ORTHOLOGY: K04718
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Entry
K04718 KO
Symbol
SPHK
Name
sphingosine kinase [EC:
2.7.1.91
]
Pathway
map00600
Sphingolipid metabolism
map01100
Metabolic pathways
map04020
Calcium signaling pathway
map04071
Sphingolipid signaling pathway
map04072
Phospholipase D signaling pathway
map04148
Efferocytosis
map04370
VEGF signaling pathway
map04371
Apelin signaling pathway
map04666
Fc gamma R-mediated phagocytosis
map05152
Tuberculosis
Module
M00100
Sphingosine degradation
Reaction
R01926
ATP:sphingosine 1-phosphotransferase
R02976
ATP:sphinganine 1-phosphotransferase
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09100 Metabolism
09103 Lipid metabolism
00600 Sphingolipid metabolism
K04718 SPHK; sphingosine kinase
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
K04718 SPHK; sphingosine kinase
04371 Apelin signaling pathway
K04718 SPHK; sphingosine kinase
04020 Calcium signaling pathway
K04718 SPHK; sphingosine kinase
04072 Phospholipase D signaling pathway
K04718 SPHK; sphingosine kinase
04071 Sphingolipid signaling pathway
K04718 SPHK; sphingosine kinase
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
K04718 SPHK; sphingosine kinase
09150 Organismal Systems
09151 Immune system
04666 Fc gamma R-mediated phagocytosis
K04718 SPHK; sphingosine kinase
09160 Human Diseases
09171 Infectious disease: bacterial
05152 Tuberculosis
K04718 SPHK; sphingosine kinase
Enzymes [BR:
ko01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.91 sphingosine kinase
K04718 SPHK; sphingosine kinase
BRITE hierarchy
Other DBs
GO:
0008481
Genes
HSA:
56848
(SPHK2)
8877
(SPHK1)
PTR:
468943
(SPHK2)
738821
(SPHK1)
PPS:
100977890
(SPHK1)
100992056
(SPHK2)
GGO:
101127850
(SPHK1)
129528634
(SPHK2)
PON:
100172513
(SPHK2)
100433232
(SPHK1)
PPYG:
129016662
(SPHK1)
129019770
(SPHK2)
NLE:
100592000
(SPHK2)
100598765
(SPHK1)
HMH:
116478244
(SPHK2)
116483058
(SPHK1)
SSYN:
129459275
(SPHK2)
129462280
(SPHK1)
MCC:
710441
(SPHK1)
718088
(SPHK2)
MCF:
101926057
(SPHK1)
102116114
(SPHK2)
MTHB:
126939236
126943556
MNI:
105469199
(SPHK1)
105478648
(SPHK2)
CSAB:
103234983
(SPHK2)
103242988
(SPHK1)
CATY:
105577691
(SPHK1)
105595245
(SPHK2)
PANU:
101010713
(SPHK2)
101020308
(SPHK1)
TGE:
112608916
(SPHK1)
112612325
(SPHK2)
MLEU:
105539178
(SPHK2)
105542321
(SPHK1)
RRO:
104666560
(SPHK2)
104681274
(SPHK1)
RBB:
108523630
(SPHK2)
108537441
(SPHK1)
TFN:
117066720
(SPHK1)
117091509
(SPHK2)
PTEH:
111520066
(SPHK2)
111542386
(SPHK1)
CANG:
105514803
(SPHK2)
105517415
(SPHK1)
CJC:
100387720
(SPHK2)
100406587
(SPHK1)
SBQ:
101029043
(SPHK1)
101044895
(SPHK2)
CIMI:
108283881
(SPHK2)
108309464
(SPHK1)
ANAN:
105718098
(SPHK1)
105722532
(SPHK2)
CSYR:
103250049
(SPHK2)
103250647
(SPHK1)
MMUR:
105865659
(SPHK2)
105878971
(SPHK1)
LCAT:
123620485
(SPHK1)
123623864
(SPHK2)
PCOQ:
105809328
(SPHK2)
105824708
(SPHK1)
OGA:
100961067
(SPHK2)
100966333
(SPHK1)
MMU:
20698
(Sphk1)
56632
(Sphk2)
MCAL:
110297874
(Sphk2)
110305526
(Sphk1)
MPAH:
110323710
(Sphk2)
110332158
(Sphk1)
RNO:
170897
(Sphk1)
308589
(Sphk2)
MCOC:
116078345
(Sphk1)
ANU:
117707319
(Sphk2)
117711591
(Sphk1)
MUN:
110550495
(Sphk2)
110564670
(Sphk1)
CGE:
100762053
(Sphk1)
100774790
(Sphk2)
MAUA:
101822923
(Sphk1)
101840320
(Sphk2)
PROB:
127213936
(Sphk2)
127219495
(Sphk1)
PLEU:
114684677
(Sphk2)
114707026
(Sphk1)
MORG:
121436240
(Sphk1)
121457079
(Sphk2)
MFOT:
126488049
126500479
AAMP:
119802538
(Sphk2)
119812963
(Sphk1)
NGI:
103732783
(Sphk1)
103742305
103743619
(Sphk2)
HGL:
101711606
(Sphk1)
101720879
(Sphk2)
CPOC:
100727266
(Sphk1)
100730608
(Sphk2)
CCAN:
109682695
(Sphk2)
109685588
(Sphk1)
DORD:
105994375
(Sphk2)
106001315
(Sphk1)
DSP:
122125497
(Sphk2)
122128393
(Sphk1)
PLOP:
125338852
