KEGG ORTHOLOGY: K07298

ORTHOLOGY: K07298

Entry

K07298                      KO

Symbol

STK11, LKB1

Name

serine/threonine-protein kinase 11 [EC:2.7.11.1]

Pathway

map04068

FoxO signaling pathway

map04140

Autophagy - animal

map04150

mTOR signaling pathway

map04151

PI3K-Akt signaling pathway

map04152

AMPK signaling pathway

map04211

Longevity regulating pathway

map04530

Tight junction

map04920

Adipocytokine signaling pathway

Disease

H00019

Pancreatic cancer

H00023

Testicular cancer

H00038

Melanoma

H00666

Peutz-Jeghers syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K07298  STK11, LKB1; serine/threonine-protein kinase 11
   04151 PI3K-Akt signaling pathway
    K07298  STK11, LKB1; serine/threonine-protein kinase 11
   04152 AMPK signaling pathway
    K07298  STK11, LKB1; serine/threonine-protein kinase 11
   04150 mTOR signaling pathway
    K07298  STK11, LKB1; serine/threonine-protein kinase 11
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07298  STK11, LKB1; serine/threonine-protein kinase 11
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K07298  STK11, LKB1; serine/threonine-protein kinase 11
09150 Organismal Systems
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K07298  STK11, LKB1; serine/threonine-protein kinase 11
  09149 Aging
   04211 Longevity regulating pathway
    K07298  STK11, LKB1; serine/threonine-protein kinase 11
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07298  STK11, LKB1; serine/threonine-protein kinase 11
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K07298  STK11, LKB1; serine/threonine-protein kinase 11
Protein kinases [BR:ko01001]
Serine/threonine kinases: CAMK group
  CAMKL family
   K07298  STK11, LKB1; serine/threonine-protein kinase 11

Genes

HSA:	6794(STK11)

PTR:	468641(STK11)

PPS:	100989684(STK11)

GGO:	101145563(STK11)

PON:	100460337(STK11)

PPYG:

129020671(STK11)

NLE:	100602473(STK11)

HMH:	116483317(STK11)

SSYN:

129465706(STK11)

MCC:	705686(STK11)

MCF:	102143615(STK11)

MTHB:

126942954

MNI:	105486273(STK11)

CSAB:

103233599(STK11)

CATY:

105591707(STK11)

TGE:	112612676(STK11)

MLEU:

105551941(STK11)

RRO:	104671422(STK11)

RBB:	108530261(STK11)

TFN:	117076307(STK11)

PTEH:

111526789(STK11)

CANG:

105527615(STK11)

CJC:	100390825(STK11)

SBQ:	101053621(STK11)

CIMI:

108293173(STK11)

ANAN:

105705962(STK11)

CSYR:

103276207(STK11)

MMUR:

105860784(STK11)

LCAT:

123632712(STK11)

PCOQ:

105811307(STK11)

OGA:	100964140(STK11)

MMU:	20869(Stk11)

MCAL:

110303223(Stk11)

MPAH:

110326255(Stk11)

RNO:	314621(Stk11)

MCOC:

116076582(Stk11)

ANU:	117696120(Stk11)

MUN:	110551353(Stk11)

CGE:	100765813(Stk11)

MAUA:

101835880(Stk11)

PROB:

127216634(Stk11)

PLEU:

114684084(Stk11)

MORG:

121459850(Stk11)

MFOT:

126489360

AAMP:

119813272(Stk11)

NGI:	103737337(Stk11)

HGL:	101707198(Stk11)

CPOC:

100730854(Stk11)

CCAN:

109691016(Stk11)

DORD:

105990430(Stk11)

DSP:	122122873(Stk11)

PLOP:

125348513(Stk11)

NCAR:

124968687

MMMA:

107157242(Stk11)

OCU:

127489204

OPI:	101531468(STK11)

TUP:	102502422(STK11)

GVR:	103586718(STK11)

