Entry
Name
porphobilinogen synthase;
aminolevulinate dehydratase;
delta-aminolevulinate dehydratase;
delta-aminolevulinic acid dehydrase;
delta-aminolevulinic acid dehydratase;
aminolevulinic dehydratase;
delta-aminolevulinic dehydratase;
5-levulinic acid dehydratase;
5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing);
hemB (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)
Reaction(IUBMB)
2 5-aminolevulinate = porphobilinogen + 2 H2O [RN:
R00036 ]
Reaction(KEGG)
Substrate
5-aminolevulinate [CPD:
C00430 ]
Product
Comment
The enzyme catalyses the asymmetric condensation and cyclization of two 5-aminolevulinate molecules, which is the first common step in the biosynthesis of tetrapyrrole pigments such as porphyrin, chlorophyll, vitamin B12, siroheme, phycobilin, and cofactor F430. The enzyme is widespread, being essential in organisms that carry out respiration, photosynthesis, or methanogenesis. The enzymes from most organisms utilize metal ions (Zn2+, Mg2+, K+, and Na+) as cofactors that reside at multiple sites, including the active site and allosteric sites. Enzymes from archaea, yeast, and metazoa (including human) contain Zn2+ at the active site. In humans, the enzyme is a primary target for the environmental toxin Pb. The enzymes from some organisms utilize a dynamic equilibrium between architecturally distinct multimeric assemblies as a means for allosteric regulation.
History
EC 4.2.1.24 created 1961
Pathway
ec01110 Biosynthesis of secondary metabolites
ec01120 Microbial metabolism in diverse environments
Orthology
K01698 porphobilinogen synthase
Genes
NCAR : 124964192 124989729
CTIG : 120298405 120308601(ALAD)
XLA : 444422(alad.L) 444744(alad.S)
SANH : 107684385 107697986
CCAR : 109088460 109088512(alad)
CAUA : 113049858 113083536(alad)
CGIB : 127958704 127958705 127989278
OMC : 131539474 131540103(alad)
PPRM : 120471954 120472193
MASI : 127428782 127434053
HCQ : 109527082 109527083 109527084 109527097
SASA : 100195823(hem2) 106563307(HEM2)
STRU : 115159587 115204048
OMY : 110509774 110523566(alad)
OKE : 118385320 118387516(alad)
SALP : 111961630 111964000
CCLU : 121541651 121582539
ARUT : 117396695 117974025
DSI : Dsimw501_GD12734(Dsim_GD12734)
TDA : 119668473 119668477 119668936
AALB : 109403180 109621792
CPII : 120429785 120430863
MSEX : 115449660 119190973
CFEL : 113370482 113370521
HVI : 124367115 124369948 124372632 124373876
DMK : 116916953 116929730 123475668
PPOI : 119099990 119101447
TAD : TRIADDRAFT_20853 TRIADDRAFT_50678
ATH : AT1G44318(hemb2) AT1G69740(HEMB1)
CSAT : 104701613 104743873 104750822 104759782 104777565 104788048
EUS : EUTSA_v10012213mg EUTSA_v10018595mg
BNA : 106364572 106406308 106414323 106432555
RSZ : 108823403 108824492 108858074
MINC : 123203327 123207168 123229579
HSYR : 120130039 120176373 120216944
TPRA : 123895032 123907406
PSAT : 127082811 127108443
LANG : 109326790 109328190
MSYL : 126605329 126631206
MEAN : 126682125 126686040
MESC : 110606158 110608976
SSPL : 121780304 121780889 121786160 121795085