(Sphk2)
125365222
(Sphk1)
NCAR:
124966668
124980283
MMMA:
107151284
(Sphk2)
107157756
(Sphk1)
OCU:
100357790
103346370
OPI:
101522075
(SPHK1)
101529238
(SPHK2)
TUP:
102471518
(SPHK1)
102476140
(SPHK2)
GVR:
103587741
103587745
103605508
(SPHK1)
CFA:
483329
(SPHK1)
484401
(SPHK2)
CLUD:
112645197
(SPHK2)
112672834
(SPHK1)
VVP:
112920827
(SPHK1)
112931373
(SPHK2)
VLG:
121474189
(SPHK1)
121484099
(SPHK2)
NPO:
129500218
(SPHK2)
129515030
(SPHK1)
AML:
100473787
(SPHK1)
100479407
(SPHK2)
UMR:
103657238
(SPHK2)
103665951
(SPHK1)
UAH:
113243339
(SPHK2)
113244597
(SPHK1)
UAR:
123776264
(SPHK2)
123803088
(SPHK1)
ELK:
111160330
111160728
LLV:
125086829
125088644
MPUF:
101672769
(SPHK2)
101688732
(SPHK1)
MNP:
132004218
(SPHK1)
132005224
(SPHK2)
MLK:
131816984
(SPHK1)
131817451
(SPHK2)
NVS:
122905958
(SPHK1)
122911860
(SPHK2)
ORO:
101375807
(SPHK1)
101376404
(SPHK2)
EJU:
114199498
(SPHK2)
114216219
(SPHK1)
ZCA:
113935283
(SPHK2)
113939284
(SPHK1)
MLX:
117998224
(SPHK2)
118024239
(SPHK1)
NSU:
110572513
(SPHK1)
110572931
(SPHK2)
LWW:
102742615
(SPHK2)
102750390
(SPHK1)
FCA:
101081345
(SPHK2)
101084918
(SPHK1)
PYU:
121017954
(SPHK1)
121018720
(SPHK2)
PBG:
122486120
(SPHK1)
122494874
(SPHK2)
PVIV:
125151970
(SPHK1)
125152726
(SPHK2)
LRUF:
124510943
124512822
PTG:
102961449
(SPHK2)
102966392
(SPHK1)
PPAD:
109253123
(SPHK2)
109276896
(SPHK1)
PUC:
125915605
125917403
125917407
AJU:
106987762
106988651
HHV:
120228097
(SPHK1)
120242882
(SPHK2)
BTA:
533103
(SPHK2)
618605
(SPHK1)
BOM:
102284142
(SPHK2)
102285123
(SPHK1)
BIU:
109572468
(SPHK2)
109573990
(SPHK1)
BBUB:
102411106
(SPHK1)
102412075
(SPHK2)
BBIS:
104995615
(SPHK2)
105000373
(SPHK1)
CHX:
102168201
(SPHK1)
102184187
(SPHK2)
OAS:
101105263
(SPHK1)
101106964
(SPHK2)
BTAX:
128062979
(SPHK2)
128064567
(SPHK1)
CSUM:
138083933
(SPHK1)
138095777
(SPHK2)
ODA:
120866745
(SPHK1)
120872180
(SPHK2)
CCAD:
122420263
(SPHK2)
122437088
(SPHK1)
MREE:
136149920
(SPHK1)
136161511
(SPHK2)
MBEZ:
129544690
(SPHK1)
129546581
(SPHK2)
SSC:
100519210
(SPHK1)
100738292
(SPHK2)
CFR:
102523205
(SPHK1)
102524512
(SPHK2)
CBAI:
105062588
(SPHK2)
105065623
(SPHK1)
CDK:
105092188
(SPHK1)
105102906
(SPHK2)
VPC:
102525050
(SPHK2)
102533298
(SPHK1)
BACU:
103003972
(SPHK1)
103010420
(SPHK2)
BMUS:
118884818
(SPHK2)
118887196
(SPHK1)
LVE:
103072023
(SPHK1)
103079519
(SPHK2)
OOR:
101286291
(SPHK1)
101289072
(SPHK2)
DLE:
111180657
(SPHK2)
111182791
(SPHK1)
PCAD:
102982912
(SPHK1)
102994529
(SPHK2)
PSIU:
116743941
(SPHK2)
116746005
(SPHK1)
NASI:
112410306
(SPHK1)
112415409
(SPHK2)
ECB:
100054066
(SPHK2)
100058875
(SPHK1)
EPZ:
103540021
(SPHK2)
103541302
(SPHK1)
EAI:
106830329
(SPHK1)
106838247
(SPHK2)
MYB:
102254173
(SPHK1)
102255740
(SPHK2)
MYD:
102762504
(SPHK1)
102766668
(SPHK2)
MMYO:
118655346
(SPHK2)
118671137
(SPHK1)
MLF:
102421251
(SPHK1)
102434379
(SPHK2)
MDT:
132216645
(SPHK2)
132219128
(SPHK1)
PKL:
118704513
(SPHK1)
118721086
(SPHK2)
EFUS:
103297659
(SPHK2)
103298394
(SPHK1)
MNA:
107531908
(SPHK2)
107536591
(SPHK1)
DRO:
112298798
(SPHK1)
112310060
(SPHK2)
SHON:
119000132
(SPHK1)
AJM:
119044423
(SPHK2)
119058541
(SPHK1)
PDIC:
114503018
(SPHK1)
114511602
(SPHK2)
PHAS:
123816681
(SPHK1)
123830182
(SPHK2)
MMF:
118634564
(SPHK1)
118638266
(SPHK2)
PPAM:
129082904
(SPHK2)
129086402
(SPHK1)
HAI:
109383749
(SPHK1)
109391059
(SPHK2)
RFQ:
117013008
(SPHK1)
117035218
(SPHK2)
PALE:
102887299
(SPHK2)
102892759
(SPHK1)
PGIG:
120600331
(SPHK1)
120606967
(SPHK2)
PVP:
105293381
(SPHK1)
105301772
(SPHK2)
RAY:
107498846
(SPHK2)
107501245
(SPHK1)
MJV:
108393157
(SPHK2)
108398675
(SPHK1)
TOD:
119232735
(SPHK1)
119249520
(SPHK2)
SARA:
101538217
(SPHK2)
101554247
(SPHK1)
SETR:
126027311
(SPHK2)
LAV:
100668199
(SPHK1)
100676401
(SPHK2)
TMU:
101349439
101357482
