KEGG   ORTHOLOGY: K25563
Entry
K25563                      KO                                     
Symbol
creL, ptmB3
Name
3-amino-4-hydroxybenzoate 2-monooxygenase [EC:1.14.13.249]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00951  Cremeomycin biosynthesis, aspartate/3,4-AHBA => cremeomycin
Reaction
R12912  3-amino-4-hydroxybenzoate,NADPH:oxygen oxidoreductase (2-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K25563  creL, ptmB3; 3-amino-4-hydroxybenzoate 2-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.249  3-amino-4-hydroxybenzoate 2-monooxygenase
     K25563  creL, ptmB3; 3-amino-4-hydroxybenzoate 2-monooxygenase
Other DBs
COG: COG0654
Genes
SGRF: SGFS_074080
SDW: K7C20_14895
SCAT: P8A18_26625
AG: ACO31289(ptmB3) ALA99209(creL) BAU09309(creL)
Reference
  Authors
Smanski MJ, Yu Z, Casper J, Lin S, Peterson RM, Chen Y, Wendt-Pienkowski E, Rajski SR, Shen B.
  Title
Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 108:13498-503 (2011)
DOI:10.1073/pnas.1106919108
  Sequence
Reference
  Authors
Waldman AJ, Pechersky Y, Wang P, Wang JX, Balskus EP.
  Title
The Cremeomycin Biosynthetic Gene Cluster Encodes a Pathway for Diazo Formation.
  Journal
Chembiochem 16:2172-5 (2015)
DOI:10.1002/cbic.201500407
  Sequence
Reference
  Authors
Sugai Y, Katsuyama Y, Ohnishi Y.
  Title
A nitrous acid biosynthetic pathway for diazo group formation in bacteria.
  Journal
Nat Chem Biol 12:73-5 (2016)
DOI:10.1038/nchembio.1991
  Sequence
LinkDB

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