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Hey Hairy/E(spl)-related with YRPW motif [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35764, updated on 2-Nov-2024

Summary

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Official Symbol
Heyprovided by FlyBase
Official Full Name
Hairy/E(spl)-related with YRPW motifprovided by FlyBase
Primary source
FLYBASE:FBgn0027788
Locus tag
Dmel_CG11194
See related
AllianceGenome:FB:FBgn0027788
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bHLHe44; CG11194; d-hey; dHey; Dmel\CG11194; hesr-1; Hesr-1; hey; HEY
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron fate determination. Located in nucleus. Is expressed in several structures, including embryonic thoracic segment; ganglia; larval CNS neuron; larval optic anlage; and presumptive embryonic/larval system. Orthologous to several human genes including HEY1 (hes related family bHLH transcription factor with YRPW motif 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See Hey in Genome Data Viewer
Location:
44A2-44A2; 2-58 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7995438..7998278, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3882943..3885783, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44272 Neighboring gene Dicarboxylate carrier 3 Neighboring gene uncharacterized protein Neighboring gene Ornithine decarboxylase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS. Mark B, et al. Elife, 2021 May 11. PMID 33973523, Free PMC Article
  2. Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split. Kokubo H, et al. Biochem Biophys Res Commun, 1999 Jul 5. PMID 10403790
  3. Expression of Hey marks a subset of enteroendocrine cells in the Drosophila embryonic and larval midgut. Skafida E, et al. Int J Dev Biol, 2022. PMID 34881798
  4. hnRNP K: one protein multiple processes. Bomsztyk K, et al. Bioessays, 2004 Jun. PMID 15170860
  5. Notch signaling and Bsh homeodomain activity are integrated to diversify Drosophila lamina neuron types. Xu C, et al. Elife, 2024 Jan 9. PMID 38193901, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Hairy/E(spl)-related with YRPW motif
Names
CG11194-PA
Hairy/E(spl)
Hairy/E(spl) related with YRPW motif
Hairy/E(spl)-related
Hey-PA
hairy and enhancer of split related protein
hairy and enhancer of split related-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7995438..7998278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078933.3 → NP_523657.1  Hairy/E(spl)-related with YRPW motif [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523657.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q058S4, Q7KM13
    Related
    FBpp0087945
    Conserved Domains (2) summary
    smart00511
    Location:172 → 218
    ORANGE; Orange domain
    cd00083
    Location:100 → 156
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KM13.1 Q7KM13

Gene LinkOut

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