ETF:
101647651
(SPHK2)
101653999
(SPHK1)
DNM:
101424126
(SPHK1)
101446304
(SPHK2)
MDO:
100026664
(SPHK1)
GAS:
123239810
(SPHK2)
123245073
(SPHK1)
SHR:
100914991
(SPHK1)
100933142
(SPHK2)
AFZ:
127556534
127560425
PCW:
110219386
(SPHK1)
110219899
(SPHK2)
TVP:
118837756
(SPHK2)
118845647
(SPHK1)
PBRV:
138152479
(SPHK1)
138173380
(SPHK2)
OAA:
100076678
(SPHK1)
GGA:
427803
(SPHK1)
PCOC:
116232614
(SPHK1)
MGP:
100539320
(SPHK1)
CJO:
107322120
(SPHK1)
TPAI:
128083264
(SPHK1)
LMUT:
125702048
(SPHK1)
NMEL:
110407457
(SPHK1)
APLA:
101798369
(SPHK1)
ACYG:
106034629
(SPHK1)
CATA:
118260382
(SPHK1)
AFUL:
116496676
(SPHK1)
TGU:
100227204
(SPHK1)
LSR:
110476572
(SPHK1)
SCAN:
103819871
(SPHK1)
PMOA:
120505529
(SPHK1)
OTC:
121338220
(SPHK1)
PRUF:
121363901
(SPHK1)
GFR:
102044859
(SPHK1)
FAB:
101818075
(SPHK1)
OMA:
130260444
(SPHK1)
PHI:
102106754
(SPHK1)
PMAJ:
107212638
(SPHK1)
CCAE:
111937276
(SPHK1)
CCW:
104694392
(SPHK1)
ETL:
114058567
(SPHK1)
ZAB:
102064646
(SPHK1)
ZLE:
135455293
(SPHK1)
SVG:
106860989
(SPHK1)
MMEA:
130581083
(SPHK1)
HRT:
120760949
(SPHK1)
SATI:
136369295
(SPHK1)
FPG:
101921272
(SPHK1)
FCH:
102060119
(SPHK1)
SHAB:
115616457
(SPHK1)
ACUN:
113486681
(SPHK1)
TALA:
116964025
(SPHK1)
ACHC:
115341172
(SPHK1)
HLE:
104839199
(SPHK1)
AGEN:
126035035
126044038
GCL:
127023959
PPUS:
135179310
(SPHK1)
BRHI:
104489450
NNI:
104022872
(SPHK1)
PADL:
103921013
(SPHK1)
AFOR:
103899022
(SPHK1)
CLV:
102093489
(SPHK1)
CUCA:
104068674
(SPHK1)
TEO:
104376105
RTD:
128917970
(SPHK1)
AROW:
112977766
(SPHK1)
NPD:
112957692
(SPHK1)
DNE:
112985338
(SPHK1)
ASN:
102374989
(SPHK2)
102385258
(SPHK1)
AMJ:
102558563
(SPHK1)
102566845
(SPHK2)
CPOO:
109315104
(SPHK1)
GGN:
109287761
(SPHK1)
PSS:
102454103
(SPHK1)
CMY:
102935501
(SPHK1)
102947921
(SPHK2)
CCAY:
125621363
(SPHK1)
125627940
(SPHK2)
DCC:
119842936
(SPHK1)
119846897
(SPHK2)
CPIC:
101949496
(SPHK1)
101953391
(SPHK2)
TST:
117887240
(SPHK2)
117887706
(SPHK1)
CABI:
116832231
(SPHK1)
116832362
(SPHK2)
MRV:
120382966
(SPHK1)
120388658
(SPHK2)
ACS:
100553167
(sphk1)
100553460
(sphk2)
ASAO:
132768583
(SPHK1)
132777851
(SPHK2)
PVT:
110081807
(SPHK2)
110085912
(SPHK1)
SUND:
121921036
(SPHK1)
121933175
(SPHK2)
PBI:
103057563
(SPHK2)
103060065
(SPHK1)
PMUR:
107283100
(SPHK2)
107290062
(SPHK1)
CTIG:
120301159
(SPHK1)
120304439
(SPHK2)
TSR:
106538472
(SPHK2)
106544340
(SPHK1)
PGUT:
117660473
(SPHK1)
117666718
(SPHK2)
APRI:
131191118
(SPHK1)
131197078
(SPHK2)
PTEX:
113437253
(SPHK1)
113443657
(SPHK2)
NSS:
113411945
(SPHK1)
113421818
(SPHK2)
VKO:
123032209
(SPHK2)
123035526
(SPHK1)
PMUA:
114582783
(SPHK2)
114590652
(SPHK1)
PRAF:
128399570
(SPHK2)
128407530
(SPHK1)
ZVI:
118079862
(SPHK1)
118094565
(SPHK2)
HCG:
128329979
(SPHK2)
128341818
(SPHK1)
GJA:
107111139
(SPHK2)
107121147
(SPHK1)
STOW:
125427641
(SPHK1)
EMC:
129328650
(SPHK1)
129340296
(SPHK2)
XLA:
108696679
(sphk2.L)
108697745
(sphk2.S)
495437
(sphk1.L)
XTR:
100494664
(sphk2)
549672
(sphk1)
NPR:
108796856
(SPHK1)
108804675
(SPHK2)
RTEM:
120915272
(SPHK2)
120918488
(SPHK1)
BBUF:
121002845
(SPHK2)
121004706
(SPHK1)
BGAR:
122926659
(SPHK2)
122942216
(SPHK1)
MUO:
115466500
(SPHK2)
115473332
(SPHK1)
GSH:
117367450
(SPHK2)
117367828
(SPHK1)
DRE:
100150090
(sphk2)
100331840
SRX:
107711736
107715483
107716839
107741344
107751628
SANH:
107677335
107696311
107700765
107702984
(sphk1)
107704932
SGH:
107552834
107567220
(sphk1)
107571948
107573493
107587860
CCAR:
109068914
(sphk1)
109080596
109101408
109106082
CAUA:
113055031
113055812
113067871
113067876
113079872
113116044
CGIB:
127941919
127952549
127974964
128030567
PTET:
122341573
122360398
(sphk2)
LROH:
127163396
127167244
127178560
(sphk2)
OMC:
131521990
(sphk2)
131535881
PPRM:
120476262
120484394
(sphk2)
RKG:
130078002
130090864