SHIS : 125207556 125221837
PSOM : 113298034 113302946 113310933 113325389
TDC : 119315135 119324790 119328648 119337109
TAES : 100859960 123132166 123136200 123143700 123148596 123156996
LPER : 127308430 127312576
LRD : 124686006 124686397 124697650 124697807
MFLO : 136519905 136526896 136526946
PVIR : 120668728 120704415
AOF : 109830409 109832777 109840256
ACAK : 137936059 137941512
SMO : SELMODRAFT_426840 SELMODRAFT_441909
MPP : MICPUCDRAFT_45299(HEMB)
NCS : NCAS_0A01900(NCAS0A01900)
NDI : NDAI_0D03830(NDAI0D03830)
TPF : TPHA_0C03980(TPHA0C03980)
TBL : TBLA_0E01590(TBLA0E01590)
TDL : TDEL_0F02800(TDEL0F02800)
KAF : KAFR_0F03680(KAFR0F03680)
KNG : KNAG_0D03790(KNAG0D03790)
LBG : 92209841(LODBEIA_P46450)
CAL : CAALFM_C203300WA(HEM2)
YLI : 2908950(YALI2_E01103g)
NTE : NEUTE1DRAFT120121(NEUTE1DRAFT_120121)
SMP : 10809897(SMAC4_02703)
FPOA : FPOAC1_003163(HEM2)
TATV : 25781491(TrAtP1_003240)
PLJ : 28890763(PLICBS_004904)
CDET : 87950492(CDEST_13992)
BFU : BCIN_04g00200(Bchem2)
PTRR : 6342105(PtrM4_094350)
CDEP : 91087833(L203_103622)
KMG : 30166092(I203_103974)
KNE : 92179025(IAR55_001766)
CCAC : CcaHIS019_0509660(HEM2)
PPL : POSPLDRAFT_102726 POSPLDRAFT_98872
ABP : AGABI1DRAFT112764(AGABI1DRAFT_112764)
ABV : AGABI2DRAFT192728(AGABI2DRAFT_192728)
SCM : SCHCO_02585770(SCHCODRAFT_02585770)
PTRC : PtA15_10A608 PtA15_17A340
PSTR : Pst134EA_019589 Pst134EA_022513
FCY : FRACYDRAFT_218256(AlaD)
BLAC : 94346879(CCR75_003111)
ECOO : ECRM13514_0478(hemB)
ECOH : ECRM13516_0349(hemB)
ECW : EcE24377A_0393(hemB)
EDJ : ECDH1ME8569_0356(hemB)
ECOI : ECOPMV1_00360(hemB)
KPU : KP1_1175(hemB) KP1_p100
KPG : KPNIH32_05555 KPNIH32_17475
KPR : KPR_3406 KPR_4409(hemB)
KPX : PMK1_02644(hemB_1) PMK1_04822(hemB_2)
KPNK : BN49_1290(hemB) BN49_3556
REE : electrica_04019(hemB)
RTG : NCTC13098_02559(hemB_1) NCTC13098_05888(hemB_2)
CLAP : NCTC11466_04388(hemB)
KOR : AWR26_04910(hemB) AWR26_19685(hemB)
KRD : A3780_04145 A3780_10555
KIE : NCTC12125_02679(hemB)
AHN : NCTC12129_01156(hemB)
PSHI : SAMEA2665130_3020(hemB)
YPG : YpAngola_A1907(hemB)
YPI : YpsIP31758_0278(hemB)
SMW : SMWW4_v1c02570(hemB)
SMAF : D781_0221 D781_1772
SRZ : AXX16_0295 AXX16_3359
SERM : CLM71_01235 CLM71_08875
SFJ : SAMEA4384070_0229(hemB)
SOF : NCTC11214_02235(hemB)
SRHZ : FO014_00950(hemB) FO014_08745(hemB) FO014_12210
SSAR : SSARUM_000212(hemB)
PROD : PCO85_00275(hemB) PCO85_01245(hemB)
PAQU : DMB82_0019365(hemB)
PARL : PEC302110_37840(hemB)
DIC : Dpoa569_003727(hemB)
PDIS : D8B20_16260 D8B20_20765(hemB)
TPTY : NCTC11468_00027(hemB)
PAKH : B0X70_22335 B0X70_22980
PLUI : CE143_22380 CE143_23020
XPO : XPG1_0714(hemB) XPG1_3069(hemB)
PHEI : NCTC12003_01938(hemB)
PRJ : NCTC6933_01984(hemB)
LRI : NCTC12151_00200(hemB)
HPIT : NCTC13334_01043(hemB)
PDAG : 4362423_01485(hemB)
ADP : NCTC12871_01147(hemB)
ALIG : NCTC10568_02384(hemB)
ASEG : NCTC10977_00526(hemB)
AVT : NCTC3438_00819(hemB)
RPNE : NCTC8284_03650(hemB_1)
PAET : NCTC13378_00033(hemB)
XFU : XFF4834R_chr39060(hemB)
XPH : XppCFBP6546_14280(hemB)
