Methylorubrum extorquens DM4: METDI2267
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Entry
METDI2267 CDS
T00947
Symbol
metH
Name
(GenBank) B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
mdi
Methylorubrum extorquens DM4
Pathway
mdi00270
Cysteine and methionine metabolism
mdi00450
Selenocompound metabolism
mdi00670
One carbon pool by folate
mdi01100
Metabolic pathways
mdi01110
Biosynthesis of secondary metabolites
mdi01230
Biosynthesis of amino acids
mdi04980
Cobalamin transport and metabolism
mdi04981
Folate transport and metabolism
Module
mdi_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
mdi00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
METDI2267 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
METDI2267 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
METDI2267 (metH)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
METDI2267 (metH)
04980 Cobalamin transport and metabolism
METDI2267 (metH)
Enzymes [BR:
mdi01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
METDI2267 (metH)
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SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
CAX23867
UniProt:
C7CDH6
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All DBs
Position
2157345..2161097
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AA seq
1250 aa
AA seq
DB search
MTAFPPVDGTEIERALRQRASEKILVLDGAMGTVIQRLKYTEEDFRGERFKDHSHDQKGN
NDLLILTQPDAIRQIHLDYFLAGADVCETNTFSGTTIAQADYGMESIIHELNAEGARLAR
EAAKLAEEQDGRRRFVAGAIGPTNRTLSISPDVNNPGYRAVTFDGVKQAYVEQVRGLIDG
GAELILIETIFDTLNAKAAIAAAWQVFDETGIRLPIQISGTITDLSGRTLSGQTPAAFWN
SLRHSSPLTFGLNCALGAKEMRGHIAELSRICDTLVCAYPNAGLPNEFGLYDESPEAMGK
LVGEFAASGLVNMVGGCCGTTPDHIRAIAEAVADKKPREIPEIPRLMRLSGLEPFVLTKE
IPFVNVGERTNVTGSAKFRKLITNNDYAAALDVARDQVAAGAQVIDVNMDEGLLDSEKAM
VEFLNLVAAEPDIARVPVMVDSSKFEVIEAGLKCIQGKPIVNSISMKEGEAKFIEAAKIC
RSYGAAVVVMAFDEQGQADSYERKVEICTKAYKILTEQVGFPPEDIIFDPNIFAVATGIE
EHNPYGVAFIEATRTIRETLPHAHISGGVSNLSFAFRGNEPVREAMHAVFLFHCIKAGMD
MGIVNAGQLAVYDEIPAELRELCEDVVLNRREDSTERLLEAAERFKTGASAQAKTADLTW
REAPVAKRIEHALVNGITEYIVSDTEEARKEAARPLHVIEGPLMAGMNVVGDLFGSGKMF
LPQVVKSARVMKQAVAYLEPFMEEEKRANGGDGKRQAAGKVLMATVKGDVHDIGKNIVGV
VLACNNYEIIDLGVMVPAAKILETAKRENVDIVGLSGLITPSLDEMVHVAAEMEREGMEM
PLLIGGATTSRVHTAVKIHPAYAKGQAVYVTDASRAVGVVSSLISKETRGATVEKVRAEY
AKVADAHRRSEADKQRLPLAKARANAFKVDWSAYKPAKPSFTGTRVYGSYEVADLVPYID
WTPFLQTYEFKGRYPAILDDPEQGPAARALFEDAQVMLKQIVEERWFNPKAVIGFWPANS
VGDDIRLFTGESRQETLATFHGLRQQLSKRDGRANTCISDFVAPAETGIADYVGAFVVTA
GLEEVRIAERFERANDDYRSILVKALADRIAEAFAERMHERVRKEFWGYAPDEAYAPEEL
VSEKYDGIRPAPGYPAQPDHTEKVQLFDLLKAESRIGVKLTESYAMWPGSSVSGLYIAHP
DAHYFGVAKVERDQVEDYALRKGMDVSEVERWLGPILNYDPVRYLKAAAE
NT seq
3753 nt
NT seq
+upstream
nt +downstream
nt
atgaccgctttcccccccgtcgacggcaccgagatcgagcgcgccctgcgtcaacgcgcg
tcggaaaagatcctcgtcctcgacggggcgatgggcacggtgatccagcggctcaaatac
acggaagaggatttccggggtgagcgcttcaaggatcacagccacgatcagaagggcaac
aacgacctcctgatcctgacgcagcccgacgcgatccggcagatccacctcgactacttc
ctcgccggcgccgacgtctgcgagacgaacacgttttccggcaccacgatcgcccaggcc
gattacggcatggaatcgatcatccacgagctgaacgccgagggcgcccgcctcgcccgc
gaggccgccaaactcgcggaagaacaggacggccgccgccgcttcgttgccggcgccatc
ggcccgaccaaccgcacgctgtcgatctcgccggacgtgaacaatcccggctaccgcgcc
gtgacgttcgatggggtgaagcaggcctatgtcgagcaggtgcgcggcctcatcgacggc
ggcgccgaactgatcctgatcgagacgatcttcgacacgctcaacgccaaggcggcgatc
