KEGG   ORTHOLOGY: K21182
Entry
K21182                      KO                                     
Symbol
sgcC1, mdpC1
Name
(S)-beta-tyrosine adenylation enzyme [EC:6.2.1.-]
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00827  C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP
M00828  Maduropeptin beta-hydroxy acid moiety biosynthesis, tyrosine => 3-(4-hydroxyphenyl)-3-oxopropanoyl-PCP
Reaction
R11367  (S)-beta-tyrosine:[peptidyl-carrier protein] ligase (AMP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21182  sgcC1, mdpC1; (S)-beta-tyrosine adenylation enzyme
Other DBs
COG: COG1020
Genes
SGB: WQO_33890
SSPO: DDQ41_30910
NEC: KGD82_07455
AJA: AJAP_16295
AAB: A4R43_37255
AMYY: YIM_40830(lgrB11)
AHG: AHOG_16440(lgrD)
ALO: CRK59452
ACTU: Actkin_05226(tycC_2)
SAQ: Sare_2093
VMA: VAB18032_18470
MPRN: Q3V37_18050 Q3V37_18455
MCAY: PVK37_23975
PFLA: Pflav_004680
AG: ABY66004(mdpC1)
 » show all
Reference
PMID:12183628 (sgcC1)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33890]
Reference
PMID:17918933 (mdpC1)
  Authors
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B
  Title
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.
  Journal
J Am Chem Soc 129:13082-94 (2007)
DOI:10.1021/ja073275o
  Sequence
[ag:ABY66004]
Reference
PMID:16887797
  Authors
Van Lanen SG, Lin S, Dorrestein PC, Kelleher NL, Shen B
  Title
Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
J Biol Chem 281:29633-40 (2006)
DOI:10.1074/jbc.M605887200
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