#=GF ID SEEK1
#=GF AC PF15357.11
#=GF DE Psoriasis susceptibility 1 candidate 1
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE Jackhmmer:Q9UIG5
#=GF GA 27.00 27.00;
#=GF TC 37.40 37.70;
#=GF NC 26.30 25.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 81514348 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22896740
#=GF RT Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic
#=GF RT sclerosis risk factors in a large independent replication study.
#=GF RA Bossini-Castillo L, Martin JE, Broen J, Simeon CP, Beretta L,
#=GF RA Gorlova OY, Vonk MC, Ortego-Centeno N, Espinosa G, Carreira P,
#=GF RA Garcia de la Pena P, Oreiro N, Roman-Ivorra JA, Castillo MJ,
#=GF RA Gonzalez-Gay MA, Saez-Comet L, Castellvi I, Schuerwegh AJ,
#=GF RA Voskuyl AE, Hoffmann-Vold AM, Hesselstrand R, Nordin A, Lunardi
#=GF RA C, Scorza R, van Laar JM, Shiels PG, Herrick A, Worthington J,
#=GF RA Fonseca C, Denton C, Tan FK, Arnett FC, Assassi S, Koeleman BP,
#=GF RA Mayes MD, Radstake TR, Martin J;
#=GF RL Ann Rheum Dis. 2012; [Epub ahead of print]
#=GF DR INTERPRO; IPR028206;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family is considered a candidate for susceptibility to
#=GF CC psoriasis.
#=GF SQ 27
#=GS Q2M3K9_HUMAN/1-89 AC Q2M3K9.1
#=GS G1R141_NOMLE/2-150 AC G1R141.2
#=GS A0A2K5N5I8_CERAT/1-90 AC A0A2K5N5I8.1
#=GS A0A1W2PNR1_HUMAN/3-151 AC A0A1W2PNR1.1
#=GS A0A2K5CL59_AOTNA/1-77 AC A0A2K5CL59.1
#=GS A0A2K5CL13_AOTNA/3-127 AC A0A2K5CL13.1
#=GS A0A8D2EU60_THEGE/4-139 AC A0A8D2EU60.1
#=GS A0A2K6N1Q1_RHIBE/1-95 AC A0A2K6N1Q1.1
#=GS A0A2K5S9S9_CEBIM/32-88 AC A0A2K5S9S9.1
#=GS A0A2R9CKE6_PANPA/4-152 AC A0A2R9CKE6.1
#=GS G3R6E7_GORGO/4-151 AC G3R6E7.1
#=GS A0A2K5S9R3_CEBIM/66-121 AC A0A2K5S9R3.1
#=GS A0A2R9CHM6_PANPA/1-104 AC A0A2R9CHM6.1
#=GS H2PKZ5_PONAB/4-152 AC H2PKZ5.2
#=GS PS1C1_HUMAN/4-152 AC Q9UIG5.2
#=GS A0A2K5KGD1_COLAP/1-80 AC A0A2K5KGD1.1
#=GS A0A2K5S9R3_CEBIM/3-62 AC A0A2K5S9R3.1
#=GS A0A8I5TLQ9_PONAB/3-146 AC A0A8I5TLQ9.1
#=GS A0A0C4DGJ2_HUMAN/1-104 AC A0A0C4DGJ2.1
#=GS A0A2K5Z4T0_MANLE/4-131 AC A0A2K5Z4T0.1
#=GS A0A6J3HA11_SAPAP/1-94 AC A0A6J3HA11.1
#=GS A0A5F4W1G7_CALJA/4-143 AC A0A5F4W1G7.2
#=GS H2RD73_PANTR/4-152 AC H2RD73.2
#=GS A0A140T8W9_HUMAN/4-55 AC A0A140T8W9.1
#=GS A0A1W2PRX9_HUMAN/3-151 AC A0A1W2PRX9.1
#=GS PS1C1_PANTR/4-152 AC Q7YR46.1
#=GS A0A1W2PQG0_HUMAN/3-150 AC A0A1W2PQG0.1
Q2M3K9_HUMAN/1-89 ............--------------.---..-.------------------------------------------MISKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRTLAPTLLYSSPPSHSPFGLSSLI......
