KEGG ENZYME: 1.2.1.103

ENZYME: 1.2.1.103

Entry

EC 1.2.1.103                Enzyme

Name

[amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase;
lysY (gene name)

Class

Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor

Sysname

[amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine]:NADP+ 5-oxidoreductase (phosphorylating)

Reaction(IUBMB)

an [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine] + phosphate + NADP+ = an [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-phosphooxy-5-oxopentyl)-L-glutamine] + NADPH + H+ [RN:R09777]

Reaction(KEGG)

R09777

Substrate

[amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine];
phosphate [CPD:C00009];
NADP+ [CPD:C00006]

Product

[amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-phosphooxy-5-oxopentyl)-L-glutamine];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme participates in an L-lysine biosynthesis in certain species of archaea and bacteria.

History

EC 1.2.1.103 created 2019

Pathway

ec00300

Lysine biosynthesis

ec01100

Metabolic pathways

Orthology

K05829

[amino group carrier protein]-6-phospho-L-2-aminoadipate/5-phospho-L-glutamate reductase

Genes

ENF:	AKI40_3666(argC1)

CARI:

FNU76_03415(argC)

ADE:

Adeh_0171

ACP:	A2cp1_0191

AFW:	Anae109_0180

ANK:	AnaeK_0180

AORY:

AMOR_27130(argC_1)

MXA:	MXAN_5110(argC)

MSD:	MYSTI_01367 MYSTI_05599

MYM:	A176_001775

MFB:	MFUL124B02_07590 MFUL124B02_30545

MYX:	QEG98_27715(argC)

MLAN:

JY572_19525(argC) JY572_39290(argC)

CCX:	COCOR_02066(argC) COCOR_02384(argC1)

MFU:	LILAB_33480

MMAS:

MYMAC_004992

PPAK:

JY651_06055(argC) JY651_31935(argC)

SUR:	STAUR_5875(argC) STAUR_7165

AGE:	AA314_09030

AVM:	JQX13_05280(argC) JQX13_36440(argC)

MBD:	MEBOL_002073

CFUS:

CYFUS_008834

VIN:	AKJ08_2701

CCRO:

CMC5_013340(argC)

MRM:	A7982_11144

LLU:	AKJ09_08207

HOH:

Hoch_4934

PMS:	KNP414_04936

PMQ:	PM3016_4338

PMW:

B2K_22475

PIH:	UB51_14595

PSWU:

SY83_08900

GEK:	kuro4_23330(argC)

SGR:

SGR_3479

SFI:

SFUL_3351

SSX:	SACTE_1738

SFA:

Sfla_0120

STRP:

F750_6904

SCI:	B446_19850(lysY)

SLC:	SL103_03075

SPRI:

SPRI_3643

SCZ:	ABE83_19105

SCX:	AS200_22010

SRW:	TUE45_06897(argC_2)

SPAV:

Spa2297_32275

STRT:

A8713_31070

SALW:

CP975_34095(argC)

SLAU:

SLA_3044

SALJ:

SMD11_6707(lysY)

STRO:

STRMOE7_34015

STIR:

DDW44_16560(argC)

SNK:	CP967_01835(argC) CP967_15200(argC)

SFIC:

EIZ62_06085

SSPO:

DDQ41_08070(argC)

SCAV:

CVT27_15445(argC)

SCYG:

S1361_31455(argC2)

SGJ:	IAG43_00725(argC)

SDD:	D9753_06835(argC)

SINE:

KI385_33355(argC)

SAKB:

K1J60_19055(argC)

SSPN:

LXH13_29735(argC)

SOV:	QZH56_15295(argC)

SROC:

RGF97_02770(argC) RGF97_22065(argC)

SLUO:

PS467_34280(argC)

STPB:

QR97_19340

STRW:

QHG49_20980(argC)

SGLY:

P8A20_28275(argC)

KAB:	B7C62_16030

KIT:	CFP65_3941

AGRA:

AGRA3207_003395(argC)

ACIR:

OG979_26755(argC)

SESP:

BN6_56700

SSYI:

EKG83_30605

MFEU:

H1D33_25925(argC)

ASE:	ACPL_7490(argC)

ACTS:

ACWT_7360

ACTR:

Asp14428_21590(argC_1)

PLK:	CIK06_18385(argC)

DAUR:

Daura_16045(argC)

CAI:

Caci_6304

NAV:	JQS30_10085(argC)

RRS:	RoseRS_1060

RCA:

Rcas_3468

CAU:

Caur_0335

CHL:	Chy400_0360

CAG:

Cagg_3596

HAU:

Haur_3307

CALL:

OZ401_000131(argC)

ATM:	ANT_12400(argC)

PSUB:

Pelsub_P1479

LEK:	hrd7_27810(argC)

CAP:	CLDAP_41080(argC)

KBS:	EPA93_38765

KBB:	ccbrp13_35980(argC_1)

THUG:

KNN16_06515(argC)

TTR:

Tter_0319

PMET:

G4Y79_18400

TRO:	trd_1518(argC)

STI:

Sthe_0216

DRA:	DR_0963(argC)

DGE:

Dgeo_0685

DDR:	Deide_10350

DMR:	Deima_1349

DGO:	DGo_CA1602(argC)

DPD:	Deipe_2758

DSW:	QR90_11525

DCH:	SY84_01780

DAB:	AUC44_08830

DPU:	SU48_07465

DEZ:	DKM44_07625

DWU:	DVJ83_06415

DFC:

DFI_07605

DEIN:

DAAJ005_07915

DGA:	DEGR_14640(argC1)

DPH:	EHF33_04575

DRD:	LMT64_04455

DRB:	N0D28_07415(argC)

DAH:	DAETH_16370(argC1)

DAQU:

M8445_13445(argC)

DTAE:

LAJ19_05170(argC)

DMB:	E5F05_13170

DSC:	ABOD76_16800(argC)

TRA:

Trad_1395

TTH:

TT_C1542

TTJ:	TTHA1904(TTHA1904)

TTS:	Ththe16_1906

TTL:	TtJL18_1988

TSC:	TSC_c01930(argC1)

THC:	TCCBUS3UF1_21020

TOS:	Theos_1932

TAQ:

TO73_0099

TPAR:

AV541_01265

TBC:	A0O31_00869(argC_1)

TANT:

KNN15_05135(argC)

MRB:

Mrub_2723

MRE:	K649_08920(argC)

MTAI:

Mtai_v1c23220

MSV:	Mesil_0436

OPR:	Ocepr_1788

MHD:	Marky_0667

UAM:	UABAM_02297

CTM:	Cabther_B0218

CVL:	J8C06_12705(argC)

CHLO:

J8C02_13760(argC)

SCOR:

J3U87_02880

MSIL:

METEAL_32710(argC1)

MSEA:

METESE_28820(argC1)

TAI:

Taci_0448

CPOR:

BED41_13055

TLI:

Tlie_1470

AMO:	Anamo_0989

ARAM:

KAR29_00425(argC)

RMR:

Rmar_0948

RMG:	Rhom172_1918

RBAR:

AWN76_002230

MRO:

MROS_0164

CABY:

Cabys_3149(argC)

PFU:

PF1683

PFI:	PFC_10190(argC)

PHO:	PH1720(PH1720)

PAB:	PAB0291(argC)

PYN:

PNA2_0328

PYS:

Py04_1635

TKO:

TK0277

THS:

TES1_0508

THV:	ADU37_CDS10060

TCH:	CHITON_1978

THEI:

K1720_00620(argC)

HDL:	HALDL1_01650

HHB:	Hhub_3649(argC)

HNO:	LT974_00085(argC)

HLU:	LT972_14175(argC)

HALH:

HTSR_0665(argC)

HHSR:

HSR6_0691(argC)

HSU:	HLASF_2138(argC)

HSF:	HLASA_2172(argC)

HAHS:

HSRCO_2860(argC)

SALR:

FQU85_04730

HALR:

EFA46_004290

HJE:	HacjB3_00985(argC)

HDO:	MUK72_02360(argC)

HALX:

M0R89_05930(argC)