(sphk2)
MAMB:
125243043
(sphk2)
125274040
CIDE:
127497163
127509926
CERY:
137017195
137033825
(sphk2)
MASI:
127449851
127451663
127453296
127453622
TROS:
130557577
(sphk2)
130561107
TDW:
130425928
130432492
(sphk2)
MANU:
129436767
129448228
(sphk2)
IPU:
108264213
108272828
108273191
IFU:
128601983
(sphk2)
128615672
128616284
PHYP:
113534020
113534313
113538397
(sphk1)
SMEO:
124381897
124384058
(sphk2)
124392618
TFD:
113650447
113659076
(sphk2)
113663689
TVC:
132842163
132845010
132846389
(sphk2)
TRN:
134309241
134310875
(sphk2)
134316557
AMEX:
103023393
103040500
103043132
(sphk2)
CMAO:
118804864
118807948
118820314
(sphk2)
EEE:
113573083
113580757
113587788
CHAR:
105898566
105900195
105901612
(sphk2)
116219735
TRU:
101062830
(sphk1)
101078125
TFS:
130514634
130532917
(sphk2)
TNG:
GSTEN00015388G001
GSTEN00032515G001
LCO:
104925615
104938506
(sphk1)
104939955
NCC:
104960464
104966924
(sphk1)
TBEN:
117480629
(sphk2)
117482322
117492858
CGOB:
115010639
(sphk1)
115011987
115021875
PGEO:
117448278
117451627
117460778
(sphk2)
GACU:
117533457
(sphk2)
117535404
117538018
EMAC:
134862107
(sphk2)
134865178
134877574
ELY:
117255019
117265927
(sphk2)
117268127
EFO:
125879259
125886215
125893379
(sphk2)
PLEP:
121942104
121945784
(sphk2)
121957167
SLUC:
116043012
116049607
(sphk2)
116065313
ECRA:
117946704
(sphk2)
117951768
117957515
ESP:
116691510
(sphk2)
116702787
116705625
(sphk1)
PFLV:
114557618
114563520
(sphk1)
114569310
GAT:
120811037
(sphk2)
120825085
120827599
PPUG:
119196948
(sphk2)
119218087
119219867
AFB:
129096202
129098263
129110024
(sphk2)
CLUM:
117728706
117734723
117745227
(sphk2)
PSWI:
130190524
130212691
(sphk2)
CANA:
137781494
(sphk2)
137786727
137795056
CVE:
137874301
137885449
137891598
(sphk2)
MSAM:
119886066
119897529
(sphk2)
119899308
SCHU:
122873582
122881924
(sphk2)
CUD:
121503886
121508668
121514234
(sphk2)
ALAT:
119005970
(sphk2)
119013253
119026682
ASTR:
137600226
137602144
(sphk2)
137609727
MZE:
101473156
(sphk1)
101482860
(sphk2)
101483399
ONL:
100699392
(sphk1)
100708657
106096428
(sphk2)
OAU:
116310662
116314592
116315714
(sphk2)
OLA:
101160262
101160322
101167592
(sphk1)
OML:
112143277
(sphk2)
112146599
112157543
CSAI:
133421817
133433194
(sphk2)
133448961
133449797
XMA:
102227445
102228021
(sphk1)
106699615
(sphk2)
XCO:
114141675
114145490
(sphk1)
114160463
XHE:
116717124
116720844
(sphk1)
116736174
PRET:
103469144
103469685
(sphk1)
103478094
(sphk2)
PFOR:
103136634
103136635
103136636
103151811
103153195
(sphk1)
PLAI:
106939249
106950841
(sphk1)
106953505
106957058
PMEI:
106909541
106914539
106918970
(sphk1)
106922021
(sphk2)
GAF:
122822302
122830248
122830556
(sphk2)
PPRL:
129363644
129371091
(sphk2)
CVG:
107088081
107088801
(sphk2)
107103816
(sphk1)
CTUL:
119771318
119783025
(sphk2)
119793533
GMU:
124862371
124863873
124865514
(sphk2)
124867716
NFU:
107374236
107379707
(sphk2)
107382243
(sphk1)
KMR:
108235466
(sphk2)
108242955
108248787
ALIM:
106518760
(sphk1)
106534563
106536159
106537015
NWH:
119409722
(sphk2)
119422178
119423195
AOCE:
111564245
111565381
111574733
EJA:
138194156
(sphk2)
138198351
138209541
MCEP:
124997336
124999858
125016870
(sphk2)
CSEM:
103383771
(sphk1)
103388269
103393189
POV:
109627230
109633239
109639502
109644606
SSEN:
122770984
122774804
(sphk2)
122785854
HHIP:
117762181
117766735
117776406
(sphk2)
HSP:
118113612
(sphk2)
118122090
118123510
PPLT:
128437296
128449078
(sphk2)
128458799
SMAU:
118289402
118301157
(sphk2)
118312185
LCF:
108875844
108880994
108881061
108885887
(sphk2)
SDU:
111229972
(sphk2)
111230210
111236346
(sphk1)
SLAL:
111647507
111652178
111659689
(sphk1)
XGL:
120783612
(sphk2)
120788173
HCQ:
109514836
109515289
(sphk2)
109519880
(sphk1)
SSCV:
125969070
125975488
