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MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [ Ovis aries (sheep) ]

Gene ID: 101109020, updated on 10-Oct-2024

Summary

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Gene symbol
MTHFD1
Gene description
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
See related
EnsemblRapid:ENSOARG00020014712
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See MTHFD1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 7 NC_056060.1 (74627359..74690639)

Chromosome 7 - NC_056060.1Genomic Context describing neighboring genes Neighboring gene estrogen receptor 2 Neighboring gene U6 spliceosomal RNA Neighboring gene coiled-coil domain-containing protein 170-like Neighboring gene uncharacterized LOC132660067 Neighboring gene zinc finger and BTB domain-containing protein 25 Neighboring gene A-kinase anchoring protein 5 Neighboring gene uncharacterized LOC114115633 Neighboring gene small nucleolar RNA SNORD2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056060.1 Chromosome 7 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables formate-tetrahydrofolate ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methenyltetrahydrofolate cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
C-1-tetrahydrofolate synthase, cytoplasmic

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056060.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    74627359..74690639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_060418156.1 → XP_060274139.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X3

  2. XM_060418155.1 → XP_060274138.1  C-1-tetrahydrofolate synthase, cytoplasmic isoform X1

  3. XM_004010715.6 → XP_004010764.2  C-1-tetrahydrofolate synthase, cytoplasmic isoform X2

    UniProtKB/TrEMBL
    A0A6P3E7Y5, W5QJ32
    Related
    ENSOARP00020018667.2, ENSOART00020022522.2
    Conserved Domains (2) summary
    PLN02759
    Location:309 → 935
    PLN02759; Formate--tetrahydrofolate ligase
    COG0190
    Location:6 → 294
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

RNA

  1. XR_009601256.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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