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ENTRY	nt06310
Name	CRH-ACTH-cortisol signaling
Category	Pathway view; Endocrine system
Pathway	hsa04024 cAMP signaling pathway hsa04927 Cortisol synthesis and secretion
Disease	H01431 Cushing syndrome
Display	drug-target relation   disease type

N00324    CRH → CRHR → GNAS → ADCY → cAMP → PKA → CREB → ACTH N00325        RASD1* ⌿ GNAI ⌿ ADCY → cAMP → PKA → CREB → ACTH     PITA3         GNAS* ↗ N01542                    PRKAR ⊣ PKA     CNC                 PRKAR1A*                                 D1,D2  |     N00297    ACTH → (MC2R+MRAP) → GNAS → ADCY → cAMP → PKA → (NR5A1,NR4A1,SP1,P.. ⇒ (STAR,CYP11B1) → Cortisol     FGD     MC2R*     FGD     MRAP*     PPNAD         GNAS* ↗                               D1,D2  |     N00323    PPNAD, BMAH             (PDE11A*,PDE8B*) ⌿ cAMP → (PRKAR1A+PRKACA) → (NR5A1,NR4A1,SP1,P.. ⇒ (STAR,CYP11B1) → Cortisol     BMAH                     PRKACA* ↗ N00298    GRA ACTH → (MC2R+MRAP) → GNAS → ADCY → cAMP → PKA → (NR5A1,NR4A1,SP1,P.. ⇒ CYP11B2* → Aldosterone N01542                    PRKAR ⊣ PKA     PPNAD                 PRKAR1A*   N00924    GC → NR3C1 = MED14 ⇒ (IGFBP1,IRF8)     GCCR     NR3C1*   N00318        EGFR → ERK1/2 → ACTH N00319    PITA4 USP8* → EGFR → ERK1/2 → ACTH                                 D1,D2,D4  | N00306                        NR0B1 ⊣ NR5A1 ⇒ (CYP11B1,CYP17A1)     AHC                     NR0B1*     Adrenal insufficiency                         NR5A1*

		Disease name	Disease category
PITA3	H01102	Pituitary adenomas	Neoplasm
CNC	H01102	Pituitary adenomas	Neoplasm
FGD	H00256	Familial glucocorticoid deficiency	Endocrine and metabolic disease
PPNAD	H00260	Pigmented micronodular adrenocortical disease	Endocrine and metabolic disease
PPNAD, BMAH	H00260	Pigmented micronodular adrenocortical disease	Endocrine and metabolic disease
	H02049	Bilateral macronodular adrenal hyperplasia	Endocrine and metabolic disease
BMAH	H02049	Bilateral macronodular adrenal hyperplasia	Endocrine and metabolic disease
GRA	H00602	Glucocorticoid-remediable aldosteronism (GRA)	Endocrine and metabolic disease
GCCR	H01702	Glucocorticoid resistance syndrome	Endocrine and metabolic disease
PITA4	H01102	Pituitary adenomas	Neoplasm
AHC	H01772	Adrenal hypoplasia, congenital	Endocrine and metabolic disease
Adrenal insufficiency	H02316	Adrenal insufficiency, NR5A1 related	Endocrine and metabolic disease

		Drug name
D1	D00410	Metyrapone (JP18/USP/INN)
D2	D10950	Levoketoconazole (USAN/INN)
D3	D11062	Osilodrostat phosphate (JAN/USAN)
D4	D00420	Mitotane (JAN/USP/INN)