KEGG   PATHWAY: oas00260
Entry
oas00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Ovis aries (sheep)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
oas00260  Glycine, serine and threonine metabolism
oas00260

Module
oas_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:oas00260]
oas_M00047  Creatine pathway [PATH:oas00260]
oas_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:oas00260]
oas_M00555  Betaine biosynthesis, choline => betaine [PATH:oas00260]
oas_M00621  Glycine cleavage system [PATH:oas00260]
oas_M00974  Betaine metabolism, animals, betaine => glycine [PATH:oas00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Ovis aries (sheep) [GN:oas]
Gene
101113775  uncharacterized protein LOC101113775 [KO:K01620] [EC:4.1.2.48]
443544  SHMT1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
101101880  SHMT2; serine hydroxymethyltransferase, mitochondrial isoform X1 [KO:K00600] [EC:2.1.2.1]
101103446  AGXT; alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
101108191  GRHPR; glyoxylate reductase/hydroxypyruvate reductase isoform X2 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
101111913  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
101108532  PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
101123502  PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
101114294  phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
101120366  LOW QUALITY PROTEIN: phosphoglycerate mutase 1-like [KO:K01834] [EC:5.4.2.11]
101121089  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
101111328  PHGDH; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
101120382  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
100145875  PSPH; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
101102469  GCAT; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform X3 [KO:K00639] [EC:2.3.1.29]
101118164  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
101121085  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
101115684  ALAS2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]
101112853  ALAS1; 5-aminolevulinate synthase, non-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
101106401  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
101106659  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
101112584  primary amine oxidase, lung isozyme-like [KO:K00276] [EC:1.4.3.21]
101106783  AOC2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]
101113086  primary amine oxidase, lung isozyme isoform X1 [KO:K00276] [EC:1.4.3.21]
101112335  AOC3; membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
101112834  primary amine oxidase, liver isozyme [KO:K00276] [EC:1.4.3.21]
101117476  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
101104276  AMT; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
101105152  DLD; dihydrolipoyl dehydrogenase, mitochondrial isoform X2 [KO:K00382] [EC:1.8.1.4]
101120772  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
101110116  glycine cleavage system H protein, mitochondrial [KO:K02437]
114116451  glycine cleavage system H protein, mitochondrial [KO:K02437]
114113596  glycine cleavage system H protein, mitochondrial [KO:K02437]
114113605  LOW QUALITY PROTEIN: glycine cleavage system H protein, mitochondrial [KO:K02437]
101115829  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
101111660  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
100174904  GATM; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
101114955  GAMT; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
101106116  CHDH; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
101108127  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase isoform X2 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
101113853  BHMT; betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
101113594  DMGDH; dimethylglycine dehydrogenase, mitochondrial isoform X1 [KO:K00315] [EC:1.5.8.4]
101108928  PIPOX; peroxisomal sarcosine oxidase isoform X2 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
101110407  SARDH; sarcosine dehydrogenase, mitochondrial isoform X1 [KO:K00314] [EC:1.5.8.3]
101111134  GNMT; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
101106301  CBS; cystathionine beta-synthase isoform X2 [KO:K01697] [EC:4.2.1.22]
101118487  CTH; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
101112089  SDSL; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
101112348  SDS; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
101118200  SRR; serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
oas00010  Glycolysis / Gluconeogenesis
oas00020  Citrate cycle (TCA cycle)
oas00230  Purine metabolism
oas00250  Alanine, aspartate and glutamate metabolism
oas00270  Cysteine and methionine metabolism
oas00290  Valine, leucine and isoleucine biosynthesis
oas00330  Arginine and proline metabolism
oas00470  D-Amino acid metabolism
oas00564  Glycerophospholipid metabolism
oas00600  Sphingolipid metabolism
oas00620  Pyruvate metabolism
oas00630  Glyoxylate and dicarboxylate metabolism
oas00640  Propanoate metabolism
oas00860  Porphyrin metabolism
oas00920  Sulfur metabolism
KO pathway
ko00260   
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