gccgccgcgtggcaggtgttcgacgagaccggcatccgcctgccgatccagatctccggc
accatcaccgatctctccggccgcaccctttcgggccagacgccggcggcgttctggaac
tcgctgcgccattcgagcccgctcaccttcggcctcaactgcgcgctcggcgccaaggaa
atgcgcggccacatcgccgagctgtcgcgcatctgcgacacgctggtctgcgcctatccg
aatgccggcctgcccaacgagttcggtctctacgacgagagcccggaagccatgggcaag
ctggtgggcgagttcgccgcctcgggcctcgtcaacatggtcggcggctgctgcggcacg
acgcccgaccacatccgcgccatcgccgaggctgtcgccgacaagaagccgcgcgagatc
cccgagatcccgcgcctgatgcgactgtcaggcctcgagcccttcgtcctgacgaaggag
attcccttcgtgaacgtgggcgagcgcaccaacgtcaccggctcggccaaattccgcaag
ctcatcaccaacaacgattacgccgccgcgctcgatgtcgcccgcgatcaggtcgcggcc
ggcgcccaggtcatcgacgtcaacatggatgagggcctgctcgacagcgagaaggcgatg
gtcgagttcctcaacctcgtcgccgccgagcccgatatcgcccgcgtgccggtgatggtc
gattcctcgaagttcgaggtgatcgaggccgggctgaaatgcatccagggcaagccgatc
gtgaactcgatctccatgaaggagggcgaggcgaagttcattgaggccgccaagatctgc
cgctcctacggcgcggcggtcgtcgtcatggccttcgacgagcagggccaggccgattcc
tacgagcgcaaggtcgagatctgcaccaaggcctacaagatcctcaccgagcaggtcggc
ttcccgcccgaagacatcatcttcgacccgaacatcttcgcggtggccacgggtatcgag
gagcacaacccctacggtgtcgccttcatcgaggcgacccgcacgatccgcgagaccctg
ccccacgcccacatctccggcggcgtctcgaacctgtccttcgccttccgcggcaacgag
ccggtgcgcgaggcgatgcacgcggtgttcctgttccactgcatcaaggccggcatggat
atgggcatcgtcaatgccggccagctggccgtctacgacgagatcccggccgaactccgc
gagctgtgcgaggacgtggtcctcaaccgtcgcgaggattcgaccgagcgcctgctggag
gccgccgagcgcttcaagaccggcgcctcggcccaggccaagaccgccgacctgacgtgg
cgtgaggcgcccgtcgccaagcgcatcgagcacgcgctggtcaacggcatcaccgagtac
atcgtctccgacaccgaggaggcgcgcaaagaagccgcgcgtccgctccacgtcatcgaa
ggcccgctcatggccggcatgaacgtggtcggcgacctgttcggctcgggcaagatgttc
ctgccgcaggtggtgaagtccgcccgcgtgatgaagcaggcggtggcctatctcgaaccc
ttcatggaggaggagaagcgggccaatggcggcgatggcaagcgccaggccgccggcaag
gtgctgatggccaccgtgaagggcgacgtccacgacatcggcaagaacatcgtcggcgtg
gttctggcctgcaacaactacgagatcatcgatctcggcgtgatggtgccggcggccaag
attctcgaaaccgccaagcgcgagaacgtcgacatcgtcggcctgtcgggcctcatcacc
ccctcgctcgacgagatggtgcatgtcgccgccgagatggagcgcgagggcatggagatg
ccgctgctgatcggcggcgccaccaccagccgcgtccacaccgcggtgaagatccacccg
gcctacgccaagggtcaggcggtctatgtcaccgatgcgagccgcgcggtcggcgtggtg
tcgagcctgatctcgaaggagacccgcggggccaccgtggagaaggtgcgcgccgaatac
gccaaggtcgccgacgcccatcgccgctcggaggccgacaagcagcgcctgccgctcgcc
aaggcgcgggcgaacgccttcaaggtggattggtcggcctacaagccggccaagcccagc
ttcaccggcacccgcgtctacggttcctacgaagtggcagacctcgtcccctacatcgac
tggacgccgttcctgcagacctacgagttcaagggccgctaccccgcgatcctcgacgat
cccgagcagggcccggcggcgcgtgcgctgttcgaggacgcgcaggtgatgctcaagcag
atcgtggaggagcgctggttcaacccgaaggcggtgatcggcttctggccggccaacagc
gtcggcgacgacatccggctcttcaccggcgagagccggcaggagacgctcgcgaccttc
cacggcctgcgccagcagctctcgaagcgcgacgggcgcgccaacacctgcatctccgac
ttcgtggcgccggccgagaccggcatcgcggactatgtcggcgccttcgtggtgacggcg
ggcctggaggaggtgcgcatcgccgagcgcttcgagcgggccaacgacgattaccgctcg
atcctcgtgaaggcgctcgccgaccgcatcgccgaggccttcgccgagcggatgcacgag
cgcgtccgcaaggagttctggggctatgcgccggacgaggcttacgcccccgaggagctg
gtctcggaaaagtacgacggcatccggcccgcgccgggctacccggcccagcccgaccat
acggaaaaggtgcagttgttcgatctgctcaaggcggagagccgcatcggcgtgaagctc
accgagtcctacgccatgtggccgggctcctcggtctcgggcctctacatcgcccatccc
gacgcgcattacttcggcgtcgccaaggtggagcgggatcaggtcgaggactacgcactg
cgcaagggcatggatgtgagcgaggtcgagcgctggctcgggccgatcctcaactacgac
ccggtccgctacctcaaggccgcggccgagtag
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