Network variation - Apoptosis (cancer)
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ENTRY
nt06231
Name
Apoptosis (cancer)
Category
Disease view; Cancer signaling
Display
drug-target relation
disease type
N00145
TNF
→
TNFRSF1A
→
(RIPK1+TRADD+TRAF2..
→
FADD
→
CASP8
→
(CASP3,CASP7)
N00146
(FASLG,TNFSF10)
→
(FAS,TNFRSF10B)
→
FADD
→
(CASP8,CASP10)
→
BID
→
(BAX,BAK1)
→
CYCS
=
APAF1
→
CASP9
→
(CASP3,CASP7)
N00166
vFLIP
⊣
CASP8P3
N00164
vBCL2
⊣
(
BAX
,
BAK1
)
N00165
vIAP
⊣
CASP3
N00098
(PMAIP1,BBC3,BAD,B..
⊣
(BCL2,BCL2L1)
⊣
(BAX,BAK1)
→
CYCS
=
APAF1
→
CASP9
→
(CASP3,CASP7)
N00100
BCL2*
⊣
BAX
→
CYCS
=
APAF1
→
CASP9
→
(
CASP3
,
CASP7
)
N00099
BAX*
⌿
CYCS
N00101
CASP3
→
DCC
→
(CASP9+APPL1)
→
CASP3
N00102
CASP3
⌿
DCC*
⌿
(
CASP9
+
APPL1
)