REOVL/2-674         DR PDB; 6ZTY H; 10-674;
#=GS MU1_REOVL/2-674         DR PDB; 1JMU B; 43-674;
#=GS MU1_REOVL/2-674         DR PDB; 6ZTZ L; 10-674;
#=GS A0A3G1HJT8_9REOV/2-673  AC A0A3G1HJT8.1
#=GS A0A0B5CN15_9REOV/2-674  AC A0A0B5CN15.1
#=GS U5PYM2_9REOV/2-676      AC U5PYM2.1
#=GS X5CT89_9REOV/2-675      AC X5CT89.1
#=GS A0A1B2FIA3_9REOV/2-652  AC A0A1B2FIA3.1
#=GS A0A193BJ74_9REOV/2-650  AC A0A193BJ74.1
#=GS W8PTM5_9REOV/2-673      AC W8PTM5.1
#=GS M1U8U1_9REOV/2-648      AC M1U8U1.1
#=GS VP4_AQRVC/2-647         AC Q8JU57.1
#=GS A0A1S6PCU2_9REOV/2-649  AC A0A1S6PCU2.1
#=GS H9XH59_9REOV/2-636      AC H9XH59.1
#=GS Q5IW22_9REOV/2-676      AC Q5IW22.1
#=GS VP4_AQRVG/2-649         AC B2BNE4.1
#=GS A0A0S2EGQ7_9REOV/2-658  AC A0A0S2EGQ7.1
#=GS A0A0A1ED71_9REOV/3-674  AC A0A0A1ED71.1
G0YZM3_9REOV/2-673                 g-AGSSVVQHFEVYGDGNVFSPDARQATSAVPQLDLNIGDINPGGICFTLVSgaRD.PS...SAG..ALrrlttrdvsqqa.....frdqthrisnddEFLSDN.TE.VYFAL.TEHAIEQFGKLENACEIDRAYLNANGLLTTTFQLRHYYY.THSCYVGVSAEQAAKNFVK-DAKIMSSRQLISYFSAVQNALTALAQWEVSIRQVMNLIPMTTPFGSTKCDMTSVVQFLDANLPEEHPVRYFPYEAALSISRRNGGIR--F.KD-KRGETLSNAVNAVSSAAGAPLSNALSPAYKSSIARQALNDLDVADIDVLSSSRPIASSVLARSMEPQQYNIRALPASSTMWLRQLYQ..NV..SfeVGWEN...T.E..THT.R.HYFEIK-...........FG.TKAIHLNSMGSMNVLVNYGNK--SYS.......APG..fDPDHKQVYLLLVQSKIPFEDWKRAEDIIAIL..P.L.........ASTTLHAE....EGSfY.NT......K..L---LDETALNVLFEKEL..IAE.SgdeV...NSYMLCTFV.SDQGRVGGNAITPfaDAWDANTTFFPLTLGDVSVNGTSTHRVTPSVLFGSYTPDILHSALPNEAGLIIGRRMARVAGAI--------KADDSTnpgevsvySTPITGRLILQQSR..AQNV.RGTAM.PH.HKGALFKLGSRALHMFMGRPESVMLSQTPIVRDSSVMVGLLQGARDGLRNKSISAEPKISNDSIGAMRSVQLLHQGLLNEVQTLYP-p..
D6MM24_9REOV/2-672                 .GNYSSIVQNYNIRGDGNVFRPTADQRSSAVPTLQLRPGILNPGGLAWRLLEgqTD.PT...APG..ALvqvttldyptlnv..cnannktgllpvsgQFIKNV.KE.EVIVI.EQSAICEFQKLQNAIELNRDYLSEQGILPQSANFSDYVV.YIDCYVGLSAEQASRNFLRSVPTTTRSRTTAYIT-IVQAALAQLNKWESALREVMTILPTSTSFGELECDMKSVVAYVDAVLPDDNLCRLYPEQAAAAIAMRTGAVR--W.KDTTTGDTPLQASNSITSVTQSVIGNAVPLGEKSDASIESLALVAKSNPDLVCSDRPTMGSVWSMLVPSKDYNIRAIPVLEAMWLRTTGD..KVgfD..ISWEE...K.A..FNN.T.YHIAIRT...........G-.MKALFLDEISSCVLSVDFKDK--NYT.......TPQ..fNPSGKVVSLLVLSSKLPLEQITKPDDIMGIV..E.V.........SNVTLRAA....PSS.-.-T......Q..GASVIATTSLTYVFEREVlpIDK.S...V...HSYLLCMFR.SNEPTNATNYPWF..DAWDANTTISMLTAGEVTLNGVVTDTIVPTSLIGAYTPEVLASALPNDAGEIMTARAQILAEAI-------KREDDTMvde.aspfSAPILGQLALQT--..KTIG.VGSIR.GW.DPPRWLKQASRALQMFLGNPKSILSVTTPVLKDPNVWVGLAQGVYDAISTKSMSAGWRKAADRLNAAQSVRQWKQKVLGKIQKGFP-p..
