Entry
Symbol
GRB2
Name
growth factor receptor-bound protein 2
Pathway
map01521 EGFR tyrosine kinase inhibitor resistance
map04072 Phospholipase D signaling pathway
map04550 Signaling pathways regulating pluripotency of stem cells
map04650 Natural killer cell mediated cytotoxicity
map04660 T cell receptor signaling pathway
map04662 B cell receptor signaling pathway
map04664 Fc epsilon RI signaling pathway
map04935 Growth hormone synthesis, secretion and action
map05163 Human cytomegalovirus infection
map05207 Chemical carcinogenesis - receptor activation
map05208 Chemical carcinogenesis - reactive oxygen species
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04013 MAPK signaling pathway - fly
K04364 GRB2; growth factor receptor-bound protein 2
04012 ErbB signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04014 Ras signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04630 JAK-STAT signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04068 FoxO signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04072 Phospholipase D signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04151 PI3K-Akt signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04150 mTOR signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
K04364 GRB2; growth factor receptor-bound protein 2
04540 Gap junction
K04364 GRB2; growth factor receptor-bound protein 2
04550 Signaling pathways regulating pluripotency of stem cells
K04364 GRB2; growth factor receptor-bound protein 2
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
K04364 GRB2; growth factor receptor-bound protein 2
04660 T cell receptor signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04662 B cell receptor signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04664 Fc epsilon RI signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04062 Chemokine signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
09152 Endocrine system
04910 Insulin signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04912 GnRH signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04915 Estrogen signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04917 Prolactin signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04926 Relaxin signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
04935 Growth hormone synthesis, secretion and action
K04364 GRB2; growth factor receptor-bound protein 2
09156 Nervous system
04722 Neurotrophin signaling pathway
K04364 GRB2; growth factor receptor-bound protein 2
09158 Development and regeneration
04320 Dorso-ventral axis formation
K04364 GRB2; growth factor receptor-bound protein 2
04380 Osteoclast differentiation
K04364 GRB2; growth factor receptor-bound protein 2
09159 Environmental adaptation
04714 Thermogenesis
K04364 GRB2; growth factor receptor-bound protein 2
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K04364 GRB2; growth factor receptor-bound protein 2
05206 MicroRNAs in cancer
K04364 GRB2; growth factor receptor-bound protein 2
05205 Proteoglycans in cancer
K04364 GRB2; growth factor receptor-bound protein 2
05207 Chemical carcinogenesis - receptor activation
K04364 GRB2; growth factor receptor-bound protein 2
05208 Chemical carcinogenesis - reactive oxygen species
K04364 GRB2; growth factor receptor-bound protein 2
05203 Viral carcinogenesis
K04364 GRB2; growth factor receptor-bound protein 2
05231 Choline metabolism in cancer
K04364 GRB2; growth factor receptor-bound protein 2
09162 Cancer: specific types
05210 Colorectal cancer
K04364 GRB2; growth factor receptor-bound protein 2
05225 Hepatocellular carcinoma
K04364 GRB2; growth factor receptor-bound protein 2
05226 Gastric cancer
K04364 GRB2; growth factor receptor-bound protein 2
05214 Glioma
K04364 GRB2; growth factor receptor-bound protein 2
05221 Acute myeloid leukemia
K04364 GRB2; growth factor receptor-bound protein 2
05220 Chronic myeloid leukemia
K04364 GRB2; growth factor receptor-bound protein 2
05211 Renal cell carcinoma
K04364 GRB2; growth factor receptor-bound protein 2
05215 Prostate cancer
K04364 GRB2; growth factor receptor-bound protein 2
05213 Endometrial cancer
K04364 GRB2; growth factor receptor-bound protein 2
05224 Breast cancer
K04364 GRB2; growth factor receptor-bound protein 2
05223 Non-small cell lung cancer
K04364 GRB2; growth factor receptor-bound protein 2
09172 Infectious disease: viral
05161 Hepatitis B
K04364 GRB2; growth factor receptor-bound protein 2
05160 Hepatitis C
K04364 GRB2; growth factor receptor-bound protein 2
05163 Human cytomegalovirus infection
K04364 GRB2; growth factor receptor-bound protein 2
05165 Human papillomavirus infection
K04364 GRB2; growth factor receptor-bound protein 2
09165 Substance dependence
05034 Alcoholism
K04364 GRB2; growth factor receptor-bound protein 2
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
K04364 GRB2; growth factor receptor-bound protein 2
01522 Endocrine resistance
K04364 GRB2; growth factor receptor-bound protein 2
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking
K04364 GRB2; growth factor receptor-bound protein 2
Membrane trafficking [BR:ko04131 ]
Endocytosis
Clathrin-mediated endocytosis
Receptor tyrosine kinase (RTK) adaptor proteins
K04364 GRB2; growth factor receptor-bound protein 2
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Taxonomy UniProt
Reference
Authors
Suen KL, Bustelo XR, Pawson T, Barbacid M
Title
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
Journal
Sequence
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