Entry
Name
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase;
gmhB (gene name);
yaeD (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphohydrolase
Reaction(IUBMB)
D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O = D-glycero-beta-D-manno-heptose 1-phosphate + phosphate [RN:
R05647 ]
Reaction(KEGG)
Substrate
D-glycero-beta-D-manno-heptose 1,7-bisphosphate [CPD:
C11472 ];
H2O [CPD:
C00001 ]
Product
D-glycero-beta-D-manno-heptose 1-phosphate [CPD:
C07838 ];
phosphate [CPD:
C00009 ]
Comment
The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria. In vitro the catalytic efficiency with the beta-anomer is 100-200-fold higher than with the alpha-anomer [3].
History
EC 3.1.3.82 created 2010
Pathway
ec00540 Lipopolysaccharide biosynthesis
Orthology
K03273 D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase
Genes
ECOO : ECRM13514_0209(yaeD)
ECOH : ECRM13516_0211(yaeD)
EDJ : ECDH1ME8569_0194(gmhB)
ECOI : ECOPMV1_00207(gmhB)
ENR : H650_19780 H650_19815
REE : electrica_04133(gmhB)
RTG : NCTC13098_06048(gmhB)
CLAP : NCTC11466_03726(gmhB)
KGO : CEW81_08860 CEW81_20025
KIE : NCTC12125_02823(gmhB)
AHN : NCTC12129_01001(gmhB)
METY : MRY16398_45980(gmhB)
PSHI : SAMEA2665130_2458(gmhB)
YPG : YpAngola_A3404(gmhB)
YPI : YpsIP31758_1044(gmhB)
YPQ : DJ40_1345(gmhB) DJ40_3509(gmhB)
YPU : BZ21_2285(gmhB) BZ21_257(gmhB)
YPR : BZ20_1032(gmhB) BZ20_3193(gmhB)
YPC : BZ23_2565(gmhB) BZ23_533(gmhB)
YMO : HRD69_00240(gmhB) HRD69_11010
SMW : SMWW4_v1c38730(gmhB)
SFJ : SAMEA4384070_3873(gmhB)
SOF : NCTC11214_02895(gmhB)
SSAR : SSARUM_003736(gmhB)
PAQU : DMB82_0004690(gmhB)
PARL : PEC302110_31050(gmhB)
DIC : Dpoa569_000813(gmhB)
EHD : ERCIPSTX3056_183(gmhB)
TPTY : NCTC11468_02997(gmhB)
PLU : plu0698 plu4825(wblZ)
PLUM : A4R40_03460 A4R40_24000
PHEI : NCTC12003_03024(gmhB)
PRJ : NCTC6933_03129(gmhB)
LRI : NCTC12151_02727(gmhB)
HIC : NTHIC486_00804(gmhB)
HPIT : NCTC13334_00812(gmhB)
HHZ : NCTC10839_00589(gmhB)
HAEG : NCTC8502_00341(gmhB)
PDAG : 4362423_02018(gmhB)
PSKY : A6B44_04235 A6B44_10005
PATL : KGI96_03470(gmhB) KGI96_09225
ADP : NCTC12871_00931(gmhB)
ALIG : NCTC10568_00502(gmhB)
ASEG : NCTC10977_00588(gmhB)
AVT : NCTC3438_00495(gmhB)
RPNE : NCTC8284_03818(gmhB)
PAET : NCTC13378_00330(gmhB)
VHR : AL538_02585 AL538_13000
VOW : A9237_04865 A9237_15350
VAU : VANGNB10_cI0784(gmhB)
VPL : SA104470976_01859(gmhB)
PGB : H744_1c0472 H744_2c0952
PPRC : PFLCHA0_c00130(gmhB)
PMUD : NCTC8068_00010(gmhB)
PFW : PF1751_v1c00090(gmhB)
PPUU : PputUW4_00006(gmhB)
PTRT : HU722_0001055(gmhB)
PTW : TUM18999_00070(gmhB)
PTAE : NCTC10697_00009(gmhB)
