Conserved Protein Domain Family
ispDF

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PRK09382: ispDF 
bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional
Statistics
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PSSM-Id: 236492
Aligned: 65 rows
Threshold Bit Score: 532.501
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
222148570  10 RSTAVILVAAGRGERAgaSSEGPKQYRRIGGKPVIVHSLLGFADLLPqATLIVVIHPDDGALLANALAPYPQlaasLTIT 89 
118474192   2 LDLSLIMLGAGNSTRF--GLQSKKQWLRTGDDPLWLYATKNISSNYLfKDVIVV--SNECEYMRKFSSHFKF-------I 70 
224372395   1 MDVTLIVLSAGNSTRL--DYPVKKQWLRIDNKPLWLYVADRLNSFYTfKQTIITSNKNDIRLYEKLCd--------YTIV 70 
152992118   2 PDITLILLGAGNSTRF--ESDVKKQWLYSGEIPLWLHVAESFEAMGAfAKIVIVSSPEDIGLMKHFAd--------YTYV 71 
78777684   15 HTITLILLAAGSSSRF--ELDIKKQWLRVGDRPLWHFVADRCEKTGYfDKIIITSSLDDIEFMKNYAd--------YTFV 84 
152990344   2 SDLTLVLLGAGNSSRF--GLDVKKQWLWCGNEPLWLYVTNRFTDMFPfHDVVITAHPKEIPFYKKFCh--------HTIV 71 
154175122   2 LDISLIMLGAGNSSRF--ELPVKKQWLRIGSDPLWLAATKNLSEFYTfKDIIVV--SKECEYMARFAPHYKF-------V 70 
154148625   2 KDITLVLLAAGDSTRF--KAPFKKQWIRIGEIPLWQYVAKDLSQKCDfSDIIIVANEKEISYMKKIERNFKY-------A 72 
157736397   2 LDVTLIVLCAGNSTRF--EHKTKKQWIRVEDEPLWLNVTKRISSFAKfDKIIVTSHQDELNYMKNFSDDFTF-------V 72 
296271785   2 SKVTLLVLCAGNSTRF--GLNCKKQWLRVGDIPLWLFVAKKITSYYNfDKVVITASKDELSYMQNFSDEYDF-------V 72 
222148570  90 HGGKTRQQSVLAGLRALRNqkpDYVLIHDAVRPFFDQLMLQRIIARLDDGaDAVLPAIPVTDTLKRGDEgarvvdTVARS 169
118474192  71 KGGETRQDSLRNAISNINS---EFVMVSDIARADIPKELITKLIESAHNA-DCIVPALKISDSVIYQNE------YINRD 140
224372395  71 AGDRERQLSLKNALKHVST---EYVMVTDVARACVPKNIIENLLSNPAD---CTVPYLKPVDTVVYQNK------TINRD 138
152992118  72 QGGETRQASLKNALEDVTT---EYVLVSDIARCCVPAAMIHRILDAREEA-SCIVPVLPVTDTLYLAQT------PLDRE 141
78777684   85 EGGQTRQQSLKNSLLHVDT---EYVLVSDVARSCIDEAFLKKIISHVGKS-DAVVPYLNITDTIVYDDK------TIDRE 154
152990344  72 KGADTRQQSLLNALEMVKT---PYVLVSDIARPCIQKEVVQKIIDNRSKA-ACIVPYIQPADTVVYKNE------TIDRN 141
154175122  71 TGGDTRQQSLKNALNLVSS---QFVLVSDIARPCITHELFSKIIEGSKQA-NCVVPALKIADTAYFGDE------VIDRD 140
154148625  73 KGGKLRQNSLANALKKVKS---EFVFVSDTARAEISKDLIGRLINECEKF-DCVSPFLGVVDTTYLGRN------QIDRN 142
157736397  73 KGGETRQLSILNSLQFVTT---KYVMITDVARACVPQSVIENLLNEKSSA-DCIVPILNVTDTVVYEND------TIDRS 142
296271785  73 LGGETRQESMTNALKSIDS---DYVMVTDVARTCVPKEVILNLISNKEKA-SCIVPVLNVSDTVIFKDE------TINRD 142
222148570 170 GLFAAQTPQSFHFAKIlaahedaASAGREDFTDDAAIAEWAGLTVHLVEGSPDNVKLTVKRDLEMADARLSHNAlpDVRT 249
118474192 141 ELKLIQTPQLSRTNMLk-----kALKTDNIFTDDSSAIKAIGGTVWYIEGDERAKKLTYKDDLKRLNLNSPSN---DIFC 212
224372395 139 EVKLIQTPQLSRTEILk-----kALDTDKLFTDERAAIEAMGGKIKYIEGSEESKKITYFKDLNLPCLTPPSK---NTLT 210
