KEGG   PATHWAY: onl00260
Entry
onl00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Oreochromis niloticus (Nile tilapia)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
onl00260  Glycine, serine and threonine metabolism
onl00260

Module
onl_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:onl00260]
onl_M00047  Creatine pathway [PATH:onl00260]
onl_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:onl00260]
onl_M00555  Betaine biosynthesis, choline => betaine [PATH:onl00260]
onl_M00621  Glycine cleavage system [PATH:onl00260]
onl_M00974  Betaine metabolism, animals, betaine => glycine [PATH:onl00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Oreochromis niloticus (Nile tilapia) [GN:onl]
Gene
100693061  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
100703155  shmt1; serine hydroxymethyltransferase, cytosolic isoform X2 [KO:K00600] [EC:2.1.2.1]
100695852  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
100691894  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
100690586  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
100695998  serine--pyruvate aminotransferase, mitochondrial [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
100707770  serine--pyruvate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
100707614  glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
100699147  grhpr; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
100698763  glyctk; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
100692737  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
100534541  pgam1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
100691625  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
100708072  bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
100697876  phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
100695776  psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
100692498  psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
100711100  gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
100702806  L-threonine 3-dehydrogenase, mitochondrial isoform X1 [KO:K15789] [EC:1.1.1.103]
100711012  L-threonine 3-dehydrogenase, mitochondrial isoform X5 [KO:K15789] [EC:1.1.1.103]
100693291  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
100692207  alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]
100697245  5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
100706625  probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
100711847  amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
102077099  amine oxidase [flavin-containing] isoform X1 [KO:K00274] [EC:1.4.3.4]
109197600  amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
100705916  primary amine oxidase, liver isozyme [KO:K00276] [EC:1.4.3.21]
100692106  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
100709695  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
100705559  dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
100702337  glycine cleavage system H protein, mitochondrial [KO:K02437]
100712533  glycine cleavage system H protein, mitochondrial [KO:K02437]
100707832  dao; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
100702026  alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
100701752  alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
100689888  gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
100693706  gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
100711832  chdh; choline dehydrogenase, mitochondrial isoform X2 [KO:K00108] [EC:1.1.99.1]
100699093  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
100704302  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
100705166  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
100705436  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
100707764  dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
100701779  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
100708425  sardh; sarcosine dehydrogenase, mitochondrial isoform X2 [KO:K00314] [EC:1.5.8.3]
100706279  gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
100707752  cystathionine beta-synthase isoform X1 [KO:K01697] [EC:4.2.1.22]
100710175  cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
100696142  uncharacterized protein LOC100696142 [KO:K01754] [EC:4.3.1.19]
100705758  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
100707808  sds; L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
100700781  uncharacterized protein LOC100700781 [KO:K20498] [EC:4.3.1.18]
100695081  uncharacterized protein LOC100695081 [KO:K20498] [EC:4.3.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
onl00010  Glycolysis / Gluconeogenesis
onl00020  Citrate cycle (TCA cycle)
onl00230  Purine metabolism
onl00250  Alanine, aspartate and glutamate metabolism
onl00270  Cysteine and methionine metabolism
onl00290  Valine, leucine and isoleucine biosynthesis
onl00330  Arginine and proline metabolism
onl00470  D-Amino acid metabolism
onl00564  Glycerophospholipid metabolism
onl00600  Sphingolipid metabolism
onl00620  Pyruvate metabolism
onl00630  Glyoxylate and dicarboxylate metabolism
onl00640  Propanoate metabolism
onl00860  Porphyrin metabolism
onl00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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