HAXZ:

M0R88_06115(argC)

HAYC:

NGM10_09015(argC)

HAXY:

NGM07_11165(argC)

SALI:

L593_07890(argC)

SAIM:

K0C01_05790(argC)

HARA:

AArcS_3062(argC)

HMA:	rrnAC2678(argC)

HHI:	HAH_3082(argC)

HHN:	HISP_15690

HAB:	SG26_07785

HTA:	BVU17_15000

HALJ:

G9465_02500

HSIN:

KDQ40_13800

NPH:	NP_5260A(argC)

NMO:	Nmlp_1242(argC)

NHO:	HWV23_08505

NSAL:

HWV07_10860

HUT:

Huta_1501

HTI:

HTIA_1540

HALA:

Hrd1104_12290

HASV:

SVXHr_0125(argC)

HABN:

HBNXHr_0122(argC)

HMU:

Hmuk_0773

HALZ:

E5139_07050

HALL:

LC1Hm_3289(argC)

HAZP:

GBQ70_07045

HALI:

BV210_07080

HSN:	DV733_03390

HDS:	HSR122_1704(argC)

HRR:	HZS55_04380

HPEL:

HZS54_04330

HLT:	I7X12_08370

HARC:

HARCEL1_01520

SSAI:

N0B31_18445(argC)

HAAD:

MW046_06600(argC)

HWA:	HQ_3715A(argC)

HWC:	Hqrw_4130(argC)

HVO:	HVO_0045(argC)

HALE:

G3A49_00605

HLN:	SVXHx_0043(argc)

HME:	HFX_0045(argC)

HGI:	ABY42_00215

HLS:	KU306_04865(argC)

HBO:	Hbor_01740

HAQ:	DU484_03080

HAJ:	DU500_03520

HAER:

DU502_01265

HRA:	EI982_12720

HLM:	DV707_00745

HALM:

FCF25_06930

HLA:

Hlac_2615

HALP:

DOS48_13130

HALB:

EKH57_10850

HEZZ:

EO776_15100

HALQ:

Hrr1229_007370

HSS:	J7656_01820

HSAI:

HPS36_07355

HAZZ:

KI388_13085(argC)

HAE:	halTADL_1874

HALN:

B4589_001580

HALG:

HUG10_12790

HALU:

HUG12_02035

HMP:	K6T50_10110(argC)

HRE:	K6T36_09875(argC)

HRM:	K6T25_06295(argC)

HACB:

Hbl1158_01730(argC)

HDF:	AArcSl_0042(argC)

HAAA:

AArcCO_0044(argC)

HAH:	Halar_1203

HTU:

Htur_0327

HSAL:

JMJ58_07540

HAKZ:

J0X25_08130(argC)

NMG:	Nmag_1760(argC)

HXA:	Halxa_1379

NAT:

NJ7G_0262

NPE:	Natpe_3685

NVR:	FEJ81_17600

NPL:	FGF80_16425

NAY:	HYG81_11425(argC)

HALY:

HYG82_14940

HJT:	DVR14_08505

HLO:	J0X27_11125

NGE:	Natgr_1613

HRU:	Halru_0400

SAWL:

NGM29_05190(argC)

HALV:

NGM15_14815(argC)

NOU:	Natoc_0149

HLR:	HALLA_05495

HLC:	CHINAEXTREME04210

NAJ:	B1756_08245

NAG:	AArcMg_3555

NAN:	AArc1_3499

NARA:

QQ977_06800(argC)

NBG:	DV706_07695

NAS:	GCU68_05000

HDA:	BB347_12545

PTO:

PTO1472

FAC:	FACI_IFERC01G1524

FAI:	FAD_0505(lysY)

CDIV:

CPM_0548

APE:	APE_1462(lysY)

ACJ:

ACAM_0921

IHO:

Igni_0728

IIS:

EYM_02375

IPC:

IPA_02535

IAG:

Igag_1754

PFM:	Pyrfu_0758

PDL:	Pyrde_1835

PABI:

PABY_17870(argC)

PARE:

PYJP_07910(argC)

STO:	STK_01950(argC_lysY)

