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ENTRY	nt06520
Name	CGAS-STING signaling
Category	Pathway view; Immune system
Pathway	hsa04623 Cytosolic DNA-sensing pathway
Disease	H00290 Aicardi-Goutieres syndrome
Display	drug-target relation   disease type

N00395    DNA → CGAS → cGAMP → STING1 → TBK1 → IRF3 ⇒ (IFNA,IFNB)     SAVI             STING1* ↗ N00569    HSV UL41 ⊣ CGAS N00570    HSV         ICP0 ⊣ STING1 N00396    HCMV         UL82 ⊣ STING1 N00946    Shigella     IpaJ ⊣ ARF1 → STING1 N00947    Shigella             Ipa4.5 ⊣ TBK1 N00440    HIV                 (Vpu,Vif,Vpr) ⊣ IRF3   N01571    (TREX1,DNASE1,DNAS.. ⊣ DNA     AGS1/SLE/CHBL1/RVCL TREX1*     SLE DNASE1*     SLEB16 DNASE1L3*     AIPCS DNASE2*   N01572    RNASEH2 ⊣ DNA     AGS4 RNASEH2A*     AGS2 RNASEH2B*     AGS3 RNASEH2C*   N01573    SAMHD1 ⊣ dNTP     AGS5/CHBL2 SAMHD1*

		Disease name	Disease category
SAVI	H01746	STING-associated vasculopathy with onset in infancy	Immune system disease
HSV	H00365	Herpes simplex virus infection	Viral infectious disease
HCMV	H00368	Cytomegalovirus infection	Viral infectious disease
Shigella	H00299	Shigellosis	Bacterial infectious disease
HIV	H01563	HIV infection	Viral infectious disease
AGS1/SLE/CHBL1/RVCL	H00290	Aicardi-Goutieres syndrome	Immune system disease
	H00080	Systemic lupus erythematosus	Immune system disease
	H00291	Familial chilblain lupus (FCL)	Immune system disease
	H01000	Retinal vasculopathy with cerebral leukodystrophy	Nervous system disease
SLE	H00080	Systemic lupus erythematosus	Immune system disease
SLEB16	H00080	Systemic lupus erythematosus	Immune system disease
AIPCS	H02608	Autoinflammatory-pancytopenia syndrome	Immune system disease
AGS4	H00290	Aicardi-Goutieres syndrome	Immune system disease
AGS2	H00290	Aicardi-Goutieres syndrome	Immune system disease
AGS3	H00290	Aicardi-Goutieres syndrome	Immune system disease
AGS5/CHBL2	H00290	Aicardi-Goutieres syndrome	Immune system disease
	H00291	Familial chilblain lupus (FCL)	Immune system disease