Entry |
|
Name |
methylthioribulose 1-phosphate dehydratase;
1-PMT-ribulose dehydratase;
S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase;
S-methyl-5-thio-D-ribulose-1-phosphate 4-hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]
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Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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Sysname |
5-(methylsulfanyl)-D-ribulose-1-phosphate 4-hydro-lyase [5-(methylsulfanyl)-2,3-dioxopentyl-phosphate-forming]
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Reaction(IUBMB) |
5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-(methylsulfanyl)-2,3-dioxopentyl phosphate + H2O [RN: R07392]
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Reaction(KEGG) |
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Substrate |
5-(methylsulfanyl)-D-ribulose 1-phosphate [CPD: C04582]
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Product |
5-(methylsulfanyl)-2,3-dioxopentyl phosphate [CPD: C15650];
H2O [CPD: C00001]
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Comment |
This enzyme forms part of the methionine-salvage pathway.
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History |
EC 4.2.1.109 created 2006
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Pathway |
ec00270 | Cysteine and methionine metabolism |
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Orthology |
K08964 | methylthioribulose-1-phosphate dehydratase |
K16054 | methylthioribulose 1-phosphate dehydratase / enolase-phosphatase E1 |
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Genes |
PPYG: | 129007541(APIP) 129044238 |
PLOP: | 125340011 125362666 |
DNM: | 101424190(APIP) 101447331 |
XLA: | 108713761(apip.L) 414636(apip.S) |
BGAR: | 122920183 122920550 |
SGH: | 107596491 107600482(apip) |
CAUA: | 113051341 113106257 |
CGIB: | 127962565 128016602 |
TROS: | 130548930 130560986(apip) |
AOCE: | 111573479 111588879(apip) |
PPLT: | 128441251 128441267 |
SASA: | 100195024(apip) 106587697 106587892 |
STRU: | 115166786 115203646 |
DME: | Dmel_CG11134(CG11134) |
DSI: | Dsimw501_GD17142(Dsim_GD17142) |
CQU: | CpipJ_CPIJ011356 CpipJ_CPIJ011357 |
CCAL: | 108627424 108630303 |
PPYR: | 116168742 116178745 |
RSAN: | 119398835 119399589 |
CEL: | CELE_ZC373.5(ZC373.5) |
PMAX: | 117335561 117345284 |
MCAF: | 127704467 127705488 127705581 127705640 127706333 127706334 127721162 |
RPHI: | 132719675 132735409 132759741 |
MAEA: | 128230346 128230354 128232211 128232372 |
DGT: | 114521568 114534355 114543315 |
CSAT: | 104725902 104728891 104761408 |
BNA: | 106371273 106380953 106390719 106418418 |
CPAP: | 110811951 110812252 |
MINC: | 123195273 123202277 |
GRA: | 105778963 105783073 105783916 |
GHI: | 107895267 107917240 107920116 107951147 107952099 |
GAB: | 108461442 108462648 108472026 108483756 |
HSYR: | 120114156 120122597 120127927 120129168 120159078 |
GMX: | 100794485 100796209 100817732 |
GSJ: | 114376590 114380047 114416856 |
CCAJ: | 109805886 109812913 |
APRC: | 113853943 113865012 |