G1R141_NOMLE/2-150 ............TYQKSHSQRALCTQ.TPA..L.QGPQLLNTDPSSEETCPPTLILTDFATLEPANHFWHAGDLQAMTSKEFHLAATQDDCRKVKTQEDILVPSSHPELFTSALPMAPEEAARLQRTQPLPPPSGIHLSPSRTPPPTLLYSPPPSHSPFGLSSLI......
A0A2K5N5I8_CERAT/1-90 ............--------------.---..-.---------------------------MEPANHFWHAGDLQAMTSKKFHLGVIQDDCRRGRTQEDILVPSSHPEL--------------LQQPQPLPPPSGIHLSTSKGLGSNSIVSSPPSHSPFGLSSLI......
A0A1W2PNR1_HUMAN/3-151 ............TDQKSHSQRALGTQ.TPA..L.QGPQLLNTDPSSKETRPPHVNPDRLCHMEPANHFWHAGDLQAMISKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRTLAPTLLYSSPPSHSPFGLSSLI......
A0A2K5CL59_AOTNA/1-77 ..........mi--------------.---..-.------------------------------SNHFWHAGDLQAVTSEEFHP------------GKDILVPSPHPEL--------------LQQPQPLPPPSGILLSASRASAPTLLCSPPPSHFPSSLSSLV......
A0A2K5CL13_AOTNA/3-127 ...........c-NQKSQSQRALHTY.NTYkyLtDLKMLLNTDPSSEETDPPHINPDPFHHMDM-SFFRHAGDLQAVTSEEFHP------------GKDILVPSPHPEL--------------LQQPQPLPPPSGILLSASRASAPTLLCSPPPSHFPSSLSSLV......
A0A8D2EU60_THEGE/4-139 ............TDQKSQSTTQSGLHlGPG..A.HRPQLLHTNPSSEETRPPRINPDRLCHMEPANHFWHAGDLQAMTSKKFHLGVIQDDCRRGRTQEDILVPSSHPEL--------------LQQPQPLPPPSGIHLSTSKGLGSNSIVSSPPSHSPFGLSSLI......
A0A2K6N1Q1_RHIBE/1-95 ............--------------.---..-.---------------------------MEPANHFWHAGDLQAMTSKKFHLGVIQDDCRRGRTQEDILVLSSHPELF---------EAARLQQPQPLPPPSGIHLSASKGLGSNSIVSSPPSHSPFGLSSLI......
A0A2K5S9S9_CEBIM/32-88 gplsppravcig--------------.---..-.--------------------------------------------------------------------------------------PARLQQPQPLPPPSGILLSASRASAPTLLCSPPPSHFPFSLSSLV......
A0A2R9CKE6_PANPA/4-152 ............TDQKSHSQRALGTQ.TPA..L.QGPQLLNTDPSSEETRPPHVYPDRLCHMEPANHFWHAGDLQAMTSKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMALEEAARLQQPQPLPPPSGIHLSASRTSAPTLLYSPPPSHSPFGLSSLI......
G3R6E7_GORGO/4-151 ............TDQKSHSQRALGTQ.TPA..L.QGPQLLNTDPSSEETRPP-VNPDRLCHMEPANHFWHAGDLQAMTSKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRTSAPTLLYSPPPSHSPFGLSSLI......
A0A2K5S9R3_CEBIM/66-121 .plsppravcig--------------.---..-.--------------------------------------------------------------------------------------PARLQQPQPLPPPSGILLSASRASAPTLLCSPPPSHFPFSLSSLV......
A0A2R9CHM6_PANPA/1-104 ............--------------.---..-.---------------------------MEPANHFWHAGDLQAMTSKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMALEEAARLQQPQPLPPPSGIHLSASRTSAPTLLYSPPPSHSPFGLSSLI......
H2PKZ5_PONAB/4-152 ...........p-DQKSHSQRALCTQ.TPA..L.QGPQLLNTDPSSEETRPPHINPDRLCHMEPANHFWHAGDLQAMTSKEFHLAATQDDCRRRRTQEDILVPSSHPELFASVLPMALEEAARLQQPQPLPPPSGIHLSASRTSAPTLLYLPPPSHSPFGLSSLI......
PS1C1_HUMAN/4-152 ............TDQKSHSQRALGTQ.TPA..L.QGPQLLNTDPSSEETRPPHVNPDRLCHMEPANHFWHAGDLQAMISKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRTLAPTLLYSSPPSHSPFGLSSLI......
