ORTHOLOGY: K22540
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Entry
K22540 KO
Symbol
HTD2
Name
3-hydroxyacyl-thioester dehydratase, animal type [EC:4.2.1.-]
Pathway
map00061
Fatty acid biosynthesis
map01100
Metabolic pathways
map01212
Fatty acid metabolism
Module
M00873
Fatty acid biosynthesis in mitochondria, animals
Reaction
R04428
(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase
R04535
(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] hydro-lyase
R04537
(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase
R04544
(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase
R04568
(3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] hydro-lyase
R04954
(3R)-3-hydroxyhexanoyl-[acyl-carrier-protein] hydro-lyase
R04965
(3R)-3-hydroxydodecanoyl-[acyl-carrier-protein] hydro-lyase
R10208
(3R)-3-hydroxyacyl-[acyl-carrier protein] hydro-lyase (trans-2-enoyl-[acyl-carrier protein]-forming)
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09100 Metabolism
09103 Lipid metabolism
00061 Fatty acid biosynthesis
K22540 HTD2; 3-hydroxyacyl-thioester dehydratase, animal type
BRITE hierarchy
Genes
HSA:
109703458
(HTD2)
PTR:
134809453
(HTD2)
GGO:
134758057
(HTD2)
PPYG:
129032453
(HTD2)
NLE:
115830346
(HTD2)
HMH:
116469177
(HTD2)
SSYN:
129479650
(HTD2)
MCF:
123566755
(HTD2)
MTHB:
126948815
MNI:
105482860
(HTD2)
CSAB:
103227809
CATY:
105585625
(RPP14)
PANU:
103875477
(HTD2)
TGE:
112619243
(HTD2)
MLEU:
105552662
(RPP14)
RRO:
104660193
(HTD2)
RBB:
108543612
(RPP14)
TFN:
117083054
(HTD2)
PTEH:
111534122
(HTD2)
CANG:
105515411
(RPP14)
CJC:
118142769
(HTD2)
SBQ:
101031682
101032558
CIMI:
108303540
(HTD2)
ANAN:
110568288
135268065
(HTD2)
MMUR:
105884315
105884919
(RPP14)
LCAT:
123623357
(HTD2)
PCOQ:
105805890
(RPP14)
OGA:
100958119
100960865
MMU:
109729085
(Htd2)
MCAL:
110307244
110309428
(Htd2)
MCOC:
116072721
(Htd2)
ANU:
117705013
(Htd2)
MUN:
110554624
(Htd2)
CGE:
113832350
(Htd2)
MAUA:
110342274
(Htd2)
PROB:
127238209
(Htd2)
PLEU:
114680727
(Htd2)
MORG:
121455129
(Htd2)
MFOT:
126513030
AAMP:
119828037
(Htd2)
CPOC:
111754587
DSP:
122108214
(Htd2)
PLOP:
125358688
(Htd2)
MMMA:
107149655
(Htd2)
OCU:
100356042
OPI:
118760304
(HTD2)
CFA:
111091303
(HTD2)
CLUD:
112665971
(HTD2)
VVP:
112909725
(HTD2)
VLG:
121495987
(HTD2)
NPO:
129516833
129522409
(HTD2)
AML:
117801905
(HTD2)
UMR:
121102488
(HTD2)
UAH:
113257018
(HTD2)
UAR:
123798796
(HTD2)
ELK:
111144067
LLV:
125078389
MNP:
132009823
(HTD2)
MLK:
131824069
(HTD2)
NVS:
122909313
(HTD2)
EJU:
114214683
(HTD2)
ZCA:
113918765
(HTD2)
MLX:
118005160
(HTD2)
NSU:
110584828
(HTD2)
LWW:
115937187
(HTD2)
FCA:
111559427
(HTD2)
PYU:
121016800
(HTD2)
PCOO:
112852604
(HTD2)
PBG:
122488173
(HTD2)
PVIV:
125148247
(HTD2)
LRUF:
124524520
PTG:
102950284
PPAD:
109279087
PUC:
125929522
AJU:
106968840
HHV:
120238602
(HTD2)
BTA:
112447889
(HTD2)
BBUB:
112577783
(HTD2)
OAS:
101122389
(HTD2)
BTAX:
128057734
(HTD2)
CSUM:
138087411
(HTD2)
ODA:
120851377
120867978
(HTD2)
CCAD:
122424321
(HTD2)
122433808
MREE:
136166715
(HTD2)
136173417
MBEZ:
129547968
(HTD2)
SSC:
100515579
CFR:
116657110
(HTD2)
CDK:
116158254
(HTD2)
VPC:
116283967
(HTD2)
BMUS:
118903892
(HTD2)
OOR:
125960234
(HTD2)
DLE:
111174244
(HTD2)
PCAD:
112064963
(HTD2)
PSIU:
116762513
(HTD2)
NASI:
112400622
(HTD2)
ECB:
111768318
EAI:
123279356
(HTD2)
MMYO:
118664981
118667943
(HTD2)
118667945
MLF:
111828449
MDT:
132215240
(HTD2)
132241912
PKL:
118715076
(HTD2)
EFUS:
114233308
(HTD2)
DRO:
112301293
(HTD2)
SHON:
118983383
(HTD2)
AJM:
119043376
(HTD2)
PDIC:
114501993
(HTD2)
PHAS:
123814511
(HTD2)
MMF:
118633528
(HTD2)
PPAM:
129088429
(HTD2)
RFQ:
117037176
(HTD2)
PALE:
112484321
(HTD2)
PGIG:
120599501
(HTD2)
PVP:
111746606
MJV:
118972544
(HTD2)
TOD:
119230488
(HTD2)
SARA:
101558095
SETR:
126013223
(HTD2)
126026117
LAV:
111750580
TMU:
111819738
ETF:
115869546
(HTD2)
DNM:
105745412
111761366
MDO:
103101327
GAS:
123230662
(HTD2)
SHR:
111719548
(HTD2)
AFZ:
127550625
PCW:
110196017
TVP:
118831621
(HTD2)
PBRV:
138158180
(HTD2)
OAA:
114806605
(HTD2)
GGA:
112533344
(HTD2)
PCOC:
116237405
(HTD2)
CJO:
116654008
(HTD2)
LMUT:
125698957
NMEL:
110404841
APLA:
101790049
(HTD2)
ACYG:
125183771
(HTD2)
CATA:
118248173
(HTD2)
AFUL:
116492979
(HTD2)
LSR:
110472415
(HTD2)
SCAN:
115483820
(HTD2)
PMOA:
120513980
(HTD2)
OTC:
121347141
(HTD2)
PRUF:
121352776
(HTD2)
FAB:
101809145
OMA:
130258439
(HTD2)
PMAJ:
117243655
(HTD2)
CCAE:
111935019
CCW:
109143331
(HTD2)
ETL:
114056798
(HTD2)
ZAB:
113459451
(HTD2)
ZLE:
135453139
(HTD2)
MMEA:
130589157
(HTD2)
HRT:
120758101
(HTD2)
SATI:
136365873
(HTD2)
FCH:
114016005
(HTD2)
SHAB:
115614776
(HTD2)
ACUN:
113485023
(HTD2)
TALA:
104355952
(HTD2)
ACHC:
115353754
(HTD2)
AGEN:
126049767
GCL:
127021558
CSTI:
104551589
PPUS:
135182618
(HTD2)
AVIT:
104268434
NNI:
104016989
PCRI:
104026759
PADL:
103918910
AFOR:
103903328
FGA:
104070237
CLV:
106145808
PLET:
104614862
CUCA:
128853311
(HTD2)
BREG:
104630373
ACAR:
114818738
(HTD2)
RTD:
128915537
(HTD2)
AROW:
112976612
(HTD2)
NPD:
112958775
(HTD2)
DNE:
112984675
(HTD2)
PSS:
112546375
(HTD2)
CMY:
114020856
(HTD2)
CCAY:
125640609
(HTD2)
DCC:
119858832
(HTD2)
TST:
117880512
(HTD2)
CABI:
116825644
(HTD2)
MRV:
120409161
(HTD2)
ASAO:
132769442
(HTD2)
PVT:
110079940
SUND:
121923711
(HTD2)
PBI:
112540543
(HTD2)
PMUR:
114923725
(HTD2)
CTIG:
120300508
(HTD2)
PGUT:
117660654
(HTD2)
APRI:
131192607
(HTD2)
PTEX:
113449587
(HTD2)
VKO:
123034614
(HTD2)
PMUA:
114591894
(HTD2)
PRAF:
128408526
(HTD2)
ZVI:
118080860
(HTD2)
HCG:
128341756
(HTD2)
STOW:
125430321
(HTD2)
EMC:
129328653
(HTD2)
XLA:
108704592
NPR:
108791848
RTEM:
120945221
BBUF:
120979511
BGAR:
122943675
(HTD2)
MUO:
115471627
(HTD2)
GSH:
117351387
(HTD2)
SRX:
107745404
SANH:
107658379
SGH:
107586974
CAUA:
113039537
113080104
CGIB:
127942961
127986977
PTET:
122327560
LROH:
127153159
OMC:
131530838
PPRM:
120492963
RKG:
130077327
MAMB:
125263596
CIDE:
127519875
CERY:
137027875
MASI:
127439254
TROS:
130548847
TDW:
130429903
130430134
MANU:
129453187
IPU:
128628638
IFU:
128625327
PHYP:
113537924
(htd2)
SMEO:
124402136
TFD:
113639071
TVC:
132838348
TRN:
134301680
AMEX:
103034148
CMAO:
118799810
EEE:
113580586
(htd2)
TFS:
130524014
TNG:
GSTEN00002197G001
GSTEN00003016G001
GSTEN00012877G001
LCO:
104940354
(rpp14)
NCC:
104948461