LANG: | 109334518 109357367 |
PCIN: | 129313526 129315969 129316792 |
QSA: | O6P43_000976 O6P43_000977 O6P43_029113 |
MSYL: | 126590158 126615686 |
MCHA: | 111010423 111012780 |
CMAX: | 111480956 111482722 |
CMOS: | 111430820 111446438 |
CPEP: | 111789157 111809725 |
HBR: | 110642497 110668312 110672188 |
MESC: | 110601905 110611776 110630407 |
CILL: | 122281741 122290091 |
QSU: | 112016792 112017800 112035008 |
VRI: | 117908754 117910663 117927369 |
SPEN: | 107002717 107026476 |
SSTN: | 125866000 125875485 |
SDUL: | 129877549 129892532 |
CANN: | 107845758 107878650 |
NTA: | 107782969 107795281 107797741 107817457 |
SIND: | 105165393 105176985 |
SSPL: | 121767549 121771799 121802280 121806324 |
SMIL: | 131013345 131024342 131024383 |
APAN: | 127247220 127249797 |
ECAD: | 122593512 122599664 |
CCAV: | 112500937 112507234 |
CSIN: | 114299341 114299702 114303792 114316542 |
AEW: | 130755624 130761034 130773855 130788939 130789156 |
MING: | 122089261 122094345 |
PSOM: | 113287615 113353628 |
TAES: | 123102660 123110845 123119853 |
MFLO: | 136482053 136482054 136483708 136486801 |
PVIR: | 120644346 120685478 120686114 |
PHAI: | 112902136 112902675 |
ZOF: | 122002619 122006862 122041634 122046160 |
MSIN: | 131240910 131245506 |
NCOL: | 116245908 116261239 |
SMO: | SELMODRAFT_187281 SELMODRAFT_266773 SELMODRAFT_416499 |
NCS: | NCAS_0D01680(NCAS0D01680) |
NDI: | NDAI_0C03090(NDAI0C03090) |
TPF: | TPHA_0A04880(TPHA0A04880) |
TBL: | TBLA_0B07580(TBLA0B07580) |
TDL: | TDEL_0E05000(TDEL0E05000) |
KAF: | KAFR_0E02000(KAFR0E02000) |
KNG: | KNAG_0M01270(KNAG0M01270) |
LBG: | 92210540(LODBEIA_P53440) |
CAL: | CAALFM_C502820CA(CaO19.4306) |
YLI: | 2909882(YALI2_B00413g) |
NTE: | NEUTE1DRAFT74605(NEUTE1DRAFT_74605) |
SMP: | 10804978(SMAC4_04853) |
FPOA: | FPOAC1_000514(MDE1) |
TATV: | 25781052(TrAtP1_000771) |
PLJ: | 28887191(PLICBS_002464) |
CDET: | 87939454(CDEST_02951) |
BFU: | BCIN_01g08310(Bcmde1) |
PTRR: | 6345893(PtrM4_140680) |
CDEP: | 91089936(L203_105727) |
KMG: | 30162632(I203_101185) |
KNE: | 92179520(IAR55_002261) |
CCAC: | CcaHIS019_0212480(MDE1) |
HIR: | HETIRDRAFT_434289 HETIRDRAFT_444980 |
ABP: | AGABI1DRAFT114084(AGABI1DRAFT_114084) |
ABV: | AGABI2DRAFT193924(AGABI2DRAFT_193924) |
PSTR: | Pst134EA_005036 Pst134EA_032374 |
LMAT: | 92513273(LSCM1_03211) |
LOI: | 92359865(LSCM4_03938) |
LEIS: | 94179518(GH5_04064) |
LENR: | 94171771(CUR178_04553) |
LEIN: | 94186842(JIQ42_03155) |
PHET: | 94289685(JKF63_03607) |
REE: | electrica_03693(mtnB) |
RTG: | NCTC13098_05404(mtnB) |
CLAP: | NCTC11466_02914(mtnB) |
METY: | MRY16398_41190(mtnB) |
YPG: | YpAngola_A3331(mtnB) |
SFJ: | SAMEA4384070_0973(mtnB_1) |
SOF: | NCTC11214_00558(mtnB_1) |
GQU: | AWC35_02415 AWC35_07675 |
TPTY: | NCTC11468_03585(mtnB) |
XPH: | XppCFBP6546_20000(XppCFBP6546P_20000) |
XHD: | LMG31886_24640(mtnB) |
LLZ: | LYB30171_01073(mtnB) |
PMUI: | G4G71_13285 G4G71_22900 |
PNT: | G5B91_11555 G5B91_19300 |
PVD: | CFBP1590__1920(mtnB) |
PPUU: | PputUW4_03699(mtnB) |
PTW: | TUM18999_23270(mtnB) |
