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tdc-1 Tyrosine decarboxylase [ Caenorhabditis elegans ]

Gene ID: 174327, updated on 2-Nov-2024

Summary

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Official Symbol
tdc-1
Official Full Name
Tyrosine decarboxylase
Primary source
WormBase:WBGene00006562
Locus tag
CELE_K01C8.3
See related
AllianceGenome:WB:WBGene00006562
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables tyrosine decarboxylase activity. Involved in octopamine biosynthetic process. Located in axon and neuronal cell body. Is expressed in hermaphrodite gonad and neurons. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tdc-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
10
Sequence:
Chromosome: II; NC_003280.10 (8270597..8273615)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene L-serine deaminase Neighboring gene CC domain-containing protein Neighboring gene ncRNA Neighboring gene GEX Interacting protein Neighboring gene Mitochondrial folate transporter/carrier Neighboring gene Large ribosomal subunit protein uL10m Neighboring gene C-type lectin domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG). Globisch D, et al. Bioorg Med Chem Lett, 2017 Aug 1. PMID 28600214, Free PMC Article
  2. A Change in the Ion Selectivity of Ligand-Gated Ion Channels Provides a Mechanism to Switch Behavior. Pirri JK, et al. PLoS Biol, 2015. PMID 26348462, Free PMC Article
  3. Nested Neuronal Dynamics Orchestrate a Behavioral Hierarchy across Timescales. Kaplan HS, et al. Neuron, 2020 Feb 5. PMID 31786012, Free PMC Article
  4. Memory in Caenorhabditis elegans is mediated by NMDA-type ionotropic glutamate receptors. Kano T, et al. Curr Biol, 2008 Jul 8. PMID 18583134, Free PMC Article
  5. A tyramine-gated chloride channel coordinates distinct motor programs of a Caenorhabditis elegans escape response. Pirri JK, et al. Neuron, 2009 May 28. PMID 19477154, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carbon-carbon lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxy-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables tyrosine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables tyrosine decarboxylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in octopamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tyrosine decarboxylase
NP_495743.1
  • Confirmed by transcript evidence
NP_495744.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8270597..8273615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063343.4 → NP_495744.1  Tyrosine decarboxylase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495744.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95ZS2
    Conserved Domains (1) summary
    pfam00282
    Location:111 → 489
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  2. NM_063342.6 → NP_495743.1  Tyrosine decarboxylase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495743.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21087, Q95ZS2
    Conserved Domains (1) summary
    pfam00282
    Location:111 → 489
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95ZS2.1

Gene LinkOut

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