KEGG   MODULE: M00377
Entry
M00377            Pathway   Module                                 
Name
Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway)
Definition
K00198 (K05299-K15022,K22015+K25123+K25124) K01938 K01491-K01500 K00297-K25007-K25008 K15023 K14138+K00197+K00194
Diagram
M00377

Orthology
K00198  
carbon-monoxide dehydrogenase [EC:1.2.7.4] [RN:R07157]
K05299,K15022  
formate dehydrogenase [EC:1.17.1.10] [RN:R00134]
K22015,K25123,K25124  
formate dehydrogenase (hydrogenase) [EC:1.17.98.-] [RN:R12754]
K01938  
formate--tetrahydrofolate ligase [EC:6.3.4.3] [RN:R00943]
K01491  
methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] [RN:R01655 R01220]
K01500  
methenyltetrahydrofolate cyclohydrolase [EC:3.5.4.9] [RN:R01655]
K00297,K25007,K25008  
methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54] [RN:R07168]
K15023  
5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase [EC:2.1.1.258] [RN:R02289]
K14138  
acetyl-CoA synthase [EC:2.3.1.169] [RN:R08433]
K00197+K00194  
acetyl-CoA decarbonylase/synthase complex [EC:2.3.1.-] [RN:R10243]
Class
Pathway modules; Energy metabolism; Carbon fixation
Pathway
map00720  Other carbon fixation pathways
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R07157  
R00134,R12754  
R00943  
R01655  
R01220  
R07168  
R02289+R08433,R10243  
Compound
C00011  CO2
C00237  CO
C00058  Formate
C00101  Tetrahydrofolate
C00234  10-Formyltetrahydrofolate
C00445  5,10-Methenyltetrahydrofolate
C00143  5,10-Methylenetetrahydrofolate
C00440  5-Methyltetrahydrofolate
C00024  Acetyl-CoA
Reference
PMID:3096193
  Authors
Ljungdahl LG
  Title
The autotrophic pathway of acetate synthesis in acetogenic bacteria.
  Journal
Annu Rev Microbiol 40:415-50 (1986)
DOI:10.1146/annurev.mi.40.100186.002215
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