KEGG   ORTHOLOGY: K22998
Entry
K22998                      KO                                     
Symbol
cotB4
Name
cyclooctatin synthase [EC:1.14.99.62]
Pathway
map00997  Biosynthesis of various other secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00921  Cyclooctatin biosynthesis, dimethylallyl-PP + isopentenyl-PP => cyclooctatin
Reaction
R12178  cyclooctat-9-ene-5,7-diol,hydrogen-donor:oxygen oxidoreductase (18-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various other secondary metabolites
    K22998  cotB4; cyclooctatin synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.62  cyclooctatin synthase
     K22998  cotB4; cyclooctatin synthase
Other DBs
COG: COG2124
Genes
SVL: Strvi_5781
SRC: M271_43265
SMAL: SMALA_0744
SSOI: I1A49_07310
SCI: B446_28650
SRN: A4G23_04519(ptlI_3)
SAUO: BV401_07570
SFB: CP974_24305
SCAE: IHE65_00210
SXT: KPP03845_200298(ptlI)
AG: BAI44340(cotB4)
 » show all
Reference
  Authors
Kim SY, Zhao P, Igarashi M, Sawa R, Tomita T, Nishiyama M, Kuzuyama T
  Title
Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases.
  Journal
Chem Biol 16:736-43 (2009)
DOI:10.1016/j.chembiol.2009.06.007
  Sequence
Reference
  Authors
Gorner C, Schrepfer P, Redai V, Wallrapp F, Loll B, Eisenreich W, Haslbeck M, Bruck T
  Title
Identification, characterization and molecular adaptation of class I redox systems for the production of hydroxylated diterpenoids.
  Journal
Microb Cell Fact 15:86 (2016)
DOI:10.1186/s12934-016-0487-6
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