A0A0B4ULC4_9REOV/2-650             .GNVQTSTNVYNINGDNNAFTPNSEMVASASPAIDLKPGVLNPNGKLYQLEA..GS.AP...DPS..NL.............................VLAVDAsEG.DFSYL.TTNTWETLSKSALETNSWEPLFAVTMTGCGPLKLADYTV.TMSGYVGASPSDAFDGGVVEDGMFISSRRLKNFKLMLSNRCEAIAKWNTSLNQAMSLLTPDLLAGSGSCQWKSILQYMQKALPPDNEVLQYPDEFYTVAVSKYPALKPGTsPDT--PAPAAGPLGEIACVMNAASASVGLMSGSSALLTSAMDTLAAKNLDLVCAEAPLPVATFTPSLAPRDYRPAFIKDADAHWITSINP..SS..N..IRVTT...T.L..SGR.T.YTVQLGP...........GA.TKVLDMNRMVDADLLLDVSGMPINWL.......DNP...DYATAVASIVLLEARVPATEIDAAGDILGVS..V.V.........ASSPLSIV....NST.V.NV......R..GQTFLEMLHLRTTFERET..IAG.K...P...YIYGFGCLL.LLSPTTSSNTRNP..TLMDGLMTVTPILLRETTYKGEIVEEIVPSDILGNHTSEEMAVALANDAVVLMENSLKEVAEVIGNAVPIASDLDDSA........TASVVSRLAVSETSslRSRS.GNPRA.LP.DFGALWKKAKRAASLFVSNPKSVLQAGVPVLASAGVIDALTSAVGTSVRTGNIGKGVQDALSILRARNSVTKLRQGFFSKIEELWP-v..
MU1_REOVL/2-674                    .GNASSIVQTINVTGDGNVFKPSAETSSTAVPSLSLSPGMLNPGGVPWIAIGdeTS.VT...SPG..ALrrmtskdipetai..intdnssgavpsesALVPYN.DE.PLVVV.TEHAIANFTKAEMALEFNREFLDKLRVLSVSPKYSDLLT.YVDCYVGVSARQALNNFQKQVPVITPTRQTMYVD-SIQAALKALEKWEIDLRVAQTLLPTNVPIGEVSCPMQSVVKLLDDQLPDDSLIRRYPKEAAVALAKRNGGIQ--W.MDVSEGTVMNEAVNAVAASALAPSASAPPLEEKSKLTEQAMDLVTAAEPEIIASLVPVPAPVFAIPPKPADYNVRTLKIDEATW------..--..-..LRMIP...K.T..MGT.P.FQIQVTDntgtnwhlnlrGG.TRVVNLDQIAPMRFVLDLGGK--SYK.......ETS..wDPNGKKVGFIVFQSKIPFELWTAASQIGQAT..V.VnyvqlyaedSSFTAQSIiattSLA.Y.NYepeqlnK..TDPEMNY-----------..---.-...-...--YLLATFI.DSAAITPTNMTQP..DVWDALLTMSPLSAGEVTVKGAVVSEVVPAELIGSYTPESLNASLPNDAARCMIDRASKIAEAI--------KIDDDAgpdeyspnSVPIQGQLAISQ--..LETG.YGVRI.FN.PKGILSKIASRAMQAFIGDPSTIITQAAPVLSDKNNWIALAQGVKTSLRTKSLSAGVKTAVSKLSSSESIQNWTQGFLDKVSTHFPA...
#=GR MU1_REOVL/2-674         SS    .XXXXXXXX-BSSTSSS-EE--BGGG---BB------TTTCSTSSEEEEESSSSS-.TS...SGG..GEEE-BGGG-XXXXX..XXXXXXXXXXXXXXXXXXXX.--.B-EE-.-HHHHHHHHHHHHHHHTTHHHHHHTTSS-S---HGGG-E.EEEEEEESSHHHHHT-EEEEEEEE-HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHTSTS--SSSB--EEHHHHHHHHHHHS-TTSGGGT-HHHHHHHHHHH-SSEE---.-BTTTSB-----STHHHHHHTS-BSSSS-HHHHHHHHHHHHHHHHHH-HHHHT-SS-EEHHHH------EEEETTTS-TTT-SS------..--..-..EEE--...T.T..SS-.E.EEEEEEBTTS-EEEEEEETT.-EEEE-TTS-SEEEEEEBTT------.......BST..B-STTEEEEEEEEEESS-GGG-SSGGGGBSEE..E.EEEEEE-EEEESSTTEEEE--B-EE.E.EE-HHHHT-..SSTT-EE-----------..---.-...-...--EEEEEEE.BSS---TTTS-SS..-STSSEEEEEES-SS-EEETTEEESEE-HHHHTT-B-HHHHHHS-TTBHHHHHHHHHHHHHHHH--------HHH----TT---TTTHHHHHHHHHHT--..TS--.BSB--.--.-HHHHHHHHHHHHHHHHH-GGGGGBTT-STTTSHHHHHHHHHHHHHHHHT-BS---HHHHHHHHHHHHHHHHHHHHHHHHHHHHS--...