TBEN:
117497889
(rpp14)
CGOB:
115008319
(htd2)
PGEO:
117446517
(rpp14)
GACU:
117537205
EMAC:
134883203
ELY:
117256521
EFO:
125895582
PLEP:
121951632
(rpp14)
SLUC:
118492913
ECRA:
117943536
(rpp14)
ESP:
116687470
(rpp14)
PFLV:
114554172
(htd2)
GAT:
120835651
PPUG:
119230215
AFB:
129106432
CLUM:
117730994
PSWI:
130208430
CANA:
137798870
CVE:
137880665
MSAM:
119885564
(rpp14)
SCHU:
122887442
CUD:
121503463
(rpp14)
ALAT:
119020380
ASTR:
137594775
(rpp14)
MZE:
101465350
(htd2)
OLA:
101155024
CSAI:
133449205
(rpp14)
XMA:
111605755
XCO:
114136073
(htd2)
XHE:
116710353
(htd2)
PLAI:
106956022
(rpp14)
PMEI:
106933158
(rpp14)
GAF:
122833999
PPRL:
129354630
129372898
CTUL:
119790336
GMU:
124856782
KMR:
112449719
ALIM:
106522356
(rpp14)
NWH:
119412702
AOCE:
111575280
111581695
111584987
EJA:
138198917
MCEP:
125007330
(rpp14)
CSEM:
103386679
POV:
109635407
SSEN:
122768499
HHIP:
117760984
HSP:
118104569
PPLT:
128455242
SMAU:
118309477
LCF:
127138913
SDU:
111219474
(rpp14)
SLAL:
111668194
XGL:
120783488
HCQ:
109510331
(rpp14)
SSCV:
125976953
SBIA:
133506958
PEE:
133408271
PTAO:
133484144
MALB:
109966375
BSPL:
114855987
SJO:
128355900
(rpp14)
STRU:
115149945
(htd2)
OTW:
112255101
OMY:
110528675
OGO:
124024739
ONE:
115124325
(htd2)
OKI:
109891466
(htd2)
OKE:
118375330
SALP:
112074118
SNH:
120037984
CCLU:
121577864
ELS:
114828651
(htd2)
SFM:
108929815
(htd2)
PKI:
111837463
AANG:
118208575
LOC:
107077419
PSPA:
121298243
(rpp14)
ARUT:
117964000
PSEX:
120539409
CMK:
103190039
RTP:
109929422
CPLA:
122559038
HOC:
132822128
LERI:
129704468
PMRN:
116952345
LRJ:
133355597
(HTD2)
BFO:
118425584
BBEL:
109467964
CIN:
108949282
SCLV:
120337342
SPU:
754233
LPIC:
129264443
ARUN:
117288571
AJC:
117111955
CLON:
129609849
AALI:
118458762
LLL:
129786936
PPAP:
129806310
MGEN:
117226667
SOC:
113004956
HST:
109503685
DQU:
106742434
CFO:
109610047
CSOL:
105366205
AROA:
105689652
SOY:
115881552
BMAN:
114241826
MJU:
123864707
MCIX:
123659263
AAGE:
121729626
ATRA:
106136914
API:
115034289
AGS:
114129397
RMD:
113550376
DVT:
126894591
BTAB:
109038585
MQU:
128989252
ZNE:
110838928
CSEC:
111864066
BROR:
134532661
IEL:
124161185
PJA:
122256737
PCHN:
125028775
PTRU:
123516689
MNZ:
135214648
DSV:
119457721
RSAN:
119374632
RMP:
119166725
TUT:
107369463
CSCU:
111622782
CVS:
136990445
LPOL:
106465753
HRO:
HELRODRAFT_175453
CRG:
105340412
CANU:
128178558
CVN:
111128521
OED:
125652182
MYI:
110467089
PMAX:
117323513
OBI:
106869720
OSN:
115217442
LAK:
106171102
SMM:
Smp_173000
OVI:
T265_12458
NVE:
116602303
EPA:
110241968
ATEN:
116299329
AMIL:
114977532
PDAM:
113668995
SPIS:
111338273
TAD:
TRIADDRAFT_52813
MBR:
MONBRDRAFT_36649
SRE:
PTSG_04866
DPP:
DICPUDRAFT_11264
PSOJ:
PHYSODRAFT_480915
TSY:
THSYN_31605
» show all
Taxonomy
UniProt
Reference
PMID:
17898086
Authors
Autio KJ, Kastaniotis AJ, Pospiech H, Miinalainen IJ, Schonauer MS, Dieckmann CL, Hiltunen JK
Title
An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing.
Journal
FASEB J 22:569-78 (2008)
DOI:
10.1096/fj.07-8986
Sequence
[hsa:
109703458
]
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DBGET
integrated database retrieval system