PI3K signaling |
N00683 |
(CD80,CD86) | → | CD28 | → | PI3K | → | PIP3 | → | AKT | ⊣ | GSK3B |
N00684 |
(F,H) | → | CBLB | ⊣ | PI3K |
| | |
TLR signaling |
N00690 |
(TLR7,TLR9) | → | MYD88 | → | (IRAK4+IRAK1) | → | IRF7 | ⇒ | (IFNA,IFNB1) |
N00691 |
| | | | V | ⊣ | IRF7 |
N00435 |
(TLR1,TLR2,TLR4) | → | (TIRAP+MYD88) | → | (IRAK4+IRAK1) | → | (TRAF6+TAK1+TAB2) | → | IKK | → | NFKBIA | → | NFKB | ⇒ | (TNF,IL6,IL12A,IL1.. |
N00692 |
| | P | → | TNFAIP3 | ⊣ | (TRAF6+TAK1+TAB2) |
| | |
RLR signaling |
N00469 |
RNA | → | RIGI | → | MAVS | → | TRAF3 | → | (TANK+NAP1+SINTBAD.. | → | (TBK1+IKBKE) | → | (IRF7,IRF3) | ⇒ | (IFNA,IFNB1) |
N00685 |
V | ⊣ | MDA5 | → | MAVS |
N00686 |
| | | | | | | | | | N | → | IRF3 | ⇒ | IFNB1 |
N00687 |
| | | | | | | | | | (V,C) | ⊣ | IRF3 |
N00688 |
RNA | → | RIGI | → | MAVS | → | IKK | → | NFKBIA | → | NFKB | ⇒ | (IFNA,IFNB1) |
N00689 |
| | | | | | | | (V,P,C) | ⊣ | NFKB |
| | |
PKR-eIF2alpha signaling |
N00571 |
| | EIF2AK2 | → | EIF2S1 | ⊣ | EIF2B |
N00696 |
C | ⊣ | EIF2AK2 |
| | |
IFN signaling |
N00150 |
(IFNA,IFNB1) | → | (IFNAR1+IFNAR2) | → | (JAK1,TYK2) | → | (STAT1+STAT2+IRF9) | ⇒ | (IRF7,EIF2AK2) |
N00693 |
| | (V,P) | ⊣ | JAK1 |
N00694 |
| | | | (V,P,C) | ⊣ | (STAT1+STAT2+IRF9) |
| | |
Transcription |
N00695 |
V | ⊣ | TP73 | ⇒ | BBC3 |
N00697 |
P | → | RCHY1 | ⊣ | TP53 |
|