A0A3G1HJT8_9REOV/2-673             .GTASSLVQNFNIYGNGNVFRPTADQVSTAVPTLSLQPGVLNPGGLAWRRINpdVD.PT...APG..ALiqmttddiptasl..tctenasglvpvnaMYMMLK.KE.ELVVV.TDHAIDQMHKLEYAMELSRAYLNEKSILPQSTSFDSYVI.RVDCYVGASALQAARNFVRGAPLITRSRMVAYMT-AIQNAFEILSDWESDIREAMNLIPSTTPYGATTCDMQSVIKFLDENLPENSLVRLYPQQAADSIARRNGGIR--W.KDEVTGDVPSLATNTVAAATLGVINNTVPLGEKSDVTSEAMSLVTVVKPDLVTSMRPVSSSVFATTVSPKTYNIRAQPVMEALWLRTAAAgvDM..V..VGWWS..eE.H..AAT.H.YTV-IRP...........-G.TKVINLQQTGSMLITVDLVDK--DYR.......TVH..fNPDGQTVILLLLQSKIPFEQLTSPTELIGVA..Q.V.........ASVVLSAS....DSS.-.-T......E..GSAIINNTNLSYLFEREI..LRG.P...DtevNTYLLCGFR.TDSQPTKENMPWY..DAWDAKTTLTPLTTGEVTLNGAAVPFVTPMSLIGAYTPEAMQGALPNDAGILLAERAMNLAEAI--KLEDDSMADEASp......fSAPIQGVLAIQQ--..HEPG.EGVKAwLG.PFDIL-RKAARAIQVFLGNPKSVLMQGVPVVSDPNVWIAMVQGIRDGIRNKSLSVGVRTALDNLNAVQSVRTWKSDFLTKVEKYYP-p..
A0A0B5CN15_9REOV/2-674             .GNASSIVQTINVTGDGNVFKPSAETSSTAVPSLSLSPGMLNPGGVPWIAVGdeTS.VT...SPG..ALrrmtskdipetai..intdnssgavpsesALVPYI.DE.PLVVV.TEHAITNFTKAEMALEFNREFLDKMRVLSVSPKYSDLLT.YVDCYVGVSARQALNNFQKQVPVITPTRQTMYVD-SIQAALKALEKWEIDLRVAQTLLPTNVPIGEVSCPMQSVVKLLDDQLPDDSLIRRYPKEAAVALAKRNGGIQ--W.MDVSEGTVMNEAVNAVAASALAPSASAPPLEEKSKLTEQAMDLVTAAEPEIIASLVPVPAPVFAIPPKPADYNVRTLRIDEATW------..--..-..LRMIP...K.S..MNT.P.FQIQVTDntgtnwhlnlrGG.TRVVNLDQIAPMRFVLDLGGK--SYK.......ETS..wDPNGKKVGFIVFQSKIPFELWTAASQIGQAT..V.VnyvqlyaedSSFTAQSIiattSLT.Y.NYepeqlnK..TDPEMNY-----------..---.-...-...--YLLATFI.DSAAITPTNMTQP..DVWDALLTMSPLSAGEVTVKGAVVSEVVPADLIGSYTPESLNASLPNDAARCMIDRASKIAEAI--------KIDDDAgpdeyspnSVPIQGQLAISQ--..LETG.YGVRI.FN.PKGILSKIASRAMQAFIGDPSTIITQAAPVLSDKNNWIALAQGVKTSLRTKSLSAGVKTAVSKLSSSESIQNWTQGFLDKVSAHFPA...