PALL : UYA_00080 UYA_23030
MSHE : MAALD49_07710(gmhB)
SBB : Sbal175_1480 Sbal175_1699
SCAA : TUM17387_22830(gmhB)
ALTR : BM528_01390 BM528_10140
SALH : HMF8227_01597(gmhB)
CBS : COXBURSA331_A0092 COXBURSA331_A0791
LLG : 44548918_00714(gmhB)
LJR : NCTC11533_00691(gmhB)
LWA : SAMEA4504053_2037(gmhB)
LSS : NCTC12082_02840(gmhB)
METL : U737_03515 U737_23155
MEEP : JWZ98_00705(gmhB) JWZ98_02800
MMOB : F6R98_05005(gmhB) F6R98_19240
MEIN : methR_P0084 methR_P2384
MESL : KKZ03_13095(gmhB) KKZ03_15135
TZO : THMIRHAT_19800(gmhB)
TNI : TVNIR_2700(gmhB_[H])
HAAH : HALA3H3_360037(gmhB)
HAXI : HAALTHF_09110n(gmhB)
AEL : NCTC12917_00255(gmhB)
CHJ : NCTC10426_00914(gmhB)
ACII : C4901_01165 C4901_08970
ATY : A9R16_000995(gmhB) A9R16_008840
CDIZ : CEDIAZO_01219(gmhB)
NMQ : NMBM04240196_1974(gmhB)
NMZ : NMBNZ0533_1964(gmhB)
NWE : SAMEA3174300_1172(gmhB)
NZO : SAMEA4504057_0845(gmhB)
NCI : NCTC10296_01034(gmhB)
NCZ : NCTC10294_01354(gmhB)
NANI : NCTC12227_01558(gmhB)
VFF : VITFI_CDS1460 VITFI_CDS2400
ECOR : SAMEA4412678_1626(gmhB)
CHIC : N8I74_04590 N8I74_17920(gmhB)
RPF : Rpic12D_0414 Rpic12D_3805
RMN : TK49_05695 TK49_18680
RWE : KOL96_05255 KOL96_10075(gmhB)
REH : H16_A0520(h16_A0520)
REU : Reut_A0506 Reut_A0723 Reut_B4387
CTI : RALTA_A0476(gmhB2) RALTA_A0586(gmhB1)
CGD : CR3_2151(gmhB) CR3_3415(hisB)
CUP : BKK80_04310 BKK80_17025 BKK80_34250
CUU : BKK79_07955 BKK79_15330
CPAU : EHF44_03155 EHF44_23160
COX : E0W60_13170(gmhB) E0W60_13725
CCAX : KZ686_15535(gmhB) KZ686_17365
CNAN : A2G96_03770 A2G96_04300
CUPR : IC580_11275(gmhB) IC580_17730
CUPE : KLP38_02300(gmhB) KLP38_24235
BMA : BMA0217 BMA2293(gmhB) BMAA1990
BMV : BMASAVP1_1013 BMASAVP1_A0535(gmhB) BMASAVP1_A2729
BML : BMA10229_A1065(wcbN) BMA10229_A2349
BMN : BMA10247_2171(wcbN) BMA10247_2429
BMAL : DM55_1491(gmhB) DM55_1618 DM55_3804
BMAE : DM78_2663(gmhB) DM78_374 DM78_4373
BMAQ : DM76_1469(gmhB) DM76_1597 DM76_4501
BMAI : DM57_06130 DM57_1068 DM57_2251
BMAF : DM51_1934(gmhB) DM51_21 DM51_3670
BMAZ : BM44_1070(gmhB) BM44_3763 BM44_863
BMAB : BM45_2459(gmhB) BM45_4539 BM45_540
BPS : BPSL0666 BPSL2793(wcbN) BPSS2256
BPM : BURPS1710b_0880 BURPS1710b_A1389
BPL : BURPS1106A_0715 BURPS1106A_3275(wcbN) BURPS1106A_A3042
BPD : BURPS668_0700 BURPS668_3240(wcbN) BURPS668_A3171
BPR : GBP346_A0628 GBP346_A3418
BPSE : BDL_1338 BDL_2652(gmhB) BDL_5730
BPSM : BBQ_2761 BBQ_3849 BBQ_516(gmhB)
BPSU : BBN_2884 BBN_5751 BBN_644(gmhB)
BPSD : BBX_1050(gmhB) BBX_3285 BBX_4897
BPZ : BP1026B_I0517(wcbN) BP1026B_I2858 BP1026B_II2429
BPQ : BPC006_I0700 BPC006_I3323 BPC006_II2992
BPK : BBK_2137(gmhB) BBK_5035 BBK_819
