Ovis aries (sheep): 493968
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Entry
493968 CDS
T03117
Symbol
CYP17A1
Name
(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase precursor
KO
K00512
steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:
1.14.14.19
1.14.14.32
]
Organism
oas
Ovis aries (sheep)
Pathway
oas00140
Steroid hormone biosynthesis
oas01100
Metabolic pathways
oas04913
Ovarian steroidogenesis
oas04917
Prolactin signaling pathway
oas04927
Cortisol synthesis and secretion
oas04934
Cushing syndrome
Module
oas_M00109
C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
oas_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
oas_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
oas_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
oas00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
493968 (CYP17A1)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
493968 (CYP17A1)
04917 Prolactin signaling pathway
493968 (CYP17A1)
04927 Cortisol synthesis and secretion
493968 (CYP17A1)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
493968 (CYP17A1)
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450 [BR:
oas00199
]
493968 (CYP17A1)
Enzymes [BR:
oas01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.19 steroid 17alpha-monooxygenase
493968 (CYP17A1)
1.14.14.32 17alpha-hydroxyprogesterone deacetylase
493968 (CYP17A1)
Cytochrome P450 [BR:
oas00199
]
Cytochrome P450, animal type
CYP17 family
493968 (CYP17A1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
p450
ZSWIM4-8_C
Motif
Other DBs
NCBI-GeneID:
493968
NCBI-ProteinID:
NP_001009483
UniProt:
Q29497
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All DBs
Position
22:complement(23170151..23176148)
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AA seq
509 aa
AA seq
DB search
MWVLLAVFLLTLAYLFWPKTKHSGAKYPRSLPSLPLVGSLPFLPRRGQQHENFFKLQEKY
GPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKGIAFADHGAH
WQLHRKLVLNAFALFKDGNLKLEKIINQEANVLCDFLATQHGQSIDLSEPLSLAVTNIIS
FICFNFSFKNEDPALKAIQNVNDGILEVLSKEVLLDIFPALKIFPSKAMEKMKGCVETRN
ELLSEILEKCQENFTSDSITNLLHILMQAKVNADNNNTGPEQDSKLLSNRHMLATIADIF
GAGVETTTSVIKWIVAYLLHHPSLKKRIQDSIDQNIGFNRTPTISDRNRLVLLEATIREV
LRIRPVAPMLIPHKAIIDSSIGDLTIDKGTDVVVNLWALHHNEKEWQQPDLFMPERFLDP
TGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFYLEIPDDGKLPSLEGNP
SLVLQIKPFKVKIEVRQAWKEAQAEGSTS
NT seq
1530 nt
NT seq
+upstream
nt +downstream
nt
atgtgggtgctcttggctgtctttctgctcaccctcgcctatttattttggcccaagacc
aagcactctggtgccaagtaccccaggagcctcccatccctgcccctggtgggcagccta
ccattcctccccagacgtggccagcaacacgagaacttcttcaagctgcaggaaaaatat
ggccccatctattcctttcgtttgggttccaagactactgtgatgattggacaccaccag
ttggccagggaggtgcttctcaagaagggcaaggaattctctgggcgtcccaaagtggcc
actctagacatcctgtcagacaaccaaaagggcattgcctttgccgaccatggtgcccac
tggcagctgcatcggaagctggtactgaatgcctttgccctgttcaaggatggcaacctg
aagttagagaagatcattaatcaggaagccaacgtgctgtgtgatttcctggctacccag
catggacagtccatagatctgtccgagcctctctctctggcggtcaccaacataatcagc
tttatctgcttcaacttctccttcaagaatgaggatcctgccctgaaggccatacaaaat
gtcaatgatggcatcctggaggttctgagcaaggaagttctgttagacatattccctgcg
ctgaagattttccccagcaaagccatggaaaagatgaagggttgtgttgaaacgcgaaat
gaattgctgagtgaaatccttgaaaaatgtcaggagaacttcaccagcgactccatcact
aacttgctgcacatactgatgcaagccaaggtgaatgcagacaataacaacactggccca
gagcaggattcaaagctgctttcaaacagacacatgctcgctaccatagcggacatcttc
ggggctggtgtggagaccaccacctctgtgataaagtggatcgtggcctacctgctacac
catccttcgttgaagaagaggatccaggatagcattgaccagaatataggtttcaatcgc
accccaaccatcagtgaccggaaccgccttgtcctgctggaggcgaccatccgagaggtg
ctccgaatccggcctgtggcccctatgctgatcccccacaaggctatcattgactccagc
attggcgaccttaccattgacaagggcacagacgttgtggtcaacctgtgggcactgcat
cacaatgagaaggagtggcagcagcccgacctgttcatgcccgagcgcttcttggacccc
acggggacacaactcatctcgccatcgttaagctacttgccctttggagccggaccccgc
tcctgtgtaggtgagatgctagcccgccaggagctcttcctcttcatgtcccggctgctg
cagaggttctacctggagatcccggatgatgggaagctaccctctctggagggcaatccc
agtctcgtcttgcagatcaaacctttcaaggtgaagatcgaggtgcgccaggcctggaag
gaagcccaggctgagggtagcacctcatga
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