U5PYM2_9REOV/2-676                 .GNATSVVQNFNITGDGNQFSPSAETTSSAVPSLQLSPGVLNPGGKAWTLIDptLS.AD...DPA..SLrlmttrdvpssltsttaagtgflpndgmyA--LSP.VE.TLTVM.TDHAISQFEKLQMACELDRSYLDARGVSPESVNIHNYLV.HVRCFVGVSARQASRNYCDDVPVISKSRMTMFMT-SVQNVLQVLGPWDKDVRELLTFLPSSTTAGRLNCDMRSVVKFIDDNLSDSSLCRLYPEAAASSVACRNGGIR--W.RSRDSDDAPSLAVNDVVASTTGGLANTTPLYDKSSSGEESMRLIGDAGVDIACSRAPISASVWSRTVEPRDYNIRTLRVEEALW------..--..-..LRECQ...T.M..TGF.D.VEYQLPDgttkk.hlwidRG.TKVVNLEQTGSMMFSVNVTGK--DYK.......KGS..fDPNGKHLVLLLMQSKIPFESWTSHEQIMGIA..Q.V.........ADVPVYAA....DSS.TpNRk....iI..GETSLSY-----LFERET..VTT.A...NteiNTYLLCTWQ.LDSKQSDATNAWF..DAWDAITTLTPLTSGTVTIKGASVSSVTPTDLVGAYTPEAMAAALPNDAGLILAKKAALIADAI-------KKEDDSVide.sspfSVPIQGVLTVQQ-L..ETTGvRGVRV.IH.PPSFLKKLASRAMHMFLGDPASILKQATPVLSDPAVWTGFIQGVRDGIRSKSLSAGIRSVYSHVTAAQSVQSWKQGFLSKVQTFF--kps
X5CT89_9REOV/2-675                 .GNATSVVQNFNIQGDGNHFSPSAETASSAVPSLSLNPGLLNPGGKAWTLID..PS.LD...ANDpsSLrlmttedipstla..sttpngtgflpssgMYTVSK.KE.TLSVV.TDHAIAQFEKLQMACELDREYLDARGVSPESVQFDNYIA.YISCYVGVSARQAAKNYRQNVPVISKSRMINYMT-SAQNVLQVLGPWEKDIREVLTFIPSSTPYGKISCDMKSVVAFMDEQLPEMNLCRMYPEAAAASIAKRNGGIRWKE.PD--SDDAPSLATNDVAASTMGALANTIPLSEKSNTTEESMRLVAESAIDVTCSRQPISSSVWAKTVEPKTYNIRTLKASEALWLRQSQT..QA..A..FNVEY...K.LpdGET.R.KNFRIMK...........GS.T-VINLEQTGSMMFVVNIAGK--SYA.......KGD..fDPNGKTLVLLVMQSKLPFESWTAASNINGIA..Q.V.........AEVTVYAA....DSS.I.NGs...kiI..GDTALTY-----LFERET..ITT.A...NteiNTYLLCTWQ.QD-TTTNDNDSWP..DAWDAATTLTPLTTGTVTIKGATVNEVTPVDLVGTYSPEALAAALPNDAAHILALRADKMARAIKN--EDDSVIDEASp......fSVPIQGVLAVQQKQ..TFGT.RGVRT.IH.PPSFLKKLASRAMHMFLGDPKSILKQTTPVLKDPEVWTSFVQGIRDGIRNKSLSAGIRAVYDNVTAVQSVRTWKQGFLTQVQTLF--kps
A0A1B2FIA3_9REOV/2-652             .GNYQTSNNQFWVTGDNNTFEAAGGLDSTNAASLDLKAGRTNPGGYLYVVTE..TD.VSgvvKWQ..NL.............................TPLRGM.DG.QYVVVlTAAATDAFDKMVNLIEMYRPLLDAGQQMTCYQDWKKQVV.IMDGYVGVSAQAAVNN-YVKDAVTINLTQLQNLGRMYQNMFGTIAKYDRDIQAALATIPHSTSIGGLTTDMHSLLLLYSKSLKKDNVVYLYPEAAIAVIRKISPTLRN-T.A--DDNTAVVETVNIFEPVFNGTGPEQPPLTDQSEIRSIARSDASRAQLSLITSTEPIEAKALKSGTPSKTYNLRLLDAVTTPWVSKASA..LT..K..ITRIT...V.Q..DSA.KkSWYTVVS...........KD.TTALHLDDITSMAITLDIGGESYYYK.......KADkevDPKKATLAFLYFTSTKPLEEIAVATDIQSAK..I.Vat....eklTSATSSIA....GAS.I.VS......N..TALHYNFSHKMLRSDRTE..VN-.-...-...-HYLLAQLL.FETLDQDTDYPQP..DAWAGRTTLQSLDSDKVTVKGVEVDRVIPATAFGNYTPAEQKSALPNDLHNVMSVHLERAAKAL-TAI---DDEDTEGvs....tiSNSVYGALIAAQ-S..PAPG.PMPWK.NI.KFEELREQANKAVSSFKRDPSQALVAHDPVLGDSTVMTSLLNGVGSAVKTKGLSTASKDSRSMLTAAQSGQELKQKILDKMAALFPA...
