#=GF ID   VCD
#=GF AC   PF20792.2
#=GF DE   VopL C-terminal dimerization domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   ECOD:3243.1.1
#=GF GA   27.00 27.00;
#=GF TC   36.30 47.60;
#=GF NC   24.90 24.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 81514348 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF RC   Paper describing PDB structure 3ryl
#=GF RN   [1]
#=GF RM   21873985
#=GF RT   Mechanism of actin filament nucleation by Vibrio VopL and
#=GF RT   implications for tandem W domain nucleation.
#=GF RA   Namgoong S, Boczkowska M, Glista MJ, Winkelman JD, Rebowski G,
#=GF RA   Kovar DR, Dominguez R;
#=GF RL   Nat Struct Mol Biol. 2011;18:1060-1067.
#=GF RC   Paper describing PDB structure 3seo
#=GF RN   [2]
#=GF RM   21873984
#=GF RT   Mechanism of actin filament nucleation by the bacterial effector
#=GF RT   VopL.
#=GF RA   Yu B, Cheng HC, Brautigam CA, Tomchick DR, Rosen MK;
#=GF RL   Nat Struct Mol Biol. 2011;18:1068-1074.
#=GF RC   Paper describing PDB structure 4m63
#=GF RN   [3]
#=GF RM   24120140
#=GF RT   The bacterial effector VopL organizes actin into filament-like
#=GF RT   structures.
#=GF RA   Zahm JA, Padrick SB, Chen Z, Pak CW, Yunus AA, Henry L, Tomchick
#=GF RA   DR, Chen Z, Rosen MK;
#=GF RL   Cell. 2013;155:423-434.
#=GF DR   INTERPRO; IPR049414;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   The VopL C-terminal dimerization domain (VCD) is found in Vibrio
#=GF CC    parahaemolyticus protein L (VopL), an actin nucleation factor
#=GF CC   that induces stress fibres when injected into eukaryotic host
#=GF CC   cells. VCD shows a mainly alpha-helical fold, forms a U-shaped
#=GF CC   dimer and interacts with the pointed end of the  actin nucleus,
#=GF CC   contributing to the nucleation activity directly [1-3].
#=GF SQ   4
#=GS U3AL96_9VIBR/249-489      AC U3AL96.1
#=GS D0I6D2_GRIHO/309-548      AC D0I6D2.1
#=GS Q87GE5_VIBPA/246-481      AC Q87GE5.1
#=GS Q87GE5_VIBPA/246-481      DR PDB; 3SEO A; 4-238;
#=GS Q87GE5_VIBPA/246-481      DR PDB; 3SEO B; 4-238;
#=GS Q87GE5_VIBPA/246-481      DR PDB; 3RYL B; 247-480;
#=GS Q87GE5_VIBPA/246-481      DR PDB; 3RYL A; 247-481;
#=GS A0A5P9CK58_9VIBR/371-528  AC A0A5P9CK58.1
U3AL96_9VIBR/249-489                 ..................................DLLFSDTLLEIAPKMDEQQKRQLCNNLSNYIVQAMPVDWTQIVTNELANYSDMNAVENAVKNMPKPIQKYWNEVKRFPDLWKKPDAVSDQAFNGSKGKrVIAEGMRRLNSGKNRTYYSDKTNGA..TEAKKGEYILESACRFANESATNEEKKTYLANNYKNSAFQVLTEMPFMEVFKAKIGNDAMQQLTQDFMDRMDSIDHLESNLSSFLSENLTNGFASYTYQGQSQKIAALLQQIAKLEN.
D0I6D2_GRIHO/309-548                 ..................................TLLLTDDLLSKCARLSESDLDALSKAAANYLVAAAEVDIRQAVIDATRKFTHVEVLKTGLQYESAYVQAFCKEILKYGDCYKEADISSPESPRGPKSS.VIETALKRLDGGRSRLFSAENKNGT..RELKKGEAILESAIKAARAAMTDEEKSALLSNNIKSATFSILCELPFMEGFSEQNGKAAFSALRRDFFAAFTSGGNAQEDITRFMRDNFENGFSSYTFSGLSDRLARLEAQLAKLV-g
Q87GE5_VIBPA/246-481                 ..................................ERLLSEDLFKQSPKLSEQELDELANNLADYLFQAADIDWHQVISEKTRGLTTEEMAKS----EHRYVQAFCREILKYPDCYKSADVASPESPKSGGGS.VIDVALKRLQTGRERLFTTTDEKGN..RELKKGDAILESAINAARMAISTEEKNTILSNNVKSATFEVFCELPCMDGFAEQNGKTAFYALRAGFYSAFKNTDTAKQDITKFMKDNLQAGFSGYSYQGLTNRVAQLEAQLAALSA.
#=GR Q87GE5_VIBPA/246-481      SS    ..................................XGGGSTCHHHHCGGS-HHHHHHHHHHHHHHHHHH----HHHHHHHHHTT--HHHHCTS----SSHHHHHHHHHHTSSGGGT-----------------.HHHHHHHHHCTTTTSEEEEEBTTSB..EECEEHHHHCHHHHHHHHHTS-HHHHHHHHCCGHHHHHHHHHTTSGGGTTHHHHHHHHHHHHHHHHHHHT--SCCGHHHHHHHHHHHHHHSTTGCCSHHHHHHHHHHHHHHHHHHHC.
A0A5P9CK58_9VIBR/371-528             pqkhqgqqqtqwqsvtevieklqinkrleatswh--------------------------------------------------------------------------------------------------.--------------------EKSGTvvRTPKESNSVFAEAQEKASKSLDNETRSALLKNNYENQVTAALKEDPIFSGLFAKIDKDAAQKLESEFRESIKNPETLEKSIGDFVLNKLQTQCKEFTYTGLTAENESLQQEIERLK-a
#=GC SS_cons                         ..................................XGGGSTCHHHHCGGS-HHHHHHHHHHHHHHHHHH----HHHHHHHHHTT--HHHHCTS----SSHHHHHHHHHHTSSGGGT-----------------.HHHHHHHHHCTTTTSEEEEEBTTSB..EECEEHHHHCHHHHHHHHHTS-HHHHHHHHCCGHHHHHHHHHTTSGGGTTHHHHHHHHHHHHHHHHHHHT--SCCGHHHHHHHHHHHHHHSTTGCCSHHHHHHHHHHHHHHHHHHHC.
#=GC seq_cons                        ..................................phLho-sLhp.ss+hsEpphctLspshusYlhtAh.lDhpQhl.pthtthop.phhcs......t.lQtahpElh+asDhaKpsDhsSspu.pustup.VIt.uh+RLpsG+pRha.spccsGs..REhKKG-uILESAhctAptuhosEEKsslLuNNhKsusFplLsEhPhM-GFttp.GKsAhptLcp-Fhsuhcss-shcpsIocFhp-NLpsGFuuYTYpGLos+lApLptQlA+Lp..
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