KEGG   ORTHOLOGY: K14251
Entry
K14251                      KO                                     
Symbol
oxyF
Name
C-methyltransferase [EC:2.1.1.-]
Pathway
map00253  Tetracycline biosynthesis
map01057  Biosynthesis of type II polyketide products
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00780  Tetracycline/oxytetracycline biosynthesis, pretetramide => tetracycline/oxytetracycline
M00823  Chlortetracycline biosynthesis, pretetramide => chlortetracycline
Reaction
R09189  S-adenosyl-L-methionine:pretetramid C-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K14251  oxyF; C-methyltransferase
   00253 Tetracycline biosynthesis
    K14251  oxyF; C-methyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14251  oxyF; C-methyltransferase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Methylase
   K14251  oxyF; C-methyltransferase
Genes
NAH: F5544_10765
SCO: SCO7452(SC5C11.09c)
SMA: SAVERM_2843
SGRF: SGFS_062850
SCB: SCAB_43351
SSX: SACTE_0249
SVL: Strvi_2536
SHY: SHJG_1196 SHJG_3677
SHO: SHJGH_1031 SHJGH_3442
SRC: M271_12995
SMAL: SMALA_6137
SSOI: I1A49_34525
SFA: Sfla_6024
SBH: SBI_02773
SVE: SVEN_6791
STRP: F750_0544
SCI: B446_17615
SLV: SLIV_02050
SVT: SVTN_35515
STRE: GZL_07664
SCW: TU94_02310
SLD: T261_1185
SLC: SL103_14205
STRM: M444_28745
SAMB: SAM23877_0753
SPRI: SPRI_1902
SCX: AS200_18475
SRW: TUE45_01299(tcmN_1) TUE45_02733(tcmN_2)
STRF: ASR50_04950
SLE: sle_64170(sle_64170)
SPAV: Spa2297_01510
STRT: A8713_14020
SCLF: BB341_04335
SGS: AVL59_45160
STSI: A4E84_27845
SGM: GCM10017557_73840
SCAD: DN051_35005
SPHW: NFX46_26155
SNR: SNOUR_35010
SALU: DC74_1539
SALL: SAZ_08220
SPLU: LK06_007875
STRD: NI25_35540
SAUO: BV401_34465
SGV: B1H19_34510
SALF: SMD44_04054
STRO: STRMOE7_05640
SFK: KY5_6672c
SGE: DWG14_04084(mmcR)
SRJ: SRO_4045
SLK: SLUN_31255
SDX: C4B68_04295
SQZ: FQU76_27385
SAST: CD934_02785
SNQ: CP978_15840
STIR: DDW44_01285
SKA: CP970_02800 CP970_07270
SNK: CP967_32665
SGAL: CP966_04280
SSPO: DDQ41_09755
SVR: CP971_03860 CP971_23975
SFY: GFH48_07750
SAQU: EJC51_03305
SGF: HEP81_04221
SSEO: D0Z67_13065
SRIM: CP984_02400
SPHV: F9278_25490
SCIN: CP977_04295
SFUG: CNQ36_31185
SPAC: B1H29_34540
STSU: B7R87_27815
SGX: H4W23_03385
SNF: JYK04_01871(mmcR_2)
SPLA: CP981_04075 CP981_34505
STUI: GCM10017668_02460
SATA: C5746_03005
SCHF: IPT68_10365
SCYG: S1361_12045(tcmN1)
SDW: K7C20_03915
SAUH: SU9_003180
SPRA: CP972_04600
SPEU: CGZ69_28180
SROI: IAG44_38015
SXN: IAG42_06660
SGJ: IAG43_25105
SANU: K7396_31575
SDD: D9753_25675
SACT: DMT42_20485
SINE: KI385_06490 KI385_25225
SDEC: L3078_24315
SYAN: NRK68_05230
SAKB: K1J60_20795
STAA: LDH80_35890
SNIG: HEK616_24460
SCAE: IHE65_21365
SSPN: LXH13_04675
SXT: KPP03845_101417(mmcR_2)
SLON: LGI35_08260
SDRZ: NEH16_29500
STUD: STRTU_006484
STEE: F3L20_22185
SENG: OJ254_22950
SGK: PET44_27275
SANT: QR300_10890
SYUN: MOV08_35565
SARG: HKX69_17085 HKX69_24965
SCYN: N8I84_19000
SLAI: P8A22_36835
SROC: RGF97_06350
STTN: BSL84_04710
SLUO: PS467_31830
STPB: QR97_02895 QR97_38770
SRPA: HEP86_05590
SMIB: SMIR_00350
STRW: QHG49_19335
STSD: HEP87_45405
SRPZ: HEP85_33730
SCHE: QRN89_03345
SGLY: P8A20_35115
SCAT: P8A18_00985
KSK: KSE_72520
KAB: B7C62_28965
KAU: B6264_27840
KIT: CFP65_3507
KIS: HUT16_34280
KCH: O1G21_06675
STRI: C7M71_028875
YIA: LO772_28845
STRH: GXP74_03085
ABRY: NYE86_14980
AGLA: OIE69_14265
AGRA: AGRA3207_002734
NOA: BKM31_22795
FRI: FraEuI1c_4747
AORI: SD37_34170
MTUA: CSH63_05015
MCRA: ID554_21305
PLK: CIK06_11105
DAUR: Daura_37880
CCAZ: COUCH_15890
CAI: Caci_4546
AG: AAZ78330(oxyF)
 » show all
Reference
PMID:16597959
  Authors
Zhang W, Ames BD, Tsai SC, Tang Y
  Title
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
  Journal
Appl Environ Microbiol 72:2573-80 (2006)
DOI:10.1128/AEM.72.4.2573-2580.2006
  Sequence
[ag:AAZ78330]
Reference
PMID:20522541
  Authors
Pickens LB, Tang Y
  Title
Oxytetracycline biosynthesis.
  Journal
J Biol Chem 285:27509-15 (2010)
DOI:10.1074/jbc.R110.130419
Reference
PMID:17631493
  Authors
Zhang W, Watanabe K, Wang CC, Tang Y
  Title
Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway.
  Journal
J Biol Chem 282:25717-25 (2007)
DOI:10.1074/jbc.M703437200
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