BPSH : DR55_1725(gmhB) DR55_427 DR55_5475
BPSA : BBU_1485 BBU_2769(gmhB) BBU_3734
BPSO : X996_1365(gmhB) X996_34 X996_5246
BUT : X994_2049 X994_3363(gmhB) X994_4795
BTD : BTI_3122 BTI_923(gmhB)
BVI : Bcep1808_2804 Bcep1808_5695
BCM : Bcenmc03_2730 Bcenmc03_6035
BCH : Bcen2424_2703 Bcen2424_6444
BCEN : DM39_2794 DM39_7010
BCEW : DM40_320 DM40_4222(gmhB) DM40_5226
BAC : BamMC406_2620 BamMC406_6400
BMJ : BMULJ_02665(gmhB) BMULJ_06057(gmhB)
BMUL : NP80_2837 NP80_5507
BCED : DM42_2369 DM42_7140
BDF : WI26_13030 WI26_27270
BLAT : WK25_13095 WK25_16805 WK25_23475
BTEI : WS51_23890 WS51_26880
BSEM : WJ12_13525 WJ12_17130
BPSL : WS57_15435 WS57_32265
BSTL : BBJ41_08325 BBJ41_15260
BARI : NLX30_15700(gmhB) NLX30_31950(gmhB)
BAEN : L3V59_15530(gmhB) L3V59_19740(gmhB)
BSER : R0290_13995(gmhB) R0290_33110
BGL : bglu_1g15020 bglu_1g30550
BUG : BC1001_0396 BC1001_5361
BGF : BC1003_0408 BC1003_4060
BGD : bgla_1g34120 bgla_2g19960
BUE : BRPE67_ACDS03910 BRPE67_ECDS00290
BUQ : AC233_02220 AC233_23265
BPLA : bpln_1g18430 bpln_1g31190
BUM : AXG89_08685 AXG89_22415
BUI : AX768_01840 AX768_24895
BGE : BC1002_0405 BC1002_6465
BPX : BUPH_04286 BUPH_05722
BUZ : AYM40_02150 AYM40_03135
BCAI : K788_0004706 K788_0006790 K788_0007830
PSPW : BJG93_10625(gmhB) BJG93_30815
PARA : BTO02_03130 BTO02_29555
PHS : C2L64_02255 C2L64_13950
PGP : CUJ91_02370 CUJ91_20280
PCJ : CUJ87_02065 CUJ87_18200
PTS : CUJ90_02270 CUJ90_31965
PMEG : FNZ07_18235 FNZ07_30430(gmhB)
PACS : FAZ98_02530(gmhB) FAZ98_11500(gmhB) FAZ98_17605
PEW : KZJ38_11350 KZJ38_20670(gmhB)
PSAA : QEN71_02155(gmhB) QEN71_19155
PKF : RW095_10645 RW095_37355(gmhB)
PHUN : U0042_03790 U0042_21380(gmhB)
BRH : RBRH_01951 RBRH_02012
POLK : PKF022_03570 PKF022_16650
PPUL : RO07_05120 RO07_21345
PVE : UC34_12545 UC34_21200
POX : MB84_01090 MB84_16915
PFG : AB870_08030 AB870_22695
PLG : NCTC10937_00006(gmhB)
TVL : FAZ95_02800(gmhB) FAZ95_17360
TCAR : U0034_03595 U0034_12660(gmhB) U0034_28240
BTRM : SAMEA390648700463(gmhB)
BBRO : BAU06_06020 BAU06_20970
BFZ : BAU07_05430 BAU07_20290
BOH : AKI39_05830 AKI39_20210
BGM : CAL15_06945 CAL15_19490
BGV : CAL12_06345 CAL12_22975
AXO : NH44784_012641 NH44784_059551
AXN : AX27061_0893 AX27061_4194
AXX : ERS451415_00881(gmhB_1) ERS451415_04215(gmhB_2)
ASW : CVS48_01960 CVS48_25690
ACHB : DVB37_03885 DVB37_19790
ACHO : H4P35_03910(gmhB) H4P35_18160
ACHM : V6V88_04210(gmhB) V6V88_19115
ACHA : KYT87_03910(gmhB) KYT87_20410
PUS : CKA81_09545 CKA81_15610
POLL : OEG81_04150(gmhB) OEG81_16675
AKA : TKWG_07735 TKWG_08190
CDN : BN940_13441 BN940_16526
PIG : EGT29_04115 EGT29_20495