PDEN: | F1C79_03645 F1C79_11295 |
MSHE: | MAALD49_24170(mtnB) |
MISZ: | MishRS11D_26600(mtnB) |
TNI: | TVNIR_2376(mtnB_[H]) |
HAAH: | HALA3H3_510072(mtnB) |
ALCA: | ASALC70_00040(mtnB) |
KAI: | K32_05370(mtnB_1) K32_34660(mtnB_2) |
SCU: | SCE1572_09815 SCE1572_50315 |
BAZ: | BAMTA208_10330(mtnB) |
BSON: | S101395_03398(mtnB) |
BAH: | BAMEG_3248 BAMEG_4298 |
BAX: | H9401_1262 H9401_4057 |
BANS: | BAPAT_1267 BAPAT_4082 |
BANV: | DJ46_173(mtnB) DJ46_2949(mtnB) |
BCZ: | BCE33L1223 BCE33L3795 |
BCR: | BCAH187_A1486 BCAH187_A4169 |
BCB: | BCB4264_A1383 BCB4264_A4147 |
BCU: | BCAH820_1420 BCAH820_4059 |
BCG: | BCG9842_B1091 BCG9842_B3961 |
BAL: | BACI_c13670 BACI_c40070 |
BCER: | BCK_01730 BCK_15010(mtnB) |
BCY: | Bcer98_1055 Bcer98_2737 |
BTK: | BT9727_1221 BT9727_3780 |
BTB: | BMB171_C1175 BMB171_C3702(mtnB) |
BTHR: | YBT1520_07755 YBT1520_21500(mtnB) |
BTHI: | BTK_07950 BTK_21350(mtnB) |
BTC: | CT43_CH1262 CT43_CH4044(mtnB) |
BTF: | YBT020_07305 YBT020_19880(mtnB) |
BTM: | MC28_0561 MC28_3330(mtnB) |
BTG: | BTB_c13750(mtnB1) BTB_c41730(mtnB2) |
BTI: | BTG_14085 BTG_29230(mtnB) |
BTN: | BTF1_04360 BTF1_18505(mtnB) |
BTHT: | H175_ch1276 H175_ch4110 |
BTHU: | YBT1518_07670 YBT1518_22370(mtnB) |
BTW: | BF38_2551(mtnB) BF38_5211(mtnB) |
BTHY: | AQ980_09660(mtnB) AQ980_23160 |
BWE: | BcerKBAB4_1246 BcerKBAB4_3867 |
BWW: | bwei_0913(mtnB) bwei_3677 |
BMYO: | BG05_1984(mtnB) BG05_4567(mtnB) |
BTY: | Btoyo_1283 Btoyo_3970 |
BMYC: | DJ92_1133(mtnB) DJ92_3972(mtnB) |
BBY: | CY96_05825 CY96_19280(mtnB) |
BWD: | CT694_07145 CT694_21730(mtnB) |
BTRO: | FJR70_13935 FJR70_28925 |
BMOB: | MLA2C4_07060 MLA2C4_21120 |
BNT: | GSN03_06745 GSN03_19135 |
BPAC: | LMD38_06895 LMD38_19700 |
BPAN: | NLJ82_06930 NLJ82_19625 |
BALU: | QRY64_09080 QRY64_23105 |
BGY: | BGLY_1454(mtnB_mtnX) |
BARD: | QRY57_08395 QRY57_19975 |
PARG: | PspKH34_28380(mtnB) |
GAJ: | MY490_13410 MY490_15810(mtnB) |
ECTO: | MUG87_00375 MUG87_06855 |
PPQ: | PPSQR21_028540(araD) |
PCHI: | PC41400_12045(mtnB) |
PNK: | AASFL403_05200(mtnB) |
NFR: | ERS450000_02673(mtnA_1) |
SLE: | sle_00940(sle_00940) |
SGM: | GCM10017557_66570(mtnB) |
SXT: | KPP03845_101548(mtnB) |
ACIT: | HPK19_08195 HPK19_10665(mtnB) |
SYH: | Syncc8109_0537(mtnB) |
SYNW: | SynWH8103_02245(mtnB) |
PRUN: | PCC7821_03270(mtnB) |
LCRE: | Pla8534_35510(mtnB_2) |
AAGG: | ETAA8_37550(mtnB_1) |
AMUC: | Pan181_15590(mtnB_1) |
LIS: | LIL_20240(araD1) LIL_20281(araD2) |
ABAC: | LuPra_00085(mtnB_1) |
» show all
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Reference |
|
Authors |
Furfine ES, Abeles RH. |
Title |
Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae. |
Journal |
J Biol Chem 263:9598-606 (1988) |
Reference |
|
Authors |
Wray JW, Abeles RH. |
Title |
The methionine salvage pathway in Klebsiella pneumoniae and rat liver. Identification and characterization of two novel dioxygenases. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 4.2.1.109 |
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LinkDB |
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