XHD : LMG31886_41500(hemB)
LLZ : LYB30171_00204(hemB)
VFU : vfu_A00421 vfu_B00633
VAU : VANGNB10_cI2651c(hemB)
VCY : IX92_00350 IX92_27445
VFL : AL536_01540 AL536_20690
VPL : SA104470976_02630(hemB)
VOS : KNV97_03225(hemB) KNV97_19185(hemB)
PGH : FH974_15535(hemB) FH974_18040(hemB)
PHOT : L4174_016075(hemB) L4174_018200(hemB)
PAEB : NCGM1900_6041(hemB)
PPU : PP_2913(hemB) PP_3322(hemBB)
PALD : LU682_013410(hemB) LU682_016075(hemB)
PFL : PFL_2290(hemB_1) PFL_5985(hemB_2)
PPRC : PFLCHA0_c23550(hemB1) PFLCHA0_c59420(hemB2)
PPRO : PPC_2331(hemB_1) PPC_5935
PFE : PSF113_3851 PSF113_5686(hemB)
PZA : HU749_011205(hemB) HU749_028885(hemB)
PFN : HZ99_06515 HZ99_16585
PFO : Pfl01_3751(hemB) Pfl01_5465(hemB)
PFS : PFLU_2147(hemB) PFLU_5913(hemB)
PFC : PflA506_2114(hemB_1) PflA506_5202(hemB_2)
PPZ : H045_06245 H045_19895
PTV : AA957_03885 AA957_15550
PCG : AXG94_14100 AXG94_25420
PVR : PverR02_10805 PverR02_30245
PAZO : AYR47_05735 AYR47_17690
POI : BOP93_09395 BOP93_25225
PRX : HRH33_10830(hemB) HRH33_26080(hemB)
PMED : E3Z27_10040(hemB) E3Z27_27125(hemB)
PKR : AYO71_01270 AYO71_20320
PMUD : NCTC8068_03233(hemB_1) NCTC8068_05196(hemB2)
PTOL : I7845_10380(hemB) I7845_27900(hemB)
PMAB : U0037_10775(hemB) U0037_29705(hemB)
PBRE : QDY63_12380(hemB) QDY63_28875(hemB)
PFW : PF1751_v1c19700(hemB) PF1751_v1c53250(hemB)
PFF : PFLUOLIPICF709345 PFLUOLIPICF726865
PFX : A7318_09565 A7318_26225
PLUL : FOB45_05310(hemB) FOB45_23550(hemB)
PBA : PSEBR_a1877 PSEBR_a5457
PBC : CD58_20030 CD58_28505
PPUU : PputUW4_01623(hemB1) PputUW4_05258(hemB2)
PSK : U771_11120 U771_30565
PCH : EY04_10535 EY04_30745
PCZ : PCL1606_02330 PCL1606_38590
PCP : JM49_01425 JM49_19365
PCHP : C4K32_2280 C4K32_6055
PSEM : TO66_11445 TO66_30205
PSOS : POS17_2279(hemB_1) POS17_5935
PFK : PFAS1_02365 PFAS1_12355
PANR : A7J50_2146 A7J50_5643
PYM : AK972_0016 AK972_3532
PKE : DLD99_18740 DLD99_27775
PUM : HGP31_09655(hemB) HGP31_30080(hemB)
PGY : AWU82_07545 AWU82_11230
PVK : EPZ47_10200 EPZ47_28615(hemB)
PBZ : GN234_07770(hemB) GN234_19455(hemB)
PATA : JWU58_01815(hemB) JWU58_09980(hemB)
PZE : HU754_020020(hemB) HU754_029070(hemB)
PMOE : HV782_019225(hemB) HV782_028125(hemB)
PSEP : C4K39_2195 C4K39_3682
PPII : QL104_12115(hemB) QL104_30270(hemB)
PVW : HU752_013215(hemB) HU752_031365(hemB)
PTRT : HU722_0011145(hemB) HU722_0028515(hemB)
PSAM : HU731_014890(hemB) HU731_025975(hemB)
PTZ : HU718_020120(hemB) HU718_029320(hemB)
PSHH : HU773_017280(hemB) HU773_027070(hemB)
PHV : HU739_000760(hemB) HU739_018970(hemB)
PASG : KSS96_10425(hemB) KSS96_27640(hemB)
PALV : KSS97_10825(hemB) KSS97_28065(hemB)
PCAS : LOY40_10305(hemB) LOY40_28045(hemB)
PIE : HU724_018755(hemB) HU724_027215(hemB)
PTAE : NCTC10697_02378(hemB)
PGF : J0G10_20020(hemB) J0G10_29675(hemB)
PIZ : LAB08_R41380(hemB) LAB08_R58400(hemB)
PPEG : KUA23_10700(hemB) KUA23_28935(hemB)
PSII : NF676_17590(hemB) NF676_26150(hemB)
PFIT : KJY40_19355(hemB) KJY40_29230(hemB)
PNB : NK667_05805(hemB) NK667_28720(hemB)
PKJ : Q1W70_01180(hemB) Q1W70_11265(hemB)