A0A2K5KGD1_COLAP/1-80 ............--------------.---..-.------------------------------------------MTSKKFHLGVIQDDCRRGRTQEDILVPSSHPELF---------EAARLQQPQPLPPPSGIHLSASKGLGSNSIVLSPPSHSPFGLSSLI......
A0A2K5S9R3_CEBIM/3-62 ...sqkekkkgm--------------.---..-.-GYTLLYSDPSSEETHPPHINPDPFHHME------HAGNFQAVTSEEFHPGKRKD----------------------------------------------------------------------------tgg...
A0A8I5TLQ9_PONAB/3-146 ........vkrk---------EKGTQ.TPA..L.QGPQLLNTDPSSEETRPPHINPDRLCHMEPANHFWHAGDLQAMTSKEFHLAATQDDCRRRRTQEDILVPSSHPELFASVLPMALEEAARLQQPQPLPPPSGIHLSASRTSAPTLLYLPPPSHSPFGLSSLI......
A0A0C4DGJ2_HUMAN/1-104 ............--------------.---..-.---------------------------MEPANHFWHAGDLQAMISKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRTLAPTLLYSSPPSHSPFGLSSLI......
A0A2K5Z4T0_MANLE/4-131 ............TDQKSPSQRALCA-.---..-.--PQLLNTNHSSEETRPTRINPDRLCHMEPANHFWHAGDLQAMTSKKFHLGVIQDDCRRGRTQEDILVPSSHPEL--------------LQQPQPLPPPSGIHLSTSKGLGSNSIVSSPPSHSPFGLSSLI......
A0A6J3HA11_SAPAP/1-94 .........msf--------------.---..-.---------------------------------LRHAGNFQAVTSEEFHPGATXHDCRRGRTQEDILVPSPHPELFASVX-------SRLQQPQPFPPPSGILLSASRASAPTLLCSPPPSHFPFSLSSLV......
A0A5F4W1G7_CALJA/4-143 ............TDQKSHSQRALRTQ.TPS..L.Q--------PSSEETHPPHINPDPLNHMEPPNHFSHAGDLQAVTSKEFHPGATN-DCRRGRTQEDILVPSSHPELFASVPPVAPEEAARLQQPQPHPPPSGILLSASRTSAPTLLCLPPPSHFPFSLSCLV......
H2RD73_PANTR/4-152 ............TDQKSHSQRALGTQ.TPA..L.QGPQLLNTDPSSEETRPPHVYPDRLCHMEPANHFWHAGDLQAMTSKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMALEEAARLQQPQPLPPPSGIHLSASRTSAPTLLYSPPPSHSPFGLSSLI......
A0A140T8W9_HUMAN/4-55 ............TDQKSHSQRALGTQ.TPA..L.QGPQLLNTDPSSEETHPPTLILTDFATW-------------------------------------------------------------------------------------------------------sqqtis
A0A1W2PRX9_HUMAN/3-151 ............TDQKSHSQRALGTQ.TPA..L.QGPQLLNTDPSSEETRPPHVNPDRLCHMEPANHFWHAGDLQAMISKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRTLAPTLLYSSPPSHSPFGLSSLI......
PS1C1_PANTR/4-152 ............TDQKSHSQRALGTQ.TPA..L.QGPQLLNTDPSSEETRPPHVYPDRLCHMEPANHFWHAGDLQAMTSKEFHLAATQDDCRKGRTQEDILVPSSHPELFSSVLPMALEEAARLQQPQPLPPPSGIHLSASRTSAPTLLYSPPPSHSPFGLSSLI......
A0A1W2PQG0_HUMAN/3-150 ............TDQKSHSQRALGTQ.TPA..L.QGPQLLNTDPSSEETH-PHVNPDRLCHMEPANHFWHAGDLQAMISKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRTLALTLLYSSPPSHSPFGLSSLI......
#=GC seq_cons ............................................SScETp.s.l..s.htpMEPANHFWHAGDLQAMTSKEFHLuspQDDCR+GRTQEDILVPSSHPELF.........EAARLQQPQPLPPPSGIHLSASRs.APTLLhSsPPSHSPFGLSSLI......
//
