KEGG ORTHOLOGY: K00415

ORTHOLOGY: K00415

Entry

K00415                      KO

Symbol

QCR2, UQCRC2

Name

ubiquinol-cytochrome c reductase core subunit 2

Pathway

map00190

Oxidative phosphorylation

map01100

Metabolic pathways

map04260

Cardiac muscle contraction

map04714

Thermogenesis

map04932

Non-alcoholic fatty liver disease

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05208

Chemical carcinogenesis - reactive oxygen species

map05415

Diabetic cardiomyopathy

Module

M00152

Cytochrome bc1 complex

Disease

H02086

Mitochondrial complex III deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
  09159 Environmental adaptation
   04714 Thermogenesis
    K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
   05012 Parkinson disease
    K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
   05014 Amyotrophic lateral sclerosis
    K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
   05016 Huntington disease
    K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
   05020 Prion disease
    K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
   05022 Pathways of neurodegeneration - multiple diseases
    K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
Peptidases and inhibitors [BR:ko01002]
Metallo peptidases
  Family M16: pitrilysin family
   K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2

Other DBs

GO:

0008121

Genes

HSA:	7385(UQCRC2)

PTR:	468094(UQCRC2)

PPS:

100972888

GGO:

101130739

PON:	100456655 103889540

PPYG:

129015030 129016311 134738563

NLE:

100592631

HMH:

116471120

SSYN:

129493207

MCC:	697967(UQCRC2)

MCF:

102135041

MTHB:

126944495

MNI:

105484999

CSAB:

103229564(UQCR2)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:

SBQ:

CIMI:

108294769 108304212 108308500

ANAN:

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	67003(Uqcrc2)

MCAL:

110298142

MPAH:

110318232

RNO:	293448(Uqcrc2)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

125339877 125339953 125339954 125340367 125344676

NCAR:

124969833 124985946

MMMA:

107146855

OCU:	100347143 100356308

OPI:

101526896

TUP:

102501413

GVR:

103603703

CFA:	479815(UQCRC2)

CLUD:

112640264 112669654

VVP:

112908289

VLG:

121487529

NPO:	129500429 129504493 129519488

AML:

UMR:

UAH:

UAR:

ELK:

LLV:	125090285 125095337

MPUF:

101672152 101685926

MNP:	132015188 132026800

MLK:	131819847 131828956

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101101684(UQCRC2)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	282394(UQCRC2)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

CSUM:

138076078(UQCRC2)

ODA:	120875801 120881749

CCAD:

122432998 122445477

MREE:

136160592(UQCRC2)

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100057847(UQCRC2)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:	119056044 119057504

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:	100026672(UQCRC2)

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138158752(UQCRC2)

OAA:

100077249

GGA:	427009(UQCRC2)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106033377(UQCRC2)

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136367839(UQCRC2)

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

TALA:

ACHC:

HALD:

HLE:

AGEN:

GCL:

CSTI:

LDI:

MNB:

DPUB:

PPUS:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PADL:

AFOR:

FGA:

GSTE:

CLV:

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

CPEA:

CVF:

RTD:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102566246(UQCRC2)

CPOO:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	380093(uqcrc2.S) 446522(uqcrc2.L)

XTR:	549420(uqcrc2)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	322549(uqcrc2b) 436930(uqcrc2a)

SRX:	107717493 107745655 107753296

SANH:

107671252 107674831 107684747 107695555

SGH:	107552131 107569185 107596603

CCAR:

109049624 109049625 109053982

CAUA:

113047560 113052964 113056317 113111914

CGIB:

127944594 127953142 127969502 128024966

PTET:

122352591 122355777

LROH:

127161388 127174353

OMC:	131538050 131551305

PPRM:

120462966 120464019

RKG:	130072207 130080490

MAMB:

125254943 125267618

CIDE:

127509771 127524277

CERY:

137007513(uqcrc2b) 137017975(uqcrc2a)

MASI:

127426844 127450582 127452303

TROS:

130561985 130569591

TDW:	130425660 130439350

MANU:

IPU:

IFU:

PHYP:

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:	101063187 101066705

TFS:	130514902 130528002

TNG:	GSTEN00024150G001 GSTEN00033383G001

LCO:	104918065 104918798

NCC:	104947688 104958528

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:	117246679 117269065

EFO:	125879831 125880799

PLEP:

121956264 121959325

SLUC:

116044244 116059626

ECRA:

117937036 117958034

ESP:	116670940 116702941

PFLV:

114547994 114569611

GAT:	120818915 120827948

PPUG:

119213320 119220206

AFB:	129091381 129098234

CLUM:

117735575 117748835

PSWI:

130188913 130203406

CANA:

137786538(uqcrc2a) 137789983(uqcrc2b)

CVE:	137878491(uqcrc2a)

MSAM:

119889359 119915659

SCHU:

122867756 122868876

CUD:	121503568 121527830

ALAT:

119010297 119014765

ASTR:

137588317(uqcrc2b) 137609322(uqcrc2a)

MZE:	101483500 101484721

ONL:	100695608 100709124

OAU:	116313051 116320106

OLA:	101158024 101175512

OML:	112146881 112154566

CSAI:

133419270 133421385

XMA:	102217635 102224767

XCO:	114151416 114160351

XHE:	116727624 116736018

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122821813 122823713

PPRL:

129352317 129363923

CVG:	107092516 107099879

CTUL:

119793266 119798362

GMU:	124862308 124864494 124875570

NFU:	107376507 107388176

KMR:

ALIM:

NWH:

AOCE:

EJA:	138198037(uqcrc2a) 138202159(uqcrc2b)

MCEP:

125023004

CSEM:

103382355 103393044

POV:	109627172 109638649

SSEN:

122759701 122784787

HHIP:

117752710 117765713

HSP:	118100826 118123807

PPLT:

128426728 128458123

SMAU:

118288134 118288832

LCF:	108879426 108880769 108894940

SDU:	111220225 111227095

SLAL:

111667549 111672023

XGL:	120788404 120794439

HCQ:	109515251 109516255

SSCV:

125983217(uqcrc2a) 125991562(uqcrc2b)

SBIA:

133495756 133514028

PEE:	133395156 133414718

PTAO:

BPEC:

MALB:

BSPL:

SJO:	128378486 128381249

SASA:

106589600(QCR2) 106601733 106606732 106609984(QCR2)

STRU:

115152902 115171647 115201408 115205227

OTW:	112224473 112239959 112259530

OMY:	110486787 110499211 110502927 110538748

OGO:	124038573 124040201

ONE:	115112871 115119155 115144246

OKI:	109869904 109900045

OKE:	118372950 118379176 118402913

SALP:

111967954 111977408

SNH:	120030091 120040625 120040643 120046819

CCLU:

121547541 121551830 121557111 121577491

ELS:	105026146 105031505

SFM:

PKI:

AANG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:	132825177 132831226

LERI:

PMRN:

LRJ:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG4169(UQCR-C2)

DER:

6544226

DSE:

6605977

DSI:	Dsimw501_GD14647(Dsim_GD14647)

DYA:	Dyak_GE19862

DAN:

6506556

DSR:

110177542

DPO:	4812382 6897314

DPE:	6587583 6599763

DMN:	108151666 108155247

DWI:

6643098

DGR:

6558205

DMO:	Dmoj_GI16551

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ011929

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105670362(UQCR-C2)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100124277(Uqcrc2)

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:	124210695(UQCR-C2)

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100127121(Uqcrc2)

BMAN:

114249586

MSEX:

115446352 115449481

DPL:	KGM_204885 KGM_205606

BANY:

112044956 112046129

MJU:	123867956 123874367

NIQ:

126774554

VCD:	124534848 124536356

MCIX:

123658958 123659942

PMAC:

106719079

PPOT:

106104619 106106467

PXU:	106121411 106122426

BPHI:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110370098 110381044

HZE:

124635234

TNL:

113496410

SLIU:

111358765 111362175

OFU:	114350217 114359879

ATRA:

106135186

GMW:

113521172

PXY:	105385400 105393490

PGW:	126370873 126372341

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:	126903587 126905884

BTAB:

109043758

DCI:

103510564

CLEC:

106665951

HHAL:

106677708(UQCR-C2)

NLU:

111063444

HVI:

124353802

MQU:	129004338 129005552

PHU:	Phum_PHUM140150

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:	110848510 110849511

DPX:	DAPPUDRAFT_200339

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

HAME:

PCLA:

123769549(UQCR-C2)

CQD:

PTRU:

ESN:

MNZ:

MRJ:	136847789(UQCR-C2)

