KEGG ENZYME: 3.4.14.1

ENZYME: 3.4.14.1

Entry

EC 3.4.14.1                 Enzyme

Name

dipeptidyl-peptidase I;
cathepsin C;
dipeptidyl aminopeptidase I;
dipeptidyl transferase;
dipeptide arylamidase I;
DAP I

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases

Reaction(IUBMB)

Release of an N-terminal dipeptide, Xaa-Yaa!Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro

Comment

A Cl--dependent, lysosomal cysteine-type peptidase maximally active at acidic pH. Also polymerizes dipeptide amides, arylamides and esters at neutral pH. In peptidase family C1 (papain family).

History

EC 3.4.14.1 created 1961 as EC 3.4.4.9, transferred 1972 to EC 3.4.14.1

Orthology

K01275

cathepsin C

Genes

HSA:	1075(CTSC)

PPS:	100987211(CTSC)

GGO:	101146804(CTSC)

PON:	100172530(CTSC)

PPYG:

129007808(CTSC)

NLE:	100599280(CTSC)

HMH:	116476792(CTSC)

SSYN:

129484715(CTSC)

MCC:	705320(CTSC)

MTHB:

126936633

MNI:	105468886(CTSC)

CSAB:

103248190(CTSC)

CATY:

105592961(CTSC)

PANU:

101017791(CTSC)

TGE:	112605750(CTSC)

MLEU:

105543127(CTSC)

RRO:	104657430(CTSC)

RBB:	108539152(CTSC)

TFN:	117081489(CTSC)

PTEH:

111540754(CTSC)

CANG:

105509301(CTSC)

CJC:	100400437(CTSC)

SBQ:	101042299(CTSC)

CIMI:

108293821(CTSC)

ANAN:

105711919(CTSC)

CSYR:

103268799(CTSC)

MMUR:

105860425(CTSC)

LCAT:

123642241(CTSC)

PCOQ:

105808237(CTSC)

OGA:	100960196(CTSC)

MMU:	13032(Ctsc)

MCAL:

110299008(Ctsc)

MPAH:

110326827(Ctsc)

RNO:	25423(Ctsc)

MCOC:

116102536(Ctsc)

ANU:	117716580(Ctsc)

MUN:	110566149(Ctsc)

CGE:	100769144(Ctsc)

MAUA:

101839953(Ctsc)

PROB:

127227875(Ctsc)

PLEU:

114710707(Ctsc)

MORG:

121448727(Ctsc)

MFOT:

126491508

AAMP:

119803098(Ctsc)

NGI:	103742959(Ctsc)

HGL:	101697606(Ctsc)

CPOC:

100714387(Ctsc)

CCAN:

109701576(Ctsc)

DORD:

105984042(Ctsc)

DSP:	122114582(Ctsc)

PLOP:

125361344(Ctsc)

NCAR:

124958603

MMMA:

107156624(Ctsc)

OCU:

100101594

OPI:

101517575

TUP:	102488201(CTSC)

GVR:	103600446(CTSC)

CFA:	403458(CTSC)

CLUD:

112642043(CTSC) 112662681

VVP:	112932296(CTSC)

VLG:	121476282(CTSC)

NPO:	129506674(CTSC)

AML:	100464355(CTSC)

UMR:	103675378(CTSC)

UAH:	113269415(CTSC)

UAR:	123792342(CTSC)

ELK:

111154405

LLV:

125078452

MPUF:

101681849(CTSC)

MNP:	132025329(CTSC)

MLK:	131839471(CTSC)

NVS:	122912507(CTSC)

ORO:	101371731(CTSC)

EJU:	114199708(CTSC)

ZCA:	113914226(CTSC)

MLX:	118013461(CTSC)

NSU:	110581898(CTSC)

FCA:	101092140(CTSC)

PYU:	121039392(CTSC)

PCOO:

112865009(CTSC) 112869911

PBG:	122483231(CTSC)

PVIV:

125176155(CTSC)

LRUF:

124505770

PTG:	102956745(CTSC)

PPAD:

109267324(CTSC)

PUC:

125938142

AJU:

106967745

HHV:	120246242(CTSC)

BTA:	352958(CTSC)

BOM:	102272716(CTSC)

BIU:	109554360(CTSC)

BBUB:

102399616(CTSC)

BBIS:

104993805(CTSC)

CHX:	102190937(CTSC)

OAS:	101112686(CTSC)

BTAX:

128068741(CTSC)

CSUM:

138084768(CTSC)

ODA:	120874825(CTSC)

CCAD:

122431180(CTSC)

MREE:

136169092(CTSC)

MBEZ:

129549076(CTSC)

SSC:	100522387(CTSC)

CFR:	102510887(CTSC)

CBAI:

105083520(CTSC)

BACU:

103017877(CTSC)

BMUS:

118899365(CTSC)

LVE:	103089091(CTSC)

DLE:	111184954(CTSC)

PSIU:

116758007(CTSC)

NASI:

112412108(CTSC)

ECB:	100060401(CTSC)

EPZ:	103547853(CTSC)

EAI:	106848234(CTSC)

MYB:	102242588(CTSC)

MYD:	102764432(CTSC)

MMYO:

118664541(CTSC)

MLF:	102431068(CTSC)

MDT:	132240694(CTSC)

PKL:	118713550(CTSC)

EFUS:

103296996(CTSC)

MNA:	107532450(CTSC)

DRO:	112316040(CTSC)

SHON:

118984754(CTSC)

AJM:	119043585(CTSC)

PDIC:

114499527(CTSC)

PHAS:

123805588(CTSC)

MMF:	118627682(CTSC)

PPAM:

129072821(CTSC)

HAI:	109383277(CTSC)

RFQ:	117030085(CTSC)

PALE:

102893721(CTSC)

PGIG:

120590510(CTSC)

PVP:	105294191(CTSC)

RAY:	107514936(CTSC)

MJV:	108393107(CTSC)

TOD:	119255701(CTSC)

SARA:

101538937(CTSC)

SETR:

126019141(CTSC)

LAV:	100676360(CTSC)

TMU:

101360788

ETF:

101662901

DNM:	101412186(CTSC)

MDO:	100010333 100010381(CTSC)

GAS:	123238811 123238812 123238813

SHR:	100914125(CTSC)

AFZ:

127555164

PCW:	110213388(CTSC)

TVP:	118837520(CTSC)

PBRV:

138148352(CTSC)

OAA:	100081326(CTSC)

GGA:	419014(CTSC)

PCOC:

116241909(CTSC)

MGP:	100551142(CTSC)

CJO:	107308454(CTSC)

TPAI:

128074258(CTSC)

LMUT:

125691147(CTSC)

NMEL:

110390807(CTSC)

APLA:

101805141(CTSC)

ACYG:

106034176(CTSC)

CATA:

118245873(CTSC)

AFUL:

116497991(CTSC)

TGU:	100230748(CTSC)

LSR:	110478418(CTSC)

SCAN:

103812503(CTSC)

PMOA:

120506624(CTSC)

OTC:	121340986(CTSC)

PRUF:

121362284(CTSC)

GFR:	102035213(CTSC)

FAB:	101814128(CTSC)

OMA:	130252127(CTSC)

PHI:	102104432(CTSC)

PMAJ:

107211449(CTSC)

CCAE:

111922076 111924959(CTSC)

CCW:	104690321(CTSC)

CBRC:

103616749(CTSC) 103623078

ETL:	114063513(CTSC)

ZAB:	102066301(CTSC)

ZLE:	135450803(CTSC)

ACHL:

103799052(CTSC)

SVG:	106853973(CTSC)

MMEA:

130577946(CTSC)

HRT:	120749327(CTSC)

SATI:

136375655(CTSC)

FPG:	101918722(CTSC)

FCH:	102058646(CTSC)

CCRI:

104163032(CTSC)

NNT:	104408430(CTSC)

SHAB:

115604083(CTSC)

ACUN:

113483328(CTSC)

TALA:

104359708(CTSC)

ACHC:

115353494(CTSC)

HALD:

104318917(CTSC)

HLE:	104838509(CTSC)

AGEN:

126048440

GCL:

127015599

CSTI:

104554318(CTSC)

MNB:	103768367(CTSC)

DPUB:

104301167(CTSC)

PPUS:

135189383(CTSC)

AVIT:

104270832(CTSC)

BRHI:

104488978(CTSC)

EGZ:	104128838(CTSC)

NNI:	104017387(CTSC)

PCRI:

104038214(CTSC)

PCAO:

104045544(CTSC)

PADL:

103914925(CTSC)

AFOR:

103904774(CTSC)

FGA:

104080078

GSTE:

104256444(CTSC)

CLV:	102095055(CTSC)

MUI:	104546823(CTSC)

PGUU:

104461146(CTSC)

PLET:

104625081(CTSC)

