Entry |
|
Symbol |
RRM1
|
Name |
ribonucleoside-diphosphate reductase subunit M1 [EC: 1.17.4.1]
|
Pathway |
map00983 | Drug metabolism - other enzymes |
|
Module |
M00053 | Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP |
M00938 | Pyrimidine deoxyribonucleotide biosynthesis, UDP => dTTP |
|
Reaction |
R02017 | 2'-deoxyadenosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase |
R02018 | 2'-deoxyuridine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase |
R02019 | 2'-deoxyguanosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase |
R02024 | 2'-deoxycytidine diphosphate:oxidized-thioredoxin 2'-oxidoreductase |
R08363 | 2'-deoxyribonucleoside-diphosphate:tryparedoxin-disulfide 2'-oxidoreductase |
R08364 | 2'-deoxyribonucleoside-diphosphate:trypanothione-disulfide 2'-oxidoreductase |
R11893 | 5-fluorodeoxyuridine-diphosphate:thioredoxin-disulfide 2'-oxidoreductase |
|
Disease |
H01395 | Autosomal recessive progressive external ophthalmoplegia |
|
Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1
00240 Pyrimidine metabolism
K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1
09106 Metabolism of other amino acids
00480 Glutathione metabolism
K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1
09111 Xenobiotics biodegradation and metabolism
00983 Drug metabolism - other enzymes
K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03400 DNA repair and recombination proteins
K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1
Enzymes [BR:ko01000]
1. Oxidoreductases
1.17 Acting on CH or CH2 groups
1.17.4 With a disulfide as acceptor
1.17.4.1 ribonucleoside-diphosphate reductase
K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic type
Other factors with a suspected DNA repair function
Modulation of nucleotide pools
K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1
|
Other DBs |
|
Genes |
» show all
|
Reference |
|
Authors |
Qiu W, Zhou B, Darwish D, Shao J, Yen Y |
Title |
Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Domkin V, Thelander L, Chabes A |
Title |
Yeast DNA damage-inducible Rnr3 has a very low catalytic activity strongly stimulated after the formation of a cross-talking Rnr1/Rnr3 complex. |
Journal |
|
Reference |
|
Authors |
Valsecchi ME, Holdbrook T, Leiby BE, Pequignot E, Littman SJ, Yeo CJ, Brody JR, Witkiewicz AK |
Title |
Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma? |
Journal |
|
LinkDB |
|