KEGG   ENZYME: 1.13.11.40
Entry
EC 1.13.11.40               Enzyme                                 
Name
arachidonate 8-lipoxygenase;
8-lipoxygenase;
8(R)-lipoxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
arachidonate:oxygen 8-oxidoreductase
Reaction(IUBMB)
arachidonate + O2 = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate [RN:R01594]
Reaction(KEGG)
R01594
Substrate
arachidonate [CPD:C00219];
O2 [CPD:C00007]
Product
(5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate [CPD:C04822]
Comment
From the coral Pseudoplexaura porosa.
History
EC 1.13.11.40 created 1989
Pathway
ec00590  Arachidonic acid metabolism
Orthology
K26082  arachidonate 8-lipoxygenase / allene oxide synthase
Genes
BFO118426513 118427444 118427757
BBEL109464474 109475945 109487011
RPHI132716691
DPOL127876274
MAEA128237471
LAK106155495 106157151
EPA110236084
ATEN116294256
ADF107346782 107346783 107349506
AMIL114963958 114963959 114968692 114968697 114970381
PDAM113675101 113685339 113685340 113685344
SPIS111326885 111326886 111326888 111338695 111338704
DGT114519829 114519830 114519831 114519872 114519873 114520506
XEN124454847 124454848
OLUOSTLU_46073
 » show all
Reference
1  [PMID:2867091]
  Authors
Bundy GL, Nidy EG, Epps DE, Mizsak SA, Wnuk RJ.
  Title
Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian coral Pseudoplexaura porosa.
  Journal
J Biol Chem 261:747-51 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.40
IUBMB Enzyme Nomenclature: 1.13.11.40
ExPASy - ENZYME nomenclature database: 1.13.11.40
BRENDA, the Enzyme Database: 1.13.11.40
CAS: 100900-72-9
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