KEGG   REACTION: R04823
Entry
R04823                      Reaction                               
Name
7alpha,12alpha-dihydroxy-5beta-cholestan-3-one:NADP+ delta4-oxidoreductase
Definition
7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one + NADP+ <=> 4-Cholesten-7alpha,12alpha-diol-3-one + NADPH + H+
Equation
C05453 + C00006 <=> C17339 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00145  C05453_C17339
Enzyme
1.3.1.3
Pathway
rn00120  Primary bile acid biosynthesis
rn01100  Metabolic pathways
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.3
     R04823  7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one + NADP+ <=> 4-Cholesten-7alpha,12alpha-diol-3-one + NADPH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.3.1.3
   R13168  3-Oxo-5beta-steroid <=> 3-Oxo-Delta4-steroid
    R04823  7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one <=> 4-Cholesten-7alpha,12alpha-diol-3-one
Orthology
K00251  3-oxo-5-beta-steroid 4-dehydrogenase [EC:1.3.1.3]
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