KEGG ENZYME: 4.2.1.105

ENZYME: 4.2.1.105

Entry

EC 4.2.1.105                Enzyme

Name

2-hydroxyisoflavanone dehydratase;
2,7,4'-trihydroxyisoflavanone hydro-lyase;
2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming)

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

2,4',7-trihydroxyisoflavanone hydro-lyase (daidzein-forming)

Reaction(IUBMB)

(1) 2,4',7-trihydroxyisoflavanone = daidzein + H2O [RN:R07317];
(2) 2,4',5,7-tetrahydroxyisoflavanone = genistein + H2O

Reaction(KEGG)

R07317;
(other) R06793 R07723

Substrate

2,4',7-trihydroxyisoflavanone [CPD:C15567];
2,4',5,7-tetrahydroxyisoflavanone [CPD:C12631]

Product

daidzein [CPD:C10208];
H2O [CPD:C00001];
genistein [CPD:C06563]

Comment

Catalyses the final step in the formation of the isoflavonoid skeleton. The reaction also occurs spontaneously.

History

EC 4.2.1.105 created 2004, modified 2013

Pathway

ec00943

Isoflavonoid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K13258

2-hydroxyisoflavanone dehydratase

Genes

GMX:	100785409 547489(HIDH)

GSJ:	114367895 114371837

PVU:	137810400 137828747

VRA:

106776973

VAR:	108319923 108324771

VUN:	114166941 114190838

VUM:

124848192

CCAJ:

109791254 109794824 109801193 109801222

APRC:

113870130 113871120

MTR:	11413175 11437326

TPRA:

123882884 123909768

CAM:	101502005 101506056

PSAT:

127076827 127097146

VVO:

131611419

ADU:

107466945

AIP:

107617879

AHF:	112711824 112776333

LANG:

109331604

QLO:

115994703

APAN:

127266629

» show all

Reference

Authors

Hakamatsuka T, Mori K, Ishida S, Ebizuka Y, Sankawa U.

Title

Purification of 2-hydroxyisoflavanone dehydratase from the cell cultures of Pueraria lobata.

Journal

Phytochemistry 49:497-505 (1998)

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.105

IUBMB Enzyme Nomenclature:

4.2.1.105

ExPASy - ENZYME nomenclature database:

4.2.1.105

BRENDA, the Enzyme Database:

4.2.1.105

CAS:	166800-10-8

LinkDB

DBGET integrated database retrieval system