KEGG   Homo sapiens (human): 10797
Entry
10797             CDS       T01001                                 
Symbol
MTHFD2, NMDMC
Name
(RefSeq) methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
  KO
K13403  methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00670  One carbon pool by folate
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    10797 (MTHFD2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.15  methylenetetrahydrofolate dehydrogenase (NAD+)
     10797 (MTHFD2)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     10797 (MTHFD2)
SSDB
Motif
Pfam: THF_DHG_CYH_C THF_DHG_CYH AlaDh_PNT_C PirA-like Memo
Other DBs
NCBI-GeneID: 10797
NCBI-ProteinID: NP_006627
OMIM: 604887
HGNC: 7434
Ensembl: ENSG00000065911
UniProt: P13995
Structure
LinkDB
Position
2:74198615..74217565
AA seq 350 aa
MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEW
VASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKL
NNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGV
WEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQL
KKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQ
KAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN
NT seq 1053 nt   +upstreamnt  +downstreamnt
atggctgcgacttctctaatgtctgctttggctgcccggctgctgcagcccgcgcacagc
tgctcccttcgccttcgccctttccacctcgcggcagttcgaaatgaagctgttgtcatt
tctggaaggaaactggcccagcagatcaagcaggaagtgcggcaggaggtagaagagtgg
gtggcctcaggcaacaaacggccacacctgagtgtgatcctggttggcgagaatcctgca
agtcactcctatgtcctcaacaaaaccagggcagctgcagttgtgggaatcaacagtgag
acaattatgaaaccagcttcaatttcagaggaagaattgttgaatttaatcaataaactg
aataatgatgataatgtagatggcctccttgttcagttgcctcttccagagcatattgat
gagagaaggatctgcaatgctgtttctccagacaaggatgttgatggctttcatgtaatt
aatgtaggacgaatgtgtttggatcagtattccatgttaccggctactccatggggtgtg
tgggaaataatcaagcgaactggcattccaaccctagggaagaatgtggttgtggctgga
aggtcaaaaaacgttggaatgcccattgcaatgttactgcacacagatggggcgcatgaa
cgtcccggaggtgatgccactgttacaatatctcatcgatatactcccaaagagcagttg
aagaaacatacaattcttgcagatattgtaatatctgctgcaggtattccaaatctgatc
acagcagatatgatcaaggaaggagcagcagtcattgatgtgggaataaatagagttcac
gatcctgtaactgccaaacccaagttggttggagatgtggattttgaaggagtcagacaa
aaagctgggtatatcactccagttcctggaggtgttggccccatgacagtggcaatgcta
atgaagaataccattattgctgcaaaaaaggtgctgaggcttgaagagcgagaagtgctg
aagtctaaagagcttggggtagccactaattaa

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