A0A193BJ74_9REOV/2-650             .GNVQTSTNVYNVNGDNNAFTPNSEMVASASPAIDLKPGVLNPNGKLYQLES..GS.AP...DPS..NL.............................VIVVDAtEG.DFSYI.TNNTWETLNKSALETNSWEPLFAVTMTGCGPLKLNDYTV.TMSGYVGASADDAFDGGVVEDGMFISSRRLKNFKLMLSNRCEAIAKWNTSLNQAMSLLTPDLLAGSGSCKWKSILQYMQATLPADNEVLQYPDEFYTVAVSKYPALKPGA.S-PNTPLPVAGPLGEIASVMNAASSSVGLMNGSSALLTSAMDTLAAKNLDLVCAEAPLPVATFAPSLVPRDYRPAFIKDADAHWITSVDP..SA..I..IRVTT...A.L..SGR.D.YTVQLGP...........GA.TKLIDMNRMVDADLLLDVSGMPINWL.......DNP...DYATAVAAIVLLEAKVPATEINVAADITGVS..V.V.........ASSPLSIV....NST.I.NV......R..GQSYLEMLHLRTTFERET..IAG.K...P...YIYGFGCLM.LLSPTTSSNTRNP..TLMDGLLTVTPILLRETTYKGEIVEEIVPSDILGNHTSEEMAVALANDAVFLMENSLKEVAEVIGSAVPIASDIDDSA........TASVVSRLAIAETIsmRARS.GNYRA.FP.DFGALWKKAKRAASLFVSNPKSVLQVGVPVLASAGVLDALTSAVGTSVRTGNIGKGVQDAVSILRARNSVTKLRQGFFSKIEELWP-v..
W8PTM5_9REOV/2-673                 .GNASSLVQNFNITGDGNSFAPTADQTSSAVPTLSLQPGILNPGGLAFKLID.pTKdPT...DPG..ALaimttedlpelai..tdtnnsagalpisgMYLDSK.PE.KLTVV.TDHALEQMRKNESAVEISRPYLSRIAVMPQSTFFTDYVVkIKGCYVGASATQASRTYVEGPYVITQSRMTTYMS-IMATASNALSKWSRAVTEVLNIIPTTTPYGKTECDMRSIIKFLDQVLPEDHLARDYPEEMAETVAKINGGIR--W.KDELTGKATSLAINDVAAPTMATLSNTMPLAEKSETTTDSLSLINDADVDLMSCDRPISSTVWARTVEPKDYNIRVLPLEASMWLRTAAL..TA..NfvVSWKS...K.E..SDA.T.NYIKIMT...........G-.ARVINLEQTGTMTFTVDLEGK--NYK.......TTS..fDPNGKTVGLVAMQSKVPFEQWTAASMVIGAT..M.V.........ASEVLVAA....QSS.-.-T......P..GASIIAKTALTYIFERET..IPL.AdteV...NTYLFCGFV.LTETPTESNYPWY..DVWDATTTLTPMTTGTVTVNGSTVNEVVPTSLIGAYTPTAMSAALPNDAGVILQGRAEKLAKAIKNEDDS-------Vade.astySMPIMGVLALQD--..AGKP.TMRAK.FD.PVGLL-KKASRAFQMFLGNPKSILDMTTPVMKDPAVWRALAQGVRDGIRNKSMGAGVKSIFDKVSATKSVQKWKQGILTQIQTLYP-p..
M1U8U1_9REOV/2-648                 .GNVQTNNTTVNINGDGNSFGAESGMRSTAAPEIMLSPGKLNPNGLAWMKVA..GS.GM...GPG..SL.............................QIVHAT.DGsPYCYI.PPDAMSSMEKSAGAVNLWEPLFAAIFETCSTVNVSDFTD.EFSAYVGVSEPEALKK-YIEKGVFMSTSQAKNFFGTLGQRMARIKGWSEDTRTAAAMIPVDTPHGSVTCDWKSLLRFWDENLPVDNVCKQYQNAVYEVALKIYPALRAGN.S----GSLLSDVVGVLAGGAAGTTASGVSMVEGVTRNEQVSRILTSADVDILTSSAPVPVSALRTPPVELSYQPSALSAKTTPWLVRYPG..TT..A..IEKTFdvgT.T..SKT.T.YYLSMGNs.........gGG.DLMIDLKRLPACGLEYSLRGIPIIYD.......TNLtaaKLAKVTPALLMLQTAKPLSAEITAADIQAITplV.V.........GTDKLNTLv..tTGF.G.NI......R..NITDFSM---SAIWEPET..VSA.A...G...NYYLWPTVIgDASMTSDWGTIST..SLANGRLRVAPLDLTHALHKGNVVESIVPSDVLGNASPEEMRSALPADVLTAFKAKLTTVASVVGRALNPNDSAHAPS........SGTVLGPLAIEN--..----.KAQSK.PK.PVSDLWIAARRGVNLFVASPSASLQTGVPVMGDSSVLTSLTGGATTALNTGDMGTPSLEATAKRAARVAGGLLRQRVMDKLARYWP-p..