(sphk2)
125983526
SBIA:
133500835
(sphk2)
133505703
133514560
PEE:
133401494
(sphk2)
133404333
133414499
PTAO:
133466624
133477510
133479818
(sphk2)
BPEC:
110160669
110162977
(sphk2)
110166231
(sphk1)
MALB:
109958866
109966257
(sphk1)
109970180
(sphk2)
BSPL:
114842665
(sphk2)
114855505
114861042
SJO:
128364649
128366336
(sphk2)
128379165
SASA:
106564913
106577300
106588251
106601398
106605728
106605743
106606991
STRU:
115171387
115176532
115178789
115189202
115201917
115208636
OTW:
112230322
112234610
112234899
(sphk2)
112245630
112258874
OMY:
110485951
110486550
110493671
110520823
(sphk2)
110536658
110538514
OGO:
123998172
124000436
124003412
124005939
124016277
124016540
ONE:
115103805
115104292
115110645
115117575
115121086
115142593
OKI:
109865275
109875968
109883204
109884473
109892277
109897380
OKE:
118364761
118365717
118377576
(sphk2)
118384195
118389218
127925035
SALP:
111951624
111980109
111982461
112069107
112073208
SNH:
120030942
120032730
120034002
120044616
120047263
120065968
CCLU:
121532654
121543826
(sphk2)
121551044
121570397
ELS:
105013154
105018992
105021624
(sphk1)
SFM:
108925996
(sphk2)
108940136
(sphk1)
PKI:
111848492
(sphk1)
111853337
(sphk2)
AANG:
118208340
(sphk2)
118219610
LOC:
102683742
(sphk1)
PSPA:
121296560
121302056
(sphk2)
ARUT:
117409982
(sphk2)
117424343
PSEX:
120517074
120518308
(sphk2)
LCM:
102350955
(SPHK1)
102367258
(SPHK2)
LERI:
129714284
PMRN:
116955083
(SPHK2)
LRJ:
133358644
BFO:
118418464
118429533
BBEL:
109472745
109473589
109487220
CIN:
100183047
SCLV:
120341167
120341186
SPU:
580005
LPIC:
129269183
129269184
APLC:
110981818
ARUN:
117292971
SKO:
100377659
DME:
Dmel_CG1747
(Sk1)
Dmel_CG32484
(Sk2)
DER:
6546465
6551618
DSE:
6610545
6619863
DSI:
Dsimw501_GD13722
(Dsim_GD13722)
Dsimw501_GD17022
(Dsim_GD17022)
DYA:
Dyak_GE15936
Dyak_GE20353
DAN:
6505204
6506895
DSR:
110185292
110191973
DPO:
4812196
4814588
DPE:
6599186
6600516
DMN:
108151324
108159991
DWI:
6644655
6646363
DGR:
6556482
6565471
DMO:
Dmoj_GI13895
Dmoj_GI15718
DAZ:
108613729
108620463
DNV:
108651782
115565289
DHE:
111597587
111601810
DVI:
6623175
CCAT:
101450021
101454265
BOD:
106616316
106617940
BDR:
105224139
105233241
RZE:
108356468
108364304
108374157
AOQ:
129237043
129242284
TDA:
119670022
119671572
119673336
MDE:
101892784
101896015
SCAC:
106081848
106087765
LCQ:
111678615
111684621
LSQ:
119602789
119608385
119614490
GFS:
119632154
119637413
ECOE:
129939422
CLON:
129610446
HIS:
119648296
AGA:
1270104
AMOU:
128302016
AAG:
5570737
AALB:
109426849
ASUA:
134210314
CQU:
CpipJ_CPIJ009965
CpipJ_CPIJ009966
CPII:
120421539
CNS:
116345651
BCOO:
119085587
LLL:
129793361
PPAP:
129804323
AME:
411349
ACER:
107996875
ALAB:
122720493
ADR:
102673260
AFLR:
100869776
BIM:
100746202
BBIF:
117215057
BVK:
117231823
BVAN:
117160241
BHUN:
126868696
BTER:
100643842
BAFF:
126918359
BPYO:
122577726
BPAS:
132907630
FVI:
122535943
CCAL:
108627556
OBB:
114883237
OLG:
117600313
MGEN:
117219614
NMEA:
116425508
CGIG:
122401397
SOC:
105202025
MPHA:
105836903
AEC:
105146244
ACEP:
105627044
PBAR:
105422757
VEM:
105562570
HST:
105181133
DQU:
106746254
CFO:
105251817
FEX:
115242182
LHU:
105675851
PGC:
109859854
OBO:
105280727
PCF:
106785800
PFUC:
122523841
VPS:
122634361
VCRB:
124430906
VVE:
124954430
NVI:
100123187
CSOL:
105361996
TPRE:
106648373
LHT:
122509062
LBD:
127289932
MDL:
103570708
CGLO:
123266326
FAS:
105272718
DAM:
107035491
AGIF:
122849559
CINS:
118069568
VCAN:
122410489
CCIN:
107267712
DSM:
124411756
NPT:
124220092
(Sk2)
NFB:
124183231
NLO:
107226518
NVG:
124306203
AROA:
105687813
TCA:
658654
DPA:
109534481
SOY:
115880618
AGRG:
126747160
ATD:
109606128
CSET:
123322922
AGB:
108912710
LDC:
111507762
DVV:
114327964
NVL:
108562198
APLN:
108745179
PPYR:
116173202
OTU:
111420660
BMOR:
101742466
BMAN:
114242193
MSEX:
115441189
DPL:
KGM_212979B
BANY:
112048390
MJU:
123868191
NIQ:
126774192
VCD:
124536256
PMAC:
106718321
PPOT:
106109649
PXU:
106121444
BPHI:
137919248
PNAP:
125057569
ZCE:
119828176
CCRC:
123694686
LSIN:
126966497
AAGE:
121739129
HAW:
110382443
HZE:
124634936
TNL:
113498002
SLIU:
111358875
OFU:
114351171
ATRA:
106135083
GMW:
113521179
PXY:
105392643
PGW:
126372470
LGLY:
125231971
CSTB:
134745546
CFEL:
113363328
CCRN:
123297744
API:
100168375
DNX:
107173358
AGS:
114123198
RMD:
113553186
ACOO:
126843503
DVT:
126902310
BTAB:
109033156
CLEC:
106671133
HHAL:
106682791
(Sk2)
NLU:
111046614
HVI:
124353604
MQU:
129003207
129004144
PHU:
Phum_PHUM281370
FOC:
113207898
TPAL:
117650374
ZNE:
110833981
CSEC:
111866849
SGRE:
126356019
BROR:
134542923
IEL:
124165884
FCD:
110844143
110850940
DPX:
DAPPUDRAFT_307617
DMK:
116916703
DPZ:
124329319
AFRA:
136026555
PVM:
113805876
PJA:
122265827
PCHN:
125039035
PMOO:
119599313
HAME:
121856586
PCLA:
123761061
PTRU:
123507062
ESN:
126982987
MNZ:
135202225
MRJ:
136847255
HAZT:
108665784
EAF:
111697768
111698791
111702704
LSM:
121118271
TCF:
131880364
131883255
131884076
131888634
PPOI:
119113662
DSV:
119440191
119454031
RSAN:
119399918
RMP:
119180361
VDE:
111252230
VJA:
111263721
TUT:
107362739
DPTE:
113797929
DFR:
124493710
CSCU:
111642211
CVS:
136983737
PTEP:
107440148
ABRU:
129989128
UDV:
129230005
SDM:
118198070
LPOL:
106467218
106475853
PMEO:
129591797
CEL:
CELE_C34C6.5
(sphk-1)
CBR:
CBG_11121
(Cbr-sphk-1)
CRQ:
GCK72_004885
TSP:
Tsp_01461
HRO:
HELRODRAFT_106711
LGI:
LOTGIDRAFT_141816
PVUL:
126809754
PCAN:
112577320
BGT:
106058011
GAE:
121379759
HRF:
124132807
HRJ:
124282272
HASI:
137284210
CRG:
105343802
CANU:
128164630
CVN:
111118144
OED:
125668494
MYI:
110446543
PMAX:
117325037
MMER:
123564343
RPHI:
132731289
DPOL:
127868476
MAEA:
128207994
OBI:
106875475
LJP:
135468329
LAK:
106164905
EGL:
EGR_07693
LLON:
135486401
NVE:
5511701
EPA:
110253867
110253868
ATEN:
116295035
ADF:
107345603
AMIL:
114958221
PDAM:
113673662
SPIS:
111334045
DGT:
114519611
XEN:
124449397
HMG:
100197951
HSY:
130649117
RES:
135691874
TAD:
TRIADDRAFT_20947
TRIADDRAFT_51430
AQU:
100632946
105313400
ATH:
AT4G21534
(SPHK2)
AT4G21540
(SPHK1)
ALY:
110226362
9305955
CRB:
17878499
17878619
CSAT:
104718177
104718178
104722903
104722904
104731385
104731386
104747506
EUS:
EUTSA_v10025046mg
EUTSA_v10025052mg
BRP:
103834191
103861234
BNA:
106421003
106432165
106433747
111197927
BOE:
106301336
106327927
RSZ:
108822328
108852951
108852952
130506928
130511080
THJ:
104806277
CPAP:
110812605
CIT:
102626139
CIC:
CICLE_v10015071mg
PVY:
116108000
MINC:
123193232
123219402
TCC:
18596946
GRA:
105768847
105777441
GHI:
107914002
107924409
107925234
121208545
GAB:
108452020
108487105
HSYR:
120183471
120210552
DZI:
111275101
EGR:
104445363
GMX:
100798935
100805656
GSJ:
114388253
114421308
PVU:
137811978
137832650
VRA:
106766761
106775123
VAR:
108334448
108341077
VUN:
114178912
114186773
VUM:
124827210
124827211
124835280
CCAJ:
109803185
109805027
APRC:
113847287
113858297
MTR:
25485929
TPRA:
123905546
CAM:
101499291
PSAT:
127082781
VVO:
131622818
131642714
LJA:
130723685
ADU:
107468660
AIP:
107623332
AHF:
112714663
112783948
LANG:
109333659
109339010
PCIN:
129285811
129306090
QSA:
O6P43_012569
O6P43_031775
FVE:
101311446
RCN:
112164982
PPER:
18779554
PMUM:
103324637
PAVI:
110758004
PDUL:
117626597
MDM:
103427837
103446472
MSYL:
126624296
PXB:
103964944
ZJU:
107422974
MNT:
21389821
CSAV:
115706893
CSV:
101206190
CMO:
103484546
BHJ:
120074359
MCHA:
111012384
CMAX:
111478387
CMOS:
111453022
CPEP:
111804471
RCU:
8289825
MEAN:
126665602
JCU:
105649467
HBR:
110664617
MESC:
110604172
POP:
7495267
PEU:
105138778