PHYG : JTY93_16650(hemB) JTY93_26310(hemB)
PHOM : KJF94_16800(hemB) KJF94_25420(hemB)
PCUC : PSH97_19065(hemB) PSH97_27025(hemB)
PPAE : LDL65_10040(hemB) LDL65_21085(hemB)
PRHZ : CRX69_00565 CRX69_18870
PSHS : JJN09_09845(hemB) JJN09_18795(hemB)
PHEF : PSH57_09975(hemB) PSH57_27780(hemB)
PLIS : NN484_05585(hemB) NN484_11325(hemB)
PSNC : C0058_19715 C0058_31345
PKV : QYQ93_10825(hemB) QYQ93_28225(hemB)
PBAM : NUH87_05530(hemB) NUH87_18400(hemB)
PQE : OSC50_14835(hemB) OSC50_25710(hemB)
MSHE : MAALD49_35600(hemB)
PSYC : DABAL43B_2065(hemB)
ABM : ABSDF1528(hemB) ABSDF2525(hemB)
AGU : AS4_08700(hemB) AS4_14530(hemB)
MCAT : MC25239_00472(hemB)
MCUN : NCTC10297_02004(hemB)
SON : SO_2587(hemB) SO_4208(hemB)
SBM : Shew185_0410 Shew185_1885
SBN : Sbal195_0422 Sbal195_1892
SBP : Sbal223_0436 Sbal223_2434
SBT : Sbal678_0431 Sbal678_1931
SBS : Sbal117_1976 Sbal117_4063
SBB : Sbal175_0505 Sbal175_2496
SPC : Sputcn32_0497 Sputcn32_1755
SHP : Sput200_0421 Sput200_1790
SHE : Shewmr4_2183 Shewmr4_3560
SHM : Shewmr7_0396 Shewmr7_2260
SHN : Shewana3_2392 Shewana3_3734
SHW : Sputw3181_2270 Sputw3181_3673
SHF : CEQ32_03850 CEQ32_18780
SPSW : Sps_01534 Sps_03058
SBJ : CF168_02110 CF168_09040
SHEW : CKQ84_10465 CKQ84_18040
SALG : BS332_04765 BS332_19225
SPOL : FH971_02230(hemB) FH971_03570(hemB)
SCAA : TUM17387_18170(hemB_1) TUM17387_34540(hemB_2)
SPSH : FM037_15945(hemB) FM037_24900(hemB)
SXM : MKD32_02560(hemB) MKD32_10830(hemB)
SHEJ : MZ182_02160(hemB) MZ182_08760(hemB)
SSEH : N7V09_04535(hemB) N7V09_11425(hemB)
SCHK : GII14_12085(hemB) GII14_19510(hemB)
SDEO : D0436_12725(hemB) D0436_20030(hemB)
SMES : K0I73_02400(hemB) K0I73_17455(hemB)
SMAY : K0H60_11745(hemB) K0H60_18695(hemB)
SOG : RA178_02260(hemB) RA178_12940(hemB)
SPSR : EGC80_02025(hemB) EGC80_02935
SHEL : JM642_02450(hemB) JM642_09550(hemB)
SALH : HMF8227_02811(hemB)
CEB : B0D95_04920 B0D95_19440
CBS : COXBURSA331_A1584(hemB)
LLG : 44548918_00747(hemB)
LJR : NCTC11533_00859(hemB)
LCJ : NCTC11976_01901(hemB)
LWA : SAMEA4504053_1997(hemB)
LSS : NCTC12082_01022(hemB)
LADL : NCTC12735_00806(hemB)
LANT : TUM19329_25070(hemB)
MISZ : MishRS11D_04960(hemB)
FHA : CDV26_06335 CDV26_08320
TIB : THMIRHAM_01470(hemB)
TSE : THMIRHAS_01520(hemB)
TZO : THMIRHAT_20880(hemB)
TFRI : Thiofri_02075(hemB)
TNI : TVNIR_0409(hemB_[H])
GAI : IMCC3135_06625(hemB)
THIC : TspCOW1_24710(hemB)
HAHE : ENC22_02625(hemB) ENC22_04170(hemB)
HBH : E4T21_03095(hemB) E4T21_19280(hemB)
HASO : B2G49_09440 B2G49_21780
HAAH : HALA3H3_590047(hemB) HALA3H3_800126(hemB)
HOL : HORIV_40830 HORIV_55700
HAXI : HAALTHF_19230n(hemB)
KUS : B9G99_02590 B9G99_07805
KMA : B9H00_07200 B9H00_12580
ALCA : ASALC70_02752(hemB)
MMW : Mmwyl1_0074 Mmwyl1_3998
AEL : NCTC12917_04202(hemB)
CHJ : NCTC10426_01963(hemB)
CDIZ : CEDIAZO_00007(hemB)
NMQ : NMBM04240196_1364(hemB)
NMZ : NMBNZ0533_0850(hemB)
NMX : NMA510612_1133(hemB)
NWE : SAMEA3174300_0318(hemB)
NZO : SAMEA4504057_1894(hemB)
NCI : NCTC10296_01274(hemB)
NCZ : NCTC10294_00447(hemB)
NANI : NCTC12227_00562(hemB)