VP4_AQRVC/2-647                    .GNVQTSVNTYNITGDGNSFTPTSDMTSTAAPAIDLKPGVLNPTGKLWRPVG..TS.VA...TID..SL.............................AIVSDR.FG.QYSFV.NEGMRETFSKALFDINMWQPLFQATKTGCGPIVLSSFTT.TTSGYVGATAGDALDN-PVTNGVFISTVQVMNLQRTIAARMRDVALWQQHLDTAMTMLTPDISAGSASCNWKSLLAFAKDILPLDNLCLTYPNEFYNVAIHRYPALKPGN.PDTKLPDAQAHPLGEVAGAFNAATSEVGSLVGSSSTLSQAISTMAGKDLDLIEADTPLPVSVFTPSLAPRSYRPAFIKPEDAKWIAEFNN..SS..L..IRKTL...T.Y..SGA.T.YAVQLGP...........GP.TRVIDMNAMIDSVLTLDVSGTILPYD.......TNP...DLSTSVPAFVLIQTSVPIQQVTTAANITAIT..V.V.........SAAGASAI....NLA.I.NV......R..GQPRFNMLHLQATFERET..ITG.I...P...YIYGLGTFL.IPSPTSSSNFSNP..TLMDGLLTVTPVLLRETTYKGEVVDAIVPATVMANQTSEEVASALANDAIVLVSNHLNKLANVVGDAIPVASKTDDSA........TSAIVSRLAVQHKL..SQVG.QTSPT.PP.DYPLLWRRAKRAASMFVSNPSLALQVGIPVLTQSGMLSALTSGVGTALRTGSLGKGVTDASEKLRARQSLTVAKQAFFDQIGSLWPG...
A0A1S6PCU2_9REOV/2-649             .GNVQTSTSVYNINGDGNSFAPTSEMVASASPAIDLKPGVLNPNGKLYVLSG..SS.AP...SPD..NL.............................VLYVTQ.KG.DYSYI.VTNTHDTLSKAALESNSWEPLFTVTRTGCGPLQLSDYTS.HHSGYVGANADDAFANGPVDEGEFISSTDLKNFKTTLANRMQSVAEWSQYLDQAMSLLTPDIMAGTAGCKWKSVLEFLTSILPLDNLVLTYPNEFYTVAVGKYPALKPGT.TPS-SPPPSAGPLGEIASVMNAASSSVGLMNGSSAVLAAAMDKIAAKNLDLISSDSPLPVATFTPSLAPRSYRPAFIKQDDAHWISVMNP..TA..I..IRVKT...E.V..SAA.H.YTVQIGP...........GP.TKMLDMNRMIDSTLLLDISGAHIDFM.......DNP...DYSSAVPAIVLLETRVPYDEVQLAADIVGVS..A.I.........AAASLAVI....NMN.V.NV......R..GKSFIEMQHLQATFERET..IVG.K...P...YVYGFGCLL.LASATASSNFKNP..TLMDGELTVTPILLRETTYKGDVVDSIIPSDIMGNQTTEELAVALANDAVVLMENNLSEIAKVIGDVVPVASDVNEAA........TSAVVSRLAIAETMsvRARS.GNPRA.FP.DFSALWSKAKRAASLFVSNPKAVLQAGVPILASSGVIDAMTSAIGTTVRTGSIGKGVQDAVSVLRARNSITRLRQGFFKKVEELWP-v..
H9XH59_9REOV/2-636                 .GNAQTSVTNVTVNGDGNVIRPSAEFQATAAPSFDLNPGVLNPNGNLYIEQPdmDA.TV...TAQ..SL.............................VLLHDK.TGsPYAYV.ADNTRETLDKIVNYIANFQPLLEASGLTCPPRMISFYCE.RMSGYVGTSAITAINN-PVEDGEFITQAKMAQFRKQLGLFYDKVKDWHVDLKMAQAMLPLNVPTGTYQLEFTSYRDFMTEYLPESNICKLYPDEALEVAANLIPAIRTGL.T-KEI--SDVNSTGLIAGAIMAPQEGGGSLTDGSNTGTSLLQDVASMNANVITASSTIPVSSLNVIPEPKSFSYDSLAPDEVYWIQQV-P..SV..Q..VRFSV...D.V..ETV.T.YYMGFEP...........AQvNTVIDLRECSSASFVFDLTGT----Q.......FAA...DYPTSKLGLLMIRLTDSITAVTPSTEIKANV..LeI.........SDATIQQR....S-R.K.AV......S..GLSQLATTVLTYTYEREV..LPNdD...A...YYYLVPCTM.QPTAYTA--LNYP..CSVGGTLTVTPIDNTEVTVNGIMVDSIIPSELIGSQTEEEQMTCLPNEAAELLKHKVQICAGTIAKMDPSGVSEDTPA........VAAVAGILALQN--..----.ETRAV.RL.DIKSLFSKARRAINMLVGRPSTVLGLAKPVISDPNVWMQIATGVAEAVASGNVNSAMRDSARRLAALRSVSGAKGKLLSLVAQRFP-p..
