ID T22D1_BOVIN Reviewed; 144 AA.
AC Q3MHL6;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 24-JUL-2024, entry version 112.
DE RecName: Full=TSC22 domain family protein 1 {ECO:0000250|UniProtKB:Q15714};
GN Name=TSC22D1 {ECO:0000250|UniProtKB:Q15714};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional repressor (By similarity). Plays a role in
CC the repression of hematopoietic precursor cell growth (By similarity).
CC Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via
CC repression of TSC22D3/GILZ transcription and activation of the caspase
CC cascade (By similarity). Positively regulates cell death in response to
CC TGFB3 during mammary gland involution (By similarity).
CC {ECO:0000250|UniProtKB:P62500, ECO:0000250|UniProtKB:Q15714}.
CC -!- SUBUNIT: Forms homodimers (By similarity). Forms a heterodimer with
CC TSC22D4/THG1 (By similarity). Interacts with histone H1-2 (By
CC similarity). Interacts with GNL3 (By similarity).
CC {ECO:0000250|UniProtKB:P62500, ECO:0000250|UniProtKB:Q15714}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62500}. Nucleus
CC {ECO:0000250|UniProtKB:P62500}.
CC -!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family. {ECO:0000305}.
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DR EMBL; BC105192; AAI05193.1; -; mRNA.
DR RefSeq; NP_001029549.1; NM_001034377.1.
DR AlphaFoldDB; Q3MHL6; -.
DR SMR; Q3MHL6; -.
DR STRING; 9913.ENSBTAP00000025431; -.
DR PaxDb; 9913-ENSBTAP00000025431; -.
DR Ensembl; ENSBTAT00000025431.4; ENSBTAP00000025431.2; ENSBTAG00000047739.3.
DR GeneID; 510359; -.
DR KEGG; bta:510359; -.
DR CTD; 8848; -.
DR VEuPathDB; HostDB:ENSBTAG00000047739; -.
DR eggNOG; KOG4797; Eukaryota.
DR GeneTree; ENSGT00940000163647; -.
DR HOGENOM; CLU_148757_0_0_1; -.
DR InParanoid; Q3MHL6; -.
DR OMA; MNSPYYT; -.
DR TreeFam; TF329224; -.
DR Proteomes; UP000009136; Chromosome 12.
DR Bgee; ENSBTAG00000047739; Expressed in myometrium and 104 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:1902034; P:negative regulation of hematopoietic stem cell proliferation; ISS:UniProtKB.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0043068; P:positive regulation of programmed cell death; ISS:UniProtKB.
DR GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd21938; ZIP_TSC22D1; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000580; TSC22/Bun.
DR InterPro; IPR047862; TSC22/BUN_CS.
DR PANTHER; PTHR46745; TSC22 DOMAIN FAMILY PROTEIN 1; 1.
DR PANTHER; PTHR46745:SF1; TSC22 DOMAIN FAMILY PROTEIN 1; 1.
DR Pfam; PF01166; TSC22; 1.
DR SUPFAM; SSF58026; Delta-sleep-inducing peptide immunoreactive peptide; 1.
DR PROSITE; PS01289; TSC22; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..144
FT /note="TSC22 domain family protein 1"
FT /id="PRO_0000285808"
FT REGION 77..98
FT /note="Leucine-zipper"
FT REGION 109..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 144 AA; 15680 MW; B8AEF42657C50892 CRC64;
MKSQWCRPVA MDLGVYQLRH FSISFLSSLL GTENASVRLD NSSSGASVVA IDNKIEQAMD
LVKSHLMYAV REEVEVLKEQ IKELIEKNSQ LEQENNLLKT LASPEQLAQF QAQLQTGSPP
ATTQPQGTTQ PPAQPASQGS GPTA
//