CFA:	485088(STK11)

CLUD:

112666174(STK11)

VVP:	112935466(STK11)

VLG:	121494342(STK11)

NPO:	129521527(STK11)

AML:	100477412(STK11)

UMR:	103681779(STK11)

UAR:	123794034(STK11)

ELK:

111161896

LLV:

125088813

MPUF:

101677390(STK11)

MNP:	132010698(STK11)

MLK:	131823185(STK11)

NVS:	122909957(STK11)

ORO:	101376688(STK11)

EJU:	114226177(STK11)

ZCA:	113916807(STK11)

MLX:	118005809(STK11)

NSU:	110593994(STK11)

LWW:	102727190(STK11)

FCA:	101085024(STK11)

PYU:	121021482(STK11)

PCOO:

112852775(STK11)

PBG:	122488590(STK11)

PVIV:

125159722(STK11)

LRUF:

124527639

PTG:	102949361(STK11)

PPAD:

109257684(STK11)

PUC:

125928796

AJU:

106983714

HHV:	120242405(STK11)

BTA:	100337329(STK11)

BOM:	102278863(STK11)

BIU:	109561062(STK11)

BBUB:

102405692(STK11)

BBIS:

104991948(STK11)

CHX:	102188214(STK11)

OAS:	101117245(STK11)

BTAX:

128050902(STK11)

CSUM:

138085502(STK11)

ODA:	120863710(STK11)

MREE:

136156075(STK11)

MBEZ:

129558567(STK11)

SSC:	100512213(STK11)

CFR:	102515362(STK11)

CBAI:

105078127(STK11)

CDK:	105104114(STK11)

VPC:	102544676(STK11)

BACU:

103015566(STK11)

BMUS:

118892403(STK11)

LVE:	103070931(STK11)

OOR:	101269612(STK11)

DLE:	111170524(STK11)

PCAD:

102991940(STK11)

PSIU:

116750705(STK11)

NASI:

112396326(STK11)

ECB:	100055913(STK11)

EAI:	106834191(STK11)

MYB:	102242649(STK11)

MYD:	102767396(STK11)

MMYO:

118659345(STK11)

MLF:	102421316(STK11)

MDT:	132235274(STK11)

PKL:	118711765(STK11)

EFUS:

103294296(STK11)

MNA:	107534576(STK11)

DRO:	112312378(STK11)

SHON:

118984411(STK11)

AJM:	119044055(STK11)

PDIC:

114504186(STK11)

PHAS:

123813698(STK11)

MMF:	118643522(STK11)

PPAM:

129073753 129073757

HAI:	109390619(STK11)

RFQ:	117038062(STK11)

PALE:

102880044(STK11)

PGIG:

120583692(STK11)

PVP:	105302230(STK11)

RAY:	107500925(STK11)

MJV:	108399430(STK11)

TOD:	119240488(STK11)

SARA:

101538651(STK11)

SETR:

126029629(STK11)

LAV:	100665182(STK11)

TMU:

101354514

ETF:	101642015(STK11)

DNM:

101426791

MDO:	100022246(STK11)

GAS:	123243678(STK11)

SHR:	100927576(STK11)

AFZ:

127545102

PCW:	110223520(STK11)

TVP:	118856702(STK11)

PBRV:

138172308(STK11)

OAA:	100090823(STK11) 114808770

GGA:	420105(STK11)

PCOC:

116235801(STK11)

MGP:	100539688(STK11)

CJO:	107325449(STK11)

TPAI:

128072044(STK11)

LMUT:

125684913(STK11)

NMEL:

110388823(STK11)

APLA:

101795686(STK11)

ACYG:

106048222(STK11)

CATA:

118260069(STK11)

AFUL:

116498971(STK11)

TGU:	100222363(STK11)

LSR:	110479120(STK11)

SCAN:

103821949(STK11)

PMOA:

120495990(STK11)

OTC:	121342002(STK11)