Q5IW22_9REOV/2-676                 .GNATSVVQNFNIQGDGNHFAPSAETTSSAVPSLSLNPGLLNPGGKAWVLID..SS.LN...ASDpsSLrlmtsadlstlsq..saignstgflptsgMYAVTA.KE.TLSVI.TEHAISQFDKLQMACELDRDYLDARGVSPESVNIHNYIV.YVDCFVGVSARQAASNFRQHVPVITKSRMTQFMT-SAQNVLQVLGPWERDVRELLTILPTSTTAGKITCDMRSVVTFIDDQLSDTSLCRMYPECAAAAVARRNGGIRWKT.PETDEAP--SLATNDIAASTMGALANTTPLAEKSDSGEESMRLVNDVGVDIVCSRAPISSSVWSRTVEPRSYNIRTLRVEEALWLRECQA..TTgfD..VQYTL...P.D..QAT.H.KHFWLQK...........GS.-VVINLEQTGSMMFDVNIAGK--DYK.......KGT..fNPDNRKLVLLVMQSKIPFESWTVASQITGIA..Q.V.........AEVTVHAA...dSST.P.NQ......KiiGETSLSY-----LFERET..VTT.S...DteiNTYLLCTWQ.LDDKQSNDANVWP..DAWDGITTLTPLTSGTVTIKGTSVDSVVPSDLVGAYTPESLAAALPNDAGLILANKATKLADAI-------KKEDDSVvde.sspfSTPIQGVLAVQQ-L..DTVGtRGARA.LQ.PPSILKRIASRALHMFLGDPRSILKQAIPVLRDPDVWTGFVQGVRDGIRTKSLSAGVRSVYNNVTATQSVQTWKQGFLTKIQMLF--kps
VP4_AQRVG/2-649                    .GNVQTSTNVYNIDGNGNTFAPSSQMASTASPAIDLKPGVLNPTGKLWQTMG..TG.AP...SAD..SL.............................VLVVDN.KG.EYTYL.SENMRETLNKAVTDVNMWQPLFQATKSGCGPVVLANFTT.ISTGYVGATADDAFSNGLVSNGPFLATMHIMELQKTIAARMRDVAIWQKHLDTAMTLMTPDVSAGDVTCKWRSLLEFAQDILPLDNLCRSYPNEFYTVAAQRYPAIRPGQ.PDTQVALPQPHPLGEVAGSFNAPTSEVGSLVGAGAALSDAISTLASKDLDLVEADTPLPVSVFTPSLAPRTYRPAFIDPQDAAWIAQWNG..DA..N..IRIIT...T.Y..QST.D.YTVQLGP...........GP.TRVIDMNAMIDAKLTLDVSGTILPFQ.......ENN...DLSSAIPAFVLIQTKVPLHSVTQASDVEGIT..V.V.........SAAESSAI....NLS.V.NV......R..GDPRFDMLHLHAMFERET..IAG.I...P...YIYGIGTFL.IPSITSSSSFCNP..TLMDGELTVTPLLLRETTYKGAVVDTVTPSEVMANQTSEEVASALANDAVLLVSGQLERLATVVGDVIPIASGEDDAA........TSAIVGRLAIEATM.rARHG.GDTRA.LP.NFGQLWKRAKRAASMFASNPALALQVGVPVLADSGILSALTSGVSTAIRTGSLGKGVSDASSKLNARQSLTLARKTFFKKVEELWPS...
A0A0S2EGQ7_9REOV/2-658             .GNYQTSNNQFWVTGDGNDFSAEGGLDSTNAASLDFKAGKTNPGGHMYVISGdnTSdVV...KWD..SL.............................TPLYGI.DG.QMVVVlTAVAMSTFEKMVNLIEMYRPLLEASQQMACYRDWKKDIV.LLDGYVGSTPQSAVTNF-VTGASVINLRELRSLGKMYQNILGVIANYDRDIQVALSLIPHSTPIGSLSADMHSILRMFSLSLKPTNVCYLYPEAALQVIRAISPTVR--N.VDTQQGGSIVETLNLFEPVFNGTGPNQPPLTDQSEVRAIARSDASLAQLSLISSTEPIEARALKSGTPTKTYDIRLVDPLTTPWVSKASAlaEK..T..ARIQF...T.D..SGRkT.WYTAVGK...........G-.TLALHLDDITSMSITMDLGGESYYYKtlannaaETV...DPESATVAFILFSVTRPLEEITTASELQTGK..I.V.........-AFEKLMV....AN-.S.SV......Q..GAKIIANTSLKYNFDHNS..ISG.D...KselNHYLLCQLL.FNNLSASTTYTQQ..DAWAGKTTMQSLDSDKVTVKGVEVDRVIPAGAFGNYTTAEQKSSLPNDLHSVMATHLERAAKAM-TAID---DEDQEGgs....tiANAIFGALISKE--..SPVA.GPIPW.KNiKFDELRVLSDKAASSFKRDPSQALISHDPVLGDSAVMTSLLGGIGNAVKTKGLSAACKDTKSALTAAQSGRSVRQTILDKIEKLFP-p..