PALZ:
118031430
PNZ:
133702630
JRE:
109013735
CILL:
122277695
CAVE:
132172331
QSU:
112012450
QLO:
115981866
115991626
TWL:
120005795
VVI:
100248229
VRI:
117924323
SLY:
101256244
101263975
SPEN:
107008754
107012868
SOT:
102581165
102590865
SSTN:
125849268
125860499
SDUL:
129873128
129895749
CANN:
107859460
107868327
LBB:
132618506
132621316
NTA:
107771177
107799091
107803682
107831053
NSY:
104239972
104241636
NTO:
104086954
104114500
NAU:
109237073
109244800
INI:
109158937
ITR:
116028362
SIND:
105175465
OEU:
111370555
EGT:
105969076
SSPL:
121745176
SMIL:
130985590
SHIS:
125186400
APAN:
127247539
127249896
HAN:
110864054
110915721
ECAD:
122581679
122595558
LSV:
111879136
111892409
CCAV:
112519730
112522399
DCR:
108196445
108197984
CSIN:
114260833
RVL:
131312606
AEW:
130782474
130794557
BVG:
104909115
SOE:
110793434
CQI:
110693533
110706812
ATRI:
130814927
130823533
MOF:
131154068
NNU:
104605677
104612605
MING:
122063922
122083606
TSS:
122639415
122648834
PSOM:
113305719
OSA:
4327845
4343607
OBR:
102702113
102721782
OGL:
127761711
127780723
BDI:
100831815
100845384
ATS:
109731823
109751945
109764430
TDC:
119269213
119277211
119354137
119363323
TAES:
123044545
123052402
123062251
123071005
123079381
123188257
TUA:
125536634
125544987
LPER:
127333076
127344034
LRD:
124667442
124677418
124678016
124689078
SBI:
8054712
8081750
ZMA:
100284895
100383275
MFLO:
136450539
136450627
136546977
136552550
SITA:
101754408
101760848
SVS:
117846535
117857987
PVIR:
120661682
120671823
120691541
PHAI:
112883238
PDA:
103714772
103719340
EGU:
105032337
105032738
MUS:
135610678
135610945
ZOF:
121967268
121967420
121970845
121970846
122021094
122023860
122036437
122052485
122052641
DCT:
110098961
110099778
110106486
PEQ:
110018855
110032442
110038734
AOF:
109829982
109849533
MSIN:
131221896
ACAK:
137942631
137966152
NCOL:
116267349
ATR:
18431601
SMO:
SELMODRAFT_153855
SELMODRAFT_79159
PPP:
112282916
112287650
CRE:
CHLRE_12g530550v5
CSL:
COCSUDRAFT_83701
CVR:
CHLNCDRAFT_134482
APRO:
F751_3234
OLU:
OSTLU_17414
BPG:
Bathy13g01230
MIS:
MICPUN_87107
MPP:
MICPUCDRAFT_20585
CME:
CYME_CMT121C
SCE:
YLR260W
(LCB5)
YOR171C
(LCB4)
SEUB:
DI49_3771
DI49_5004
SPAO:
SPAR_L02850
SPAR_O02980
AGO:
AGOS_AGR256W
ERC:
Ecym_3138
KLA:
KLLA0_F20504g
KMX:
KLMA_40194
(LCB5)
LTH:
KLTH0C10406g
VPO:
Kpol_1037p37
Kpol_1042p1
ZRO:
ZYRO0C07084g
CGR:
2890448
(GVI51_K05819)
2890643
(GVI51_L04389)
NCS:
NCAS_0D02510
(NCAS0D02510)
NCAS_0F00230
(NCAS0F00230)
NDI:
NDAI_0I02370
(NDAI0I02370)
NDAI_0K02870
(NDAI0K02870)
TPF:
TPHA_0F02490
(TPHA0F02490)
TPHA_0J00530
(TPHA0J00530)
TBL:
TBLA_0E03180
(TBLA0E03180)
TBLA_0G00430
(TBLA0G00430)
TGB:
HG536_0H04320
TDL:
TDEL_0G04220
(TDEL0G04220)
KAF:
KAFR_0A05250
(KAFR0A05250)
KAFR_0G02620
(KAFR0G02620)
KNG:
KNAG_0E02730
(KNAG0E02730)
KNAG_0M01110
(KNAG0M01110)
ZMK:
HG535_0G02670
SLUD:
SCDLUD_000912
DHA:
DEHA2B11088g
PIC:
PICST_54239
(SPH1)
PGU:
PGUG_01720
SPAA:
SPAPADRAFT_55773
LEL:
PVL30_000437
(LCB4)
LBG:
92205841
(LODBEIA_P06450)
CAL:
CAALFM_C112080WA
(LCB4)
CTP:
CTRG_03443
COT:
CORT_0A04990
CDU:
CD36_11310
CTEN:
18248485
(LCB4)
CLU:
CLUG_03851
CLUS:
A9F13_01g02827
CAUR:
CJI96_0001048
PPA:
PAS_chr3_0399
PKZ:
C5L36_0A00790
BNN:
FOA43_000981
BBRX:
BRETT_003732
OPA:
HPODL_02198
YLI:
2906996
(YALI2_C00346g)
SLB:
AWJ20_3638
(LCB4)
NCR:
NCU07937
NTE:
NEUTE1DRAFT120743
(NEUTE1DRAFT_120743)
SMP:
10807796
(SMAC4_01184)
PAN:
PODANSg465
PBEL:
QC761_301800
(LCB4)
PPSD:
QC762_301800
(LCB4)
PPSP:
QC763_301800
(LCB4)
PPSA:
QC764_301800
(LCB4)
TTT:
THITE_2116096
MTM:
MYCTH_2299645
CTHR:
CTHT_0031500
MGR:
MGG_05147
PPEI:
PpBr36_03520
PGRI:
PgNI_09616
TMN:
UCRPA7_7104
SSCK:
SPSK_07175
FGR:
FGSG_12199
FPU:
FPSE_10313
FPOA:
FPOAC1_002914
FVN:
FVRRES_03231
FVR:
FVEG_08919
FOX:
FOXG_10270
NHE:
NECHADRAFT_104662
FFC:
NCS54_00791400
FKR:
NCS57_00834000
FMU:
J7337_005472
TRE:
TRIREDRAFT_68412
TRR:
M419DRAFT_89774
TATV:
25774990
(TrAtP1_002966)
TASP:
36610326
(TrAFT101_006689)
MAW:
19253955
(LCB4_1)
MAJ:
MAA_00275
MBRN:
26243221
(LCB5)
PCHM:
VFPPC_05461
CMT:
CCM_00739
AMUS:
LMH87_001015
PLJ:
28885306
(PLICBS_006876)
PTKZ:
JDV02_005419
(LCB4)
VAL:
VDBG_01425
VDA:
VDAG_07821
CFJ:
CFIO01_00332
CLUP:
CLUP02_05144
CHIG:
CH63R_00061
CDET:
87938748
(CDEST_02245)
SAPO:
SAPIO_CDS0061
ELA:
UCREL1_2933
PFY:
PFICI_00694
SSL:
SS1G_01552
SS1G_09867
BFU:
BCIN_07g02640
BCIN_11g02340
MBE:
MBM_05749
PSCO:
LY89DRAFT_691311
GLZ:
GLAREA_08844
ANI:
ANIA_01176
AFM:
AFUA_1G10980
ACT:
ACLA_024530
NFI:
NFIA_014650
AOR:
AO090038000306
ANG:
An08g03280
AFV:
AFLA_008793
ALUC:
AKAW2_30695A
(LCB4)
ACHE:
ACHE_30152A
(LCB4)
APUU:
APUU_50567S
(LCB4)
PCS:
N7525_002671
PDP:
PDIP_27490
POU:
POX_c04116
TMF:
EYB26_002993
TRG:
TRUGW13939_03072
CIM:
CIMG_06936
CPW:
9695626
(LCB4)
URE:
UREG_05912
ABE:
ARB_02821
TVE:
TRV_04958
PBL:
PAAG_03005
PBN:
PADG_02876
AJE:
HCAG_01797
BGH:
BDBG_00264
PNO:
SNOG_15083
PTE:
PTT_06596
PTRR:
6349712
(PtrM4_000910)
BZE:
COCCADRAFT_101632
BSC:
COCSADRAFT_129645
BOR:
COCMIDRAFT_90014
AALT:
CC77DRAFT_976530
ARAB:
EKO05_0001319
ZTR:
MYCGRDRAFT_66426
PFJ:
MYCFIDRAFT_32681
FFU:
CLAFUR5_00487
CBET:
CB0940_00605
BCOM:
BAUCODRAFT_180475
NPA:
UCRNP2_2270
SPO:
2543328
(lcb4)
SOM:
SOMG_03679
(lcb4)
CNE:
CND02910
CNB:
CNBD3450
CNG:
CNAG_01165
CGI:
CGB_D5450C
CDEU:
CNBG_0734
CDEP:
91084382
(L203_100166)
KMG:
30163199
(I203_102189)
KNE:
92180056
(IAR55_002798)
TMS:
TREMEDRAFT_67509
TASA:
A1Q1_07643
CCAC:
CcaHIS019_0308140
(LCB4)
TVS:
TRAVEDRAFT_175806
DSQ:
DICSQDRAFT_77846
PCO:
PHACADRAFT_256300
SHS:
STEHIDRAFT_169861
HIR:
HETIRDRAFT_311241
PSQ:
PUNSTDRAFT_144839
ADL:
AURDEDRAFT_96953
FME:
FOMMEDRAFT_168804
GTR:
GLOTRDRAFT_137011
LBC:
LACBIDRAFT_306015
CCI:
CC1G_13902
ABP:
AGABI1DRAFT104558
(AGABI1DRAFT_104558)
ABV:
AGABI2DRAFT176573
(AGABI2DRAFT_176573)
MRR:
Moror_16723
MORE:
E1B28_008854
SCM:
SCHCO_02682446
(SCHCODRAFT_02682446)
CPUT:
CONPUDRAFT_79840
SLA:
SERLADRAFT_473900
WSE:
WALSEDRAFT_21414
WALSEDRAFT_61561
WIC:
J056_003046
J056_003047
UMA:
UMAG_11808
PFP:
PFL1_02150
SGRA:
EX895_003506
MGL:
MGL_3927
MRT:
MRET_2774
MSYM:
MSY001_3166
PGR:
PGTG_01874
PTRC:
PtA15_10A680
PSTR:
Pst134EA_019705
MLR:
MELLADRAFT_25264
RIE:
OCT59_016281
OCT59_022936
MBR:
MONBRDRAFT_33671
SRE:
PTSG_00923
DDI:
DDB_G0272522
(sgkA)
DDB_G0284545
(sgkB)
DPP:
DICPUDRAFT_158914
DICPUDRAFT_76939
DFA:
DFA_12044
(sgkA)
EHI:
EHI_023410
(25.t00015)
EDI:
EDI_063170
EIV:
EIN_170600
ACAN:
ACA1_068230
ACA1_176060
TET:
TTHERM_00459289
TTHERM_00600340
PTM:
GSPATT00016286001
PTI:
PHATRDRAFT_44806
FCY:
FRACYDRAFT_277329
TPS:
THAPSDRAFT_21109
AAF:
AURANDRAFT_63325
PIF:
PITG_13546
PSOJ:
PHYSODRAFT_289129
PHYSODRAFT_356119
PHYSODRAFT_566103
SPAR:
SPRG_03950
SPRG_06259
SPRG_12353
SPRG_18667
NGR:
NAEGRDRAFT_69820
NAEGRDRAFT_78781
EHX:
EMIHUDRAFT_207387
EMIHUDRAFT_246668
EMIHUDRAFT_437034
GTT:
GUITHDRAFT_147110
AMR:
AM1_1694
CHON:
NIES4102_18350
ARP:
NIES39_J01510
LFS:
HFV01_16505
OXY:
HCG48_24885
» show all
Taxonomy
UniProt
Reference
PMID:
10802064
Authors
Nava VE, Lacana E, Poulton S, Liu H, Sugiura M, Kono K, Milstien S, Kohama T, Spiegel S
Title
Functional characterization of human sphingosine kinase-1.
Journal
FEBS Lett 473:81-4 (2000)
DOI:
10.1016/S0014-5793(00)01510-6
Sequence
[hsa:
8877
]
Reference
PMID:
10751414
Authors
Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S
Title
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.
Journal
J Biol Chem 275:19513-20 (2000)
DOI:
10.1074/jbc.M002759200
Sequence
[hsa:
56848
]
LinkDB
All DBs
DBGET
integrated database retrieval system