PRUF:

121361588(STK11)

GFR:	102045531(STK11)

FAB:	101809216(STK11)

OMA:	130264344(STK11)

PHI:	102112772(STK11)

PMAJ:

107215598(STK11)

CCAE:

111940414(STK11)

CCW:	104697015(STK11)

CBRC:

103622186(STK11)

ETL:	114066360(STK11)

ZAB:	102072162(STK11)

ZLE:	135458992(STK11)

ACHL:

103799764(STK11)

SVG:	106857085(STK11)

MMEA:

130580188(STK11)

HRT:	120763345(STK11)

SATI:

136371914(STK11)

FPG:	101921472(STK11)

FCH:	102055692(STK11)

CCRI:

104155913(STK11)

NNT:	104411558(STK11)

SHAB:

115618025(STK11)

ACUN:

113489386(STK11)

TALA:

104359476(STK11)

ACHC:

115348852(STK11)

HALD:

104315710(STK11)

HLE:	104829096(STK11)

AGEN:

126041753

GCL:

127025687

CSTI:

104561508(STK11)

DPUB:

104300169(STK11)

PPUS:

135192098(STK11)

BRHI:

104491427(STK11)

EGZ:	104127394(STK11)

NNI:	104016253(STK11)

PCRI:

104032412(STK11)

PCAO:

104042881(STK11)

PADL:

103922944(STK11)

AFOR:

103899327(STK11)

FGA:	104079556(STK11)

GSTE:

104256871(STK11)

CLV:	102085404(STK11)

MUI:	104534418(STK11)

PGUU:

104459456(STK11)

PLET:

104628082(STK11)

CMAC:

104475745(STK11)

CUCA:

104065751(STK11)

TEO:	104378718(STK11)

BREG:

104641582(STK11)

OHA:	104339572(STK11)

ACAR:

104528884(STK11)

CPEA:

104386558(STK11)

CVF:	104287161(STK11)

RTD:	128900501(STK11)

AAM:	106493536(STK11)

AROW:

112965617(STK11)

NPD:	112946923(STK11)

TGT:	104578474(STK11)

DNE:	112988086(STK11)

SCAM:

104139524(STK11)

ASN:	102379013(STK11)

AMJ:	102565922(STK11)

CPOO:

109312303(STK11)

GGN:	109294941(STK11)

PSS:	102460756(STK11)

CMY:	102947941(STK11)

CCAY:

125626952(STK11)

DCC:	119848491(STK11)

CPIC:

101950526(STK11)

TST:	117868836(STK11)

CABI:

116829306(STK11)

MRV:	120391650(STK11)

ACS:	100552624(stk11)

ASAO:

132780931(STK11)

PVT:	110079304(STK11)

SUND:

121937353(STK11)

PBI:	103056184(STK11)

PMUR:

107282874(STK11)

CTIG:

120297051(STK11)

TSR:	106543111(STK11)

PGUT:

117668633(STK11)

APRI:

131188327(STK11)

PTEX:

113435337(STK11)

VKO:	123036626(STK11)

PMUA:

114588439(STK11)

PRAF:

128405814(STK11)

ZVI:	118086432(STK11)

HCG:	128348012(STK11)

GJA:	107107346(STK11)

STOW:

125432462(STK11)

EMC:	129330122(STK11)

XLA:	108706844(stk11.S) 399100(stk11.L)

XTR:	549287(stk11)

NPR:	108789501(STK11)

RTEM:

120913719(STK11)

BBUF:

120989457(STK11)

BGAR:

122920142(STK11)

MUO:	115480094(STK11)

GSH:	117365983(STK11)

DRE:	550537(stk11)

SRX:	107712391 107729609

SANH:

107681921 107702084(stk11)

SGH:	107570363(stk11)

CCAR:

109064729 109109110(stk11)

CAUA:

113045078 113045176 113111478

CGIB:

127938779 127951412

PTET:

122362039(stk11)

