KEGG PATHWAY: crf00525

PATHWAY: crf00525

Entry

crf00525                    Pathway

Name

Acarbose and validamycin biosynthesis - Corynebacterium rouxii

Class

Metabolism; Biosynthesis of other secondary metabolites

Pathway map

crf00525

Acarbose and validamycin biosynthesis

Organism

Corynebacterium rouxii [GN:crf]

Gene

FRC0190_00358

glucose-1-phosphate thymidylyltransferase [KO:K00973] [EC:2.7.7.24]

FRC0190_00360

dTDP-glucose 4,6-dehydratase [KO:K01710] [EC:4.2.1.46]

Compound

C00103

D-Glucose 1-phosphate

C00842

dTDP-glucose

C04268

dTDP-4-amino-4,6-dideoxy-D-glucose

C06802

Acarbose

C11907

dTDP-4-oxo-6-deoxy-D-glucose

C12112

Validamycin A

C17691

2-epi-5-epi-Valiolone

C17692

2-epi-5-epi-Valiolone 7-phosphate

C17693

5-epi-Valiolone 7-phosphate

C17694

5-epi-Valiolone

C17695

2-Keto-5-epi-valiolone

C17696

Valienone

C17697

Valienone 7-phosphate

C17698

Salbostatin

C17699

Cetoniacytone A

C17700

Validoxylamine A

C20956

alpha-D-Sedoheptulopyranose 7-phosphate

C21156

Acarbose 7IV-phosphate

C21204

5-epi-Valiolol 7-phosphate

C21205

1-epi-Valienol 7-phosphate

C21206

1,7-Diphospho-1-epi-valienol

C21207

NDP-1-epi-valienol 7-phosphate

C21208

dTDP-acarviose-7-phosphate

C21209

1-epi-Valienol 1-phosphate

C21210

NDP-1-epi-valienol

C21211

Salbostatin 6'-phosphate

C21216

Validamine 7-phosphate

C21218

Validone 7-phosphate

C21219

Validoxylamine A 7'-phosphate

C21247

2-Amino-5-epi-valiolone

C21248

2-Aminovalienone

C21249

Cetoniacytone B

C21293

Validamycin B

C21367

Valienol 1-phosphate

C21368

GDP-valienol

C21415

Valienol 7-phosphate

Reference

PMID:17390001

Authors

Flatt PM, Mahmud T

Title

Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds.

Journal

Nat Prod Rep 24:358-92 (2007)
DOI:10.1039/b603816f

Reference

PMID:17661520

Authors

Mahmud T, Flatt PM, Wu X

Title

Biosynthesis of unusual aminocyclitol-containing natural products.

Journal

J Nat Prod 70:1384-91 (2007)
DOI:10.1021/np070210q

Reference

PMID:22944206

Authors

Wendler S, Hurtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Puhler A

Title

The cytosolic and extracellular proteomes of Actinoplanes sp. SE50/110 led to the identification of gene products involved in acarbose metabolism.

Journal

J Biotechnol 167:178-89 (2013)
DOI:10.1016/j.jbiotec.2012.08.011

Reference

PMID:22443545

Authors

Schwientek P, Szczepanowski R, Ruckert C, Kalinowski J, Klein A, Selber K, Wehmeier UF, Stoye J, Puhler A

Title

The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110.

Journal

BMC Genomics 13:112 (2012)
DOI:10.1186/1471-2164-13-112

Reference

PMID:17003911

Authors

Deng Z, Bai L

Title

Antibiotic biosynthetic pathways and pathway engineering--a growing research field in China.

Journal

Nat Prod Rep 23:811-27 (2006)
DOI:10.1039/b611140h

Reference

PMID:21766819

Authors

Asamizu S, Yang J, Almabruk KH, Mahmud T

Title

Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.

Journal

J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u

Reference

PMID:18648803

Authors

Choi WS, Wu X, Choeng YH, Mahmud T, Jeong BC, Lee SH, Chang YK, Kim CJ, Hong SK

Title

Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838.

Journal

Appl Microbiol Biotechnol 80:637-45 (2008)
DOI:10.1007/s00253-008-1591-2

Reference

PMID:19101977

Authors

Wu X, Flatt PM, Xu H, Mahmud T

Title

Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.

Journal

Chembiochem 10:304-14 (2009)
DOI:10.1002/cbic.200800527

Related
pathway

crf00030

Pentose phosphate pathway

crf00520

Amino sugar and nucleotide sugar metabolism

KO pathway

ko00525

LinkDB

DBGET integrated database retrieval system