ECOR : SAMEA4412678_0801(hemB)
BMV : BMASAVP1_A3139(hemB)
BML : BMA10229_A1954(hemB)
BPM : BURPS1710b_3746(hemB)
BPL : BURPS1106A_3774(hemB)
PPAI : E1956_04460(hemB) E1956_32935(hemB)
PLG : NCTC10937_05116(hemB)
LMIR : NCTC12852_00764(hemB)
CABA : SBC2_09180(hemB_1) SBC2_32520(hemB_2)
BUO : BRPE64_ACDS25550(hemB)
BTRM : SAMEA390648701293(hemB)
AXX : ERS451415_06102(hemB)
LIM : L103DPR2_00347(hemB_1) L103DPR2_00966(hemB_2)
LIH : L63ED372_02851(hemB)
SMIO : CATMQ487_00630(hemB)
URU : DSM104443_00032(hemB)
UPL : DSM104440_00029(hemB)
AZI : AzCIB_0866 AzCIB_2309
THAG : CKCBHOJB_01131(hemB)
FPHO : SHINM1_001580(hemB) SHINM1_002770
ERW : ERWE_CDS_02770(hemB)
ERG : ERGA_CDS_02720(hemB)
RBS : RHODOSMS8_01240(hemB)
SMEL : SM2011_c01766(hemB)
SFD : USDA257_c09250(hemB)
AGR : AGROH133_05357(hemB)
ALF : CFBP5473_20660(hemB)
AVV : RvVAT039_28170(hemB)
AVF : RvVAR031_15330(hemB)
ASAL : CFBP5507_03935(hemB)
RPUS : CFBP5875_04530(hemB)
ALEG : CFBP4996_04200(hemB)
REC : RHECIAT_CH0001574(hemB)
REL : REMIM1_CH01519(hemB)
REP : IE4803_CH01508(hemB)
REI : IE4771_CH01559(hemB)
RTR : RTCIAT899_CH06435(hemB)
RGA : RGR602_CH01392(hemB)
RPHA : AMC79_CH01528(hemB)
RLW : RlegWSM1455_06345(hemB)
RBW : RLCC275e_06360(hemB) RLCC275e_34015 RLCC275e_34025(hemB)
NEN : NCHU2750_10860(hemB)
BIO : BR141012304_11890(hemB)
BRAD : BF49_6537 BF49_6538
BSEP : HAP48_0041460(hemB)
BCAN : BcanWSM471_22450(hemB)
VGO : GJW-30_1_03130(hemB)
MAQU : Maq22A_1p30770(hemB)
MMES : MMSR116_11365(hemB)
MTAD : M6G65_18815(hemB) M6G65_24505(hemB)
MTUN : MTUNDRAET4_0856(hemB)
FIL : BN1229_v1_3351(hemB)
FIY : BN1229_v1_2571(hemB)
BVY : NCTC9239_01212(hemB)
TSV : DSM104635_01746(hemB_2) DSM104635_02146(hemB_3)
RLI : RLO149_c018060(hemB)
PHP : PhaeoP97_01487(hemB)
PPIC : PhaeoP14_01394(hemB)
SINL : DSM14862_01407(hemB)
SPSE : SULPSESMR1_01618(hemB)
RMM : ROSMUCSMR3_00706(hemB)
AHT : ANTHELSMS3_03187(hemB)
LALG : LentiSH36_01287(hemB)
LVS : LOKVESSMR4R_01483(hemB)
AALK : LGT41_0013135(hemB)
SPAG : sphantq_03053(hemB)
SFLA : SPHFLASMR4Y_02036(hemB)
HPO : HMPREF4655_20405(hemB)
HPX : HMPREF0462_0216(hemB)
HCL : NCTC13205_00632(hemB)
HSH : NHP194022_01710(hemB)
HPUL : NCTC13154_00455(hemB)
CJV : MTVDSCj20_0996(hemB)
CFV : CFVI03293_1605(hemB)
CAMP : CFT03427_1533(hemB)
CCOC : CCON33237_0662(hemB)
CLR : UPTC16701_1102(hemB)
CLM : UPTC16712_1133(hemB)
CAMR : CAQ16704_1124(hemB)
CHV : CHELV3228_1552(hemB)
CPIN : CPIN18020_1383(hemB)
CAMZ : CVIC12175_0027(hemB)
GEC : GEO60473_30170(hemB)
GBN : GEOBRER4_04040(hemB)
PACE : A6070_00050 A6070_14775
PPOR : JCM14722_28880(hemB)
DTI : Desti_0802 Desti_2957
BAMA : RBAU_2657(hemB) RBAU_3894
BAZ : BAMTA208_13805(hemB)
BSON : S101395_01546(hemB)
BFD : NCTC4823_01494(hemB)
PARG : PspKH34_08410(hemB)
LMAC : I6G82_03755(hemB) I6G82_11680(hemB)
BLEN : NCTC4824_01533(hemB)
SAX : USA300HOU_1660(hemB)
SUQ : HMPREF0772_11482(hemB)
SUX : SAEMRSA15_15790(hemB)
SUF : SARLGA251_15610(hemB)
SAUT : SAI1T1_2012110(hemB)
SAUJ : SAI2T2_1012130(hemB)
SAUK : SAI3T3_1012110(hemB)
SAUQ : SAI4T8_1012120(hemB)