SOH:	D1869_00450

SSO:	SSO0155(argC)

SOL:

Ssol_1133

SSOA:

SULA_1169

SSOL:

SULB_1170

SSOF:

SULC_1168

SSHI:

J5U23_00109

SCAS:

SACC_00680

SAI:	Saci_0750(argC)

SACN:

SacN8_03645(argC)

SACR:

SacRon12I_03630(argC)

SACS:

SUSAZ_03360

SIS:	LS215_2149

SIA:	M1425_1984

SIM:	M1627_2062

SID:

M164_1990

SIY:	YG5714_2107

SIN:	YN1551_0811

SII:

LD85_2245

SIH:

SiH_1928

SIR:

SiRe_1855

SIC:

SiL_1837

SULA:

BFU36_05160

SULE:

GFS03_10865

SULL:

EWF20_01890

MSE:

Msed_0164

MEMJ:

MJ1HA_0243

MCN:

Mcup_1909

MHK:	DFR87_05990

MPRU:

DFR88_05820

MTEN:

GWK48_06270

MJN:	MjAS7_0747

AHO:

Ahos_0883

AMAN:

B6F84_08265

ABRI:

DFR85_06580

ASUL:

DFR86_07280

AAMB:

D1866_12310

ACIH:

HS5_22580

SACD:

HS1genome_0844

SAZO:

D1868_01595

CSTY:

KN1_18170

STEP:

IC006_1902

SMET:

RQ359_002321(argC)

PAI:

PAE2881

PIS:

Pisl_0276

PCL:

Pcal_0373

PAS:

Pars_0966

PYR:

P186_1636

POG:

Pogu_1380

TNE:

Tneu_1837

PYW:	PYWP30_01976

CMA:

Cmaq_1301

TTN:	TTX_0120(lysY_argC)

TUZ:

TUZN_1285

VDI:

Vdis_0193

VMO:

VMUT_1533

VSO:	Vsou_14280

KCR:

Kcr_0809

NMR:

Nmar_1289

NIR:	NSED_07155(argC)

NKR:	NKOR_07275(argC)

NID:	NPIRD3C_0835(argC)

NIN:	NADRNF5_0667(argC)

NIW:	Nisw_07285

NCL:	C5F47_06945

NOX:	C5F49_06955

NUE:	C5F50_09710

NIP:	NsoK4_01590

NZT:	NZOSNM25_000522

NCT:

NMSP_0399

NIC:	DSQ20_07910

NGA:	Ngar_c29960(argC)

NVN:	NVIE_016490(argC)

NEV:

NTE_00734

TAA:	NMY3_02222(argC2)

NFN:	NFRAN_2984(lysY)

NCV:	NCAV_1251(lysY)

NDV:	NDEV_1624(argC)

CSY:	CENSYa_1203

CSU:	CSUB_C1303

NBV:	T478_1044(argC)

TAH:	SU86_009075

NIU:	DSQ19_03220

CCAI:

NAS2_0267

BARB:

AOA66_0020

» show all

Reference

1 [PMID:10613839]

Authors

Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H.

Title

A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis.

Journal

Genome Res 9:1175-83 (1999)
DOI:10.1101/gr.9.12.1175

Reference

2 [PMID:19620981]

Authors

Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M

Title

Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.

Journal

Nat Chem Biol 5:673-9 (2009)
DOI:10.1038/nchembio.198

Sequence

[tth:TT_C1542]

Reference

3 [PMID:26966182]

Authors

Shimizu T, Tomita T, Kuzuyama T, Nishiyama M

Title

Crystal Structure of the LysY.LysW Complex from Thermus thermophilus.

Journal

J Biol Chem 291:9948-59 (2016)
DOI:10.1074/jbc.M115.707034

Sequence

[tth:TT_C1542]

Other DBs

ExplorEnz - The Enzyme Database:

1.2.1.103

IUBMB Enzyme Nomenclature:

1.2.1.103

ExPASy - ENZYME nomenclature database:

1.2.1.103

BRENDA, the Enzyme Database:

1.2.1.103

LinkDB

DBGET integrated database retrieval system