KEGG   ORTHOLOGY: K14366
Entry
K14366                      KO                                     
Symbol
eryF, CYP107A
Name
6-deoxyerythronolide B hydroxylase [EC:1.14.15.35]
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00774  Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
Reaction
R05270  6-deoxyerythronolide-B,reduced ferredoxin:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01052 Type I polyketide structures
    K14366  eryF, CYP107A; 6-deoxyerythronolide B hydroxylase
   00522 Biosynthesis of 12-, 14- and 16-membered macrolides
    K14366  eryF, CYP107A; 6-deoxyerythronolide B hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K14366  eryF, CYP107A; 6-deoxyerythronolide B hydroxylase
   00199 Cytochrome P450
    K14366  eryF, CYP107A; 6-deoxyerythronolide B hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.35  6-deoxyerythronolide B hydroxylase
     K14366  eryF, CYP107A; 6-deoxyerythronolide B hydroxylase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Oxygenase
   K14366  eryF, CYP107A; 6-deoxyerythronolide B hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP107 family
   K14366  eryF, CYP107A; 6-deoxyerythronolide B hydroxylase
Other DBs
COG: COG2124
Genes
SNR: SNOUR_10185
SGF: HEP81_07903
AER: AERYTH_15880
SEN: SACE_0730(eryF)
AEY: CDG81_13145
Reference
PMID:2011746
  Authors
Weber JM, Leung JO, Swanson SJ, Idler KB, McAlpine JB
  Title
An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea.
  Journal
Science 252:114-7 (1991)
DOI:10.1126/science.2011746
  Sequence
[sen:SACE_0730]
Reference
PMID:19625248
  Authors
Savino C, Montemiglio LC, Sciara G, Miele AE, Kendrew SG, Jemth P, Gianni S, Vallone B
  Title
Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate.
  Journal
J Biol Chem 284:29170-9 (2009)
DOI:10.1074/jbc.M109.003590
LinkDB

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