SAUV : SAI7S6_1012130(hemB)
SAUW : SAI5S5_1012080(hemB)
SAUX : SAI6T6_1012090(hemB)
SAUY : SAI8T7_1012120(hemB)
SDP : NCTC12225_01344(hemB)
SPIC : SAMEA4384060_1290(hemB)
SSH : NCTC13712_01657(hemB)
SSIM : SAMEA4384339_1550(hemB)
SSTE : SAMEA4384403_1086(hemB)
LMOC : LMOSLCC5850_1618(hemB)
LMW : LMOSLCC2755_1562(hemB)
LMX : LMOSLCC2372_1617(hemB)
LMZ : LMOSLCC2482_1611(hemB)
LMON : LMOSLCC2376_1510(hemB)
LMOS : LMOSLCC7179_1528(hemB)
LMOO : LMOSLCC2378_1572(hemB)
LMOY : LMOSLCC2479_1616(hemB)
LMOT : LMOSLCC2540_1634(hemB)
LMOA : LMOATCC19117_1565(hemB)
LGZ : NCTC10812_01543(hemB)
BAYD : BSPP4475_14095(hemB)
PPQ : PPSQR21_039200(hemB)
PNK : AASFL403_01795(hemB)
COHN : KCTCHS21_19180(hemB)
SMEN : SAMEA4412692_0376(hemB)
LRU : HMPREF0538_20888(hemB)
CCOH : SAMEA4530647_0613(hemB)
CFB : CLFE_000160(hemB_1) CLFE_017020(hemB_2)
CGEL : psyc5s11_37450(hemB)
CCL : Clocl_1787 Clocl_3587
RHER : EHE19_014860(hemB) EHE19_016070(hemB)
BPRO : PMF13cell1_04243(hemB)
BLUI : Blut17040_11650(hemB)
CSCI : HDCHBGLK_00098(hemB)
CBAR : PATL70BA_0236(hemB)
AMIC : Ami3637_03235(hemB)
ABUT : Ami103574_05880(hemB)
PDF : CD630DERM_34190(hemB)
PHX : KGNDJEFE_01185(hemB)
EAC : EAL2_808p01120(hemB)
NCD : ACONDI_00760(hemB_1) ACONDI_01872(hemB_2)
VRM : 44547418_01500(hemB)
VDN : NCTC11831_01529(hemB)
DHO : Dia5BBH33_07130(hemB)
MANA : MAMMFC1_00901(hemB)
PFAC : PFJ30894_00525(hemB)
AARG : Aargi30884_00620(hemB)
ABSI : A9CBEGH2_02500(hemB)
CDIA : CaldiYA01_13080(hemB)
MMAE : MMARE11_07950(hemB)
MHAD : B586_18420 B586_19455
MBAI : MB901379_00724(hemB)
MHEK : JMUB5695_04138(hemB)
MKY : IWGMT90018_08420(hemB)
MPHL : MPHLCCUG_04492(hemB)
MTHN : 4412656_00604(hemB)
MAUU : NCTC10437_00708(hemB)
MFLV : NCTC10271_04464(hemB)
MSAL : DSM43276_03806(hemB)
MTER : 4434518_00499(hemB)
CDIP : ERS451417_00326(hemB)
COI : CPCIP5297_01470(hemB)
CUN : Cul210932_0335(hemB)
CUQ : Cul210931_0320(hemB)
CUJ : CUL131002_0321(hemB)
CMIN : NCTC10288_02228(hemB)
CRL : NCTC7448_01146(hemB)
CCYS : SAMEA4530656_2166(HemB)
NFR : ERS450000_04718(hemB)
NAD : NCTC11293_00083(hemB)
NIE : KV110_09015(hemB) KV110_37980(hemB)
NSPU : IFM12276_57380(hemB)
RCR : NCTC10994_03577(hemB)
RANT : RHODO2019_01745(hemB)
TPUL : TPB0596_06800(hemB)
SRC : M271_22460 M271_24170
SVT : SVTN_16540 SVTN_27930
SAMB : SAM23877_4245(hemB)
SLE : sle_31450(sle_31450)
SGM : GCM10017557_47260(hemB)
SRK : FGW37_02240(hemB) FGW37_05530 FGW37_14855(hemB)
SPAD : DVK44_05325 DVK44_12950
SSUB : CP968_11150(hemB) CP968_14810(hemB)
STSU : B7R87_18905 B7R87_19350
STUI : GCM10017668_39880(hemB)
SHUN : DWB77_00055(hemB_1) DWB77_03408(hemB_2) DWB77_07540(hemB_3)
SMOB : J7W19_14680(hemB) J7W19_28215(hemB)
SPEU : CGZ69_10920 CGZ69_20235
SGOB : test1122_15160(hemB)
STAA : LDH80_11420(hemB) LDH80_22690(hemB)
SXT : KPP03845_103440(hemB)
SLON : LGI35_00235(hemB) LGI35_25530(hemB)
KBU : Q4V64_24660 Q4V64_28075 Q4V64_30075(hemB)
SPRF : K4G22_09590 K4G22_12555(hemB)
KAB : B7C62_12920 B7C62_14160
KIT : CFP65_3143 CFP65_3313
AMAU : DSM26151_01610(hemB)
