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ENTRY	nt06460
Name	Alzheimer disease
Category	Disease view; Neurodegenerative disease
Pathway	hsa05010 Alzheimer disease
Disease	H00056 Alzheimer disease
Display	drug-target relation   disease type

Calcium signaling N00984        Glutamate → GRM5 → GNAQ → PLCB → IP3 → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7)     D1,D2,D3  |                                                     N01002    APP* → Abeta → GRM5 → GNAQ → PLCB → IP3 → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → CASP3 N01008                        PSEN1* → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS N01007                        (PSEN1*,PSEN2*) → RYR3 → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N01000        ACh → mAChR → GNAQ → PLCB → IP3 → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS     D1,D2,D3  |                                         N01001    APP* → Abeta → mAChR → GNAQ → PLCB → IP3 → ITPR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS N00967                        Ca2+(extracellular.. − VGCC → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS = APAF1 → CASP9 → (CASP3,CASP7)                     D1,D2,D3  |                         N01004                    APP* → Abeta → VGCC(L-type) → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS                                 D1,D2,D3  |             N01006                                APP* → Abeta → PPID → MPTP → CYCS N00970                        Glutamate → NMDAR → Ca2+                     D1,D2,D3  |                         N01003                    APP* → Abeta → NMDAR → Ca2+ − MCU → Ca2+(mito) − MPTP → CYCS   Ubiquitin-proteasome system N01029        (Protein+UB) − 26S → Peptide     D1,D2,D3  |     N01060    APP* → Abeta ⊣ 26S   Unfolded protein response (UPR) signaling N01009        EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01010    PSEN1* ⊣ EIF2AK3 → EIF2S1 → ATF4 ⇒ DDIT3 N01011        ERN1 → XBP1 ⇒ DDIT3 N01012    PSEN1* ⊣ ERN1 → XBP1 N01013    ERN1 → TRAF2 → MAP3K5 → MAP2K7 → JNK     D1,D2,D3  |             N01014    APP* → Abeta → MAP3K5 → MAP2K7 → JNK N01015        ATF6 ⇒ (DDIT3,XBP1,HSPA5) N01016    PSEN1* ⊣ ATF6 ⇒ (DDIT3,XBP1)   Apoptosis N00146        (FASLG,TNFSF10) → (FAS,TNFRSF10B) → FADD → (CASP8,CASP10) → BID → (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7)     D1,D2,D3  |                                     N01005    APP* → Abeta → FAS → FADD → CASP8 → BID → (BAX,BAK1) → CYCS = APAF1 → CASP9 → CASP3   AGE-RAGE signaling N00994        AGE → AGER → RAS → RAF → MEK → ERK → NFKB ⇒ (TNF,IL6,NOS2)     D1,D2,D3  |                             N00996    APP* → Abeta → AGER → RAS → RAF → MEK → ERK → NFKB ⇒ (TNF,IL6,NOS2)   Oxidative phosphorylation N00995                                NADH − CxI → Q     D1,D2,D3  |                                 N00997    APP* → Abeta → CHRNA7 → Ca2+ → CAPN → CDK5R1 = CDK5 → MAPT ⊣ CxI → Q N00988    Succinate − CxII → QH2 N01402    Mn2+ ⊣ CxII → QH2 N00998        CytC − CxIV → H2O     D1,D2,D3  |         N00999    APP* → Abeta ⊣ CxIV → H2O   Microtubule-based transport N00978                                (KIF5+KLC) = (TUBA+TUBB) N01017                        PSEN1* → GSK3B ⊣ (KIF5+KLC)     D1,D2,D3  |                             N01018    APP* → Abeta → CHRNA7 → Ca2+ → CAPN → CDK5R1 = CDK5 → MAPT ⊣ (TUBA+TUBB) N01403                        Zn2+ → GSK3B → MAPT ⊣ (TUBA+TUBB) N01414                        Fe2+ → CDK5 → MAPT ⊣ (TUBA+TUBB)   Environmental pollutant         D1,D2,D3  | N01415        NEP ⊣ Abeta N01416    Hg ⊣ NEP

		Drug name
D1	D10541	Aducanumab (USAN)
D2	D11500	Donanemab (USAN/INN)
D3	D11678	Lecanemab (USAN)