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mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [ Poecilia formosa (Amazon molly) ]

Gene ID: 103151860, updated on 11-Mar-2024

Summary

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Gene symbol
mthfd2
Gene description
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
See related
Ensembl:ENSPFOG00000010913
Gene type
protein coding
RefSeq status
MODEL
Organism
Poecilia formosa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae; Poecilia
Orthologs
human zebrafish all
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Genomic context

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See mthfd2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Poecilia_formosa-5.1.2 (GCF_000485575.1) Unplaced Scaffold NW_006800234.1 (498198..503619)

NW_006800234.1Genomic Context describing neighboring genes Neighboring gene MOB kinase activator 1A Neighboring gene TRAF-type zinc finger domain containing 1 Neighboring gene membrane-associated phosphatidylinositol transfer protein 2-like Neighboring gene ADP-ribosylation factor-like 6 interacting protein 4 Neighboring gene N-lysine methyltransferase KMT5A-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006800234.1 Unplaced Scaffold Reference Poecilia_formosa-5.1.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables methenyltetrahydrofolate cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Names
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, met

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Poecilia formosa Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Poecilia_formosa-5.1.2

Genomic

  1. NW_006800234.1 Reference Poecilia_formosa-5.1.2

    Range
    498198..503619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007572116.2 → XP_007572178.1  bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

    UniProtKB/TrEMBL
    A0A087XYS1
    Related
    ENSPFOP00000010924.2, ENSPFOT00000010940.1
    Conserved Domains (3) summary
    cd01080
    Location:143 → 322
    NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    COG0190
    Location:32 → 322
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:32 → 148
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Nucleotide Protein
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