MALK : MalAC0309_0270(hemB)
PSEV : USB125703_00799(hemB)
LYH : FrondiHNR_02565(hemB)
AAGI : NCTC2676_1_02085(hemB)
PSNI : NIBR502771_11810(hemB)
GCR : GcLGCM259_1914(hemB)
MICK : B1A86_00007600(hemB)
RDN : HMPREF0733_10108(hemB)
DCO : SAMEA4475696_0683(hemB)
PAK : HMPREF0675_3345(hemB)
CGRN : 4412665_00204(hemB)
PAUS : NCTC13651_02435(hemB)
PPC : HMPREF9154_1798(hemB)
RAIN : Rai3103_10015(hemB)
BROO : brsh051_09730(hemB)
NAQU : ENKNEFLB_04153(hemB)
STRR : EKD16_01660(hemB1) EKD16_25150(hemB2)
AGRA : AGRA3207_004714(hemB)
SPIQ : OHA34_13185(hemB) OHA34_20455(hemB)
MSAG : GCM10017556_18980(hemB)
ACTR : Asp14428_53440(hemB)
MCU : HMPREF0573_10733(hemB)
TBW : NCTC13354_01103(hemB)
AHW : NCTC11636_01879(hemB)
AIR : NCTC12972_02067(hemB)
ASLA : NCTC11923_00430(hemB)
AVC : NCTC10951_02028(hemB)
BALA : DSM104299_05839(hemB)
SBAE : DSM104329_05739(hemB)
SYJ : D082_26140 D082_27140(hemB)
SYNH : HTZ78_00420(hemB) HTZ78_12435(hemB)
SYR : SynRCC307_0315(hemB)
SYX : SynWH7803_2099(hemB)
SYNW : SynWH8103_02207(HEMB)
WNA : KA717_22845(hemB) KA717_23400(hemB)
TVN : NIES2134_119770(hemB)
AMR : AM1_3071(hemB) AM1_4803(hemB)
ACAM : HRE53_12300(hemB) HRE53_20000(hemB)
LET : O77CONTIG1_00832(hemB)
LBO : LBWT_14510 LBWT_1660
LEPT : JVX88_13935(hemB) JVX88_18775(hemB)
LSK : J5X98_00495(hemB) J5X98_18085(hemB)
HHG : XM38_046950(hemB_1) XM38_053140(hemB_2)
GLP : Glo7428_2561 Glo7428_3045
CHON : NIES4102_00270(hemB)
GDU : P0S91_19865(hemB) P0S91_23810(hemB)
GEE : GM3708_2409 GM3708_2964
CAN : Cyan10605_0252 Cyan10605_3339
SYP : SYNPCC7002_A1753(hemB) SYNPCC7002_G0127(hemB-II)
SYV : AWQ23_08970 AWQ23_15225
SYL : AWQ21_01445 AWQ21_09725
SYNN : NIES970_04820(hemB) NIES970_28140(hemB-II)
MAR : MAE_22850(hemB) MAE_39770(hemB)
MIQ : B5D77_13235 B5D77_25305
MVZ : myaer102_14570(hemB_1) myaer102_55480(hemB_2)
CYT : cce_1489(hemB3) cce_1659(hemB2) cce_4852(hemB1)
CYP : PCC8801_0777 PCC8801_1560
CYH : Cyan8802_0804 Cyan8802_1584
CYC : PCC7424_3843 PCC7424_4525
PAGH : NIES204_13600(hemB)
PRUN : PCC7821_01579(hemB)
OXY : HCG48_05090(hemB) HCG48_20955(hemB)
OAC : Oscil6304_0245 Oscil6304_3369
MIC : Mic7113_0227 Mic7113_3013
NOP : Nos7524_1414 Nos7524_1857
NON : NOS3756_02040 NOS3756_36770
NOE : CLI64_13060 CLI64_26905
NED : HUN01_04255(hemB) HUN01_14990(hemB)
NLK : NIES25_55290 NIES25_58230
NCW : NIES2107_01050 NIES2107_12680
AVA : Ava_1946 Ava_3297 Ava_B0225
ANB : ANA_C10691(hemB) ANA_C11406(hemB)
ACY : Anacy_0537 Anacy_5206
AWA : AA650_23230 AA650_24065
ANN : EH233_09540(hemB) EH233_23675(hemB) EH233_24425(hemB)
CALT : Cal6303_2884 Cal6303_4758
CALH : IJ00_02670 IJ00_15360
RIV : Riv7116_1615 Riv7116_2270
MDP : NIES3275_24420 NIES3275_38860
FIS : FIS3754_15200 FIS3754_50030
NSPH : BDGGKGIB_00930(hemB)
DOU : BMF77_01497(hemB_1) BMF77_02613(hemB_2)
DFS : HGD76_04390(hemB) HGD76_10425(hemB)
DHT : NG743_11745(hemB) NG743_12590(hemB)
DCM : NIES806_05240 NIES806_10520
DOT : EZY12_05925(hemB) EZY12_25290(hemB)
DOZ : HEP80_11220(hemB) HEP80_20710(hemB)
DOC : HEQ26_09520(hemB) HEQ26_12600(hemB)