LROH:

127173908(stk11)

OMC:	131525215(stk11)

PPRM:

120471323(stk11)

RKG:	130103362(stk11)

MAMB:

125250627(stk11)

CIDE:

127496481 127501770

CERY:

137003498(stk11)

MASI:

127441346 127443033

TROS:

130554285(stk11)

TDW:	130417545(stk11)

MANU:

129441522(stk11)

IPU:

108280802

IFU:	128624436(stk11)

PHYP:

113533304(stk11)

SMEO:

124403058(stk11)

TFD:	113645258(stk11)

TVC:	132844972(stk11)

TRN:	134302347(stk11)

AMEX:

103025761(stk11)

CMAO:

118796994(stk11)

EEE:	113582890(stk11)

CHAR:

105909249(stk11) 105909250

TRU:	101074528(stk11)

TFS:	130538358(stk11)

TNG:	GSTEN00028502G001

LCO:	104929660(stk11)

NCC:	104948984(stk11)

TBEN:

117488743(stk11)

CGOB:

115022113(stk11)

PGEO:

117462025(stk11)

GACU:

117532607(stk11)

EMAC:

134865815(stk11)

ELY:	117271781(stk11)

EFO:	125902413(stk11)

PLEP:

121951259(stk11)

SLUC:

116037249(stk11)

ECRA:

117954694(stk11)

ESP:	116699531(stk11)

PFLV:

114565857(stk11)

GAT:	120815818(stk11)

PPUG:

119209121(stk11)

AFB:	129114179(stk11)

CLUM:

117747050(stk11)

PSWI:

130197517(stk11)

CANA:

137782168(stk11)

CVE:	137866220(stk11)

MSAM:

119902904(stk11)

SCHU:

122886527(stk11)

CUD:	121520303(stk11)

ALAT:

119011218(stk11)

ASTR:

137612794(stk11)

MZE:	101464183(stk11)

ONL:	100696052(stk11)

OAU:	116318921(stk11)

OLA:	101172766(stk11)

OML:	112147794(stk11)

CSAI:

133452638(stk11)

XMA:	102223537(stk11)

XCO:	114146932(stk11)

XHE:	116721365(stk11)

PRET:

103479439(stk11)

PFOR:

103153544 103153545

PLAI:

106935695(stk11)

PMEI:

106905428(stk11) 106933334

GAF:	122840985(stk11)

PPRL:

129362256(stk11)

CVG:	107092291(stk11)

CTUL:

119773264(stk11)

GMU:	124870426(stk11)

NFU:	107384096(stk11)

KMR:	108239546(stk11)

ALIM:

106526658(stk11)

NWH:	119414605(stk11)

AOCE:

111572315(stk11)

EJA:	138202845(stk11)

MCEP:

125010363(stk11)

CSEM:

103395954(stk11)

POV:	109645115(stk11)

SSEN:

122768115(stk11)

HHIP:

117778177(stk11)

HSP:	118117305(stk11)

PPLT:

128454978(stk11)

SMAU:

118310652(stk11)

LCF:

108883583

SDU:	111228977(stk11)

SLAL:

111652612(stk11)

XGL:	120799373(stk11)

HCQ:	109507428(stk11)

SSCV:

125984983(stk11)

SBIA:

133511111(stk11)

PEE:	133411839(stk11)

PTAO:

133488658(stk11)

BPEC:

110158021(stk11)

MALB:

109969373(stk11)

BSPL:

114844335(stk11)

SJO:	128368988(stk11)

SASA:

106569546 106573605 106599971 106613746

STRU:

115151815 115157419 115158222 115169402

OTW:	112226590 112250849 112260836

OMY:	110508403 110524266 110530706

OGO:	123997101 124009658 124041515

ONE:	115108285 115116369 115117588

OKI:	109874880 109901012 109902480

OKE:	118389281 118395066 118401802

SALP:

111952830 111956885 111975623 111979148

SNH:	120020158 120053185 120054759 120056015

CCLU:

121533554 121535482 121576759 121581209

ELS:	105011530 105020679

SFM:	108919871 108921657(stk11)

PKI:	111836657(stk11)

AANG:

118226569(stk11) 118230589

LOC:	102684679(stk11)

PSPA:

121300738 121301678

ARUT:

117428959 117962902

PSEX:

120537605(stk11)

LCM:	102364462(STK11)

CMK:	103189923(stk11)

RTP:	109931437(stk11)

CPLA:

122565356(stk11)

HOC:	132829097(stk11)

LERI:

129711310(stk11)

PMRN:

116951881(STK11)

LRJ:	133348928(STK11)

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG9374(Lkb1)

DER:

6553426

DSE:

6606498

DSI:	Dsimw501_GD18919(Dsim_GD18919)

DYA:	Dyak_GE26287

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI22066

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ014002

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105678390(Lkb1)

PGC:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124217631(Lkb1)

NFB:

NLO:

NVG:

AROA:

TCA:	662493(Stk11)

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100145906(Lkb1)

BMAN:

114241016

MSEX:

115441083 119188506 119191242

DPL:	KGM_215872

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137930798(Lkb1)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110375260 135116709

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106677060(Lkb1)

NLU:

111043217

HVI:

124367606

MQU:

128986722

PHU:	Phum_PHUM576030

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_189230(LKB1)

AFRA:

136034837

PVM:	113805071 113805075

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123746807(Lkb1)

CQD:

128699137

PTRU:

123511270

ESN:

126989007

MRJ:	136835887(Lkb1)

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:	107359349 107366125

DPTE:

113788499 113796877

DFR:	124496052 124496060

CSCU:

111633404

CVS:	136969058(Lkb1)

PTEP:

107448241 107451572

ABRU:

129956055 129958932

UDV:	129216018 129231775

SDM:	118180975 118197733

LPOL:

106465847

PMEO:

129589965

CEL:	CELE_Y59A8B.14(par-4)

CBR:	CBG_05647(Cbr-par-4)

CRQ:	GCK72_021838

NAI:	NECAME_04758

BMY:	BM_BM6930(Bma-par-4)

LOA:	LOAG_03149

TSP:

Tsp_07420

HRO:	HELRODRAFT_70072 HELRODRAFT_94423

LGI:	LOTGIDRAFT_208293

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:	124260778 124261324

HASI:

CRG:

CANU:

CVN:

OED:

MYI:	110444656 110454541

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114521968 114536314

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_29179

AQU:

100632250

CME:	CYME_CMT325C

GSL:	Gasu_09610

CCP:	CHC_T00008378001

MBR:	MONBRDRAFT_16805

SRE:	PTSG_08374

DDI:	DDB_G0279629(lkb1)

DPP:	DICPUDRAFT_47007

DFA:	DFA_05386(lkb1)

ACAN:

ACA1_369700

TET:	TTHERM_00038950

NGR:	NAEGRDRAFT_79301

TVA:	TVAG_2v0261550 TVAG_2v0321450 TVAG_2v0341770 TVAG_2v0464380 TVAG_2v0487910 TVAG_2v0675660 TVAG_2v1009820 TVAG_2v1056290

EHX:	EMIHUDRAFT_194068

GTT:	GUITHDRAFT_122766 GUITHDRAFT_41016

» show all

Reference

PMID:14976552

Authors

Lizcano JM, Goransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Makela TP, Hardie DG, Alessi DR

Title

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

Journal

EMBO J 23:833-43 (2004)
DOI:10.1038/sj.emboj.7600110

Reference

PMID:9425897

Authors

Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Muller O, Back W, Zimmer M

Title

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.

Journal

Nat Genet 18:38-43 (1998)
DOI:10.1038/ng0198-38

Sequence

[hsa:6794]

LinkDB

DBGET integrated database retrieval system