KEGG   ORTHOLOGY: K20169
Entry
K20169                      KO                                     
Symbol
nox, nicA2
Name
nicotine dehydrogenase [EC:1.4.2.2]
Pathway
map00760  Nicotinate and nicotinamide metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Module
M00811  Nicotine degradation, pyrrolidine pathway, nicotine => succinate semialdehyde
Reaction
R11175  (S)-nicotine:cytochrome c oxidoreductase (N-methylmimosine-forming)
R11177  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K20169  nox, nicA2; nicotine dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.2  With a cytochrome as acceptor
    1.4.2.2  nicotine dehydrogenase
     K20169  nox, nicA2; nicotine dehydrogenase
Other DBs
COG: COG1231
Genes
PPT: PPS_4081
PMON: X969_19995
PMOT: X970_19630
PMED: E3Z27_20810
PVK: EPZ47_21960
PSJY: AA098_04100 AA098_21435
SLAA: EUU25_06970
AG: AGH68979(nox)
Reference
PMID:22267672
  Authors
Qiu J, Ma Y, Wen Y, Chen L, Wu L, Liu W
  Title
Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine.
  Journal
Appl Environ Microbiol 78:2154-60 (2012)
DOI:10.1128/AEM.07025-11
Reference
PMID:23335761
  Authors
Qiu J, Ma Y, Zhang J, Wen Y, Liu W
  Title
Cloning of a novel nicotine oxidase gene from Pseudomonas sp. strain HZN6 whose product nonenantioselectively degrades nicotine to pseudooxynicotine.
  Journal
Appl Environ Microbiol 79:2164-71 (2013)
DOI:10.1128/AEM.03824-12
  Sequence
[ag:AGH68979]
Reference
PMID:24204321
  Authors
Tang H, Wang L, Wang W, Yu H, Zhang K, Yao Y, Xu P
  Title
Systematic unraveling of the unsolved pathway of nicotine degradation in Pseudomonas.
  Journal
PLoS Genet 9:e1003923 (2013)
DOI:10.1371/journal.pgen.1003923
  Sequence
[ppt:PPS_4081]
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