HAZT:

108671615

EAF:

111706870

LSM:	121117823 121119848

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CVS:	136976102(UQCR-C2)

PTEP:

107438972

ABRU:

129968746

UDV:	129227238 129227239

SDM:

118188737

LPOL:

106470612

PMEO:

129600275

CEL:	CELE_T10B10.2(ucr-2.2) CELE_T24C4.1(ucr-2.3) CELE_VW06B3R.1(ucr-2.1)

CBR:	CBG_07617(Cbr-ucr-2.2) CBG_16195(Cbr-ucr-2.1) CBG_18586(Cbr-ucr-2.3)

CRQ:	GCK72_019604 GCK72_023252 GCK72_025575 GCK72_025577

NAI:	NECAME_05666

BMY:	BM_BM5980(Bm5980)

LOA:	LOAG_04876

HRO:	HELRODRAFT_185865

LGI:	LOTGIDRAFT_156673

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

HASI:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MMER:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

OVI:	T265_15312

LLON:

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:	124447795 124448654

HMG:

100203136

HSY:

130649036

RES:

135691610

TAD:	TRIADDRAFT_53663

AQU:

105312725

SCE:	YPR191W(QCR2)

SEUB:

DI49_5635

SPAO:

SPAR_P04330

AGO:	AGOS_ACL199C

ERC:

Ecym_2822

KLA:	KLLA0_B03564g

KMX:	KLMA_40479(QCR2)

LTH:	KLTH0A00594g

VPO:	Kpol_1050p115

ZRO:	ZYRO0E00528g

CGR:	2887999(GVI51_G09977)

NCS:	NCAS_0A15320(NCAS0A15320)

NDI:	NDAI_0J00110(NDAI0J00110)

TPF:	TPHA_0G00220(TPHA0G00220)

TBL:	TBLA_0B05010(TBLA0B05010)

TGB:	HG536_0F00270

TDL:	TDEL_0H00230(TDEL0H00230)

KAF:	KAFR_0B00230(KAFR0B00230)

KNG:	KNAG_0F04030(KNAG0F04030)

ZMK:	HG535_0C06270

SLUD:

SCDLUD_000014

DHA:	DEHA2E09834g

PIC:	PICST_78316(UQC2)

PGU:	PGUG_05422

SPAA:

SPAPADRAFT_61245

LEL:	PVL30_004669(QCR2)

LBG:	92210801(LODBEIA_P56050)

CAL:	CAALFM_C503350WA(QCR2)

CTP:	CTRG_02693

COT:	CORT_0B02160

CDU:	CD36_53130

CTEN:

18247015(QCR2)

CLU:	CLUG_05174

CLUS:

A9F13_03g00616

CAUR:

CJI96_0002599

PPA:	PAS_chr2-2_0430

PKZ:	C5L36_0D01450

BNN:	FOA43_001148

BBRX:

BRETT_003527

OPA:	HPODL_03957

YLI:	2908481(YALI2_F00810g)

SLB:	AWJ20_2729(QCR2)

NCR:

NCU03559

NTE:	NEUTE1DRAFT123473(NEUTE1DRAFT_123473)

SMP:	10809978(SMAC4_07797)

PAN:	PODANSg7008

PBEL:

QC761_604730(QCR2)

PPSD:

QC762_604730(QCR2)

PPSP:

QC763_604730(QCR2)

PPSA:

QC764_604730(QCR2)

TTT:	THITE_2082556

MTM:	MYCTH_2145409

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_8262

SSCK:

SPSK_09469

FGR:	FGSG_00644

FPU:	FPSE_04727

FPOA:

FPOAC1_000670

FVN:	FVRRES_00825

FVR:	FVEG_00552

FOX:	FOXG_00961

NHE:	NECHADRAFT_65760

FFC:	NCS54_00128100

FKR:	NCS57_00125800

FMU:	J7337_001416

TRE:	TRIREDRAFT_48883

TRR:	M419DRAFT_137160

TATV:

25775007(TrAtP1_005736)

TASP:

36615096(QCR2)

MAW:	19249973(QCR2)

MAJ:

MAA_01867

MBRN:

26239454(ucr-1)

PCHM:

VFPPC_01850

CMT:

CCM_05194

AMUS:

LMH87_011257

PLJ:	28889218(PLICBS_008320)

PTKZ:

JDV02_006327(QCR2)

