igf2bp3.S insulin like growth factor 2 mRNA binding protein 3 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: igf2bp3.S
Official Full Name: insulin like growth factor 2 mRNA binding protein 3 S homeolog
Primary source: Xenbase:XB-GENE-6255198
Locus tag: XELAEV_18000039mg
See related: EnsemblRapid:ENSXLAG00005003777 AllianceGenome:Xenbase:XB-GENE-6255198
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: B3; IMP; imp3; vera; comp37; vg1rbp; vickz3; Vg1-RBP; igf2bp3; vickz3-b; igf2bp3-a; igf2bp3-b
Summary: Predicted to enable mRNA 3'-UTR binding activity. Predicted to act upstream of or within mRNA transport; nervous system development; and regulation of translation. Predicted to be located in cytosol; endoplasmic reticulum; and nucleus. Orthologous to human IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 6S

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6S	NC_054382.1 (32802290..32886927, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (87476190..87482776)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694895.1 (121354..221333, complement)

Chromosome 6S - NC_054382.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor 2 mRNA-binding protein 3-B

Names: 69 kDa RNA-binding protein B; B3.65 protein B; IGF-II mRNA-binding protein 3-B; IGF2 mRNA-binding protein 3-B; IMP-3-B; KH domain-containing transcription factor B3; KH domain-containing transcription factor B3-B; RNA-binding protein Vera-B; VICKZ family member 3-B; VLE-binding protein B; Vg1 RBP; insulin-like growth factor 2 mRNA binding protein 3; trans-acting factor B3-B; vg1 RBP-B; vg1 RNA-binding protein B; vg1 localization element binding protein B; vgLE-binding and ER association protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001086463.2 → NP_001079932.1 insulin-like growth factor 2 mRNA-binding protein 3-B

See identical proteins and their annotated locations for NP_001079932.1

Status: VALIDATED

Source sequence(s)

BC057700

UniProtKB/Swiss-Prot

O57526

UniProtKB/TrEMBL

A0A974BQY7

Related

ENSXLAP00005011280.1, ENSXLAT00005011454.1

Conserved Domains (3) summary

cd00105
Location:207 → 270

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd12627
Location:1 → 77

RRM1_IGF2BP3; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

cd12630
Location:81 → 156

RRM2_IGF2BP3; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

32802290..32886927 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041567076.1 → XP_041423010.1 insulin-like growth factor 2 mRNA-binding protein 3-B isoform X3

UniProtKB/TrEMBL

A0A8J1L0D0

Conserved Domains (4) summary

smart00322
Location:181 → 253

KH; K homology RNA-binding domain

smart00360
Location:82 → 134

RRM; RNA recognition motif

PRK12705
Location:127 → 274

PRK12705; hypothetical protein; Provisional

cl17169
Location:1 → 77

RRM_SF; RNA recognition motif (RRM) superfamily
XM_041567074.1 → XP_041423008.1 insulin-like growth factor 2 mRNA-binding protein 3-B isoform X1

UniProtKB/TrEMBL

A0A8J1L1X6

Conserved Domains (3) summary

smart00322
Location:203 → 273

KH; K homology RNA-binding domain

smart00360
Location:82 → 151

RRM; RNA recognition motif

cl17169
Location:1 → 77

RRM_SF; RNA recognition motif (RRM) superfamily
XM_041567077.1 → XP_041423011.1 insulin-like growth factor 2 mRNA-binding protein 3-B isoform X4

UniProtKB/TrEMBL

A0A8J1L0D1

Conserved Domains (1) summary

smart00322
Location:46 → 116

KH; K homology RNA-binding domain
XM_041567075.1 → XP_041423009.1 insulin-like growth factor 2 mRNA-binding protein 3-B isoform X2

UniProtKB/TrEMBL

A0A8J1L356

Related

ENSXLAP00005011286.1, ENSXLAT00005011460.1

Conserved Domains (3) summary

smart00322
Location:188 → 258

KH; K homology RNA-binding domain

smart00360
Location:67 → 136

RRM; RNA recognition motif

cl17169
Location:45 → 62

RRM_SF; RNA recognition motif (RRM) superfamily