A0A0A1ED71_9REOV/3-674             .GNATSIVQNFNIKGDGNTFSPSAETASSAVPSLSLNPGLLNPGGKAWTLIDptVP.AT...APG..SLrlmttedfpaalgt.silgsngaapssgmYLVP-V.KE.TLNVV.TEHAIAQFEKLQSAYELDRDYLDAKGVAPESVSFKNYLS.HVDCYVGVSARQAATNFQKNVPVITKS-KMMSFMTSAQNILSLLGPWEKSVREVLTMLPSSTPYGTLKCDMKAIVAMLEEQLPEDNLCRLYPQAAACSIARRNGGVR--W.KEPTSDEAPSMATNDVAASTMGALANTTPLAEKSNTTEESMRLVAESSVDLICSRRPISASVWARTVEPKSYNIRTLKVSEALWLRQSQV..TT..G..FDVAY...TlT..DST.K.KHFWITK...........G-.TTVINLEQTGSMMFEVNIEGK--DYK.......KGS..fDPNGSTLVLLVMQSRLPFETWTVASQIEGIA..Q.V.........ASIVVTAG...sGST.V.NTs....iI..GSTSLSY-----LFERET..ITT.S...NtevNTYLLCTWQ.SPTECVDAN-SWP..DAWDAITTLTPLTTGTVTVKGSTVEKVTPVDLIGSYTPESLTAALPNDAGNILALRAETLAKAVKNE--DDSVTDESSp......fSAPIQGILALQQKE..TEGT.AGSPD.PK.PPGTLQKIASRAMHMFLGDPKSVLKQTTPVLKDPQVWTSFVQGVRDGIRNKSLSAGVRSIVDNLSAVQSVKEWKQNVLGKIQKLF--kp.
#=GC SS_cons                       .XXXXXXXX-BSSTSSS-EE--BGGG---BB------TTTCSTSSEEEEESSSSS-.TS...SGG..GEEE-BGGG-XXXXX..XXXXXXXXXXXXXXXXXXXX.--.B-EE-.-HHHHHHHHHHHHHHHTTHHHHHHTTSS-S---HGGG-E.EEEEEEESSHHHHHT-EEEEEEEE-HHHHHHHHH-HHHHHHHHHHHHHHHHHHHHHTSTS--SSSB--EEHHHHHHHHHHHS-TTSGGGT-HHHHHHHHHHH-SSEE---.-BTTTSB-----STHHHHHHTS-BSSSS-HHHHHHHHHHHHHHHHHH-HHHHT-SS-EEHHHH------EEEETTTS-TTT-SS------..--..-..EEE--...T.T..SS-.E.EEEEEEBTTS-EEEEEEETT.-EEEE-TTS-SEEEEEEBTT------.......BST..B-STTEEEEEEEEEESS-GGG-SSGGGGBSEE..E.EEEEEE-EEEESSTTEEEE--B-EE.E.EE-HHHHT-..SSTT-EE-----------..---.-...-...--EEEEEEE.BSS---TTTS-SS..-STSSEEEEEES-SS-EEETTEEESEE-HHHHTT-B-HHHHHHS-TTBHHHHHHHHHHHHHHHH--------HHH----TT---TTTHHHHHHHHHHT--..TS--.BSB--.--.-HHHHHHHHHHHHHHHHH-GGGGGBTT-STTTSHHHHHHHHHHHHHHHHT-BS---HHHHHHHHHHHHHHHHHHHHHHHHHHHHS--...
#=GC seq_cons                      .GNsposVpsaNIsGDGNsFsPou-hsSoAsPoLsLpPGlLNPGGhhahlls..su.ss...sss..uL.............................hhlsst.ct.shssl.T-pAhsphpKhthshEh.RshLssptshssshphssYhs.hhssYVGsSAppAhsNhhhpssshhsoRpht.hp.slpsthpslupWcpclcpAhollPsssshGshoC-M+SllpahccpLPcDNLs+hYPcpAhsslup+ssulR..h.h-.ppsss.utslNplAuuh.ushussssLs-pSsssppuhshlussslDllsSppPlsuoVasholtP+sYslRslcsp-AhWlpphts..ss..t..lchph...s.h..sus.s.aphplss...........Gs.T+VlsLcphsshthslDluGc..sYp.......css..hDPsspslulllhQo+lPhEphTsAupItuls..h.V.........uusslpuh....suo.h.Ns......p..Gps.lsh..hphhFEREo..lss.t...s....hYLLssah..sshsossNhs.P..DsWDuhhTlTPLssscVTlKGssV-pVlPu-llGsYTPEphsuALPNDAshlhts+hpclAcAI.p.....pctD-su........SssIhGhLAlpp....tthu.tsstt.h..shuhLh+hAsRAhphFlusPpolLptusPVLuDssVhsuLspGVtsulRTKSlusGl+suhspLsAtpSlpph+QshLsKlppLaP....
//