STHM : IS481_02675(gmhB) IS481_02680(gmhB) IS481_05490
PBH : AAW51_3914 AAW51_4710(gmhB) AAW51_4711(gmhB)
SAQA : OMP39_04325 OMP39_12735(gmhB) OMP39_12740(gmhB)
RGE : RGE_13750(gmhB) RGE_24880 RGE_43650(gmhB)
RBN : RBXJA2T_02951 RBXJA2T_05568
RDP : RD2015_4383 RD2015_724
ROI : N4261_11930 N4261_23320(gmhB)
KIA : G8A07_12505(gmhB) G8A07_24155(gmhB)
IDC : LRM40_02960(gmhB) LRM40_12170(gmhB)
ATER : MW290_08435 MW290_20905(gmhB) MW290_29200(gmhB)
HSE : Hsero_0715 Hsero_4418
HSZ : ACP92_03575 ACP92_22065
HEW : HBDW_06980(gmhB) HBDW_45240(gmhB)
MASW : AM586_20885 AM586_24220
MASS : CR152_12640 CR152_16730 CR152_19320
MTIM : DIR46_17320 DIR46_20625
MANC : IV454_02990(gmhB) IV454_31645
MFY : HH212_11805(gmhB) HH212_15140
MVAR : MasN3_38230 MasN3_44790
MLIR : LPB04_09180(gmhB) LPB04_12430
NOK : FAY22_00120(gmhB) FAY22_03165
AON : DEH84_03645 DEH84_07605 DEH84_17475
ETB : N7L95_07920 N7L95_10895(gmhB) N7L95_10900(gmhB)
NMU : Nmul_A0549 Nmul_A1793
MBAT : BN1208_0902 BN1208_1096
MEU : ACJ67_08015 ACJ67_11880
SULF : CAP31_06165 CAP31_12295
ARES : IWH25_00700(gmhB) IWH25_01545(gmhB)
NIV : JY500_12310 JY500_17155(gmhB)
ABRE : pbN1_11380(gmhB) pbN1_34640
PECT : BN1012_Phect1092 BN1012_Phect1149
VGO : GJW-30_1_00119(gmhB)
MTUN : MTUNDRAET4_1389(gmhB)
CMB : CSW64_01365 CSW64_13105
BVY : NCTC9239_03184(gmhB)
BND : KWG56_04300 KWG56_16270
AZL : AZL_014410(gmhB) AZL_f01270(gmhB)
HTQ : FRZ44_03370 FRZ44_22300
HADH : FRZ61_03650 FRZ61_24810
TLU : R1T41_04430 R1T41_15770
THAR : T8K17_01260 T8K17_08655
HPO : HMPREF4655_20736(gmhB)
HPX : HMPREF0462_0548(gmhB)
HCL : NCTC13205_00424(gmhB)
HSH : NHP194022_13490(gmhB)
HPUL : NCTC13154_00056(gmhB)
CJV : MTVDSCj20_1159(gmhB)
CFV : CFVI03293_1454(gmhB)
CAMP : CFT03427_1378(gmhB)
CCOC : CCON33237_0836(gmhB)
CLR : UPTC16701_0473(gmhB)
CLM : UPTC16712_0481(gmhB)
CAMR : CAQ16704_0496(gmhB)
CHV : CHELV3228_0620(gmhB)
CPIN : CPIN18020_0877(gmhB)
CAMZ : CVIC12175_0215(gmhB)
ALK : ALEK_0998(gmhB1) ALEK_2526(gmhB2)
HMR : Hipma_0444 Hipma_1690
GEC : GEO60473_15290(gmhB)
GBN : GEOBRER4_17130(gmhB)
DAX : FDQ92_03915 FDQ92_03950
DMP : FAK_14260(gmhB) FAK_22680(gmhB)
PSTI : SOO65_10605 SOO65_19840
CSPG : LS684_05320 LS684_23115
POF : GS400_01920 GS400_12385 GS400_16435
ALKG : MOJ78_03045 MOJ78_10845
PPSC : EHS13_07970 EHS13_15360 EHS13_28185
SOB : CSE16_09980 CSE16_12860
SPOO : J3U78_03285 J3U78_17180
UTH : DKZ56_04125 DKZ56_05260
CRS : FQB35_10980 FQB35_11420(gmhB)
CPRF : K7H06_02385 K7H06_12285 K7H06_14845
PROM : QO263_15690 QO263_16845
AMIC : Ami3637_06450(gmhB)
FAA : HMPREF0389_01481(gmhB)
HHL : Halha_1640 Halha_2292