VAL:	VDBG_01502

VDA:	VDAG_04054

CFJ:	CFIO01_10813

CLUP:

CLUP02_00708

CHIG:

CH63R_12672

CDET:

87942839(CDEST_06336)

SAPO:

SAPIO_CDS2897

ELA:	UCREL1_5524

PFY:	PFICI_09048

SSL:	SS1G_01597

BFU:	BCIN_02g02520(Bcqcr2)

MBE:

MBM_00091

PSCO:

LY89DRAFT_658808

GLZ:	GLAREA_05631

ANI:	ANIA_08273

AFM:	AFUA_5G04210

ACT:	ACLA_000950

NFI:	NFIA_037890

AOR:	AO090102000625

ANG:	An09g06650

AFV:	AFLA_012059

ALUC:

AKAW2_40662S(QCR2)

ACHE:

ACHE_60767A(QCR2)

APUU:

APUU_60569A(QCR2)

PCS:	N7525_001994

PDP:	PDIP_34810

POU:	POX_a00857

TMF:	EYB26_007013

TRG:	TRUGW13939_07879

CIM:	CIMG_06296

CPW:	9695126(QCR2)

URE:	UREG_04088

ABE:

ARB_07081

TVE:

TRV_04704

PBL:	PAAG_08088

PBN:	PADG_08394

AJE:	HCAG_06996

BGH:	BDBG_05852

PNO:	SNOG_01693

PTE:

PTT_02105

PTRR:

6341673(PtrM4_099060)

BZE:	COCCADRAFT_109496

BSC:	COCSADRAFT_185112

BOR:	COCMIDRAFT_99736

AALT:

CC77DRAFT_1013978

ARAB:

EKO05_0008507

ZTR:	MYCGRDRAFT_101464

PFJ:	MYCFIDRAFT_72474

FFU:	CLAFUR5_03109

CBET:

CB0940_03324

BCOM:

BAUCODRAFT_69548

NPA:	UCRNP2_10417

TML:	GSTUM_00005280001

SPO:	2538983(qcr2)

SOM:	SOMG_02548(qcr2)

CNE:

CNL04470

CNB:

CNBI2370

CNG:	CNAG_05179

CGI:	CGB_D2590C

CDEU:

CNBG_4517

CDEP:

91086965(L203_102754)

KMG:	30164014(I203_103705)

KNE:	92179061(IAR55_001802)

TMS:	TREMEDRAFT_38220

TASA:

A1Q1_02061

CCAC:

CcaHIS019_0509470(QCR2)

TVS:	TRAVEDRAFT_128283

DSQ:	DICSQDRAFT_60689

PCO:	PHACADRAFT_260537

SHS:	STEHIDRAFT_121207

HIR:	HETIRDRAFT_35301

PSQ:	PUNSTDRAFT_75017

ADL:	AURDEDRAFT_178883

FME:	FOMMEDRAFT_132694

GTR:	GLOTRDRAFT_76230

RSX:	RhiXN_12014

LBC:	LACBIDRAFT_191797

CCI:	CC1G_01555

ABP:	AGABI1DRAFT63517(QCR2)

ABV:	AGABI2DRAFT210545(QCR2)

PCUB:

JR316_0010746

MRR:	Moror_16091

E1B28_008453

SCM:	SCHCO_02617840(SCHCODRAFT_02617840)

CPUT:

CONPUDRAFT_129807

SLA:	SERLADRAFT_352076(QCR2)

WSE:	WALSEDRAFT_31628

WIC:	J056_004231

UMA:	UMAG_01478

PFP:	PFL1_01127

SGRA:

MGL:

MRT:

MSYM:

PGR:	PGTG_00730

PTRC:

PtA15_1A609

PSTR:

Pst134EA_000338 Pst134EA_032312

MLR:	MELLADRAFT_41910

RIE:	OCT59_018562

MBR:	MONBRDRAFT_33628

SRE:	PTSG_00919

» show all

Reference

PMID:2547763

Authors

Hosokawa Y, Suzuki H, Toda H, Nishikimi M, Ozawa T

Title

Complementary DNA encoding core protein II of human mitochondrial cytochrome bc1 complex. Substantial diversity in deduced primary structure from its yeast counterpart.

Journal

J Biol Chem 264:13483-8 (1989)

Sequence

[hsa:7385]

LinkDB

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