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TPO thyroid peroxidase [ Trichechus manatus latirostris (Florida manatee) ]

Gene ID: 101356790, updated on 8-Mar-2024

Summary

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Gene symbol
TPO
Gene description
thyroid peroxidase
Gene type
protein coding
RefSeq status
MODEL
Organism
Trichechus manatus latirostris (sub-species: latirostris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Sirenia; Trichechidae; Trichechus
Orthologs
human mouse all
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Genomic context

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See TPO in Genome Data Viewer
Location:
chromosome: Un
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_01 current TriManLat1.0 (GCF_000243295.1) Unplaced Scaffold NW_004443959.1 (18893630..19008722, complement)

NW_004443959.1Genomic Context describing neighboring genes Neighboring gene peroxidasin Neighboring gene src substrate cortactin pseudogene Neighboring gene syntrophin gamma 2 Neighboring gene uncharacterized LOC111819981

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004443959 Unplaced Scaffold Reference TriManLat1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iodide peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in thyroid hormone generation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
thyroid peroxidase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000243295.1-RS_2024_01

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference TriManLat1.0 Primary Assembly

Genomic

  1. NW_004443959.1 Reference TriManLat1.0 Primary Assembly

    Range
    18893630..19008722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023728304.1 → XP_023584072.1  thyroid peroxidase isoform X2

    UniProtKB/TrEMBL
    A0A2Y9QPY8
    Conserved Domains (3) summary
    cd00033
    Location:754 → 807
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:179 → 746
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    smart00179
    Location:808 → 851
    EGF_CA; Calcium-binding EGF-like domain

  2. XM_012554564.2 → XP_012410018.2  thyroid peroxidase isoform X5

    UniProtKB/TrEMBL
    A0A2Y9FVI6
    Conserved Domains (3) summary
    cd00033
    Location:587 → 640
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00179
    Location:641 → 684
    EGF_CA; Calcium-binding EGF-like domain
    cl14561
    Location:19 → 579
    An_peroxidase_like; Animal heme peroxidases and related proteins

  3. XM_012554563.2 → XP_012410017.2  thyroid peroxidase isoform X4

    UniProtKB/TrEMBL
    A0A2Y9FVT1
    Conserved Domains (3) summary
    cd00033
    Location:703 → 756
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:185 → 695
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    smart00179
    Location:757 → 800
    EGF_CA; Calcium-binding EGF-like domain

  4. XM_012554562.2 → XP_012410016.2  thyroid peroxidase isoform X3

    UniProtKB/TrEMBL
    A0A2Y9FVJ5
    Conserved Domains (2) summary
    cd00033
    Location:760 → 813
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:185 → 752
    thyroid_peroxidase; Thyroid peroxidase (TPO)

  5. XM_004373091.2 → XP_004373148.2  thyroid peroxidase isoform X1

    UniProtKB/TrEMBL
    A0A2Y9DEJ8
    Conserved Domains (3) summary
    cd00033
    Location:760 → 813
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:185 → 752
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    smart00179
    Location:814 → 857
    EGF_CA; Calcium-binding EGF-like domain
Nucleotide Protein
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