VRM : 44547418_00767(gmhB)
VDN : NCTC11831_01190(gmhB)
PUF : UFO1_0232 UFO1_1090 UFO1_3329
MANA : MAMMFC1_02294(gmhB)
PFAC : PFJ30894_00057(gmhB)
NFR : ERS450000_01706(gmhB)
SLE : sle_14960(sle_14960)
SRN : A4G23_00209(gmhB_1) A4G23_00479(gmhB_2)
SLS : SLINC_0243 SLINC_6687
SHAW : CEB94_02340 CEB94_32475
SCOE : CP976_34420 CP976_40800
SCHF : IPT68_05045 IPT68_29205
SFB : CP974_01135 CP974_02495
SPEU : CGZ69_25255 CGZ69_28250
AAGI : NCTC2676_1_01801(gmhB)
ACTY : OG774_01260 OG774_29585
MTUA : CSH63_27350 CSH63_33035
CYN : Cyan7425_0618 Cyan7425_1221 Cyan7425_3729
LET : O77CONTIG1_02060(gmhB)
LEPT : JVX88_05260 JVX88_18020
KOV : K9N68_00245 K9N68_00480
CWA : CwatDRAFT_1325 CwatDRAFT_4904
MVAG : D0A34_03955 D0A34_26265
GLJ : GKIL_0946(gmhB) GKIL_0985 GKIL_2221(gmhB)
SCYT : SAMD_32930 SAMD_75560
SCYS : NIES4073_26130 NIES4073_66680
BSEN : DP114_09605 DP114_31870
BOX : DP113_09565 DP113_31970
KBS : EPA93_20975 EPA93_25250(gmhB)
ABIW : Abiwalacus_14390(wcbN)
ROO : G5S37_00875 G5S37_28080
FPES : NXS98_01640 NXS98_14960
GES : VT84_07080(gmhB_1) VT84_27690(gmhB_3)
GOG : C1280_03060 C1280_17630
GMS : SOIL9_45920 SOIL9_49870
AGV : OJF2_33170(gmhB) OJF2_78440(gmhB)
JET : L3J17_02780 L3J17_05240
PBAP : Pla133_23620(gmhB) Pla133_25210
VBL : L21SP4_01065(gmhB) L21SP4_01548
ADIN : H7849_01345 H7849_21260
SCOR : J3U87_13600 J3U87_13805
HABY : HLVA_01560(gmhB) HLVA_19730(wcbN)
BTHO : Btheta7330_02885(gmhB)
CHIH : GWR21_07440 GWR21_30925
COY : HF329_01630 HF329_02875
CFIL : MYF79_14775 MYF79_22190
CHF : KTO58_05015 KTO58_06610
CHIM : CK934_22450 CK934_24155
NKO : Niako_2231 Niako_2550
PEX : IZT61_01905 IZT61_08505
PMUO : LOK61_06665 LOK61_12590
PSN : Pedsa_0186 Pedsa_1259
STHA : NCTC11429_04545(gmhB)
MGIK : GO620_003220 GO620_006195
MDJ : LLH06_07350 LLH06_11325
SRD : SD10_02825 SD10_26985
SRHO : HH216_05490 HH216_16780
SOQ : LQ777_00130 LQ777_11865
PSEZ : HME7025_00118(gmhB)
DYC : NFI80_04165 NFI80_20345
DFQ : NFI81_04420 NFI81_21435
DCN : MUK70_05895 MUK70_25635
PROC : Ptc2401_02075(gmhB)
MSCH : N508_001060(hisB_1)
TVO : TVG0590688(TVG0590688)
» show all
Taxonomy
Reference
Authors
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P.
Title
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
Journal
Sequence
Reference
Authors
Valvano MA, Messner P, Kosma P
Title
Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides.
Journal
Reference
Authors
Wang L, Huang H, Nguyen HH, Allen KN, Mariano PS, Dunaway-Mariano D
Title
Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.82
ExPASy - ENZYME nomenclature database: 3.1.3.82
LinkDB
All DBs