EHS:	104511337(CTSC)

CMAC:

104481621(CTSC)

CUCA:

104064198(CTSC)

TEO:	104376003(CTSC)

BREG:

104632432(CTSC)

OHA:	104327661(CTSC)

ACAR:

104522986(CTSC)

CPEA:

104394780(CTSC)

CVF:	104283097(CTSC)

RTD:	128918932(CTSC)

AAM:	106491260(CTSC)

AROW:

112962635(CTSC)

NPD:	112951484(CTSC)

TGT:	104580967(CTSC)

DNE:	112986680(CTSC)

SCAM:

104153281(CTSC)

ASN:	102386282(CTSC)

AMJ:	102576717(CTSC)

CPOO:

109305553(CTSC)

GGN:	109302203(CTSC)

PSS:	102453891(CTSC)

CMY:	102935389(CTSC)

CCAY:

125632948(CTSC)

DCC:	119844022(CTSC)

CPIC:

101935953(CTSC)

TST:	117871234(CTSC)

CABI:

116818082(CTSC)

MRV:	120406503(CTSC)

ACS:	100565042(ctsc)

ASAO:

132772245(CTSC)

PVT:	110071074(CTSC)

SUND:

121925165(CTSC)

PBI:	103055898(CTSC)

PMUR:

107294161(CTSC)

CTIG:

120307812(CTSC)

PGUT:

117659762(CTSC)

PTEX:

113440429(CTSC)

NSS:	113420131(CTSC)

VKO:	123029200(CTSC)

PMUA:

114595610(CTSC)

PRAF:

128412526(CTSC)

ZVI:	118085417(CTSC)

HCG:	128352210(CTSC)

GJA:	107113356(CTSC)

STOW:

125431259 125431442

EMC:	129325840(CTSC)

XLA:	108710023(ctsc.S) 380203(ctsc.L)

XTR:	407938(ctsc)

NPR:	108784428(CTSC)

RTEM:

120928963(CTSC)

BBUF:

120996451(CTSC)

BGAR:

122930404 122931039(CTSC)

MUO:	115468442(CTSC)

GSH:	117362607(CTSC)

DRE:	368704(ctsc)

SRX:	107731820 107737423

SANH:

107669915 107670127

SGH:	107558840 107570111

CCAR:

109063991 109064009

CAUA:

113058764 113058774 113114714

CGIB:

127972975 128029070

PTET:

122358826(ctsc)

LROH:

127177464(ctsc)

OMC:	131554176(ctsc)

PPRM:

120470732(ctsc)

RKG:	130073161(ctsc)

MAMB:

125248615(ctsc)

CIDE:

127495246

CERY:

137004365(ctsc)

MASI:

127422030 127430087

TROS:

130549342(ctsc)

TDW:	130428410(ctsc)

MANU:

129438656(ctsc)

IPU:

108278259

IFU:	128621335(ctsc)

PHYP:

113544528(ctsc)

SMEO:

124394181(ctsc)

TFD:	113637939(ctsc)

TVC:	132858141(ctsc)

TRN:	134334566(ctsc)

AMEX:

103046262(ctsc)

CMAO:

118800560(ctsc)

EEE:	113578742(ctsc)

CHAR:

105894113(ctsc)

TRU:	101061497(ctsc)

TFS:	130535563(ctsc)

LCO:	104920118(ctsc)

TBEN:

117470315(ctsc)

CGOB:

115018232(ctsc)

PGEO:

117457219(ctsc)

GACU:

117552267(ctsc)

EMAC:

134880129(ctsc)

ELY:	117259914(ctsc)

EFO:	125888772(ctsc)

PLEP:

121943061(ctsc)

SLUC:

116048242(ctsc)

ECRA:

117942172(ctsc)

ESP:	116683060(ctsc)

PFLV:

114553131(ctsc)

GAT:	120815703(ctsc)

PPUG:

119194756(ctsc)

AFB:	129090456(ctsc)

CLUM:

117741381(ctsc)

PSWI:

130211088(ctsc)

CANA:

137790901(ctsc)

CVE:	137871641(ctsc)

MSAM:

119882707(ctsc)

SCHU:

122879444(ctsc)

CUD:	121521405(ctsc)

ALAT:

119010035(ctsc)

ASTR:

137596671(ctsc)

MZE:	101475307(ctsc)

ONL:	100707260(ctsc)

OAU:	116322925(ctsc)

OLA:	101170449(ctsc)

OML:	112149107(ctsc)