CRK : L3I90_03275(hemB) L3I90_09335(hemB)
AFLO : HEQ12_00570(hemB) HEQ12_07690(hemB)
STOQ : K2F26_11615(hemB) K2F26_15900(hemB)
SKV : NIES73_06390 NIES73_20320
RCS : NIES932_12560 NIES932_20550(hemB)
OCF : WJM97_01470(hemB) WJM97_11355(hemB)
SCYT : SAMD_31930 SAMD_73400
BSEN : DP114_05105 DP114_05150 DP114_07975
BOX : DP113_05055 DP113_05100 DP113_07930
NCN : BZZ01_10350 BZZ01_29970
PLP : Ple7327_2988 Ple7327_4063
DEIN : DAAJ005_11605(hemB)
OBG : Verru16b_02722(hemB)
ABIW : Abiwalacus_21220(hemB)
PIR : VN12_03725(hemB_1) VN12_24640(hemB_2)
LCRE : Pla8534_63690(hemB)
FPOL : ERS445057_01834(hemB)
PPIO : CE91St28_12120(hemB)
PSPC : Strain318_000108(hemB)
PCRE : NCTC12858_00577(hemB)
PCAG : NCTC12856_00729(hemB)
CBAM : PIECOFPK_00072(hemB)
SMIZ : 4412673_00612(hemB)
SDJ : NCTC13534_00677(hemB)
STHA : NCTC11429_00964(hemB)
PSEZ : HME7025_00052(hemB)
FOK : KK2020170_07630(hemB)
PHG : KCTC32516_01502(hemB)
AALG : AREALGSMS7_01513(hemB)
KOS : KORDIASMS9_01325(hemB)
KAN : IMCC3317_27330(hemB)
SPON : HME9304_01658(hemB)
FBU : UJ101_01988(hemB|ALAD)
OHM : MSHRCOH1_07000(hemB)
CGLE : NCTC11432_02280(hemB)
CTAI : NCTC12078_00980(hemB)
CTAK : 4412677_02264(hemB)
CHRJ : CHRYMOREF3P_1854(hemB)
CJG : NCTC13459_02806(hemB)
CANT : NCTC13489_02858(hemB)
KFA : Q73A0000_15940(hemB)
PTAN : CRYO30217_02109(hemB)
PROC : Ptc2401_00659(hemB)
HALA : Hrd1104_10560(hemB)
HALQ : Hrr1229_006850(hemB)
HACB : Hbl1158_14435(hemB)
TVO : TVG1155064(TVG1155064)
NGA : Ngar_c23060(hemB1) Ngar_c26840(hemB2)
NVN : NVIE_000740(hemB21) NVIE_016230(hemB2)
TAA : NMY3_01276(hemB_1) NMY3_02204(hemB_2)
NFN : NFRAN_2249(hemB) NFRAN_2968(hemB)
LOKI : Lokiarch_29930(hemB_1) Lokiarch_30610(hemB_2)
» show all
Taxonomy
Reference
Authors
GIBSON KD, NEUBERGER A, SCOTT JJ.
Title
The purification and properties of delta-aminolaevulic acid dehydrase.
Journal
Reference
Authors
Komai H, Neilands JB.
Title
The metalloprotein nature of Ustilago delta-aminolevulinate dehydratase.
Journal
Reference
Authors
Yamasaki H, Moriyama T.
Title
Delta-aminolevulinic acid dehydratase of Mycobacterium phlei.
Journal
Reference
Authors
Mitchell LW, Jaffe EK
Title
Porphobilinogen synthase from Escherichia coli is a Zn(II) metalloenzyme stimulated by Mg(II).
Journal
Reference
Authors
Jaffe EK, Ali S, Mitchell LW, Taylor KM, Volin M, Markham GD
Title
Characterization of the role of the stimulatory magnesium of Escherichia coli porphobilinogen synthase.
Journal
Reference
Authors
Warren MJ, Cooper JB, Wood SP, Shoolingin-Jordan PM
Title
Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase.
Journal
Reference
Authors
Jaffe EK, Lawrence SH
Title
Allostery and the dynamic oligomerization of porphobilinogen synthase.
Journal
Reference
Authors
Tian BX, Erdtman E, Eriksson LA
Title
Catalytic mechanism of porphobilinogen synthase: the chemical step revisited by QM/MM calculations.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.24
ExPASy - ENZYME nomenclature database: 4.2.1.24
LinkDB
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