152992118 142 QVRIIQTPQLSVTKTLk-----qALQTDQLFTDDSSAVASMGKKVHFVEGSHEAHKLTTISDLKKLPCIEAPSG--KTLT 214
78777684  155 RVKRVQTPQLSLTTALk-----sALLREEEFTDESSAIVANGGSREFILGQESAHKITHIEDLKKLSCLSAPSS--DTLS 227
152990344 142 EVKLIQTPQLSSTDILr-----kALTQGKEFTDESSAIQALGEKVFYILGNRKQHKLTYKEDMKLLNCLQKPSA--TKRI 214
154175122 141 KIKLIQTPQLSKTNLLk-----qALETDTLYTDDSSAMRAVGASVWHVLGDERAHKITTKSDLAKIPCLIPPSN--EHFT 213
154148625 143 DLKLIQTPQISRANLLk-----kALESNEIFTDDSAAVAFAGGKLGFVEGDEKARKITFTSDLAHFDFTPASG---TIFT 214
157736397 143 NVKLIQTPQLSSTQVLr-----dALNTPIEFTDESSAIKAIDGKIKYIQGSTFSKKLTLGDELDELPCLKAPSN--NFFT 215
296271785 143 EVRLIQTPQLSNTKILk-----kALDTDTFFTDDSSAIKNIDEPIFYVKGSIESNKLTFQEDLKSNPCLEGPSN--NFFT 215
222148570 250 GNGYDVHQLVPGDGVTLCGIFIAHDQALSGHSDADVALHALTDALLATCGAGDIGDHFPPSDPQWRGAASRIFLEHAANI 329
118474192 213 GNGFDVHAFKEGDFITLCGVKIPYSKAFIAHSDGDVALHALCDALLGAASAPDIGELYPDNDSKFKDIDSKILLQNSVNL 292
224372395 211 GNGYDTHAFEENKNMILGGVEIDVPYGLKAHSDGDVVIHSLIDALLGAAGFGDIGEFFPDTDERYKGISSVELLKEVINT 290
152992118 215 GFGLDIHPFEEGKAMVLCGVKIAVDYGFKAHSDGDVAIHALIDALLGAAGMGDIGELYPDTDQSYAGANSTRLLSDTVRK 294
78777684  228 GVGFDVHAFDDKGEMFLGGIKIDSEYGFLAHSDGDVAIHALIDALLGAAGMGDIGMMFPDNDVKYKGADSKELLGTLVTK 307
152990344 215 GNGLDVHAFCEDRKLYLCGIEIPYDKGLAGHSDADVAIHALIDALLGAAGFGDIGELFPDSDETYKDIDSKKLLCETVRL 294
154175122 214 GIGFDAHEFERGRELWLCGEKIEYEFGLKAHSDGDVALHALTDAILGAAGLGDIGELFPDTDAEFKGISSLLLLQEAYKK 293
154148625 215 GNGFDVHAFAKGEFITLGGVKIPCEYSLVGHSDADAAIHALMDAILGACGLGDIGELFPDTDDSFKGIDSKILLQKVVNF 294
157736397 216 GTGFDIHAFEEIKDMYLGGVKLPYEYGFKAHSDGDVLIHSVIDALLGACGAGDIGEFFPDTDDKYKGIDSKLLLGQIVNF 295
296271785 216 GFGIDTHAFEKNKQMILGGIQIDSDIGFKAHSDGDVLIHSVIDALLGAIGAGDIGDFFPDTDNTYKNIDSKILLEKIVNF 295
222148570 330 VRDAGGTIMNADISLIAEAPKIGPHRQIMREKLSEILGIALERCSVKATTNEKIGFVGRGEGIAAIATATVVFQG 404
118474192 293 IRSIGFDIINADITIIAQSPKISPYKDAMAKIVADILGIPLHKVNIKATTTEHLGFIGRNEGIAANAIVNLKYFN 367
224372395 291 LTYKGYEIINADISIIAQKPKLKEYKTKIQRNLSKILN---AQVNIKATTNEKMGFIGRGEGIAVISTATLQYKD 362
152992118 295 IRTHGYTIGNVDMTILAQAPRLLPYKEKMKHSIASLLEIRPHLVNIKATTAEKLGFVGRKEGVTVHAVANLTYYN 369
78777684  308 LRHFGFVIVNVDITIAAEKPRIGNYKMAMRKKISSILGIDAQRVNIKATTTEKLGFIGRGEGVGVIANANLKYFD 382
152990344 295 LRACGFVIEHVDLTIVAQNPKIGPFKEKMKESLHDLLQIPYHLINLKATTTEHLGFVGRNEGIAAMATATLHYFD 369
154175122 294 VQSVGFELVNADITIMAERPKISKFKRKMEANIAGALNLAPNRINVKATTTEKLGFVGRGEGIAVIASANLKYYD 368
154148625 295 VHLLGFKIINADITIIAQKPKISPYKEKMCEILSEIL--QTSRVNVKASTTEKLGFVGRVEGVAAIASANLGYFD 367
157736397 296 INNVGYEIVNVDLTIIAQKPKINPFKDEIKKSMAKLLRIEKQFVNVKATTAEKLGFIGRAEGVAVQSIATLKYYN 370
296271785 296 VYNVGYEIINVDFTILAQKPKINPYKSQIKKSMAQLLNVNMQYVNVKATTSEELGFVGRSEGVTVHSVATLKYFD 370
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