CSAI:

133441686(ctsc)

XMA:	102223206(ctsc)

XCO:	114133233(ctsc)

XHE:	116707783(ctsc)

PRET:

103474488(ctsc)

PFOR:

103146262(ctsc)

PLAI:

106958869(ctsc)

PMEI:

106918012(ctsc)

GAF:	122833315(ctsc)

PPRL:

129359386(ctsc)

CVG:	107091945(ctsc)

CTUL:

119771811(ctsc)

GMU:	124884351(ctsc)

NFU:	107380452(ctsc)

KMR:	108244622(ctsc)

ALIM:

106517256(ctsc)

NWH:	119411089(ctsc)

AOCE:

111572660(ctsc)

EJA:	138197231(ctsc)

MCEP:

125012978(ctsC)

CSEM:

103378542(ctsc)

POV:	109634615(ctsc)

SSEN:

122765550(ctsc)

HHIP:

117773206(ctsc)

HSP:	118106176(ctsc)

PPLT:

128440337(ctsc)

SMAU:

118299448(ctsc)

LCF:

108886624

SDU:	111224142(ctsc)

SLAL:

111655299(ctsc)

XGL:	120792483(ctsc)

HCQ:	109525508(ctsc)

SSCV:

125972249(ctsc)

SBIA:

133505000(ctsc)

PEE:	133405124(ctsc)

PTAO:

133482465(ctsc)

BPEC:

110174272(ctsc)

MALB:

109971607(ctsc)

BSPL:

114867489(ctsc)

SJO:	128360958(ctsc)

SASA:

100196094(catc) 106581413(ctsc) 106613233

STRU:

115206584 115206587

OTW:	112267292(ctsc) 112267304

OMY:	100136230 110503180

OGO:	124006275 124006475

ONE:	115142003(ctsc)

OKI:	109909278 116354737

OKE:

118382223

SNH:	120028730 120036499

CCLU:

121566813 121567808(ctsc)

ELS:	105024067(ctsc)

SFM:	108932123(ctsc)

PKI:	111833927(ctsc)

AANG:

118209880(ctsc)

LOC:	102695252(ctsc)

PSPA:

121320348(ctsc)

ARUT:

117405993 117973058

PSEX:

120523151(ctsc)

LCM:	102365650(CTSC)

CMK:	103184353(ctsc)

CPLA:

122550591(ctsc)

HOC:	132816416(ctsc)

LERI:

129698245(ctsc)

PMRN:

116949405 116955225

LRJ:	133342585 133358772 133358862

BFO:	118404660 118405126 118414050

BBEL:

109475624 109476393 109476394

CIN:

104266675

SCLV:

120334333

SPU:	115919030 586157 764711

LPIC:

129257294 129267619 129267675

APLC:

110975353 110986457

ARUN:

117300703 117307193

AJC:

117120486

SKO:

100378978

FOC:

113203984

TPAL:

117649276

ZNE:

110840885

CSEC:

111869219

SGRE:

126283468 126284976 126356164 126356173 126356183 126356193

BROR:

134536570 134538718

IEL:	124159114 124159119 124159126

DPX:	DAPPUDRAFT_221708

DMK:

116921754

DPZ:

124337033

AFRA:

136038626

PVM:	113824311 113827608 113827616 113827622 113827638

PJA:	122243119 122251070 122264789 122264790 122264791 122264792 122264793

PCHN:

125026766 125027227 125027228 125027640 125027641 125047871

PMOO:

119592897 119592913 119592924 119595014

HAME:

121863392 121863393 121863395 121863396 121863397 121868723 121874598

PCLA:

123749605 123749606 123752289 123763955 123772472

CQD:	128696690 128701844 128701845 128701895

PTRU:

123508001 123508571 123512275

ESN:	126981419 126981583 127008644

MNZ:	135220874 135221025 135226537

MRJ:	136832282 136833188

HAZT:

108669401 108678133

EAF:

111708638

PPOI:

119089752 119090287 119092275

DSV:	119465131 119465154

RSAN:

119402464

RMP:

119166691

DPTE:

113797519

DFR:

124490781

PTEP:

107450228 107450247

ABRU:

129968477 129968616

UDV:	129227263 129228242 129228635

SDM:	118181606 118181607

TSP:	Tsp_02997 Tsp_02998 Tsp_13095

HRO:	HELRODRAFT_91967

LGI:	LOTGIDRAFT_203670 LOTGIDRAFT_221343

PVUL:

126808610 126828546

PCAN:

112571494

BGT:

106053063

GAE:	121369412 121377090

HRF:

124122018

HRJ:

124283287

HASI:

137296241

CRG:

105339566

CANU:

128160425

CVN:

111107171

OED:

125653285

MYI:

110449444

PMAX:

117331605

MCAF:

127707956

MMER:

123528583 123539634

RPHI:

132737973 132739757

DPOL:

127832083 127856961

MAEA:

128206041 128217077 128217689

LJP:	135463536 135470131

LAK:

106172182

SMM:	Smp_019030

SHX:	MS3_00005822

OVI:	T265_10719

LLON:

135490912

ADF:

107355896

AMIL:

114955731

PDAM:

113685567 113685587

SPIS:

111344749 111344752

DGT:	114528914 114537470

HMG:	100205671 100207605

HSY:	130624988 130624989

TAD:	TRIADDRAFT_28083

PFA:	PF3D7_1116700 PF3D7_1247800

PFD:	PFDG_01282 PFDG_02904

PFH:	PFHG_03743 PFHG_04038

PREI:

PRSY57_1115100 PRSY57_1247200

PGAB:

PGSY75_1116700 PGSY75_1247800

PLAG:

39742394(PADL01_1114800) 39743189(PADL01_1248000)

PYO:	PY17X_0933300 PY17X_1463300

PCB:	PCHAS_0913000 PCHAS_1463000

PBE:	PBANKA_0931300 PBANKA_1460700

PVV:	PVVCY_0901490 PVVCY_0901500 PVVCY_1406280

PKN:	PKNH_0914400 PKNH_1467500

PVX:	PVX_091465 PVX_101280

PCY:	PCYB_092280 PCYB_147220

PMAL:

PMUG01_09026000(DPAP1) PMUG01_14081000(DPAP2)

PBRS:

92370855(MKS88_002767) 92373940(MKS88_005853)

PREL:

PRELSG_0913500(DPAP1) PRELSG_1462900(DPAP2)

PCOT:

PCOAH_00024850 PCOAH_00051940

TAN:	TA04105 TA15665

TPV:	TP02_0883 TP03_0357

TOT:	TOT_020000865 TOT_030000923

BEQ:	BEWA_014540 BEWA_035230

BBO:	BBOV_I000540 BBOV_II000170

BMIC:

BMR1_03g02385

BBIG:

BBBOND_0212020 BBBOND_0300890

CPV:

cgd4_2110

CHO:	Chro.40239

TGO:	TGME49_267490 TGME49_289620(CPC1)

BBES:

BESB_020410 BESB_029880

TET:	TTHERM_00445920 TTHERM_00502690

PTM:	GSPATT00003347001 GSPATT00016000001 GSPATT00020193001 GSPATT00022413001 GSPATT00024351001 GSPATT00031929001 GSPATT00033761001

NGR:	NAEGRDRAFT_37577 NAEGRDRAFT_75630 NAEGRDRAFT_79989 NAEGRDRAFT_80477 NAEGRDRAFT_81796

GLA:	GL50803_0014566 GL50803_0022553 GL50803_0028651 GL50803_008741

SSAO:

94301218(SS50377_27195)

» show all

Reference

1 [PMID:14209333]

Authors

PLANTA RJ, GORTER J, GRUBER M.

Title

THE CATALYTIC PROPERTIES OF CATHEPSIN C.

Journal

Biochim Biophys Acta 89:511-9 (1964)
DOI:10.1016/0926-6569(64)90077-x

Reference

2 [PMID:5961281]

Authors

Metroione RM, Neves AG, Fruton JS.

Title

Purification and properties of dipeptidyl transferase (Cathepsin C).

Journal

Biochemistry 5:1597-604 (1966)
DOI:10.1021/bi00869a021

Reference

3 [PMID:4306035]

Authors

McDonald JK, Zeitman BB, Reilly TJ, Ellis S.

Title

New observations on the substrate specificity of cathepsin C (dipeptidyl aminopeptidase I). Including the degradation of beta-corticotropin and other peptide hormones.

Journal

J Biol Chem 244:2693-709 (1969)

Reference

Authors

McDonald JK, Schwabe C.

Title

Intracellular exopeptidases.

Journal

In: Barrett AJ (ed). Proteinases in Mammalian Cells and Tissues. Amsterdam: North-Holland Publishing Co.; 1977. p. 311-391.

Other DBs

ExplorEnz - The Enzyme Database:

3.4.14.1